BS3027

FRS3 antibody from Bioworld Technology, Inc
FRS2B, FRS2beta, SNT-2

Antibody data

Product number
BS3027
Provider
Bioworld Technology, Inc
Product name
FRS3 (F219) polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS3027
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 191-240 of Human FRS3.
Description
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-ÉÇ), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -