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- Antibody Data
- Antigen structure
- References [3]
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- Immunohistochemistry [1]
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- Product number
- ABIN500509 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 1 (PLEKHM1) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- PLEKHM1 antibody was raised against an 18 amino acid peptide from near the amino terminus of human PLEKHM1.
- Description
- Peptide affinity chromatography
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/mL
- Storage
- Store the antibody (in aliquots) at -20°C.
- Handling
- Avoid repeated freezing and thawing.
Submitted references A new heterozygous mutation (R714C) of the osteopetrosis gene, pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts.
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.
Localization of the gene causing the osteopetrotic phenotype in the incisors absent (ia) rat on chromosome 10q32.1.
Del Fattore A, Fornari R, Van Wesenbeeck L, de Freitas F, Timmermans JP, Peruzzi B, Cappariello A, Rucci N, Spera G, Helfrich MH, Van Hul W, Migliaccio S, Teti A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 Mar;23(3):380-91
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 Mar;23(3):380-91
Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.
Van Wesenbeeck L, Odgren PR, Coxon FP, Frattini A, Moens P, Perdu B, MacKay CA, Van Hul E, Timmermans JP, Vanhoenacker F, Jacobs R, Peruzzi B, Teti A, Helfrich MH, Rogers MJ, Villa A, Van Hul W
The Journal of clinical investigation 2007 Apr;117(4):919-30
The Journal of clinical investigation 2007 Apr;117(4):919-30
Localization of the gene causing the osteopetrotic phenotype in the incisors absent (ia) rat on chromosome 10q32.1.
van Wesenbeeck L, Odgren PR, Mackay CA, Van Hul W
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Feb;19(2):183-9
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Feb;19(2):183-9
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of PLEKHM1 in human lung tissue with AP30677PU-N at 5 ?g/ml.
