IFNL2

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Description

Interferon lambda 2

Tissue specificity

Not detected

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

19 (39268396 - 39270188)

Ensembl ID

ENSG00000183709  (ver. 103.38)

Orthologs

-

UniProt

Q8IZJ0

neXtProt

NX_Q8IZJ0

Human splice variants

Protein structure