Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS2677 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Dyrk1B (T356) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 325-372 of Human Dyrk1B.
- Description
- Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is self regulated by tyrosine phosphorylation. Several related mammalian proteins compose the Dyrk family of dual specificity protein kinases, including Dyrk1A, Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B. The Dyrk family members are thought to be involved in the regulation of cellular growth and/or development. Dyrk1B localizes to the nucleus in muscle and testis. Specifically, Dyrk1B plays a critical role in muscle differentiation by regulating motility, transcription, cell cycle progression and cell survival. Dyrk1B is also found is several solid tumors, where it acts as a downstream effector of Rac1 or K-ras to mediate cell survival.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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