Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 55456-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55456-1-AP, RRID:AB_11232209
- Product name
- TRIM63 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM63 antibody (Cat. #55456-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting.
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia.
Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching.
Heat stress during late pregnancy of sows influences offspring longissimus dorsi muscle growth at weaning.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.
Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia.
Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors.
FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway.
Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways.
Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten/Akt pathway.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Fucoxanthinol attenuates oxidative stress-induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes.
A novel oncogene TRIM63 promotes cell proliferation and migration via activating Wnt/β-catenin signaling pathway in breast cancer.
Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.
Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis.
Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades.
Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles.
Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.
Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge.
Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.
Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis.
Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.
Shen Q, Kuang JX, Miao CX, Zhang WL, Li YW, Zhang XW, Liu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153858
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153858
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting.
Li L, Liu H, Tao W, Wen S, Fu X, Yu S
Frontiers in pharmacology 2021;12:731386
Frontiers in pharmacology 2021;12:731386
Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Zhang W, You B, Qi D, Qiu L, Ripley-Gonzalez JW, Zheng F, Fu S, Li C, Dun Y, Liu S
Scientific reports 2021 Sep 27;11(1):19116
Scientific reports 2021 Sep 27;11(1):19116
Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia.
Xie K, Xiong H, Xiao W, Xiong Z, Hu W, Ye J, Xu N, Shi J, Yuan C, Chen Z, Miao D, Zhang X, Yang H
Cancer cell international 2021 Nov 27;21(1):627
Cancer cell international 2021 Nov 27;21(1):627
Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching.
Deprez A, Orfi Z, Radu A, He Y, Ravizzoni Dartora D, Dort J, Dumont NA, Nuyt AM
Clinical science (London, England : 1979) 2021 Nov 26;135(22):2589-2605
Clinical science (London, England : 1979) 2021 Nov 26;135(22):2589-2605
Heat stress during late pregnancy of sows influences offspring longissimus dorsi muscle growth at weaning.
Li Y, Fan G, Liu Y, Yao W, Albrecht E, Zhao R, Yang X
Research in veterinary science 2021 May;136:336-342
Research in veterinary science 2021 May;136:336-342
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice.
Yoshikawa M, Hosokawa M, Miyashita K, Nishino H, Hashimoto T
Nutrients 2021 Mar 26;13(4)
Nutrients 2021 Mar 26;13(4)
Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.
Wang L, Zheng ZG, Meng L, Zhu L, Li P, Chen J, Yang H
Cell biology and toxicology 2021 Jun;37(3):441-460
Cell biology and toxicology 2021 Jun;37(3):441-460
Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia.
Miao C, Zhang W, Feng L, Gu X, Shen Q, Lu S, Fan M, Li Y, Guo X, Ma Y, Liu X, Wang H, Zhang X
Molecular therapy. Nucleic acids 2021 Jun 4;24:923-938
Molecular therapy. Nucleic acids 2021 Jun 4;24:923-938
Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Zhang L, Zhang Y, Zhou M, Wang S, Li T, Hu Z, Jin C
International journal of molecular medicine 2021 Jul;48(1)
International journal of molecular medicine 2021 Jul;48(1)
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα+ mesenchymal progenitors.
Shang GK, Han L, Wang ZH, Song M, Wang D, Tan YM, Li YH, Li YL, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-α pathway.
Guo A, Li K, Tian HC, Fan Z, Chen QN, Yang YF, Yu J, Wu YX, Xiao Q
Journal of cellular and molecular medicine 2021 Apr;25(7):3585-3600
Journal of cellular and molecular medicine 2021 Apr;25(7):3585-3600
Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways.
Wei X, Yang B, Chen X, Wen L, Kan J
Food & function 2021 Apr 21;12(8):3740-3753
Food & function 2021 Apr 21;12(8):3740-3753
Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.
Wen C, Li F, Guo Q, Zhang L, Duan Y, Wang W, Li J, He S, Chen W, Yin Y
Journal of animal science and biotechnology 2020;11:56
Journal of animal science and biotechnology 2020;11:56
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten/Akt pathway.
Wang M, Wu X, Gan L, Teng Z, Zhang H, Zhang Y
Experimental physiology 2020 Nov;105(11):1918-1927
Experimental physiology 2020 Nov;105(11):1918-1927
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy.
Sun X, Zhao D, Lu F, Peng S, Yu M, Liu N, Sun Y, Du H, Wang B, Chen J, Dong S, Lu F, Zhang W
British journal of pharmacology 2020 Feb;177(4):836-856
British journal of pharmacology 2020 Feb;177(4):836-856
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Lu F, Lu B, Zhang L, Wen J, Wang M, Zhang S, Li Q, Shu F, Sun Y, Liu N, Peng S, Zhao Y, Dong S, Zhao D, Lu F, Zhang W
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Journal of cellular and molecular medicine 2020 Aug;24(16):9362-9377
Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Shang GK, Han L, Wang ZH, Liu YP, Yan SB, Sai WW, Wang D, Li YH, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Journal of cachexia, sarcopenia and muscle 2020 Aug;11(4):1104-1120
Fucoxanthinol attenuates oxidative stress-induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes.
Yoshikawa M, Hosokawa M, Miyashita K, Fujita T, Nishino H, Hashimoto T
Molecular biology reports 2020 Apr;47(4):2703-2711
Molecular biology reports 2020 Apr;47(4):2703-2711
A novel oncogene TRIM63 promotes cell proliferation and migration via activating Wnt/β-catenin signaling pathway in breast cancer.
Li K, Pan W, Ma Y, Xu X, Gao Y, He Y, Wei L, Zhang J
Pathology, research and practice 2019 Oct;215(10):152573
Pathology, research and practice 2019 Oct;215(10):152573
Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.
Ding J, Li F, Cong Y, Miao J, Wu D, Liu B, Wang L
Life sciences 2019 Oct 15;235:116800
Life sciences 2019 Oct 15;235:116800
Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis.
Liu H, Li L, Zou J, Zhou T, Wang B, Sun H, Yu S
BMC complementary and alternative medicine 2019 Oct 15;19(1):267
BMC complementary and alternative medicine 2019 Oct 15;19(1):267
Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades.
Changchien CY, Lin YH, Cheng YC, Chang HH, Peng YS, Chen Y
Chemico-biological interactions 2019 May 1;304:43-51
Chemico-biological interactions 2019 May 1;304:43-51
Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles.
Chen CN, Liao YH, Tsai SC, Thompson LV
GeroScience 2019 Dec;41(6):871-880
GeroScience 2019 Dec;41(6):871-880
Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.
Duan Y, Zhong Y, Song B, Zheng C, Xu K, Kong X, Li F
Aging 2019 Dec 24;11(24):11922-11936
Aging 2019 Dec 24;11(24):11922-11936
Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge.
Duan Y, Zheng C, Zhong Y, Song B, Yan Z, Kong X, Deng J, Li F, Yin Y
Food & function 2019 Aug 1;10(8):5152-5165
Food & function 2019 Aug 1;10(8):5152-5165
Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.
Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3547-3559
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3547-3559
Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
Singh RK, Kolonin AM, Fiorotto ML, Cooper TA
Cell reports 2018 Jul 3;24(1):197-208
Cell reports 2018 Jul 3;24(1):197-208
Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.
Zhang L, Gong H, Sun Q, Zhao R, Jia Y
Journal of agricultural and food chemistry 2018 Jan 17;66(2):540-550
Journal of agricultural and food chemistry 2018 Jan 17;66(2):540-550
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis.
Miao C, Lv Y, Zhang W, Chai X, Feng L, Fang Y, Liu X, Zhang X
Frontiers in pharmacology 2017;8:915
Frontiers in pharmacology 2017;8:915
Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.
Guo D, Wang C, Wang Q, Qiao Z, Tang H
Oncotarget 2017 Jun 13;8(24):39640-39648
Oncotarget 2017 Jun 13;8(24):39640-39648
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 55456-1-AP(TRIM63 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM63 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TRIM63. This antibody recognizes human,mouse,rat antigen. The TRIM63 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55456-1-AP(TRIM63 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55456-1-AP(TRIM63 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue