Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [3]
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- Product number
- ABIN152476 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ubiquitin antibody
- Antibody type
- Monoclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse, Rat, Bovine, Chicken/Avian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- Ubi-1
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Salmonella escapes antigen presentation through K63 ubiquitination mediated endosomal proteolysis of MHC II via modulation of endosomal acidification in dendritic cells.
Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury.
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.
Analysis of macroautophagy by immunohistochemistry.
COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses.
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
IkappaB is a substrate for a selective pathway of lysosomal proteolysis.
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain.
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
Gogoi M, Ravikumar V, Dixit NM, Chakravortty D
Pathogens and disease 2018 Mar 1;76(2)
Pathogens and disease 2018 Mar 1;76(2)
Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.
Michel MA, Swatek KN, Hospenthal MK, Komander D
Molecular cell 2017 Oct 5;68(1):233-246.e5
Molecular cell 2017 Oct 5;68(1):233-246.e5
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Gersch M, Gladkova C, Schubert AF, Michel MA, Maslen S, Komander D
Nature structural & molecular biology 2017 Nov;24(11):920-930
Nature structural & molecular biology 2017 Nov;24(11):920-930
The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D
Molecular cell 2016 Jul 21;63(2):261-276
Molecular cell 2016 Jul 21;63(2):261-276
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D
Cell 2016 Aug 25;166(5):1215-1230.e20
Cell 2016 Aug 25;166(5):1215-1230.e20
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Schwab AJ, Ebert AD
Stem cell reports 2015 Dec 8;5(6):1039-1052
Stem cell reports 2015 Dec 8;5(6):1039-1052
Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury.
Begum G, Yan HQ, Li L, Singh A, Dixon CE, Sun D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 5;34(10):3743-55
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 5;34(10):3743-55
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F
The Journal of biological chemistry 2013 Jun 14;288(24):17313-35
The Journal of biological chemistry 2013 Jun 14;288(24):17313-35
Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.
Maroui MA, Kheddache-Atmane S, El Asmi F, Dianoux L, Aubry M, Chelbi-Alix MK
PloS one 2012;7(9):e44949
PloS one 2012;7(9):e44949
Analysis of macroautophagy by immunohistochemistry.
Rosenfeldt MT, Nixon C, Liu E, Mah LY, Ryan KM
Autophagy 2012 Jun;8(6):963-9
Autophagy 2012 Jun;8(6):963-9
COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.
Stuttmann J, Lechner E, Guérois R, Parker JE, Nussaume L, Genschik P, Noël LD
The Journal of biological chemistry 2009 Mar 20;284(12):7920-30
The Journal of biological chemistry 2009 Mar 20;284(12):7920-30
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.
Dayal S, Sparks A, Jacob J, Allende-Vega N, Lane DP, Saville MK
The Journal of biological chemistry 2009 Feb 20;284(8):5030-41
The Journal of biological chemistry 2009 Feb 20;284(8):5030-41
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.
Watson MR, Lagow RD, Xu K, Zhang B, Bonini NM
The Journal of biological chemistry 2008 Sep 5;283(36):24972-81
The Journal of biological chemistry 2008 Sep 5;283(36):24972-81
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M
Cell 2006 Feb 10;124(3):601-13
Cell 2006 Feb 10;124(3):601-13
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Cripps D, Thomas SN, Jeng Y, Yang F, Davies P, Yang AJ
The Journal of biological chemistry 2006 Apr 21;281(16):10825-38
The Journal of biological chemistry 2006 Apr 21;281(16):10825-38
Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses.
Lichtenfels R, Kellner R, Atkins D, Bukur J, Ackermann A, Beck J, Brenner W, Melchior S, Seliger B
Biochimica et biophysica acta 2003 Mar 21;1646(1-2):21-31
Biochimica et biophysica acta 2003 Mar 21;1646(1-2):21-31
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
Marti A, Wirbelauer C, Scheffner M, Krek W
Nature cell biology 1999 May;1(1):14-9
Nature cell biology 1999 May;1(1):14-9
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Sternsdorf T, Puccetti E, Jensen K, Hoelzer D, Will H, Ottmann OG, Ruthardt M
Molecular and cellular biology 1999 Jul;19(7):5170-8
Molecular and cellular biology 1999 Jul;19(7):5170-8
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
Laroia G, Cuesta R, Brewer G, Schneider RJ
Science (New York, N.Y.) 1999 Apr 16;284(5413):499-502
Science (New York, N.Y.) 1999 Apr 16;284(5413):499-502
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
Verdier F, Chrétien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C, Mayeux P
The Journal of biological chemistry 1998 Oct 23;273(43):28185-90
The Journal of biological chemistry 1998 Oct 23;273(43):28185-90
IkappaB is a substrate for a selective pathway of lysosomal proteolysis.
Cuervo AM, Hu W, Lim B, Dice JF
Molecular biology of the cell 1998 Aug;9(8):1995-2010
Molecular biology of the cell 1998 Aug;9(8):1995-2010
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
Sternsdorf T, Jensen K, Will H
The Journal of cell biology 1997 Dec 29;139(7):1621-34
The Journal of cell biology 1997 Dec 29;139(7):1621-34
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M
Cell 1992 Jul 24;70(2):293-301
Cell 1992 Jul 24;70(2):293-301
Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain.
Shaw G, Chau V
Proceedings of the National Academy of Sciences of the United States of America 1988 Apr;85(8):2854-8
Proceedings of the National Academy of Sciences of the United States of America 1988 Apr;85(8):2854-8
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
Perry G, Friedman R, Shaw G, Chau V
Proceedings of the National Academy of Sciences of the United States of America 1987 May;84(9):3033-6
Proceedings of the National Academy of Sciences of the United States of America 1987 May;84(9):3033-6
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Supportive validation
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