CABT-B10144

antibody from Creative Diagnostics
Targeting: DUSP3 VHR
Provider product page for CABT-B10144
Western blot
ELISA
Immunocytochemistry

Antibody data

Product number
CABT-B10144 - Provider product page
Provider
Creative Diagnostics
Product name
Mouse anti-Human DUSP3 monoclonal antibody, clone 6C8
Antibody type
Monoclonal
Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
6C8
Vial size
50 _g
Storage
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
DUSP3 protein structure - CABT-B10144 shown in red.