XCR1

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]

Description

X-C motif chemokine receptor 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

3 (46017007 - 46027487)

Ensembl ID

ENSG00000173578  (ver. 103.38)

Orthologs

Mouse Xcr1: ENSMUSG00000060509

UniProt

P46094

neXtProt

NX_P46094

Human splice variants
Mouse splice variants

Protein structure