BS8070

antibody from Bioworld Technology, Inc
Targeting: SF3B2 Cus1, SAP145, SF3b1, SF3b145
Provider product page for BS8070
Western blot
Immunohistochemistry

Antibody data

Product number
BS8070 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SF3B2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SF3B2.
Description
SF3b is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3b contains the spliceosomal proteins SAP 49, SAP 130, SAP 145, and SAP 155. SAP 130, SAP 145, and SAP 155 are present in a protein complex in HeLa nuclear extracts and associate with one another. While SAP 155 and SAP 130 interact with each other (directly or indirectly) within this complex, SAP 49 and SAP 145 are known to interact directly with each other. Unexpectedly, the SAP 49-SAP 145 protein-protein interaction requires the amino-terminus of SAP 49, which contains two RNA-recognition motifs. The observation that SAP 49 and SAP 145 interact directly with both U2 snRNP and the pre-mRNA suggests that this protein complex plays a role in tethering U2 snRNP to the branch site.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SF3B2 protein structure - BS8070 shown in red.