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LearnFAB151P-025
antibody from R&D Systems
Targeting: CCR2
CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB151P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CCR2 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human CCR-2 transfectants but not the parental cell line or CCR-5 transfectants.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
NP_001116868- Isotype
- IgG
- Antibody clone number
- 48607
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering.
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells.
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis.
Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue: ROLE OF ILE198.
Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes.
CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD.
IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1.
Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10.
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities.
Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction.
Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions.
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques.
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces.
Armas-González E, Domínguez-Luis MJ, Díaz-Martín A, Arce-Franco M, Castro-Hernández J, Danelon G, Hernández-Hernández V, Bustabad-Reyes S, Cantabrana A, Uguccioni M, Díaz-González F
Arthritis research & therapy 2018 Jun 7;20(1):114
Arthritis research & therapy 2018 Jun 7;20(1):114
Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering.
Monsuur HN, Weijers EM, Niessen FB, Gefen A, Koolwijk P, Gibbs S, van den Broek LJ
PloS one 2016;11(11):e0167056
PloS one 2016;11(11):e0167056
Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells.
Faivre V, Lukaszewicz AC, Payen D
PloS one 2016;11(11):e0164489
PloS one 2016;11(11):e0164489
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis.
Walscheid K, Weinhage T, Foell D, Heinz C, Kasper M, Heiligenhaus A
Clinical immunology (Orlando, Fla.) 2016 Oct 28;
Clinical immunology (Orlando, Fla.) 2016 Oct 28;
Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue: ROLE OF ILE198.
Lau G, Labrecque J, Metz M, Vaz R, Fricker SP
The Journal of biological chemistry 2015 Apr 24;290(17):11041-51
The Journal of biological chemistry 2015 Apr 24;290(17):11041-51
Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes.
Carvallo L, Lopez L, Che FY, Lim J, Eugenin EA, Williams DW, Nieves E, Calderon TM, Madrid-Aliste C, Fiser A, Weiss L, Angeletti RH, Berman JW
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3246-58
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3246-58
CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD.
Falk MK, Singh A, Faber C, Nissen MH, Hviid T, Sørensen TL
PloS one 2014;9(12):e112473
PloS one 2014;9(12):e112473
IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I
Journal of immunology (Baltimore, Md. : 1950) 2014 Mar 15;192(6):2634-42
Journal of immunology (Baltimore, Md. : 1950) 2014 Mar 15;192(6):2634-42
Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1.
Bednar F, Song C, Bardi G, Cornwell W, Rogers TJ
Journal of immunology (Baltimore, Md. : 1950) 2014 Jun 1;192(11):5305-13
Journal of immunology (Baltimore, Md. : 1950) 2014 Jun 1;192(11):5305-13
Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10.
Vujanovic L, Ballard W, Thorne SH, Vujanovic NL, Butterfield LH
Oncoimmunology 2012 Jul 1;1(4):448-457
Oncoimmunology 2012 Jul 1;1(4):448-457
Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
Badr G, Lefevre EA, Mohany M
PloS one 2011;6(9):e23741
PloS one 2011;6(9):e23741
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Röhrl J, Yang D, Oppenheim JJ, Hehlgans T
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6688-94
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6688-94
CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
Carbone T, Nasorri F, Pennino D, Eyerich K, Foerster S, Cifaldi L, Traidl-Hoffman C, Behrendt H, Cavani A
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):1102-10
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):1102-10
The lupane-type triterpene 30-oxo-calenduladiol is a CCR5 antagonist with anti-HIV-1 and anti-chemotactic activities.
Barroso-González J, El Jaber-Vazdekis N, García-Expósito L, Machado JD, Zárate R, Ravelo AG, Estévez-Braun A, Valenzuela-Fernández A
The Journal of biological chemistry 2009 Jun 12;284(24):16609-20
The Journal of biological chemistry 2009 Jun 12;284(24):16609-20
Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction.
Tsujioka H, Imanishi T, Ikejima H, Kuroi A, Takarada S, Tanimoto T, Kitabata H, Okochi K, Arita Y, Ishibashi K, Komukai K, Kataiwa H, Nakamura N, Hirata K, Tanaka A, Akasaka T
Journal of the American College of Cardiology 2009 Jul 7;54(2):130-8
Journal of the American College of Cardiology 2009 Jul 7;54(2):130-8
Expression of CXC and CC type of chemokines and its receptors in tuberculous and non-tuberculous effusions.
Pokkali S, Das SD, R L
Cytokine 2008 Mar;41(3):307-14
Cytokine 2008 Mar;41(3):307-14
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8053-67
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8053-67
Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
Journal of neuroimmunology 2008 Aug 13;199(1-2):35-45
Journal of neuroimmunology 2008 Aug 13;199(1-2):35-45
Bleomycin treatment causes enhancement of virus replication in the lungs of SHIV-infected macaques.
Dhillon NK, Pinson D, Dhillon S, Tawfik O, Danley M, Davis M, Nemon O, Mayo M, Kumar A, Tsai YJ, Kumar A, Buch S
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1233-40
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1233-40
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ
Blood 2007 Apr 1;109(7):2936-43
Blood 2007 Apr 1;109(7):2936-43
Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK
International journal of cancer 2006 May 1;118(9):2147-57
International journal of cancer 2006 May 1;118(9):2147-57
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
Blood 2005 Feb 1;105(3):931-9
Blood 2005 Feb 1;105(3):931-9
CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
Gessler P, Pretre R, Hohl V, Rousson V, Fischer J, Dahinden C
Shock (Augusta, Ga.) 2004 Dec;22(6):513-20
Shock (Augusta, Ga.) 2004 Dec;22(6):513-20
Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
Liu LY, Jarjour NN, Busse WW, Kelly EA
The Journal of allergy and clinical immunology 2003 Sep;112(3):556-62
The Journal of allergy and clinical immunology 2003 Sep;112(3):556-62
Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
Journal of leukocyte biology 2003 May;73(5):584-90
Journal of leukocyte biology 2003 May;73(5):584-90
Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces.
Vanbervliet B, Homey B, Durand I, Massacrier C, Aït-Yahia S, de Bouteiller O, Vicari A, Caux C
European journal of immunology 2002 Jan;32(1):231-42
European journal of immunology 2002 Jan;32(1):231-42
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 APC-conjugated Monoclonal Antibody (Catalog # FAB3832A) and either (A) Mouse Anti-Human CCR2 PE-conjugated Monoclonal Antibody (Catalog # FAB151P) or (B) Mouse IgG2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.
