Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS2066 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CARP (A243) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 212-262 of Human CARP.
- Description
- A proposed genetic marker of cardiac hypertrophy, CARP (cardiac ankyrin repeat protein, ANKRD1, Ankyrin repeat domain-containing protein 1,) is a nuclear protein with an established role in regulation of cardiac gene expression. A distinct increase in CARP expression occurs in rats with abdominal aorta constriction, spontaneous hypertension and Dahl salt-sensitivity. In cardiomyocytes, CARP inhibits transcription of both cardiac troponin C and atrial natriuretic factor. Specifically, expression of the CARP gene, which lies downstream of the cardiac homeobox gene Nkx2.5, inhibits Nkx2.5 transactivation of atrial natriuretic factor promoter. An increase in CARP expression is observed in the ventricular tissue of patients with endstage heart failure.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CARP (A243) pAb at 1:500 dilutionLane1:Hela cell lysateLane2:Jurkat cell lysateLane3:H9C2 cell lysateLane4:NIH-3T3 cell lysate