CABT-L1818

antibody from Creative Diagnostics

Targeting: PHLPP2 KIAA0931, PHLPPL, PPM3B

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1818

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human PHLPP2 monoclonal antibody, clone TQ330

Antibody type

Monoclonal

Description

PHLPP2 (PH domain and leucine-rich repeat protein phosphatases 2) is a membrane-bound protein with dual functions as a tumor suppressor and a protein phosphatase. It mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA as well as AKT3 phosphorylation. Dephosphorylation of AKT1, PRKCA and PRKCB leads to their destabilization and degradation and inhibits cancer cell proliferation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TQ330

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.