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LearnAb169252
antibody from Aladdin Scientific Corporation
Targeting: CCR5
CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
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- Antigen structure
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- Product number
- Ab169252 - Provider product page
- Provider
- Aladdin Scientific Corporation
- Product name
- Leronlimab (anti-CCR5)
- Antibody type
- Recombinant
- Description
- Product Description：Leronlimab (anti-CCR5) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.In vitroLeronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca2+ signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.In vivoIn xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis. Purity>95% (SDS-PAGE&SEC)Endotoxin Level< 1.0EU/mg
- Reactivity
- Human
- Conjugate
- Unconjugated
- Vial size
- 10mg,1mg,5mg
- Concentration
- Lot by Lot
- Storage
- Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
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