NOB1

In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]). [supplied by OMIM, Nov 2010]

Description

NIN1 (RPN12) binding protein 1 homolog

Tissue specificity

Low tissue specificity

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (69741871 - 69754926)

Ensembl ID

ENSG00000141101  (ver. 103.38)

Orthologs

Mouse Nob1: ENSMUSG00000003848

UniProt

Q9ULX3

neXtProt

NX_Q9ULX3

Human splice variants
Mouse splice variants

Protein structure