Tissue expression
Cell line expression
Protein structure

PEG10

Paternally expressed 10
HB-1, KIAA1051, Mar2, Mart2, MEF3L, RGAG3, RTL2, SIRH1 
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
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453 antibodies from 34 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Novus Biologicals
15 antibodies
Invitrogen Antibodies
14 antibodies
antibodies-online
139 antibodies
Biorbyt
57 antibodies
OriGene
13 antibodies
GeneTex
4 antibodies
Acris Antibodies GmbH
5 antibodies
Abnova Corporation
5 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Atlas Antibodies
3 antibodies
NovoPro Bioscience Inc.
3 antibodies
Affinity Biosciences
1 antibody
FineTest Biotech
1 antibody
St John's Laboratory
5 antibodies
Abgent
5 antibodies
Arigo
1 antibody
R&D Systems
9 antibodies
Bioworld Technology, Inc
1 antibody
Aviva Systems Biology
3 antibodies
Creative Biolabs
15 antibodies
ProSci
2 antibodies
Creative Diagnostics
5 antibodies
Abbexa
12 antibodies
RayBiotech, Inc.
2 antibodies
Abbiotec
3 antibodies
MyBioSource
7 antibodies
Leading Biology
4 antibodies
Boster Biological Technology
2 antibodies
Bethyl Laboratories
1 antibody
United States Biological
43 antibodies
MilliporeSigma / Merck KGaA
2 antibodies