Antibody data

Product number
10-4106-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-CD73 Antibody
Antibody type
Monoclonal
Description
CD73, also known as ecto-5'-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant CD73 p
rotein (amino acids 145-346) was us
ed as the immunogen for this antibo
dy.
Isotype
IgG
Antibody clone number
ABM40E2
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
NT5E protein structure - 10-4106-25 shown in red.