Antibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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Validation data
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- Product number
- 12948-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12948-1-AP, RRID:AB_2127351
- Product name
- IMPDH2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IMPDH2 antibody (Cat. #12948-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Anti-rods/rings autoantibodies in a patient with pancreatic injury.
Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.
Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells.
Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.
IMPDH forms the cytoophidium in zebrafish.
Nuclear IMPDH Filaments in Human Gliomas.
Rewiring of purine metabolism in response to acidosis stress in glioma stem cells.
Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer.
CTPS and IMPDH form cytoophidia in developmental thymocytes.
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.
IMP dehydrogenase rod/ring structures in acral melanomas.
IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.
SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs.
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.
Interfilament interaction between IMPDH and CTPS cytoophidia.
Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies.
'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures.
Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction.
Molecular cell biology and immunobiology of mammalian rod/ring structures.
Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions.
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α.
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
A simple Fourier filter for suppression of the missing wedge ray artefacts in single-axis electron tomographic reconstructions.
Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells.
Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis.
Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.
Katayama S, Kubota T, Takahashi H, Shiwaku H
Autoimmunity reviews 2022 Jan;21(1):102922
Autoimmunity reviews 2022 Jan;21(1):102922
Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.
Wang S, Chao F, Zhang C, Han D, Xu G, Chen G
Cancer letters 2022 Jan 1;524:109-120
Cancer letters 2022 Jan 1;524:109-120
Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells.
Ni S, Zhang T, Zhou C, Long M, Hou X, You L, Li H, Shi L, Su YQ
Frontiers in cell and developmental biology 2021;9:690536
Frontiers in cell and developmental biology 2021;9:690536
Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.
Morimune T, Tano A, Tanaka Y, Yukiue H, Yamamoto T, Tooyama I, Maruo Y, Nishimura M, Mori M
PloS one 2021;16(4):e0248517
PloS one 2021;16(4):e0248517
IMPDH forms the cytoophidium in zebrafish.
Keppeke GD, Chang CC, Antos CL, Peng M, Sung LY, Andrade LEC, Liu JL
Developmental biology 2021 Oct;478:89-101
Developmental biology 2021 Oct;478:89-101
Nuclear IMPDH Filaments in Human Gliomas.
Ahangari N, Munoz DG, Coulombe J, Gray DA, Engle EC, Cheng L, Woulfe J
Journal of neuropathology and experimental neurology 2021 Oct 26;80(10):944-954
Journal of neuropathology and experimental neurology 2021 Oct 26;80(10):944-954
Rewiring of purine metabolism in response to acidosis stress in glioma stem cells.
Xu X, Wang L, Zang Q, Li S, Li L, Wang Z, He J, Qiang B, Han W, Zhang R, Peng X, Abliz Z
Cell death & disease 2021 Mar 15;12(3):277
Cell death & disease 2021 Mar 15;12(3):277
Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer.
Wang W, Wu Y, Chen S, Liu X, He J, Wang S, Lu W, Tang Y, Huang J
Phytotherapy research : PTR 2021 Jan;35(1):463-476
Phytotherapy research : PTR 2021 Jan;35(1):463-476
CTPS and IMPDH form cytoophidia in developmental thymocytes.
Peng M, Chang CC, Liu JL, Sung LY
Experimental cell research 2021 Aug 1;405(1):112662
Experimental cell research 2021 Aug 1;405(1):112662
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.
Zheng P, Li L
OncoTargets and therapy 2020;13:451-463
OncoTargets and therapy 2020;13:451-463
IMP dehydrogenase rod/ring structures in acral melanomas.
Keppeke GD, Barcelos D, Fernandes M, Comodo AN, Guimarães DP, Cardili L, Carapeto FCL, Andrade LEC, Landman G
Pigment cell & melanoma research 2020 May;33(3):490-497
Pigment cell & melanoma research 2020 May;33(3):490-497
IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.
Ruan H, Song Z, Cao Q, Ni D, Xu T, Wang K, Bao L, Tong J, Xiao H, Xiao W, Cheng G, Xiong Z, Liang H, Liu D, Wang L, Olivier T, Jane BH, Yang H, Zhang X, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1299-1313
Molecular therapy : the journal of the American Society of Gene Therapy 2020 May 6;28(5):1299-1313
SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network.
Chakraborty A, Lin WC, Lin YT, Huang KJ, Wang PY, Chang IY, Wang HI, Ma KT, Wang CY, Huang XR, Lee YH, Chen BC, Hsieh YJ, Chien KY, Lin TY, Liu JL, Sung LY, Yu JS, Chang YS, Pai LM
Journal of cell science 2020 May 11;133(9)
Journal of cell science 2020 May 11;133(9)
ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.
Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Molecular cell 2020 Jun 18;78(6):1178-1191.e6
Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs.
Keppeke GD, Calise SJ, Chan EKL, Andrade LEC
Antiviral research 2019 Feb;162:130-135
Antiviral research 2019 Feb;162:130-135
Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments.
Calise SJ, Abboud G, Kasahara H, Morel L, Chan EKL
Frontiers in immunology 2018;9:2789
Frontiers in immunology 2018;9:2789
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.
Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY, Liu JL
Cell division 2018;13:5
Cell division 2018;13:5
Interfilament interaction between IMPDH and CTPS cytoophidia.
Chang CC, Keppeke GD, Sung LY, Liu JL
The FEBS journal 2018 Oct;285(20):3753-3768
The FEBS journal 2018 Oct;285(20):3753-3768
Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies.
Keppeke GD, Prado MS, Nunes E, Perazzio SF, Rodrigues SH, Ferraz ML, Chan EK, Andrade LE
Clinical immunology (Orlando, Fla.) 2016 Dec;173:149-156
Clinical immunology (Orlando, Fla.) 2016 Dec;173:149-156
'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
Calise SJ, Purich DL, Nguyen T, Saleem DA, Krueger C, Yin JD, Chan EK
Journal of cell science 2016 Aug 1;129(15):3042-52
Journal of cell science 2016 Aug 1;129(15):3042-52
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures.
Keppeke GD, Andrade LE, Grieshaber SS, Chan EK
Cell & bioscience 2015;5(1):1
Cell & bioscience 2015;5(1):1
Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction.
Keppeke GD, Calise SJ, Chan EK, Andrade LE
Journal of genetics and genomics = Yi chuan xue bao 2015 Jun 20;42(6):287-99
Journal of genetics and genomics = Yi chuan xue bao 2015 Jun 20;42(6):287-99
Molecular cell biology and immunobiology of mammalian rod/ring structures.
Carcamo WC, Calise SJ, von Mühlen CA, Satoh M, Chan EK
International review of cell and molecular biology 2014;308:35-74
International review of cell and molecular biology 2014;308:35-74
Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions.
Juda P, Smigová J, Kováčik L, Bártová E, Raška I
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2014 Oct;62(10):739-50
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2014 Oct;62(10):739-50
Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α.
Keppeke GD, Satoh M, Ferraz ML, Chan EK, Andrade LE
Immunologic research 2014 Oct;60(1):38-49
Immunologic research 2014 Oct;60(1):38-49
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Calise SJ, Carcamo WC, Krueger C, Yin JD, Purich DL, Chan EK
Cellular and molecular life sciences : CMLS 2014 Aug;71(15):2963-73
Cellular and molecular life sciences : CMLS 2014 Aug;71(15):2963-73
A simple Fourier filter for suppression of the missing wedge ray artefacts in single-axis electron tomographic reconstructions.
Kováčik L, Kereïche S, Kerïeche S, Höög JL, Jůda P, Matula P, Raška I
Journal of structural biology 2014 Apr;186(1):141-52
Journal of structural biology 2014 Apr;186(1):141-52
Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.
Lake JI, Tusheva OA, Graham BL, Heuckeroth RO
The Journal of clinical investigation 2013 Nov;123(11):4875-87
The Journal of clinical investigation 2013 Nov;123(11):4875-87
Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells.
Carcamo WC, Satoh M, Kasahara H, Terada N, Hamazaki T, Chan JY, Yao B, Tamayo S, Covini G, von Mühlen CA, Chan EK
PloS one 2011;6(12):e29690
PloS one 2011;6(12):e29690
Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis.
He Y, Mou Z, Li W, Liu B, Fu T, Zhao S, Xiang D, Wu Y
International journal of colorectal disease 2009 Nov;24(11):1271-9
International journal of colorectal disease 2009 Nov;24(11):1271-9
Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.
Gunter JH, Thomas EC, Lengefeld N, Kruger SJ, Worton L, Gardiner EM, Jones A, Barnett NL, Whitehead JP
The international journal of biochemistry & cell biology 2008;40(9):1716-28
The international journal of biochemistry & cell biology 2008;40(9):1716-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 12948-1-AP(IMPDH2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using IMPDH2 antibody 12948-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IMPDH2 (IP:12948-1-AP, 3ug; Detection:12948-1-AP 1:800) with K-562 cells lysate 4000ug.
- Sample type
- cell line