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Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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- Product number
- NB100-402 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-402, RRID:AB_10003309
- Product name
- Rabbit Polyclonal SLC31A1/CTR1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Canine, Porcine, Xenopus, Zebrafish
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.
Oleandrin sensitizes human osteosarcoma cells to cisplatin by preventing degradation of the copper transporter 1.
Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome.
Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells.
Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs.
Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level.
Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.
Evaluation of effects of copper histidine on copper transporter 1-mediated accumulation of platinum and oxaliplatin-induced neurotoxicity in vitro and in vivo.
Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.
Association of copper transporter expression with platinum resistance in epithelial ovarian cancer.
Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.
Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice.
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1.
Expression of the human copper influx transporter 1 in normal and malignant human tissues.
PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.
Morrell A, Tripet BP, Eilers BJ, Tegman M, Thompson D, Copié V, Burkhead JL
The Journal of nutritional biochemistry 2020 Apr;78:108316
The Journal of nutritional biochemistry 2020 Apr;78:108316
Oleandrin sensitizes human osteosarcoma cells to cisplatin by preventing degradation of the copper transporter 1.
Yong L, Ma Y, Liang C, He G, Zhao Z, Yang C, Hai B, Pan X, Liu Z, Liu X
Phytotherapy research : PTR 2019 Jul;33(7):1837-1850
Phytotherapy research : PTR 2019 Jul;33(7):1837-1850
Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome.
Ishihara K, Kawashita E, Shimizu R, Nagasawa K, Yasui H, Sago H, Yamakawa K, Akiba S
Free radical biology & medicine 2019 Apr;134:248-259
Free radical biology & medicine 2019 Apr;134:248-259
Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells.
Buß I, Hamacher A, Sarin N, Kassack MU, Kalayda GV
Metallomics : integrated biometal science 2018 Mar 1;10(3):414-425
Metallomics : integrated biometal science 2018 Mar 1;10(3):414-425
Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs.
Ahn C, Choi JS, Jeung EB
Molecular medicine reports 2018 Aug;18(2):1773-1781
Molecular medicine reports 2018 Aug;18(2):1773-1781
Transporter-Mediated Interaction Between Platinum Drugs and Sorafenib at the Cellular Level.
Schneider V, Chaib S, Spanier C, Knapp M, Moscvin V, Scordovillo L, Ewertz A, Jaehde U, Kalayda GV
The AAPS journal 2017 Nov 30;20(1):9
The AAPS journal 2017 Nov 30;20(1):9
Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.
Doherty B, Lawlor D, Gillet JP, Gottesman M, O'Leary JJ, Stordal B
Anticancer research 2014 Jan;34(1):503-7
Anticancer research 2014 Jan;34(1):503-7
Evaluation of effects of copper histidine on copper transporter 1-mediated accumulation of platinum and oxaliplatin-induced neurotoxicity in vitro and in vivo.
Ip V, Liu JJ, McKeage MJ
Clinical and experimental pharmacology & physiology 2013 Jun;40(6):371-8
Clinical and experimental pharmacology & physiology 2013 Jun;40(6):371-8
Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.
Liu JJ, Kim Y, Yan F, Ding Q, Ip V, Jong NN, Mercer JF, McKeage MJ
Biochemical pharmacology 2013 Jan 15;85(2):207-15
Biochemical pharmacology 2013 Jan 15;85(2):207-15
Association of copper transporter expression with platinum resistance in epithelial ovarian cancer.
Yoshida H, Teramae M, Yamauchi M, Fukuda T, Yasui T, Sumi T, Honda K, Ishiko O
Anticancer research 2013 Apr;33(4):1409-14
Anticancer research 2013 Apr;33(4):1409-14
Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.
Stordal B, Hamon M, McEneaney V, Roche S, Gillet JP, O'Leary JJ, Gottesman M, Clynes M
PloS one 2012;7(7):e40717
PloS one 2012;7(7):e40717
Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice.
Chen DB, Feng L, Lin XP, Zhang W, Li FR, Liang XL, Li XH
PloS one 2012;7(5):e37709
PloS one 2012;7(5):e37709
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA
FEBS letters 2012 Jul 30;586(16):2423-7
FEBS letters 2012 Jul 30;586(16):2423-7
Role of the copper transporter, CTR1, in platinum-induced ototoxicity.
More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jul 14;30(28):9500-9
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jul 14;30(28):9500-9
Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1.
Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 15;15(2):553-60
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Jan 15;15(2):553-60
Expression of the human copper influx transporter 1 in normal and malignant human tissues.
Holzer AK, Varki NM, Le QT, Gibson MA, Naredi P, Howell SB
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Sep;54(9):1041-9
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Sep;54(9):1041-9
PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.
Peng F, Lu X, Janisse J, Muzik O, Shields AF
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006 Oct;47(10):1649-52
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006 Oct;47(10):1649-52
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: SLC31A1/CTR1 Antibody [NB100-402] - Panel 1: human CTR1 staining of breast cancer tissue. Panel 2: human CTR1-antigen competition in breast cancer tissue.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: SLC31A1/CTR1 Antibody [NB100-402] - Left panel: Antibody staining of hCTR1 overexpressing cell line. Right panel: Antibody plus peptide competition staining.
