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- Antibody Data
- Antigen structure
- References [189]
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- Western blot [4]
- Immunohistochemistry [4]
- Flow cytometry [1]
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- Product number
- ABIN153145 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Porcine, Simian, Zebrafish
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury.
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model.
Whole-Genome Sequencing of African Dogs Provides Insights into Adaptations against Tropical Parasites.
Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.
Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury.
RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron.
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery.
Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury.
Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism.
Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation.
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells.
Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.
Dopamine elevates intracellular zinc concentration in cultured rat embryonic cortical neurons through the cAMP-nitric oxide signaling cascade.
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells.
Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy.
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer.
Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.
Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice.
Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer.
HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells.
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome.
LRRK2 interferes with aggresome formation for autophagic clearance.
Autophagy proteins are not universally required for phagosome maturation.
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice.
Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model.
Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells.
A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.
Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer.
Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas.
Inducing mitophagy in diabetic platelets protects against severe oxidative stress.
Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway.
Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress.
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.
Punicalagin promotes autophagy to protect primary human syncytiotrophoblasts from apoptosis.
Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid.
Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure.
Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.
Measuring autophagy in stressed cells.
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.
A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments.
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents.
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry.
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae.
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.
Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.
Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.
Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages.
AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1.
Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features.
Caffeine promotes autophagy in skeletal muscle cells by increasing the calcium-dependent activation of AMP-activated protein kinase.
Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells.
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells.
Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease.
Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.
ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells.
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells.
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.
DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway.
WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.
Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke.
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.
scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Nutrient-sensing nuclear receptors coordinate autophagy.
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation.
Autophagy is required for glucose homeostasis and lung tumor maintenance.
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.
Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish.
Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro.
Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.
Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling.
Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy.
Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells.
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.
p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP⁺-treated human SH-SY5Y cells.
Inhibition of nonsense-mediated RNA decay activates autophagy.
Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy.
High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs.
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.
Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration.
UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
An autophagy-independent role for LC3 in equine arteritis virus replication.
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.
Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival.
Knockdown of core binding factorβ alters sphingolipid metabolism.
Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation.
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.
CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines.
Amyloid-β secretion, generation, and lysosomal sequestration in response to proteasome inhibition: involvement of autophagy.
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
Proliferative and survival effects of PUMA promote angiogenesis.
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.
Caspase activation regulates the extracellular export of autophagic vacuoles.
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.
MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma.
BNip3 regulates mitochondrial function and lipid metabolism in the liver.
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions.
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.
Impaired cardiac autophagy in patients developing postoperative atrial fibrillation.
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
A quantitative TR-FRET plate reader immunoassay for measuring autophagy.
Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells.
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.
Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor.
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.
Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.
Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells.
Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.
Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses.
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis.
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.
JNK regulates FoxO-dependent autophagy in neurons.
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation.
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Inflammasome-independent modulation of cytokine response by autophagy in human cells.
Pancreatic cancers require autophagy for tumor growth.
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.
Autophagy pathways in glioblastoma.
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.
IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo.
Induction of autophagic cell death by a novel molecule is increased by hypoxia.
OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma.
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Magnaghi P, Salom B, Cozzi L, Amboldi N, Ballinari D, Tamborini E, Gasparri F, Montagnoli A, Raddrizzani L, Somaschini A, Bosotti R, Orrenius C, Bozzi F, Pilotti S, Galvani A, Sommer J, Stacchiotti S, Isacchi A
Molecular cancer therapeutics 2018 Mar;17(3):603-613
Molecular cancer therapeutics 2018 Mar;17(3):603-613
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
Parcon PA, Balasubramaniam M, Ayyadevara S, Jones RA, Liu L, Shmookler Reis RJ, Barger SW, Mrak RE, Griffin WST
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Feb;14(2):230-242
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 Feb;14(2):230-242
SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model.
Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE
Neurobiology of disease 2018 Feb;110:154-165
Neurobiology of disease 2018 Feb;110:154-165
Whole-Genome Sequencing of African Dogs Provides Insights into Adaptations against Tropical Parasites.
Liu YH, Wang L, Xu T, Guo X, Li Y, Yin TT, Yang HC, Hu Y, Adeola AC, Sanke OJ, Otecko NO, Wang M, Ma Y, Charles OS, Sinding MS, Gopalakrishnan S, Alfredo Samaniego J, Hansen AJ, Fernandes C, Gaubert P, Budd J, Dawuda PM, Knispel Rueness E, Jiang L, Zhai W, Gilbert MTP, Peng MS, Qi X, Wang GD, Zhang YP
Molecular biology and evolution 2018 Feb 1;35(2):287-298
Molecular biology and evolution 2018 Feb 1;35(2):287-298
Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.
Pascarella A, Terracciano C, Farina O, Lombardi L, Esposito T, Napolitano F, Franzese G, Panella G, Tuccillo F, la Marca G, Bernardini S, Boffo S, Giordano A, Di Iorio G, Melone MAB, Sampaolo S
Journal of cellular physiology 2018 Aug;233(8):5829-5837
Journal of cellular physiology 2018 Aug;233(8):5829-5837
Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury.
Gao Y, Zhuang Z, Gao S, Li X, Zhang Z, Ye Z, Li L, Tang C, Zhou M, Han X, Li J
American journal of translational research 2017;9(3):887-899
American journal of translational research 2017;9(3):887-899
RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.
Muniz-Feliciano L, Doggett TA, Zhou Z, Ferguson TA
Autophagy 2017;13(12):2072-2085
Autophagy 2017;13(12):2072-2085
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, Wu H, Ye X
PloS one 2017;12(7):e0180865
PloS one 2017;12(7):e0180865
Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron.
Sioutas A, Vainikka LK, Kentson M, Dam-Larsen S, Wennerström U, Jacobson P, Persson HL
Journal of inflammation research 2017;10:29-39
Journal of inflammation research 2017;10:29-39
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.
Garcia-Peterson LM, Ndiaye MA, Singh CK, Chhabra G, Huang W, Ahmad N
Genes & cancer 2017 Sep;8(9-10):701-712
Genes & cancer 2017 Sep;8(9-10):701-712
Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery.
Kemp V, Dautzenberg IJC, Limpens RW, van den Wollenberg DJM, Hoeben RC
Viruses 2017 Sep 21;9(10)
Viruses 2017 Sep 21;9(10)
Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury.
Zhu Y, Shui M, Liu X, Hu W, Wang Y
Metabolic brain disease 2017 Oct;32(5):1449-1458
Metabolic brain disease 2017 Oct;32(5):1449-1458
Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism.
Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, Tschan MP, Marinoni I, Perren A
Molecular cancer therapeutics 2017 Nov;16(11):2502-2515
Molecular cancer therapeutics 2017 Nov;16(11):2502-2515
Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation.
Germic N, Stojkov D, Oberson K, Yousefi S, Simon HU
Immunology 2017 Nov;152(3):517-525
Immunology 2017 Nov;152(3):517-525
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Kristensen LV, Oppermann FS, Rauen MJ, Hartmann-Petersen R, Thirstrup K
Neurochemistry international 2017 May;105:42-50
Neurochemistry international 2017 May;105:42-50
Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells.
Saha SK, Yin Y, Kim K, Yang GM, Dayem AA, Choi HY, Cho SG
International journal of molecular sciences 2017 May 12;18(5)
International journal of molecular sciences 2017 May 12;18(5)
Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling.
Lu Y, Bradley JS, McCoski SR, Gonzalez JM, Ealy AD, Johnson SE
American journal of physiology. Regulatory, integrative and comparative physiology 2017 May 1;312(5):R806-R815
American journal of physiology. Regulatory, integrative and comparative physiology 2017 May 1;312(5):R806-R815
Dopamine elevates intracellular zinc concentration in cultured rat embryonic cortical neurons through the cAMP-nitric oxide signaling cascade.
Hung HH, Kao LS, Liu PS, Huang CC, Yang DM, Pan CY
Molecular and cellular neurosciences 2017 Jul;82:35-45
Molecular and cellular neurosciences 2017 Jul;82:35-45
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.
Pagliassotti MJ, Estrada AL, Hudson WM, Wei Y, Wang D, Seals DR, Zigler ML, LaRocca TJ
The Journal of nutritional biochemistry 2017 Jul;45:15-23
The Journal of nutritional biochemistry 2017 Jul;45:15-23
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.
Sun QZ, Lin GF, Li LL, Jin XT, Huang LY, Zhang G, Yang W, Chen K, Xiang R, Chen C, Wei YQ, Lu GW, Yang SY
Journal of medicinal chemistry 2017 Jul 27;60(14):6337-6352
Journal of medicinal chemistry 2017 Jul 27;60(14):6337-6352
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells.
Liu YH, Weng YP, Lin HY, Tang SW, Chen CJ, Liang CJ, Ku CY, Lin JY
Scientific reports 2017 Jan 30;7:41437
Scientific reports 2017 Jan 30;7:41437
Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy.
Wang J, Cao B, Han D, Sun M, Feng J
Aging and disease 2017 Feb;8(1):71-84
Aging and disease 2017 Feb;8(1):71-84
Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL.
Humbert M, Federzoni EA, Tschan MP
Journal of leukocyte biology 2017 Dec;102(6):1357-1370
Journal of leukocyte biology 2017 Dec;102(6):1357-1370
A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer.
Sanborn RE, Ross HJ, Aung S, Acheson A, Moudgil T, Puri S, Hilton T, Fisher B, Coffey T, Paustian C, Neuberger M, Walker E, Hu HM, Urba WJ, Fox BA
Journal for immunotherapy of cancer 2017 Dec 19;5(1):103
Journal for immunotherapy of cancer 2017 Dec 19;5(1):103
Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.
Jiang P, Gan M, Yen SH, McLean PJ, Dickson DW
Scientific reports 2017 Aug 9;7(1):7690
Scientific reports 2017 Aug 9;7(1):7690
Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice.
Cao B, Parnell LA, Diamond MS, Mysorekar IU
The Journal of experimental medicine 2017 Aug 7;214(8):2303-2313
The Journal of experimental medicine 2017 Aug 7;214(8):2303-2313
Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer.
Niklaus M, Adams O, Berezowska S, Zlobec I, Graber F, Slotta-Huspenina J, Nitsche U, Rosenberg R, Tschan MP, Langer R
Oncotarget 2017 Aug 15;8(33):54604-54615
Oncotarget 2017 Aug 15;8(33):54604-54615
HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells.
Tang L, Chai W, Ye F, Yu Y, Cao L, Yang M, Xie M, Yang L
Oncotarget 2017 Apr 18;8(16):27314-27327
Oncotarget 2017 Apr 18;8(16):27314-27327
IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL
Autophagy 2016;12(2):397-409
Autophagy 2016;12(2):397-409
Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.
Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu M, Hiramoto M, Tsukahara K, Miyazawa K
PloS one 2016;11(12):e0164529
PloS one 2016;11(12):e0164529
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome.
Liu HM, Ferrington DA, Baumann CW, Thompson LV
PloS one 2016;11(11):e0166831
PloS one 2016;11(11):e0166831
LRRK2 interferes with aggresome formation for autophagic clearance.
Bang Y, Kim KS, Seol W, Choi HJ
Molecular and cellular neurosciences 2016 Sep;75:71-80
Molecular and cellular neurosciences 2016 Sep;75:71-80
Autophagy proteins are not universally required for phagosome maturation.
Cemma M, Grinstein S, Brumell JH
Autophagy 2016 Sep;12(9):1440-6
Autophagy 2016 Sep;12(9):1440-6
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
Qi X, Man SM, Malireddi RK, Karki R, Lupfer C, Gurung P, Neale G, Guy CS, Lamkanfi M, Kanneganti TD
The Journal of experimental medicine 2016 Sep 19;213(10):2081-97
The Journal of experimental medicine 2016 Sep 19;213(10):2081-97
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.
Vodicka P, Chase K, Iuliano M, Tousley A, Valentine DT, Sapp E, Kegel-Gleason KB, Sena-Esteves M, Aronin N, DiFiglia M
Journal of Huntington's disease 2016 Oct 1;5(3):249-260
Journal of Huntington's disease 2016 Oct 1;5(3):249-260
Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice.
Shui M, Liu X, Zhu Y, Wang Y
Canadian journal of physiology and pharmacology 2016 Nov;94(11):1187-1192
Canadian journal of physiology and pharmacology 2016 Nov;94(11):1187-1192
Cerebral ischemic post‑conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model.
Wang J, Han D, Sun M, Feng J
Molecular medicine reports 2016 Nov;14(5):4162-4172
Molecular medicine reports 2016 Nov;14(5):4162-4172
Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells.
Bauckman KA, Mysorekar IU
Autophagy 2016 May 3;12(5):850-63
Autophagy 2016 May 3;12(5):850-63
A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.
Gschweitl M, Ulbricht A, Barnes CA, Enchev RI, Stoffel-Studer I, Meyer-Schaller N, Huotari J, Yamauchi Y, Greber UF, Helenius A, Peter M
eLife 2016 Mar 23;5:e13841
eLife 2016 Mar 23;5:e13841
Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer.
Schläfli AM, Adams O, Galván JA, Gugger M, Savic S, Bubendorf L, Schmid RA, Becker KF, Tschan MP, Langer R, Berezowska S
Oncotarget 2016 Jun 28;7(26):39544-39555
Oncotarget 2016 Jun 28;7(26):39544-39555
Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas.
Adams O, Dislich B, Berezowska S, Schläfli AM, Seiler CA, Kröll D, Tschan MP, Langer R
Oncotarget 2016 Jun 28;7(26):39241-39255
Oncotarget 2016 Jun 28;7(26):39241-39255
Inducing mitophagy in diabetic platelets protects against severe oxidative stress.
Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J
EMBO molecular medicine 2016 Jul;8(7):779-95
EMBO molecular medicine 2016 Jul;8(7):779-95
Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway.
Zhou M, Wen Z, Cheng F, Ma J, Li W, Ren H, Sheng Y, Dong H, Lu L, Hu HM, Wang LX
Oncoimmunology 2016 Jul;5(7):e1180485
Oncoimmunology 2016 Jul;5(7):e1180485
Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress.
Alán L, Špaček T, Pajuelo Reguera D, Jabůrek M, Ježek P
Toxicology and applied pharmacology 2016 Jul 1;302:31-40
Toxicology and applied pharmacology 2016 Jul 1;302:31-40
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.
Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE
Nature medicine 2016 Jan;22(1):46-53
Nature medicine 2016 Jan;22(1):46-53
Punicalagin promotes autophagy to protect primary human syncytiotrophoblasts from apoptosis.
Wang Y, Chen B, Longtine MS, Nelson DM
Reproduction (Cambridge, England) 2016 Feb;151(2):97-104
Reproduction (Cambridge, England) 2016 Feb;151(2):97-104
Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.
Santanam U, Banach-Petrosky W, Abate-Shen C, Shen MM, White E, DiPaola RS
Genes & development 2016 Feb 15;30(4):399-407
Genes & development 2016 Feb 15;30(4):399-407
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC
Nature 2016 Aug 25;536(7617):479-83
Nature 2016 Aug 25;536(7617):479-83
Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid.
Boman A, Svensson S, Boxer A, Rojas JC, Seeley WW, Karydas A, Miller B, Kågedal K, Svenningsson P
Journal of Parkinson's disease 2016 Apr 2;6(2):307-15
Journal of Parkinson's disease 2016 Apr 2;6(2):307-15
Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure.
Dever SM, Rodriguez M, Lapierre J, Costin BN, El-Hage N
Frontiers in microbiology 2015;6:653
Frontiers in microbiology 2015;6:653
Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.
Stander XX, Stander BA, Joubert AM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(4):1499-526
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;35(4):1499-526
Measuring autophagy in stressed cells.
Sharifi MN, Mowers EE, Drake LE, Macleod KF
Methods in molecular biology (Clifton, N.J.) 2015;1292:129-50
Methods in molecular biology (Clifton, N.J.) 2015;1292:129-50
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M
Autophagy 2015;11(2):253-70
Autophagy 2015;11(2):253-70
Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.
Koukourakis MI, Kalamida D, Giatromanolaki A, Zois CE, Sivridis E, Pouliliou S, Mitrakas A, Gatter KC, Harris AL
PloS one 2015;10(9):e0137675
PloS one 2015;10(9):e0137675
A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments.
del Mar N, von Buttlar X, Yu AS, Guley NH, Reiner A, Honig MG
Experimental neurology 2015 Sep;271:53-71
Experimental neurology 2015 Sep;271:53-71
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Chourasia AH, Tracy K, Frankenberger C, Boland ML, Sharifi MN, Drake LE, Sachleben JR, Asara JM, Locasale JW, Karczmar GS, Macleod KF
EMBO reports 2015 Sep;16(9):1145-63
EMBO reports 2015 Sep;16(9):1145-63
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents.
Yu Y, Xie Y, Cao L, Yang L, Yang M, Lotze MT, Zeh HJ, Kang R, Tang D
Molecular & cellular oncology 2015 Oct-Dec;2(4):e1054549
Molecular & cellular oncology 2015 Oct-Dec;2(4):e1054549
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.
Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E
Oncogene 2015 Nov 5;34(45):5662-76
Oncogene 2015 Nov 5;34(45):5662-76
Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum.
Muñoz-Sáez E, de Munck García E, Arahuetes Portero RM, Martínez A, Solas Alados MT, Miguel BG
Neurotoxicology 2015 May;48:192-205
Neurotoxicology 2015 May;48:192-205
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.
Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagıroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG
Nature genetics 2015 May;47(5):528-34
Nature genetics 2015 May;47(5):528-34
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.
Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S, Molven A
Nature genetics 2015 May;47(5):518-522
Nature genetics 2015 May;47(5):518-522
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry.
Schläfli AM, Berezowska S, Adams O, Langer R, Tschan MP
European journal of histochemistry : EJH 2015 May 5;59(2):2481
European journal of histochemistry : EJH 2015 May 5;59(2):2481
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.
Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D
Nature communications 2015 May 22;6:7250
Nature communications 2015 May 22;6:7250
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner LB
Science signaling 2015 Mar 10;8(367):ra27
Science signaling 2015 Mar 10;8(367):ra27
A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
Hu G, McQuiston T, Bernard A, Park YD, Qiu J, Vural A, Zhang N, Waterman SR, Blewett NH, Myers TG, Maraia RJ, Kehrl JH, Uzel G, Klionsky DJ, Williamson PR
Nature cell biology 2015 Jul;17(7):930-942
Nature cell biology 2015 Jul;17(7):930-942
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
Zhang L, Wang H, Ding K, Xu J
Toxicology letters 2015 Jul 2;236(1):43-59
Toxicology letters 2015 Jul 2;236(1):43-59
Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium.
Toops KA, Tan LX, Jiang Z, Radu RA, Lakkaraju A
Molecular biology of the cell 2015 Jan 1;26(1):1-14
Molecular biology of the cell 2015 Jan 1;26(1):1-14
Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae.
Yang Q, Stevenson HL, Scott MJ, Ismail N
The American journal of pathology 2015 Feb;185(2):446-61
The American journal of pathology 2015 Feb;185(2):446-61
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D
Molecular pharmacology 2015 Dec;88(6):1045-54
Molecular pharmacology 2015 Dec;88(6):1045-54
Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.
Brigger D, Schläfli AM, Garattini E, Tschan MP
Cell death & disease 2015 Aug 27;6:e1861
Cell death & disease 2015 Aug 27;6:e1861
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N
Nature 2015 Aug 20;524(7565):361-5
Nature 2015 Aug 20;524(7565):361-5
Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.
Owczarczyk AB, Schaller MA, Reed M, Rasky AJ, Lombard DB, Lukacs NW
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 15;195(4):1637-46
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 15;195(4):1637-46
Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.
Xie X, Koh JY, Price S, White E, Mehnert JM
Cancer discovery 2015 Apr;5(4):410-23
Cancer discovery 2015 Apr;5(4):410-23
Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Vodicka P, Lim J, Williams DT, Kegel KB, Chase K, Park H, Marchionini D, Wilkinson S, Mead T, Birch H, Yates D, Lyons K, Dominguez C, Beconi M, Yue Z, Aronin N, DiFiglia M
Journal of Huntington's disease 2014;3(2):159-74
Journal of Huntington's disease 2014;3(2):159-74
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.
Bernard M, Dieudé M, Yang B, Hamelin K, Underwood K, Hébert MJ
Autophagy 2014;10(12):2193-207
Autophagy 2014;10(12):2193-207
Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.
Haimovici A, Brigger D, Torbett BE, Fey MF, Tschan MP
Leukemia research 2014 Sep;38(9):1041-7
Leukemia research 2014 Sep;38(9):1041-7
Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages.
Juárez E, Carranza C, Hernández-Sánchez F, Loyola E, Escobedo D, León-Contreras JC, Hernández-Pando R, Torres M, Sada E
BMC pulmonary medicine 2014 Sep 25;14:152
BMC pulmonary medicine 2014 Sep 25;14:152
AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1.
Li Y, Chen C, Yao F, Su Q, Liu D, Xue R, Dai G, Fang R, Zeng J, Chen Y, Huang H, Ma Y, Li W, Zhang L, Liu C, Dong Y
Archives of biochemistry and biophysics 2014 Sep 15;558:79-86
Archives of biochemistry and biophysics 2014 Sep 15;558:79-86
Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features.
Pacheco FJ, Almaguel FG, Evans W, Rios-Colon L, Filippov V, Leoh LS, Rook-Arena E, Mediavilla-Varela M, De Leon M, Casiano CA
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014 Oct;63(10):859-71
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014 Oct;63(10):859-71
Caffeine promotes autophagy in skeletal muscle cells by increasing the calcium-dependent activation of AMP-activated protein kinase.
Mathew TS, Ferris RK, Downs RM, Kinsey ST, Baumgarner BL
Biochemical and biophysical research communications 2014 Oct 24;453(3):411-8
Biochemical and biophysical research communications 2014 Oct 24;453(3):411-8
Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells.
Wang J, Gu S, Huang J, Chen S, Zhang Z, Xu M
BMC cancer 2014 Oct 17;14:768
BMC cancer 2014 Oct 17;14:768
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature 2014 May 15;509(7500):366-70
Nature 2014 May 15;509(7500):366-70
Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells.
Huang YL, Chang CL, Tang CH, Lin YC, Ju TK, Huang WP, Lee H
Cellular signalling 2014 Mar;26(3):611-8
Cellular signalling 2014 Mar;26(3):611-8
Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease.
Armstrong A, Mattsson N, Appelqvist H, Janefjord C, Sandin L, Agholme L, Olsson B, Svensson S, Blennow K, Zetterberg H, Kågedal K
Neuromolecular medicine 2014 Mar;16(1):150-60
Neuromolecular medicine 2014 Mar;16(1):150-60
Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.
Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB
The Journal of biological chemistry 2014 Mar 7;289(10):6404-14
The Journal of biological chemistry 2014 Mar 7;289(10):6404-14
ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells.
Stellrecht CM, Vangapandu HV, Le XF, Mao W, Shentu S
Journal of hematology & oncology 2014 Mar 14;7:23
Journal of hematology & oncology 2014 Mar 14;7:23
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP
Human molecular genetics 2014 Mar 1;23(5):1376-86
Human molecular genetics 2014 Mar 1;23(5):1376-86
Autophagy inhibits chemotherapy-induced apoptosis through downregulating Bad and Bim in hepatocellular carcinoma cells.
Zhou Y, Sun K, Ma Y, Yang H, Zhang Y, Kong X, Wei L
Scientific reports 2014 Jun 20;4:5382
Scientific reports 2014 Jun 20;4:5382
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.
Stein LR, Imai S
The EMBO journal 2014 Jun 17;33(12):1321-40
The EMBO journal 2014 Jun 17;33(12):1321-40
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.
Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK
Cellular and molecular life sciences : CMLS 2014 Jul;71(13):2561-76
Cellular and molecular life sciences : CMLS 2014 Jul;71(13):2561-76
DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway.
Pang Y, Si M, Sun B, Niu L, Xu X, Lu T, Yuan H, Lou H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2014 Jul;69:163-74
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2014 Jul;69:163-74
WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.
Brigger D, Proikas-Cezanne T, Tschan MP
Cell death & disease 2014 Jul 3;5:e1315
Cell death & disease 2014 Jul 3;5:e1315
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.
Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C
The Journal of biological chemistry 2014 Jul 25;289(30):20845-57
The Journal of biological chemistry 2014 Jul 25;289(30):20845-57
Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke.
Murray LS, Lu Y, Taggart A, Van Regemorter N, Vilain C, Abramowicz M, Kadler KE, Van Agtmael T
Human molecular genetics 2014 Jan 15;23(2):283-92
Human molecular genetics 2014 Jan 15;23(2):283-92
p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines.
Chang MA, Morgado M, Warren CR, Hinton CV, Farach-Carson MC, Delk NA
The Prostate 2014 Feb;74(2):149-63
The Prostate 2014 Feb;74(2):149-63
scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
Lai AY, Lan CP, Hasan S, Brown ME, McLaurin J
The Journal of biological chemistry 2014 Feb 7;289(6):3666-76
The Journal of biological chemistry 2014 Feb 7;289(6):3666-76
Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.
Dai Y, Zheng K, Clark J, Swerdlow RH, Pulst SM, Sutton JP, Shinobu LA, Simon DK
Human molecular genetics 2014 Feb 1;23(3):637-47
Human molecular genetics 2014 Feb 1;23(3):637-47
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):958-68
Journal of immunology (Baltimore, Md. : 1950) 2014 Feb 1;192(3):958-68
Nutrient-sensing nuclear receptors coordinate autophagy.
Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD
Nature 2014 Dec 4;516(7529):112-5
Nature 2014 Dec 4;516(7529):112-5
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation.
Ciccia F, Accardo-Palumbo A, Rizzo A, Guggino G, Raimondo S, Giardina A, Cannizzaro A, Colbert RA, Alessandro R, Triolo G
Annals of the rheumatic diseases 2014 Aug;73(8):1566-74
Annals of the rheumatic diseases 2014 Aug;73(8):1566-74
Autophagy is required for glucose homeostasis and lung tumor maintenance.
Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E
Cancer discovery 2014 Aug;4(8):914-27
Cancer discovery 2014 Aug;4(8):914-27
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC
Cancer discovery 2014 Aug;4(8):905-13
Cancer discovery 2014 Aug;4(8):905-13
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Akbari M, Keijzers G, Maynard S, Scheibye-Knudsen M, Desler C, Hickson ID, Bohr VA
DNA repair 2014 Apr;16:44-53
DNA repair 2014 Apr;16:44-53
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.
Stein LR, Wozniak DF, Dearborn JT, Kubota S, Apte RS, Izumi Y, Zorumski CF, Imai S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Apr 23;34(17):5800-15
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Apr 23;34(17):5800-15
Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish.
Clancey LF, Beirl AJ, Linbo TH, Cooper CD
PloS one 2013;8(5):e65096
PloS one 2013;8(5):e65096
Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.
Behrens C, Binotti B, Schmidt C, Robinson CV, Chua JJ, Kühnel K
PloS one 2013;8(10):e76355
PloS one 2013;8(10):e76355
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
Magnaghi P, D'Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Cervi G, Casale E, Xiao Y, Wong C, Anderson DJ, Galvani A, Donati D, O'Brien T, Jackson PK, Isacchi A
Nature chemical biology 2013 Sep;9(9):548-56
Nature chemical biology 2013 Sep;9(9):548-56
Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro.
Liu YQ, Ji Y, Li XZ, Tian KL, Young CY, Lou HX, Yuan HQ
Acta pharmacologica Sinica 2013 Sep;34(9):1183-91
Acta pharmacologica Sinica 2013 Sep;34(9):1183-91
Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.
Hämäläinen RH, Manninen T, Koivumäki H, Kislin M, Otonkoski T, Suomalainen A
Proceedings of the National Academy of Sciences of the United States of America 2013 Sep 17;110(38):E3622-30
Proceedings of the National Academy of Sciences of the United States of America 2013 Sep 17;110(38):E3622-30
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.
Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, McNiven MA
The Journal of cell biology 2013 Oct 28;203(2):315-26
The Journal of cell biology 2013 Oct 28;203(2):315-26
Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling.
Gorbea C, Rechsteiner M, Vallejo JG, Bowles NE
Science signaling 2013 Oct 1;6(295):ra86
Science signaling 2013 Oct 1;6(295):ra86
Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy.
Tran E, Chow A, Goda T, Wong A, Blakely K, Rocha M, Taeb S, Hoang VC, Liu SK, Emmenegger U
Biochemical and biophysical research communications 2013 Nov 29;441(4):726-31
Biochemical and biophysical research communications 2013 Nov 29;441(4):726-31
Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Raina K, Agarwal C, Wadhwa R, Serkova NJ, Agarwal R
Autophagy 2013 May;9(5):697-713
Autophagy 2013 May;9(5):697-713
Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells.
Moriya S, Che XF, Komatsu S, Abe A, Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K
International journal of oncology 2013 May;42(5):1541-50
International journal of oncology 2013 May;42(5):1541-50
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD
Nature immunology 2013 May;14(5):480-8
Nature immunology 2013 May;14(5):480-8
Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.
Xingyong C, Xicui S, Huanxing S, Jingsong O, Yi H, Xu Z, Ruxun H, Zhong P
BMC neuroscience 2013 May 20;14:56
BMC neuroscience 2013 May 20;14:56
p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.
Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, Miyazaki Y, Iida M, Tohnai G, Qiang Q, Tanaka F, Yanagawa T, Warabi E, Ishii T, Sobue G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 1;33(18):7710-27
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 1;33(18):7710-27
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.
Kenzelmann Broz D, Spano Mello S, Bieging KT, Jiang D, Dusek RL, Brady CA, Sidow A, Attardi LD
Genes & development 2013 May 1;27(9):1016-31
Genes & development 2013 May 1;27(9):1016-31
Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Martinet W, Schrijvers DM, Timmermans JP, Bult H, De Meyer GR
Autophagy 2013 Mar;9(3):386-402
Autophagy 2013 Mar;9(3):386-402
Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP⁺-treated human SH-SY5Y cells.
Verhaar R, Drukarch B, Bol JG, Jongenelen CA, Wilhelmus MM
Neurochemistry international 2013 Mar;62(4):486-91
Neurochemistry international 2013 Mar;62(4):486-91
Inhibition of nonsense-mediated RNA decay activates autophagy.
Wengrod J, Martin L, Wang D, Frischmeyer-Guerrerio P, Dietz HC, Gardner LB
Molecular and cellular biology 2013 Jun;33(11):2128-35
Molecular and cellular biology 2013 Jun;33(11):2128-35
Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy.
Selvakumaran M, Amaravadi RK, Vasilevskaya IA, O'Dwyer PJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 1;19(11):2995-3007
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 1;19(11):2995-3007
High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs.
Roy C, Gagné V, Fernandes MJ, Marceau F
Toxicology and applied pharmacology 2013 Jul 15;270(2):77-86
Toxicology and applied pharmacology 2013 Jul 15;270(2):77-86
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.
Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E
Genes & development 2013 Jul 1;27(13):1447-61
Genes & development 2013 Jul 1;27(13):1447-61
Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration.
Liao CC, Ho MY, Liang SM, Liang CM
Autophagy 2013 Jan;9(1):5-19
Autophagy 2013 Jan;9(1):5-19
UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts.
Bess AS, Ryde IT, Hinton DE, Meyer JN
Journal of biochemical and molecular toxicology 2013 Jan;27(1):28-41
Journal of biochemical and molecular toxicology 2013 Jan;27(1):28-41
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM
Nature 2013 Jan 31;493(7434):679-83
Nature 2013 Jan 31;493(7434):679-83
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
Humbert M, Medová M, Aebersold DM, Blaukat A, Bladt F, Fey MF, Zimmer Y, Tschan MP
Biochemical and biophysical research communications 2013 Feb 8;431(2):264-9
Biochemical and biophysical research communications 2013 Feb 8;431(2):264-9
An autophagy-independent role for LC3 in equine arteritis virus replication.
Monastyrska I, Ulasli M, Rottier PJ, Guan JL, Reggiori F, de Haan CA
Autophagy 2013 Feb 1;9(2):164-74
Autophagy 2013 Feb 1;9(2):164-74
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.
Zhirnov OP, Klenk HD
Journal of virology 2013 Dec;87(24):13107-14
Journal of virology 2013 Dec;87(24):13107-14
Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival.
Hung HH, Huang WP, Pan CY
Cell biology and toxicology 2013 Dec;29(6):415-29
Cell biology and toxicology 2013 Dec;29(6):415-29
Knockdown of core binding factorβ alters sphingolipid metabolism.
Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng SW, Berkowitz RS, Cardelli J, Meyers S, Davis JN
Journal of cellular physiology 2013 Dec;228(12):2350-64
Journal of cellular physiology 2013 Dec;228(12):2350-64
Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation.
Brigger D, Torbett BE, Chen J, Fey MF, Tschan MP
Biochemical and biophysical research communications 2013 Aug 23;438(2):283-8
Biochemical and biophysical research communications 2013 Aug 23;438(2):283-8
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.
Pallet N, Sirois I, Bell C, Hanafi LA, Hamelin K, Dieudé M, Rondeau C, Thibault P, Desjardins M, Hebert MJ
Proteomics 2013 Apr;13(7):1108-20
Proteomics 2013 Apr;13(7):1108-20
CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
Guo L, Stripay JL, Zhang X, Collage RD, Hulver M, Carchman EH, Howell GM, Zuckerbraun BS, Lee JS, Rosengart MR
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3620-8
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3620-8
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E
PloS one 2012;7(7):e41831
PloS one 2012;7(7):e41831
Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines.
Gwak HS, Kim TH, Jo GH, Kim YJ, Kwak HJ, Kim JH, Yin J, Yoo H, Lee SH, Park JB
PloS one 2012;7(10):e47449
PloS one 2012;7(10):e47449
Amyloid-β secretion, generation, and lysosomal sequestration in response to proteasome inhibition: involvement of autophagy.
Agholme L, Hallbeck M, Benedikz E, Marcusson J, Kågedal K
Journal of Alzheimer's disease : JAD 2012;31(2):343-58
Journal of Alzheimer's disease : JAD 2012;31(2):343-58
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
Lai AY, McLaurin J
Biochimica et biophysica acta 2012 Oct;1822(10):1629-37
Biochimica et biophysica acta 2012 Oct;1822(10):1629-37
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung AL, Bradner JE, Weinstock DM
Blood 2012 Oct 4;120(14):2843-52
Blood 2012 Oct 4;120(14):2843-52
Proliferative and survival effects of PUMA promote angiogenesis.
Zhang F, Li Y, Tang Z, Kumar A, Lee C, Zhang L, Zhu C, Klotzsche-von Ameln A, Wang B, Gao Z, Zhang S, Langer HF, Hou X, Jensen L, Ma W, Wong W, Chavakis T, Liu Y, Cao Y, Li X
Cell reports 2012 Nov 29;2(5):1272-85
Cell reports 2012 Nov 29;2(5):1272-85
Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Elrick MJ, Yu T, Chung C, Lieberman AP
Human molecular genetics 2012 Nov 15;21(22):4876-87
Human molecular genetics 2012 Nov 15;21(22):4876-87
Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages.
Kawano A, Tsukimoto M, Mori D, Noguchi T, Harada H, Takenouchi T, Kitani H, Kojima S
Biochemical and biophysical research communications 2012 Mar 30;420(1):102-7
Biochemical and biophysical research communications 2012 Mar 30;420(1):102-7
Caspase activation regulates the extracellular export of autophagic vacuoles.
Sirois I, Groleau J, Pallet N, Brassard N, Hamelin K, Londono I, Pshezhetsky AV, Bendayan M, Hébert MJ
Autophagy 2012 Jun;8(6):927-37
Autophagy 2012 Jun;8(6):927-37
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.
Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS
Human molecular genetics 2012 Jun 15;21(12):2651-62
Human molecular genetics 2012 Jun 15;21(12):2651-62
MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma.
Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jun 1;18(11):3030-41
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jun 1;18(11):3030-41
BNip3 regulates mitochondrial function and lipid metabolism in the liver.
Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW 2nd, Brady MJ, Macleod KF
Molecular and cellular biology 2012 Jul;32(13):2570-84
Molecular and cellular biology 2012 Jul;32(13):2570-84
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions.
Chang Y, Yan W, He X, Zhang L, Li C, Huang H, Nace G, Geller DA, Lin J, Tsung A
Gastroenterology 2012 Jul;143(1):177-87.e8
Gastroenterology 2012 Jul;143(1):177-87.e8
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.
Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 3;109(27):11008-13
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 3;109(27):11008-13
Impaired cardiac autophagy in patients developing postoperative atrial fibrillation.
Garcia L, Verdejo HE, Kuzmicic J, Zalaquett R, Gonzalez S, Lavandero S, Corbalan R
The Journal of thoracic and cardiovascular surgery 2012 Feb;143(2):451-9
The Journal of thoracic and cardiovascular surgery 2012 Feb;143(2):451-9
SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition.
Gal J, Bang Y, Choi HJ
Neurochemistry international 2012 Dec;61(7):992-1000
Neurochemistry international 2012 Dec;61(7):992-1000
A quantitative TR-FRET plate reader immunoassay for measuring autophagy.
Hancock MK, Hermanson SB, Dolman NJ
Autophagy 2012 Aug;8(8):1227-44
Autophagy 2012 Aug;8(8):1227-44
Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells.
Delk NA, Farach-Carson MC
Autophagy 2012 Apr;8(4):650-63
Autophagy 2012 Apr;8(4):650-63
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.
Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE
Autophagy 2012 Apr;8(4):609-22
Autophagy 2012 Apr;8(4):609-22
Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor.
Dehvari N, Mahmud T, Persson J, Bengtsson T, Graff C, Winblad B, Rönnbäck A, Behbahani H
Neurochemistry international 2012 Apr;60(5):533-42
Neurochemistry international 2012 Apr;60(5):533-42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.
Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA
The Journal of experimental medicine 2012 Apr 9;209(4):855-69
The Journal of experimental medicine 2012 Apr 9;209(4):855-69
Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.
Desmolaize B, Rose S, Wilhelm C, Warrass R, Douthwaite S
Antimicrobial agents and chemotherapy 2011 Sep;55(9):4128-33
Antimicrobial agents and chemotherapy 2011 Sep;55(9):4128-33
Role and regulation of autophagy in the development of acinar structures formed by bovine BME-UV1 mammary epithelial cells.
Sobolewska A, Motyl T, Gajewska M
European journal of cell biology 2011 Oct;90(10):854-64
European journal of cell biology 2011 Oct;90(10):854-64
Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice.
Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP
PLoS genetics 2011 Oct;7(10):e1002321
PLoS genetics 2011 Oct;7(10):e1002321
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.
Castino R, Fiorentino I, Cagnin M, Giovia A, Isidoro C
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):523-41
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):523-41
Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses.
Morris S, Swanson MS, Lieberman A, Reed M, Yue Z, Lindell DM, Lukacs NW
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct 15;187(8):3953-61
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct 15;187(8):3953-61
"Autophagic flux" in normal mouse tissues: focus on endogenous LC3A processing.
Zois CE, Giatromanolaki A, Sivridis E, Papaiakovou M, Kainulainen H, Koukourakis MI
Autophagy 2011 Nov;7(11):1371-8
Autophagy 2011 Nov;7(11):1371-8
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy.
Ma X, Jin M, Cai Y, Xia H, Long K, Liu J, Yu Q, Yuan J
Chemistry & biology 2011 Nov 23;18(11):1474-81
Chemistry & biology 2011 Nov 23;18(11):1474-81
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL
Human molecular genetics 2011 May 1;20(9):1820-33
Human molecular genetics 2011 May 1;20(9):1820-33
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
Haspel J, Shaik RS, Ifedigbo E, Nakahira K, Dolinay T, Englert JA, Choi AM
Autophagy 2011 Jun;7(6):629-42
Autophagy 2011 Jun;7(6):629-42
Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis.
Lithanatudom P, Wannatung T, Leecharoenkiat A, Svasti S, Fucharoen S, Smith DR
Annals of hematology 2011 Jul;90(7):747-58
Annals of hematology 2011 Jul;90(7):747-58
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR
Human molecular genetics 2011 Jan 1;20(1):40-50
Human molecular genetics 2011 Jan 1;20(1):40-50
Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.
Appelqvist H, Nilsson C, Garner B, Brown AJ, Kågedal K, Ollinger K
The American journal of pathology 2011 Feb;178(2):629-39
The American journal of pathology 2011 Feb;178(2):629-39
JNK regulates FoxO-dependent autophagy in neurons.
Xu P, Das M, Reilly J, Davis RJ
Genes & development 2011 Feb 15;25(4):310-22
Genes & development 2011 Feb 15;25(4):310-22
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Zheng L, Terman A, Hallbeck M, Dehvari N, Cowburn RF, Benedikz E, Kågedal K, Cedazo-Minguez A, Marcusson J
Autophagy 2011 Dec;7(12):1528-45
Autophagy 2011 Dec;7(12):1528-45
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation.
Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, Pagès G, Pouysségur J, McGargill MA, Green DR, Kanneganti TD
The Journal of biological chemistry 2011 Dec 16;286(50):42981-91
The Journal of biological chemistry 2011 Dec 16;286(50):42981-91
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 15;17(16):5353-66
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 15;17(16):5353-66
Inflammasome-independent modulation of cytokine response by autophagy in human cells.
Crişan TO, Plantinga TS, van de Veerdonk FL, Farcaş MF, Stoffels M, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG
PloS one 2011 Apr 7;6(4):e18666
PloS one 2011 Apr 7;6(4):e18666
Pancreatic cancers require autophagy for tumor growth.
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC
Genes & development 2011 Apr 1;25(7):717-29
Genes & development 2011 Apr 1;25(7):717-29
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K
Blood 2010 Sep 30;116(13):2266-76
Blood 2010 Sep 30;116(13):2266-76
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S
Human molecular genetics 2010 Jun 15;19(12):2445-55
Human molecular genetics 2010 Jun 15;19(12):2445-55
Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.
Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hähnel B, Hosser H, Gröne HJ, Kriz W
The American journal of pathology 2010 Aug;177(2):632-43
The American journal of pathology 2010 Aug;177(2):632-43
Autophagy pathways in glioblastoma.
Jiang H, White EJ, Conrad C, Gomez-Manzano C, Fueyo J
Methods in enzymology 2009;453:273-86
Methods in enzymology 2009;453:273-86
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.
Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M
The American journal of pathology 2009 May;174(5):1891-909
The American journal of pathology 2009 May;174(5):1891-909
Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.
Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE
Human molecular genetics 2009 Jun 1;18(11):1937-50
Human molecular genetics 2009 Jun 1;18(11):1937-50
IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma.
Dien Bard J, Gelebart P, Anand M, Zak Z, Hegazy SA, Amin HM, Lai R
The American journal of pathology 2009 Aug;175(2):825-34
The American journal of pathology 2009 Aug;175(2):825-34
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE
The American journal of pathology 2009 Aug;175(2):736-47
The American journal of pathology 2009 Aug;175(2):736-47
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.
Liu MT, Kuan YH, Wang J, Hen R, Gershon MD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Aug 5;29(31):9683-99
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Aug 5;29(31):9683-99
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo.
Ulasov IV, Sonabend AM, Nandi S, Khramtsov A, Han Y, Lesniak MS
British journal of cancer 2009 Apr 7;100(7):1154-64
British journal of cancer 2009 Apr 7;100(7):1154-64
Induction of autophagic cell death by a novel molecule is increased by hypoxia.
Tafani M, Schito L, Anwar T, Indelicato M, Sale P, Di Vito M, Morgante E, Beraldi R, Makovec F, Letari O, Caselli G, Spadafora C, Pucci B, Russo MA
Autophagy 2008 Nov;4(8):1042-53
Autophagy 2008 Nov;4(8):1042-53
OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma.
Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, Lee WC, Feng WC, Chen CS, Kuo ML, Cheng AL
Cancer research 2008 Nov 15;68(22):9348-57
Cancer research 2008 Nov 15;68(22):9348-57
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S
Autophagy 2008 May;4(4):467-75
Autophagy 2008 May;4(4):467-75
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK
Autophagy 2008 Apr;4(3):315-21
Autophagy 2008 Apr;4(3):315-21
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.
Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y
Molecular pharmacology 2007 Jul;72(1):29-39
Molecular pharmacology 2007 Jul;72(1):29-39
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