11-8022

antibody from ABEOMICS Inc.

Targeting: MAPKAP1 MGC2745, MIP1, SIN1

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

11-8022

Provider

ABEOMICS Inc.

Product name

Anti-SAPK interacting protein 1/Mip1 Antibody

Antibody type

Polyclonal

Description

Stress-activated map kinase (SAPK )-interacting protein 1, also called as Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1), belongs to Stress-activated map kinase interacting protein 1 (SIN1) family. It is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors and also plays a critical role in AKT1 'Ser-473' phosphorylation. Except isoform 4 from its 6 isoforms , all can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. It is ubiquitously expressed in heart and skeletal muscle. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia and nephrogenic systemic fibrosis.

Reactivity

Human

Host

Rabbit

Antigen sequence

A partial length recombinant Mip1 p
rotein (amino acids 250-522) was us
ed as the immunogen for this antibo
dy.


Vial size

100 µg

Concentration

0.5 mg/ml

Storage

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing

Western blot

Supportive validation

Submitted by

ABEOMICS Inc. (provider)

Main image

Experimental details

Western blot analysis of SAPK interacting protein 1/Mip1. Anti- SAPK interacting protein 1/Mip1 antibody (11-8022) was used at 1 µg/ml on Hela lysate.