Antibody data

Product number
681102 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#681102, RRID:AB_2566443
Product name
Purified anti-FGF-19
Antibody type
Monoclonal
Antigen
Partial human FGF-19 recombinant protein (25-216 a.a.) expressed in E. coli.
Description
FGF-19 belongs to a subfamily of the fibroblast growth factors (FGFs) called endocrine FGFs, which consists of FGF-19, FGF-21, and FGF-23. Unlike other subfamily of FGFs, FGF-19 has a low binding affinity to heparin sulfate and functions as a circulating hormone with effects on distant tissues. FGF-19 has reduced binding affinity to the FGF receptors and the interaction requires two necessary cofactors that are α-Klotho and β-Klotho. In the ileum, FGF-19 expression is initiated by bile acids-induced activation of farnesoid X receptor (FXR). In response to bile acid stimulation, FGF-19 is secreted and enters the portal venous circulation, which subsequently down-regulates hepatic bile acid synthesis through repression of the CYP7A1 gene encoding cholesterol 7-alpha-monooxygenase. The impaired regulation of bile acids by FGF-19 leads to bile acid diarrhea also known as idiopathic bile acid malabsorption. FGF-19 has also been demonstrated to regulate carbohydrate and lipid metabolism.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
13D9C80
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
FGF19 protein structure - 681102 shown in red.