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LearnNB100-132
antibody from Novus Biologicals
Targeting: EPAS1
bHLHe73, HIF2A, HLF, MOP2, PASD2
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [173]
- Comments [0]
- Validations
- Western blot [9]
- Immunohistochemistry [4]
- Flow cytometry [1]
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- Product number
- NB100-132 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-132, RRID:AB_10000898
- Product name
- Mouse Monoclonal HIF-2 alpha/EPAS1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. This HIF-2 alpha/EPAS1 Antibody (ep190b) is specific for HIF-2 alpha/EPAS1, and does not cross-react with HIF-1 alpha.
- Reactivity
- Human, Mouse, Rat, Bovine, Hamster
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Expression of HIF-2a in clear-cell renal cell carcinoma independently predicts overall survival.
ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma.
USP37 promotes deubiquitination of HIF2α in kidney cancer.
c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells.
Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells.
The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression.
Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor.
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer.
MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells.
Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism.
Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis.
HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts.
Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells.
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas.
Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma.
The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations.
Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells.
Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells.
Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer.
Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency.
Opposite prognostic roles of HIF1α and HIF2α expressions in bone metastatic clear cell renal cell cancer.
HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy.
An ID2-dependent mechanism for VHL inactivation in cancer.
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype.
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5.
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness.
The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.
Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
Development of a novel interferon-α2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro.
An acetate switch regulates stress erythropoiesis.
Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution.
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.
Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male.
Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness.
NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2α.
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model.
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
The contributions of HIF-target genes to tumor growth in RCC.
CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration.
Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme.
Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells.
The role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells.
PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway.
Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90.
Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration.
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.
HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs.
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.
The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
CD24 is an effector of HIF-1-driven primary tumor growth and metastasis.
Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities.
Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.
Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy.
HIF-2α expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1α is repressed.
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
Expression and stability of hypoxia inducible factor 1α in osteosarcoma.
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells.
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice.
The von Hippel–Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.
Oxygen regulation of the epithelial Na channel in the collecting duct.
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.
EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling.
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Ligand migration through the internal hydrophobic cavities in human neuroglobin.
Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment.
Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.
Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.
Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.
Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization.
Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha.
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor.
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
AMP-activated protein kinase is essential for survival in chronic hypoxia.
Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours.
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.
HIF gene expression in cancer therapy.
Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function.
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.
Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.
Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine.
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein.
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Oxygen-regulated gene expression in bovine blastocysts.
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment.
HIF activation by pH-dependent nucleolar sequestration of VHL.
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations.
Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors.
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
von Hippel-Lindau protein complex is regulated by cell density.
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Gkagkalidis K, Kampantais S, Dimitriadis G, Gourvas V, Kapoukranidou D, Mironidou-Tzouveleki M
Medical molecular morphology 2020 Mar 26;
Medical molecular morphology 2020 Mar 26;
ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma.
Persson CU, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, Mohlin S
Experimental cell research 2020 Mar 15;388(2):111845
Experimental cell research 2020 Mar 15;388(2):111845
USP37 promotes deubiquitination of HIF2α in kidney cancer.
Hong K, Hu L, Liu X, Simon JM, Ptacek TS, Zheng X, Liao C, Baldwin AS, Zhang Q
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 9;117(23):13023-13032
Proceedings of the National Academy of Sciences of the United States of America 2020 Jun 9;117(23):13023-13032
c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells.
Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E
Cells 2020 Feb 11;9(2)
Cells 2020 Feb 11;9(2)
Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells.
Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, Wei K, Li F, Lv J, Xie J, Liu Y, Huang B
Oncogene 2019 Oct;38(44):6970-6984
Oncogene 2019 Oct;38(44):6970-6984
The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments.
Knowles HJ
Cells 2019 Jun 21;8(6)
Cells 2019 Jun 21;8(6)
Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression.
Krueger K, Catanese L, Sciesielski LK, Kirschner KM, Scholz H
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):71-83
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Jan;1862(1):71-83
Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor.
Han JS, Lee JH, Kong J, Ji Y, Kim J, Choe SS, Kim JB
Molecular and cellular biology 2019 Jan 15;39(2)
Molecular and cellular biology 2019 Jan 15;39(2)
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, Wei Z, Xie X, Yin B, Chen F, Luo S, Liu H, Wang J, Jiang K, Gong F, Tang ZH, Cheng X, Li H, Li Z, Laurence A, Wang G, Yang XP
The Journal of clinical investigation 2019 Feb 1;129(2):631-646
The Journal of clinical investigation 2019 Feb 1;129(2):631-646
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer.
Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, Rotili D, Strigari L, Pinto F, Bassi PF, Mai A, Grassi C, Pontecorvi A, Falcioni R, Farsetti A, Nanni S
International journal of molecular sciences 2019 Aug 17;20(16)
International journal of molecular sciences 2019 Aug 17;20(16)
MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells.
Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, Talukdar J, Sandhya S, Bhuyan S, Gogoi G, Gouw AM, Baishya D, Gotlib JR, Kataki AC, Felsher DW
Cancer research 2019 Aug 15;79(16):4015-4025
Cancer research 2019 Aug 15;79(16):4015-4025
Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism.
Duan LJ, Fong GH
Development (Cambridge, England) 2019 Apr 17;146(8)
Development (Cambridge, England) 2019 Apr 17;146(8)
Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis.
Moreno Roig E, Yaromina A, Houben R, Groot AJ, Dubois L, Vooijs M
Frontiers in oncology 2018;8:224
Frontiers in oncology 2018;8:224
HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts.
Sasagawa T, Nagamatsu T, Morita K, Mimura N, Iriyama T, Fujii T, Shibuya M
Scientific reports 2018 Nov 26;8(1):17375
Scientific reports 2018 Nov 26;8(1):17375
Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma.
Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, Ding Y, Yin J, Wang L, Zhang H, Yu Y, Hou J, Thompson TC, Cao G
Chinese journal of cancer 2018 Jan 22;37(1):2
Chinese journal of cancer 2018 Jan 22;37(1):2
Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C.
Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, Chen Q, Li J, Gao X
Stem cell research & therapy 2018 Feb 26;9(1):47
Stem cell research & therapy 2018 Feb 26;9(1):47
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells.
Chen R, Xu M, Nagati J, Garcia JA
PloS one 2017;12(12):e0190241
PloS one 2017;12(12):e0190241
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR
The Journal of clinical investigation 2017 Sep 1;127(9):3407-3420
The Journal of clinical investigation 2017 Sep 1;127(9):3407-3420
Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas.
Carew JS, Espitia CM, Zhao W, Mita MM, Mita AC, Nawrocki ST
Oncotarget 2017 Oct 17;8(49):86769-86783
Oncotarget 2017 Oct 17;8(49):86769-86783
Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma.
Liu W, Chen H, Wong N, Haynes W, Baker CM, Wang X
Cancer letters 2017 May 28;394:65-75
Cancer letters 2017 May 28;394:65-75
The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations.
Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M
Oncogene 2017 May 18;36(20):2824-2834
Oncogene 2017 May 18;36(20):2824-2834
Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells.
Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, Yamashita T, Bando H, Hara H, Ohneda O
Cancer science 2017 Mar;108(3):362-372
Cancer science 2017 Mar;108(3):362-372
Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells.
Padró M, Louie RJ, Lananna BV, Krieg AJ, Timmerman LA, Chan DA
BMC cancer 2017 Mar 20;17(1):203
BMC cancer 2017 Mar 20;17(1):203
Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
Espana-Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson DA, Adams DJ, Matakidou A
PloS one 2016;11(2):e0148055
PloS one 2016;11(2):e0148055
Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer.
Leszczynska KB, Dobrynin G, Leslie RE, Ient J, Boumelha AJ, Senra JM, Hawkins MA, Maughan T, Mukherjee S, Hammond EM
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2016 Nov;121(2):232-238
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2016 Nov;121(2):232-238
Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency.
Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dötsch J, Nüsken KD
Endocrinology 2016 May;157(5):1813-25
Endocrinology 2016 May;157(5):1813-25
Opposite prognostic roles of HIF1α and HIF2α expressions in bone metastatic clear cell renal cell cancer.
Szendrői A, Szász AM, Kardos M, Tőkés AM, Idan R, Szűcs M, Kulka J, Nyirády P, Szendrői M, Szállási Z, Győrffy B, Tímár J
Oncotarget 2016 Jul 5;7(27):42086-42098
Oncotarget 2016 Jul 5;7(27):42086-42098
HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy.
Kwak JH, Lee NH, Lee HY, Hong IS, Nam JS
Oncotarget 2016 Jul 12;7(28):43518-43533
Oncotarget 2016 Jul 12;7(28):43518-43533
An ID2-dependent mechanism for VHL inactivation in cancer.
Lee SB, Frattini V, Bansal M, Castano AM, Sherman D, Hutchinson K, Bruce JN, Califano A, Liu G, Cardozo T, Iavarone A, Lasorella A
Nature 2016 Jan 14;529(7585):172-7
Nature 2016 Jan 14;529(7585):172-7
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Kim Y, Nam HJ, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H, Koh GY, Baek SH
Nature communications 2016 Jan 13;7:10347
Nature communications 2016 Jan 13;7:10347
Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype.
Seidl CI, Martinez-Sanchez A, Murphy CL
Arthritis & rheumatology (Hoboken, N.J.) 2016 Feb;68(2):398-409
Arthritis & rheumatology (Hoboken, N.J.) 2016 Feb;68(2):398-409
Oxygen concentration controls epigenetic effects in models of familial paraganglioma.
Her YF, Nelson-Holte M, Maher LJ 3rd
PloS one 2015;10(5):e0127471
PloS one 2015;10(5):e0127471
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.
Påhlman S, Lund LR, Jögi A
PloS one 2015;10(5):e0125771
PloS one 2015;10(5):e0125771
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
Chen R, Xu M, Nagati JS, Hogg RT, Das A, Gerard RD, Garcia JA
PloS one 2015;10(2):e0116515
PloS one 2015;10(2):e0116515
Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5.
Chen T, Zhou G, Zhou Q, Tang H, Ibe JC, Cheng H, Gou D, Chen J, Yuan JX, Raj JU
American journal of respiratory and critical care medicine 2015 Mar 15;191(6):678-92
American journal of respiratory and critical care medicine 2015 Mar 15;191(6):678-92
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
Espana-Agusti J, Tuveson DA, Adams DJ, Matakidou A
Scientific reports 2015 Jun 5;5:11061
Scientific reports 2015 Jun 5;5:11061
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC
The Journal of investigative dermatology 2015 Feb;135(2):454-461
The Journal of investigative dermatology 2015 Feb;135(2):454-461
The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness.
Su J, Li Z, Cui S, Ji L, Geng H, Chai K, Ma X, Bai Z, Yang Y, Wuren T, Ge RL, Rondina MT
High altitude medicine & biology 2015 Dec;16(4):318-30
High altitude medicine & biology 2015 Dec;16(4):318-30
The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.
Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S
PloS one 2014;9(5):e97938
PloS one 2014;9(5):e97938
Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.
Duan LJ, Takeda K, Fong GH
PloS one 2014;9(1):e84736
PloS one 2014;9(1):e84736
Development of a novel interferon-α2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro.
Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka-Kondoh S, Hiraoka M, Shinojima T, Suzuki K, Oya M
International journal of clinical oncology 2014;19(3):497-504
International journal of clinical oncology 2014;19(3):497-504
An acetate switch regulates stress erythropoiesis.
Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA
Nature medicine 2014 Sep;20(9):1018-26
Nature medicine 2014 Sep;20(9):1018-26
Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution.
Evans CE, Wadoodi A, Humphries J, Lu X, Grover SP, Saha P, Smith A
Thrombosis research 2014 Sep;134(3):757-60
Thrombosis research 2014 Sep;134(3):757-60
Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats.
Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR
The Journal of physiology 2014 Sep 1;592(17):3841-58
The Journal of physiology 2014 Sep 1;592(17):3841-58
Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma.
Motzer RJ, Hutson TE, Hudes GR, Figlin RA, Martini JF, English PA, Huang X, Valota O, Williams JA
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
Cancer chemotherapy and pharmacology 2014 Oct;74(4):739-50
HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S
European journal of clinical investigation 2014 Oct;44(10):989-99
European journal of clinical investigation 2014 Oct;44(10):989-99
Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male.
Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, Komada Y
Pediatrics 2014 Jun;133(6):e1787-91
Pediatrics 2014 Jun;133(6):e1787-91
Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness.
Raspaglio G, Petrillo M, Martinelli E, Li Puma DD, Mariani M, De Donato M, Filippetti F, Mozzetti S, Prislei S, Zannoni GF, Scambia G, Ferlini C
Gene 2014 Jun 1;542(2):173-81
Gene 2014 Jun 1;542(2):173-81
NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2α.
Gregg JL, Turner RM 2nd, Chang G, Joshi D, Zhan Y, Chen L, Maranchie JK
Cancer research 2014 Jul 1;74(13):3501-3511
Cancer research 2014 Jul 1;74(13):3501-3511
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.
Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR
Blood 2014 Jan 16;123(3):366-76
Blood 2014 Jan 16;123(3):366-76
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Duan LJ, Takeda K, Fong GH
The American journal of pathology 2014 Apr;184(4):1240-1250
The American journal of pathology 2014 Apr;184(4):1240-1250
Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model.
Bruells CS, Maes K, Rossaint R, Thomas D, Cielen N, Bleilevens C, Bergs I, Loetscher U, Dreier A, Gayan-Ramirez G, Behnke BJ, Weis J
PloS one 2013;8(8):e70524
PloS one 2013;8(8):e70524
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M
PloS one 2013;8(7):e66987
PloS one 2013;8(7):e66987
Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
Adamski J, Price A, Dive C, Makin G
PloS one 2013;8(6):e65304
PloS one 2013;8(6):e65304
The contributions of HIF-target genes to tumor growth in RCC.
Zhang T, Niu X, Liao L, Cho EA, Yang H
PloS one 2013;8(11):e80544
PloS one 2013;8(11):e80544
CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration.
Tsang WP, Shu Y, Kwok PL, Zhang F, Lee KK, Tang MK, Li G, Chan KM, Chan WY, Wan C
PloS one 2013;8(10):e76153
PloS one 2013;8(10):e76153
Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme.
Jamil S, Cedervall J, Hultman I, Ali R, Margaryan NV, Rasmuson A, Johnsen JI, Sveinbjörnsson B, Dalianis T, Kanter L, Orrego A, Strizzi L, Hendrix MJ, Sandstedt B, Kogner P, Ahrlund-Richter L
International journal of oncology 2013 Sep;43(3):831-8
International journal of oncology 2013 Sep;43(3):831-8
Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells.
Park YK, Park B, Lee S, Choi K, Moon Y, Park H
The Journal of biological chemistry 2013 Sep 6;288(36):26311-22
The Journal of biological chemistry 2013 Sep 6;288(36):26311-22
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, Ehrmann A, Summer H, Flamme I, Oehme F, Thierauch K, Michels M, Hess-Stumpp H, Ziegelbauer K
Cancer medicine 2013 Oct;2(5):611-24
Cancer medicine 2013 Oct;2(5):611-24
Concerted inhibition of HIF-1α and -2α expression markedly suppresses angiogenesis in cultured RPE cells.
Nakajima T, Nakajima E, Shearer TR, Azuma M
Molecular and cellular biochemistry 2013 Nov;383(1-2):113-22
Molecular and cellular biochemistry 2013 Nov;383(1-2):113-22
The role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Jeong CW, Yoon CY, Jeong SJ, Hong SK, Byun SS, Kwak C, Lee SE
Urologic oncology 2013 Nov;31(8):1448-56
Urologic oncology 2013 Nov;31(8):1448-56
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells.
David JM, Owens TA, Barwe SP, Rajasekaran AK
Molecular cancer therapeutics 2013 Nov;12(11):2296-307
Molecular cancer therapeutics 2013 Nov;12(11):2296-307
PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G
Molecular cancer research : MCR 2013 Nov;11(11):1337-48
Molecular cancer research : MCR 2013 Nov;11(11):1337-48
Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway.
Sun HX, Xu Y, Yang XR, Wang WM, Bai H, Shi RY, Nayar SK, Devbhandari RP, He YZ, Zhu QF, Sun YF, Hu B, Khan M, Anders RA, Fan J
Hepatology (Baltimore, Md.) 2013 Mar;57(3):1088-97
Hepatology (Baltimore, Md.) 2013 Mar;57(3):1088-97
Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90.
Lee WH, Lee JM, Lim C, Kim S, Kim SG
Chemico-biological interactions 2013 Jun 25;204(1):49-57
Chemico-biological interactions 2013 Jun 25;204(1):49-57
Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
Xue X, Shah YM
Carcinogenesis 2013 Jan;34(1):163-9
Carcinogenesis 2013 Jan;34(1):163-9
Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration.
Havasi A, Haegele JA, Gall JM, Blackmon S, Ichimura T, Bonegio RG, Panchenko MV
The American journal of pathology 2013 Jan;182(1):152-62
The American journal of pathology 2013 Jan;182(1):152-62
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.
Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB
Blood 2013 Jan 3;121(1):188-96
Blood 2013 Jan 3;121(1):188-96
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.
Anderson ER, Taylor M, Xue X, Ramakrishnan SK, Martin A, Xie L, Bredell BX, Gardenghi S, Rivella S, Shah YM
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 10;110(50):E4922-30
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 10;110(50):E4922-30
HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM
The Biochemical journal 2013 Dec 1;456(2):195-204
The Biochemical journal 2013 Dec 1;456(2):195-204
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.
Nakayama K
The Journal of biological chemistry 2013 Aug 2;288(31):22584-95
The Journal of biological chemistry 2013 Aug 2;288(31):22584-95
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK
Nature chemical biology 2013 Apr;9(4):271-6
Nature chemical biology 2013 Apr;9(4):271-6
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells.
Onnis B, Fer N, Rapisarda A, Perez VS, Melillo G
The Journal of clinical investigation 2013 Apr;123(4):1615-29
The Journal of clinical investigation 2013 Apr;123(4):1615-29
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development.
Kucharzewska P, Christianson HC, Welch JE, Svensson KJ, Fredlund E, Ringnér M, Mörgelin M, Bourseau-Guilmain E, Bengzon J, Belting M
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 30;110(18):7312-7
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 30;110(18):7312-7
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
Vaapil M, Helczynska K, Villadsen R, Petersen OW, Johansson E, Beckman S, Larsson C, Påhlman S, Jögi A
PloS one 2012;7(9):e46543
PloS one 2012;7(9):e46543
Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.
Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R
PloS one 2012;7(7):e41462
PloS one 2012;7(7):e41462
Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs.
Huang C, Hales BF
PloS one 2012;7(12):e51937
PloS one 2012;7(12):e51937
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
Demachi-Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K
PloS one 2012;7(10):e47126
PloS one 2012;7(10):e47126
ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.
Carew JS, Esquivel JA 2nd, Espitia CM, Schultes CM, Mülbaier M, Lewis JD, Janssen B, Giles FJ, Nawrocki ST
PloS one 2012;7(1):e31120
PloS one 2012;7(1):e31120
The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.
Lim CS, Kiriakidis S, Paleolog EM, Davies AH
Journal of vascular surgery 2012 Oct;56(4):1069-77
Journal of vascular surgery 2012 Oct;56(4):1069-77
BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, Volpin F, Indraccolo S, Scienza R, Basso G
Cell death & disease 2012 Oct 18;3:e412
Cell death & disease 2012 Oct 18;3:e412
CD24 is an effector of HIF-1-driven primary tumor growth and metastasis.
Thomas S, Harding MA, Smith SC, Overdevest JB, Nitz MD, Frierson HF, Tomlins SA, Kristiansen G, Theodorescu D
Cancer research 2012 Nov 1;72(21):5600-12
Cancer research 2012 Nov 1;72(21):5600-12
Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities.
Poey ME, Albini M, Saona G, Laviña M
Microbial pathogenesis 2012 May;52(5):292-301
Microbial pathogenesis 2012 May;52(5):292-301
Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.
Mihaylova S, Killian A, Mayer K, Pullamsetti SS, Schermuly R, Rosengarten B
Journal of neuroinflammation 2012 Jul 25;9:183
Journal of neuroinflammation 2012 Jul 25;9:183
Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy.
Holland WS, Tepper CG, Pietri JE, Chinn DC, Gandara DR, Mack PC, Lara PN Jr
Cancer chemotherapy and pharmacology 2012 Jan;69(1):185-94
Cancer chemotherapy and pharmacology 2012 Jan;69(1):185-94
HIF-2α expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1α is repressed.
Munksgaard Persson M, Johansson ME, Monsef N, Planck M, Beckman S, Seckl MJ, Rönnstrand L, Påhlman S, Pettersson HM
The American journal of pathology 2012 Feb;180(2):494-504
The American journal of pathology 2012 Feb;180(2):494-504
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.
Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M, Rini B, Yan Q, Yang H
Oncogene 2012 Feb 9;31(6):776-86
Oncogene 2012 Feb 9;31(6):776-86
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2784-9
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2784-9
Expression and stability of hypoxia inducible factor 1α in osteosarcoma.
El Naggar A, Clarkson P, Zhang F, Mathers J, Tognon C, Sorensen PH
Pediatric blood & cancer 2012 Dec 15;59(7):1215-22
Pediatric blood & cancer 2012 Dec 15;59(7):1215-22
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Chen R, Xu M, Hogg RT, Li J, Little B, Gerard RD, Garcia JA
The Journal of biological chemistry 2012 Aug 31;287(36):30800-11
The Journal of biological chemistry 2012 Aug 31;287(36):30800-11
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1955-65
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1955-65
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
Li Q, Michaud M, Canosa S, Kuo A, Madri JA
Angiogenesis 2011 May;14(2):173-85
Angiogenesis 2011 May;14(2):173-85
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha.
Lin Q, Cong X, Yun Z
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Molecular cancer research : MCR 2011 Jun;9(6):757-65
Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells.
Xie L, Collins JF
American journal of physiology. Cell physiology 2011 Jun;300(6):C1298-305
American journal of physiology. Cell physiology 2011 Jun;300(6):C1298-305
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice.
Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, Shah YM
Gastroenterology 2011 Jun;140(7):2044-55
Gastroenterology 2011 Jun;140(7):2044-55
The von Hippel–Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
X Niu, T Zhang, L Liao, L Zhou, D J Lindner, M Zhou, B Rini, Q Yan, H Yang
Oncogene 2011 Jul;():-
Oncogene 2011 Jul;():-
Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.
Place TL, Fitzgerald MP, Venkataraman S, Vorrink SU, Case AJ, Teoh ML, Domann FE
PloS one 2011 Jan 28;6(1):e14617
PloS one 2011 Jan 28;6(1):e14617
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.
Nakamura K, Tan F, Li Z, Thiele CJ
Molecular and cellular neurosciences 2011 Feb;46(2):498-506
Molecular and cellular neurosciences 2011 Feb;46(2):498-506
Oxygen regulation of the epithelial Na channel in the collecting duct.
Husted RF, Lu H, Sigmund RD, Stokes JB
American journal of physiology. Renal physiology 2011 Feb;300(2):F412-24
American journal of physiology. Renal physiology 2011 Feb;300(2):F412-24
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.
Heikkilä M, Pasanen A, Kivirikko KI, Myllyharju J
Cellular and molecular life sciences : CMLS 2011 Dec;68(23):3885-901
Cellular and molecular life sciences : CMLS 2011 Dec;68(23):3885-901
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.
Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA
The Journal of biological chemistry 2011 Apr 22;286(16):13869-78
The Journal of biological chemistry 2011 Apr 22;286(16):13869-78
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, Ribatti D, Greenberger LM, Horak ID, Ponzoni M
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Oct 1;16(19):4809-21
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Oct 1;16(19):4809-21
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC
Haematologica 2010 May;95(5):776-84
Haematologica 2010 May;95(5):776-84
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O
Endocrine-related cancer 2010 Jun;17(2):303-16
Endocrine-related cancer 2010 Jun;17(2):303-16
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.
Werth N, Beerlage C, Rosenberger C, Yazdi AS, Edelmann M, Amr A, Bernhardt W, von Eiff C, Becker K, Schäfer A, Peschel A, Kempf VA
PloS one 2010 Jul 14;5(7):e11576
PloS one 2010 Jul 14;5(7):e11576
EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.
Bougatef F, Menashi S, Khayati F, Naïmi B, Porcher R, Podgorniak MP, Millot G, Janin A, Calvo F, Lebbé C, Mourah S
PloS one 2010 Aug 31;5(8):e12265
PloS one 2010 Aug 31;5(8):e12265
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O
Cancer research 2010 Apr 15;70(8):3071-9
Cancer research 2010 Apr 15;70(8):3071-9
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling.
Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ
Molecular pharmacology 2009 Sep;76(3):588-95
Molecular pharmacology 2009 Sep;76(3):588-95
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK
The Journal of biological chemistry 2009 Oct 16;284(42):29065-76
The Journal of biological chemistry 2009 Oct 16;284(42):29065-76
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C
PloS one 2009 Nov 18;4(11):e7875
PloS one 2009 Nov 18;4(11):e7875
Ligand migration through the internal hydrophobic cavities in human neuroglobin.
Abbruzzetti S, Faggiano S, Bruno S, Spyrakis F, Mozzarelli A, Dewilde S, Moens L, Viappiani C
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 10;106(45):18984-9
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 10;106(45):18984-9
Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment.
Burkitt K, Chun SY, Dang DT, Dang LH
Molecular cancer therapeutics 2009 May;8(5):1148-56
Molecular cancer therapeutics 2009 May;8(5):1148-56
Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.
Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A, Schini-Kerth VB
The Journal of pharmacology and experimental therapeutics 2009 May;329(2):699-707
The Journal of pharmacology and experimental therapeutics 2009 May;329(2):699-707
Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.
Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T
British journal of cancer 2009 May 19;100(10):1666-73
British journal of cancer 2009 May 19;100(10):1666-73
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
Ndubuizu OI, Chavez JC, LaManna JC
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jul;297(1):R158-65
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Jul;297(1):R158-65
Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.
Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR
BMC cancer 2009 Jul 14;9:229
BMC cancer 2009 Jul 14;9:229
Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.
Li Y, Qiu X, Zhang S, Zhang Q, Wang E
Cancer biology & therapy 2009 Feb;8(4):322-30
Cancer biology & therapy 2009 Feb;8(4):322-30
Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells.
Li Y, Qiu X, Zhang S, Zhang Q, Wang E
Cancer biology & therapy 2009 Feb;8(4):322-30
Cancer biology & therapy 2009 Feb;8(4):322-30
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC
International journal of cancer 2009 Feb 15;124(4):763-71
International journal of cancer 2009 Feb 15;124(4):763-71
Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity.
Kim Y, Lin Q, Zelterman D, Yun Z
Cancer research 2009 Dec 15;69(24):9271-80
Cancer research 2009 Dec 15;69(24):9271-80
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization.
Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, Påhlman S
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Dec 1;15(23):7130-6
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Dec 1;15(23):7130-6
Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha.
Figlin RA, de Souza P, McDermott D, Dutcher JP, Berkenblit A, Thiele A, Krygowski M, Strahs A, Feingold J, Boni J, Hudes G
Cancer 2009 Aug 15;115(16):3651-60
Cancer 2009 Aug 15;115(16):3651-60
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor.
Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Akçetin Z, Behrens J
Molecular and cellular biology 2009 Apr;29(7):1707-18
Molecular and cellular biology 2009 Apr;29(7):1707-18
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells.
Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T
Stem cells and development 2008 Oct;17(5):869-81
Stem cells and development 2008 Oct;17(5):869-81
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D, Keswani A, Kordeluk E, Raji A, Winter JN, Jovanovic BD, Holmgren A, Nelson BP, Gordon LI
British journal of haematology 2008 May;141(5):676-80
British journal of haematology 2008 May;141(5):676-80
AMP-activated protein kinase is essential for survival in chronic hypoxia.
Borger DR, Gavrilescu LC, Bucur MC, Ivan M, Decaprio JA
Biochemical and biophysical research communications 2008 May 30;370(2):230-4
Biochemical and biophysical research communications 2008 May 30;370(2):230-4
Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours.
Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M
The Journal of bone and joint surgery. British volume 2008 Mar;90(3):364-70
The Journal of bone and joint surgery. British volume 2008 Mar;90(3):364-70
The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS
Experimental cell research 2008 Jun 10;314(10):2016-27
Experimental cell research 2008 Jun 10;314(10):2016-27
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O
Molecular cell 2008 Dec 26;32(6):838-48
Molecular cell 2008 Dec 26;32(6):838-48
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.
Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T
Carcinogenesis 2008 Apr;29(4):696-703
Carcinogenesis 2008 Apr;29(4):696-703
HIF gene expression in cancer therapy.
Chan DA, Krieg AJ, Turcotte S, Giaccia AJ
Methods in enzymology 2007;435:323-45
Methods in enzymology 2007;435:323-45
Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function.
Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK
Methods in enzymology 2007;435:3-24
Methods in enzymology 2007;435:3-24
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M
Carcinogenesis 2007 Mar;28(3):529-36
Carcinogenesis 2007 Mar;28(3):529-36
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
Yan Q, Bartz S, Mao M, Li L, Kaelin WG Jr
Molecular and cellular biology 2007 Mar;27(6):2092-102
Molecular and cellular biology 2007 Mar;27(6):2092-102
Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.
Bernhardt WM, Wiesener MS, Weidemann A, Schmitt R, Weichert W, Lechler P, Campean V, Ong AC, Willam C, Gretz N, Eckardt KU
The American journal of pathology 2007 Mar;170(3):830-42
The American journal of pathology 2007 Mar;170(3):830-42
Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.
Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ
Cancer research 2007 Jun 15;67(12):5896-905
Cancer research 2007 Jun 15;67(12):5896-905
Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine.
Harvey AJ, Kind KL, Thompson JG
Biology of reproduction 2007 Jul;77(1):93-101
Biology of reproduction 2007 Jul;77(1):93-101
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Monsef N, Helczynski L, Lundwall A, Påhlman S, Anders-Bjartell.
The Prostate 2007 Aug 1;67(11):1219-29
The Prostate 2007 Aug 1;67(11):1219-29
In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
Kyriacou HM, Steen KE, Raza A, Arman M, Warimwe G, Bull PC, Havlik I, Rowe JA
Antimicrobial agents and chemotherapy 2007 Apr;51(4):1321-6
Antimicrobial agents and chemotherapy 2007 Apr;51(4):1321-6
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH
The Journal of clinical investigation 2007 Apr;117(4):1068-77
The Journal of clinical investigation 2007 Apr;117(4):1068-77
Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.
Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW
British journal of cancer 2007 Apr 23;96(8):1284-92
British journal of cancer 2007 Apr 23;96(8):1284-92
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.
Koizume S, Jin MS, Miyagi E, Hirahara F, Nakamura Y, Piao JH, Asai A, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y
Cancer research 2006 Oct 1;66(19):9453-60
Cancer research 2006 Oct 1;66(19):9453-60
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Carroll PA, Kenerson HL, Yeung RS, Lagunoff M
Journal of virology 2006 Nov;80(21):10802-12
Journal of virology 2006 Nov;80(21):10802-12
Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.
Kim CM, Vocke C, Torres-Cabala C, Yang Y, Schmidt L, Walther M, Linehan WM
The Journal of urology 2006 May;175(5):1908-14
The Journal of urology 2006 May;175(5):1908-14
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.
Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T
Molecular and cellular biology 2006 Jun;26(12):4628-41
Molecular and cellular biology 2006 Jun;26(12):4628-41
Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.
Eul B, Rose F, Krick S, Savai R, Goyal P, Klepetko W, Grimminger F, Weissmann N, Seeger W, Hänze J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jan;20(1):163-5
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jan;20(1):163-5
Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein.
Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, Kotani H, Manabe T, Zhang GJ, Kondo K, Nosé V, Kaelin WG Jr
The American journal of pathology 2006 Feb;168(2):574-84
The American journal of pathology 2006 Feb;168(2):574-84
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.
Bilton R, Mazure N, Trottier E, Hattab M, Déry MA, Richard DE, Pouysségur J, Brahimi-Horn MC
The Journal of biological chemistry 2005 Sep 2;280(35):31132-40
The Journal of biological chemistry 2005 Sep 2;280(35):31132-40
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L
Cancer cell 2005 Aug;8(2):143-53
Cancer cell 2005 Aug;8(2):143-53
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, Shen Y
Cancer research 2005 Aug 15;65(16):7249-58
Cancer research 2005 Aug 15;65(16):7249-58
Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia.
Tissot van Patot MC, Bendrick-Peart J, Beckey VE, Serkova N, Zwerdlinger L
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
American journal of physiology. Lung cellular and molecular physiology 2004 Sep;287(3):L525-32
Oxygen-regulated gene expression in bovine blastocysts.
Harvey AJ, Kind KL, Pantaleon M, Armstrong DT, Thompson JG
Biology of reproduction 2004 Oct;71(4):1108-19
Biology of reproduction 2004 Oct;71(4):1108-19
Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.
Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R
Proceedings of the National Academy of Sciences of the United States of America 2004 May 25;101(21):8132-7
Proceedings of the National Academy of Sciences of the United States of America 2004 May 25;101(21):8132-7
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.
Martín-Puig S, Temes E, Olmos G, Jones DR, Aragonés J, Landázuri MO
The Journal of biological chemistry 2004 Mar 5;279(10):9504-11
The Journal of biological chemistry 2004 Mar 5;279(10):9504-11
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment.
Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC
Oncogene 2004 Jun 24;23(29):4975-83
Oncogene 2004 Jun 24;23(29):4975-83
HIF activation by pH-dependent nucleolar sequestration of VHL.
Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S
Nature cell biology 2004 Jul;6(7):642-7
Nature cell biology 2004 Jul;6(7):642-7
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E
Oncogene 2004 Jul 22;23(33):5624-31
Oncogene 2004 Jul 22;23(33):5624-31
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O
Molecular cancer research : MCR 2004 Feb;2(2):89-95
Molecular cancer research : MCR 2004 Feb;2(2):89-95
Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression.
Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M, Nagasue N
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Dec 15;10(24):8554-60
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Dec 15;10(24):8554-60
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations.
Rathmell WK, Hickey MM, Bezman NA, Chmielecki CA, Carraway NC, Simon MC
Cancer research 2004 Dec 1;64(23):8595-603
Cancer research 2004 Dec 1;64(23):8595-603
Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors.
Toussaint-Smith E, Donner DB, Roman A
Oncogene 2004 Apr 15;23(17):2988-95
Oncogene 2004 Apr 15;23(17):2988-95
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr
PLoS biology 2003 Dec;1(3):E83
PLoS biology 2003 Dec;1(3):E83
von Hippel-Lindau protein complex is regulated by cell density.
Mohan S, Burk RD
Oncogene 2003 Aug 14;22(34):5270-80
Oncogene 2003 Aug 14;22(34):5270-80
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K
Urology 2002 May;59(5):774-8
Urology 2002 May;59(5):774-8
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K
Urology 2002 May;59(5):774-8
Urology 2002 May;59(5):774-8
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL
Cancer research 2002 May 1;62(9):2493-7
Cancer research 2002 May 1;62(9):2493-7
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL
Cancer research 2001 Nov 1;61(21):7992-8
Cancer research 2001 Nov 1;61(21):7992-8
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL
Cancer research 2001 Mar 1;61(5):1830-2
Cancer research 2001 Mar 1;61(5):1830-2
Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines.
Blancher C, Moore JW, Talks KL, Houlbrook S, Harris AL
Cancer research 2000 Dec 15;60(24):7106-13
Cancer research 2000 Dec 15;60(24):7106-13
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL
The American journal of pathology 2000 Aug;157(2):411-21
The American journal of pathology 2000 Aug;157(2):411-21
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL
The American journal of pathology 2000 Aug;157(2):411-21
The American journal of pathology 2000 Aug;157(2):411-21
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH
Blood 1998 Oct 1;92(7):2260-8
Blood 1998 Oct 1;92(7):2260-8
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Supportive validation
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- Simple Western: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Lane view shows a specific band for HIF-2 alpha in 0.5 mg/mL of Hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Analysis of HepG2 without Cobalt (II) Chloride (1), HepG2 with Cobalt (II) Chloride (2), HepG2 normoxic (3), HepG2 hypoxic (4), HepG2 without Cobalt (II) Chloride (5), HepG2 with Cobalt (II) Chloride (6), HepG2 normoxic (7), and HepG2 hypoxic (8) using this antibody (NB100-132) at 1 - 2 ug/mL.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - HRP conjugated HIF-2 alpha detected in hypoxic human lysate. Lane 1: normoxic A549 lysate control, lane 2: hypoxic A549 lysate.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - C57B6 5 week old Mouse Kidney Tissue 60ug. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Analysis of HIF-2 alpha stabilization over time in 791T cells following exposure to hypoxia. [PMID: 23785417]. Image using the HRP form of this antibody.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Mouse aortic endothelial cells treated (1%) or not treated (20.9%) in hypoxia for 3 hrs. Cells where also transfected with a specific siRNA against (siHIF-2) or a control siRNA (-). Western blot image submitted by a verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - 4-OOHCPA exposure induced HIF-2 alpha/EPAS1. A: Western blot analysis of HIF-2 alpha/EPAS1 protein (118KD) and actin (43KD) in limbs at 10 min, 1, 3, 6, and 24 h after treatment with 4-OOHCPA at 0.3 ug/mL (L) 1.0 ug/mL (M) or 3.0 ug/mL (H). P represents the positive control. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0051937), licensed under a CC-BY licence.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Western blot analysis and quantification of HIF-2 alpha expression in the cortex 4.5 hours after lipopolysaccharide (LPS) administration for all LPS groups and the control group (SHAM, white bar). With the exception of the vagotomy group (VGX LPS, gray bar), no significant differences to the SHAM group were found in the LPS-treated and sham-operated (SHAM+LPS, light gray bar) or vagus nerve-stimulated groups (VGX LPS+STIM, black bar). The significant increase in the VGX LPS (gray bar) group is an indicator of a hypoxic condition; * P
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- Western Blot: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - [HRP] [NB100-132H] - Analysis of HIF-2 alpha stabilization over time in HOS cells following exposure to hypoxia. [PMID: 23785417]. Image using the HRP form of this antibody.
Supportive validation
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- Immunohistochemistry-Paraffin: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Analysis of HIF-2 alpha in paraffin-embedded mouse kidney tissue using anti-HIF-2 alpha antibody. Image from verified customer review.
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- Immunohistochemistry-Paraffin: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Analysis of HIF-2 in human cardiac myocytes using HIF-2 alpha/EPAS1 Antibody (ep190b).
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- Immunohistochemistry: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Analysis of HIF-2 alpha in human endometrium using. Donkey anti-mouse Alexa Fluor 488 secondary antibody was used. IHC image submitted by a verified customer review.
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- Immunohistochemistry-Paraffin: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - Renal tubule specific models of Vhl deletion. Histological images of representative renal sections from 12 month old control, Pax8-CreERT2/Vhldelta/delta and Slc22a6-CreERT2/Vhldelta/delta mice (stains and antibodies as indicated, arrowheads indicate abnormal vascularization). Scale bars, 100 um. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0148055), licensed under a CC-BY licence.
Supportive validation
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- Flow Cytometry: HIF-2 alpha/EPAS1 Antibody (ep190b) [NB100-132] - HIF-2 alpha antibody was tested at 1:400 in HepG2 cells using an Alexa Fluor 488 secondary (shown in purple). M1 is defined by unstained cells.
