335303

antibody from BioLegend
Targeting: CCR2 CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R
Provider product page for 335303
Flow cytometry

Antibody data

Product number
335303 - Provider product page
Provider
BioLegend
Product name
PerCP/Cy5.5 anti-human CD192 (CCR2)
Antibody type
Monoclonal
Antigen
CCR2 transfectants
Description
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails (1). Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 has been associated to atheroscletotic plaques (2, 3). MCP-1 is induced by modified-LDL in endothelial cells, and may trigger firm adhesion of monocytes to vascular endothelium under flow. Local overexpression of MCP-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion (4). Absence of MCP-1 reduces the lesion size in MCP-1−/− apoE−/− mice in the apoE gene deleted mouse atherosclerosis model (5, 6). Obesity induces an inflammation state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation (7).
Reactivity
Human
Host
Mouse
Conjugate
Far-Red dye
Isotype
IgG
Vial size
25 tests
Storage
The CD192 antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
CCR2 protein structure - 335303 shown in red.