Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS8432 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- TREX1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human TREX1.
- Description
- TREX-1 (three prime repair exonuclease 1), also known as trophoblast expressed 1, CRV, AGS1, AGS5, DRN3, HERNS or DNase III, is a member of the exonuclease superfamily and belongs to the TREX family. Members of the TREX family are involved in DNA metabolism and repair. TREX-1 is expressed in spleen, liver, thymus, colon, heart, brain and small intestine. It localizes to the nucleus and exists as a homodimer. TREX-1 is an exonuclease and its activity requires magnesium as a cofactor. TREX-1 has a preference for double stranded DNA and functions in the 3£ª-5£ª direction yielding nucleoside 5£ª-phosphates. TREX-1 also interacts with the SET complex (an endoplasmic reticulum (ER)-associated complex) and participates in granzyme A-mediated apoptosis. Mutations or defects in the gene encoding TREX-1 have been associated with a variety of diseases, including systemic lupus erythematosus, chilblain lupus (CHBL), Aicardi-Goutieres syndrome type 1 (AGS1) and type 5 (AGS5) and autosomal dominant retinal vasculopathy with cerebral leukodystrophy (CRV).
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western Blot (WB) analysis of TREX1 polyclonal antibody