APG00306G
antibody from Leading Biology
Targeting: SH2D1A
DSHP, EBVS, IMD5, LYP, MTCP1, SAP, XLP, XLPD
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- APG00306G - Provider product page
- Provider
- Leading Biology
- Product name
- Goat Anti-SH2D1A / SAP Antibody
- Antibody type
- Polyclonal
- Description
- This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
- Reactivity
- Human
- Host
- Goat
- Isotype
- IgG
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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