Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 321402 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-human CD195 (CCR5)
- Antibody type
- Monoclonal
- Antigen
- RBL-CCR5 cells
- Description
- CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. It binds to MIP-1α, MIP-1β, and RANTES and is expressed on a subset of T cells and monocytes. CD195 mediates an intracellular signal thought to induce differentiation and proliferation. CCR5 has also been shown to act as a co-receptor for R5 HIV-1 cell entry; modification of CCR5 by sulfation contributes to the efficiency of HIV-1 entry. The T21/8 monoclonal antibody has high affinity to CCR5 N-terminal epitope (Met1-Lys22) and is useful for flow cytometric analysis, immunoprecipitation, immunofluorescence microscopy, and ELISA assay of CCR5 expression.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5.
Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K
The Journal of biological chemistry 2007 Dec 21;282(51):36923-32
The Journal of biological chemistry 2007 Dec 21;282(51):36923-32
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified T21/8, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated