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Learn14119-1-AP
antibody from Proteintech Group
Targeting: MARCHF8
c-MIR, CMIR, MARCH-VIII, MARCH8, MIR, RNF178
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
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- Product number
- 14119-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14119-1-AP, RRID:AB_2140168
- Product name
- MARCH8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MARCH8 antibody (Cat. #14119-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction.
EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein.
Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells.
Elucidating the Antiviral Mechanism of Different MARCH Factors.
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.
BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy.
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Cell adhesion in zebrafish embryos is modulated by March 8.
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
Xu F, Liu X, Zhang D, Zhao F, Fan Z, Hu S, Mei S, Huang Y, Sun H, Wei L, Guo L, Wang J, Cen S, Liang C, Guo F
Human gene therapy 2021 Sep;32(17-18):936-948
Human gene therapy 2021 Sep;32(17-18):936-948
EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein.
Wang H, Kong N, Jiao Y, Dong S, Sun D, Chen X, Zheng H, Tong W, Yu H, Yu L, Zhang W, Tong G, Shan T
Journal of virology 2021 Sep 9;95(19):e0064521
Journal of virology 2021 Sep 9;95(19):e0064521
Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
Qian G, Guo J, Vallega KA, Hu C, Chen Z, Deng Y, Wang Q, Fan S, Ramalingam SS, Owonikoko TK, Wei W, Sun SY
Molecular cancer research : MCR 2021 Oct;19(10):1622-1634
Molecular cancer research : MCR 2021 Oct;19(10):1622-1634
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy.
Jiao Y, Kong N, Wang H, Sun D, Dong S, Chen X, Zheng H, Tong W, Yu H, Yu L, Huang Y, Wang H, Sui B, Zhao L, Liao Y, Zhang W, Tong G, Shan T
Microbiology spectrum 2021 Oct 31;9(2):e0090821
Microbiology spectrum 2021 Oct 31;9(2):e0090821
MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells.
Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H
Cancers 2021 May 22;13(11)
Cancers 2021 May 22;13(11)
Elucidating the Antiviral Mechanism of Different MARCH Factors.
Umthong S, Lynch B, Timilsina U, Waxman B, Ivey EB, Stavrou S
mBio 2021 Mar 2;12(2)
mBio 2021 Mar 2;12(2)
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes.
Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F
Nature communications 2021 Jul 20;12(1):4427
Nature communications 2021 Jul 20;12(1):4427
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation.
Yu C, Li S, Zhang X, Khan I, Ahmad I, Zhou Y, Li S, Shi J, Wang Y, Zheng YH
mBio 2020 Sep 15;11(5)
mBio 2020 Sep 15;11(5)
BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy.
Kong N, Shan T, Wang H, Jiao Y, Zuo Y, Li L, Tong W, Yu L, Jiang Y, Zhou Y, Li G, Gao F, Yu H, Zheng H, Tong G
Autophagy 2020 Oct;16(10):1737-1752
Autophagy 2020 Oct;16(10):1737-1752
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J
Molecular cell 2017 Oct 19;68(2):308-322.e4
Molecular cell 2017 Oct 19;68(2):308-322.e4
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.
Wang Q, Chen Q, Zhu L, Chen M, Xu W, Panday S, Wang Z, Li A, Røe OD, Chen R, Wang S, Zhang R, Zhou J
Oncogenesis 2017 Jul 3;6(7):e353
Oncogenesis 2017 Jul 3;6(7):e353
Cell adhesion in zebrafish embryos is modulated by March 8.
Kim MH, Rebbert ML, Ro H, Won M, Dawid IB
PloS one 2014;9(4):e94873
PloS one 2014;9(4):e94873
The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
Chen R, Li M, Zhang Y, Zhou Q, Shu HB
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14128-33
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14128-33
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MARCH8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MARCH8. This antibody recognizes human, mouse antigen. The MARCH8 antibody has been validated for the following applications: ELISA, WB, IP analysis.
