CABT-B9779

antibody from Creative Diagnostics

Targeting: APPL2 DIP13B, FLJ10659

No application information provided.

Antibody Data

Product number

CABT-B9779

Provider

Creative Diagnostics

Product name

Mouse anti-Human APPL2 monoclonal antibody, clone 2D21

Antibody type

Monoclonal

Description

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12