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- Antigen structure
- References [654]
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- Western blot [12]
- Immunohistochemistry [5]
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- Product number
- ABIN250638 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) (AA 1-100), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Bacteria, Bovine, Canine, Porcine, Simian, Zebrafish
- Host
- Rabbit
- Epitope
- N-Term, AA 1-100
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2).
Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.
Subcellular Localization and Functional Characterization of GII.4 Norovirus-Encoded NTPase.
Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.
Autophagy, Apoptosis, and Cell Proliferation in Exstrophy-Epispadias Complex.
Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction.
N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis.
TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation.
Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection.
In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients.
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
Erratum to "Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis".
Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes.
Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis.
A Coupled Approach Utilizing Immunohistochemistry and Immunocytochemistry to Visualize Cellular Lipophagy.
NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.
Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.
Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice.
Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death.
Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy.
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.
Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection.
Axonal dystrophy in the brain of mice with Sanfilippo syndrome.
Multi-targeted therapy of everolimus in Kaposi's sarcoma associated herpes virus infected primary effusion lymphoma.
Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms.
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Guanine nucleotide exchange factor -H1 promotes inflammatory cytokine production and intracellular mycobacterial elimination in macrophages.
Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells.
TFEB-mediated activation of the lysosome-autophagy system affects the transduction efficiency of adeno-associated virus 2.
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome.
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells.
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation.
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.
MG-132 reduces virus release in Bovine herpesvirus-1 infection.
Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.
Influence of endurance training on skeletal muscle mitophagy regulatory proteins in type 2 diabetic men.
High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells.
Sarsaparilla (Smilax Glabra Rhizome) Extract Activates Redox-Dependent ATM/ATR Pathway to Inhibit Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy.
Natural history of Helicobacter pylori VacA toxin in human gastric epithelium in vivo: vacuoles and beyond.
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
miR-130a Deregulates PTEN and Stimulates Tumor Growth.
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
DJ-1 activates autophagy in the repression of cardiac hypertrophy.
Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle-Induced Liver Injury.
Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cells.
HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition.
Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis.
C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy.
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme.
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.
Inflammation modulates LC3 expression in human preterm delivery.
Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.
Roles of p62 in BDNF-dependent autophagy suppression and neuroprotection against mitochondrial dysfunction in rat cortical neurons.
Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells.
Glucocorticoids differentially regulate the innate immune responses of TLR4 and the cytosolic DNA sensing pathway.
Loss of WDFY3 ameliorates severity of serum transfer-induced arthritis independently of autophagy.
Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer.
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.
Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.
AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.
Mechanisms of autophagy induction by sex steroids in bovine mammary epithelial cells.
The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae.
Studying Autophagy in Zebrafish.
Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.
The role of ZKSCAN3 in the transcriptional regulation of autophagy.
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy.
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells.
mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells.
Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice.
Peroxisomal protein PEX13 functions in selective autophagy.
Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells.
Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease.
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.
Relationships between mitochondrial DNA content, mitochondrial activity, and boar sperm motility.
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway.
Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes.
3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons.
Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death.
Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress.
Gambogic acid counteracts mutant p53 stability by inducing autophagy.
Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes.
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
Activating Autophagy by Aerobic Exercise in Mice.
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.
Interleukin-6 downregulated vascular smooth muscle cell contractile proteins via ATG4B-mediated autophagy in thoracic aortic dissection.
Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy.
Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.
Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
MTOR controls genesis and autophagy of GABAergic interneurons during brain development.
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma.
Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells.
Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction.
Accumulation of autophagosomes confers cytotoxicity.
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.
The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer.
Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages.
The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.
Measuring Autophagy in the Context of Cancer.
MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole.
Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway.
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.
Autophagy induced by a sulphamoylated estrone analogue contributes to its cytotoxic effect on breast cancer cells.
LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells.
Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?
Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats.
Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings.
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?
Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells.
Size, organization, and dynamics of soluble SQSTM1 and LC3-SQSTM1 complexes in living cells.
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.
Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388.
Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria.
Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.
The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes.
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
MicroRNA expression profiling of Leishmania donovani-infected host cells uncovers the regulatory role of MIR30A-3p in host autophagy.
Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Regulation and role of ERK phosphorylation in glial cells following a nigrostriatal pathway injury.
Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.
Potential protective effects of autophagy activated in MPP+ treated astrocytes.
Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism.
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.
Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain.
LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.
Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice.
Autophagy-mediated clearance of ubiquitinated mutant huntingtin by graphene oxide.
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential.
Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells.
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3.
The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer.
Ramalin-Mediated Apoptosis Is Enhanced by Autophagy Inhibition in Human Breast Cancer Cells.
Low-grade inflammatory polarization of monocytes impairs wound healing.
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.
Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels.
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress.
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.
Chaperone-like protein HYPK and its interacting partners augment autophagy.
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.
Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB.
The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway.
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
LAP-like process as an immune mechanism downstream of IFN-γ in control of the human malaria Plasmodium vivax liver stage.
Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway.
Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction.
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.
Lanthanide co-doped paramagnetic spindle-like mesocrystals for imaging and autophagy induction.
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.
α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart.
Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis.
Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy.
FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection.
Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720.
Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer.
Hinokitiol induces autophagy in murine breast and colorectal cancer cells.
Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity.
Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism.
Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells.
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.
Cell death and cell proliferation in human spina bifida.
Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance.
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis.
Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.
Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation.
WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation.
Role of neutral ceramidase in colon cancer.
Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial.
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.
CCT complex restricts neuropathogenic protein aggregation via autophagy.
Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect.
Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.
Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.
Cocaine induces astrocytosis through ER stress-mediated activation of autophagy.
TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.
Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation.
Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.
Nuclear LC3 Associates with Slowly Diffusing Complexes that Survey the Nucleolus.
Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance.
Intracellular pH Modulates Autophagy and Mitophagy.
Glutamine Modulates Macrophage Lipotoxicity.
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Autophagy inhibition enhances sensitivity of endometrial carcinoma cells to paclitaxel.
The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells.
Antiproliferative, Apoptotic, and Autophagic Activity of Ranibizumab, Bevacizumab, Pegaptanib, and Aflibercept on Fibroblasts: Implication for Choroidal Neovascularization.
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury.
Cocaine-mediated microglial activation involves the ER stress-autophagy axis.
Differential use of autophagy by primary dendritic cells specialized in cross-presentation.
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.
BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy.
ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells.
Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model.
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.
The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure.
Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.
Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.
Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models.
Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells.
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury.
Muscle LIM protein/CSRP3: a mechanosensor with a role in autophagy.
AKT mediated glycolytic shift regulates autophagy in classically activated macrophages.
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.
Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy.
Pyruvate stimulates mitophagy via PINK1 stabilization.
MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury.
Atg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma.
Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.
Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.
The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Multi-functionality and plasticity characterize epithelial cells in Hydra.
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression.
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer.
Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection.
Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells.
BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.
Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis.
Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages.
Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.
The activation of KSHV lytic cycle blocks autophagy in PEL cells.
Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1'10-phenanthroline-treated cells.
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway.
NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death.
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism.
Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth.
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.
Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Autophagy in zebrafish.
A novel GBE1 mutation and features of polyglucosan bodies autophagy in adult polyglucosan body disease.
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.
Alteration of lysosome fusion and low-grade inflammation mediated by super-low-dose endotoxin.
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway.
Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle.
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration.
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway.
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.
Excessive autophagy induces the failure of trophoblast invasion and vasculature: possible relevance to the pathogenesis of preeclampsia.
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death.
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia.
Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis.
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity.
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy.
Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1.
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine.
Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.
Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.
Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways.
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
LC3B globular structures correlate with survival in esophageal adenocarcinoma.
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.
Autophagy stimulation abrogates herpes simplex virus-1 infection.
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.
Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis.
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.
Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach.
Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation.
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
Gambogenic acid kills lung cancer cells through aberrant autophagy.
High level of microtubule-associated protein light chain 3 predicts poor prognosis in resectable esophageal squamous cell carcinoma.
Targeting CREB inhibits radiation-induced neuroendocrine differentiation and increases radiation-induced cell death in prostate cancer cells.
Growth factor receptor-bound protein 2 promotes autophagic removal of amyloid-β protein precursor intracellular domain overload in neuronal cells.
Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion.
Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures.
The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo.
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury.
Inhibition of autophagy enhances the anticancer activity of silver nanoparticles.
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.
Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles.
Use of Shigella flexneri to study autophagy-cytoskeleton interactions.
Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.
PICALM modulates autophagy activity and tau accumulation.
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.
Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.
Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.
In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice.
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis.
Size, stoichiometry, and organization of soluble LC3-associated complexes.
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Inhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro.
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: heme oxygenase-1 as a possible regulator.
The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.
Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway.
Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation.
Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats.
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Hepatitis C virus present in the sera of infected patients interferes with the autophagic process of monocytes impairing their in-vitro differentiation into dendritic cells.
Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10.
Preferential estrogen receptor β ligands reduce Bcl-2 expression in hormone-resistant breast cancer cells to increase autophagy.
Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
Enteral leptin administration affects intestinal autophagy in suckling piglets.
Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods.
Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet.
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics.
Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.
De novo prion aggregates trigger autophagy in skeletal muscle.
Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.
Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs.
NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection.
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly.
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.
Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.
Antibody-derived in vivo imaging of tau pathology.
Palmitic acid and oleic acid differentially regulate choline transporter-like 1 levels and glycerolipid metabolism in skeletal muscle cells.
Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.
YY1-MIR372-SQSTM1 regulatory axis in autophagy.
Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma.
Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A.
Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts.
Alcohol-induced autophagy contributes to loss in skeletal muscle mass.
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
Autophagy is essential for cardiac morphogenesis during vertebrate development.
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.
TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells.
Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Autophagy, senescence, and apoptosis.
Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes.
Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.
Insulin-stimulated degradation of apolipoprotein B100: roles of class II phosphatidylinositol-3-kinase and autophagy.
Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma.
Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation.
Orientia tsutsugamushi subverts dendritic cell functions by escaping from autophagy and impairing their migration.
Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function.
Spatiotemporally controlled induction of autophagy-mediated lysosome turnover.
Beading of the astrocytic processes (clasmatodendrosis) following head trauma is associated with protein degradation pathways.
Autophagy and human parturition: evaluation of LC3 expression in placenta from spontaneous or medically induced onset of labor.
Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis.
Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.
Diverse autophagosome membrane sources coalesce in recycling endosomes.
Glutathione peroxidase activity is neuroprotective in models of Huntington's disease.
Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro.
Autophagy negatively regulates early axon growth in cortical neurons.
Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.
Piperlongumine induces autophagy by targeting p38 signaling.
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.
Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells.
Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment.
Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology.
A proautophagic antiviral role for the cellular prion protein identified by infection with a herpes simplex virus 1 ICP34.5 mutant.
Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death.
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells.
Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells.
Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.
Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy.
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells.
Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction.
MDA5 localizes to stress granules, but this localization is not required for the induction of type I interferon.
Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent.
Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model.
Effect of Immortalization-Upregulated Protein-2 (IMUP-2) on Cell Death of Trophoblast.
Primary proteasome inhibition results in cardiac dysfunction.
mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy.
UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts.
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.
A sensitive and quantitative autolysosome probe for detecting autophagic activity in live and prestained fixed cells.
Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells.
Defective autophagy and mTORC1 signaling in myotubularin null mice.
Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells.
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Insufficient autophagy in idiopathic pulmonary fibrosis.
Active escape of Orientia tsutsugamushi from cellular autophagy.
Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins.
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.
Autophagy is required for IL-2-mediated fibroblast growth.
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.
Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?
The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS quantum dots.
The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells.
Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection.
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death.
The secretion of IL-1β and options for release.
Autophagy mediates anti-melanogenic activity of 3'-ODI in B16F1 melanoma cells.
Functional RIG-I-like receptors control the survival of mesenchymal stem cells.
ARP101 inhibits α-MSH-stimulated melanogenesis by regulation of autophagy in melanocytes.
Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.
Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling.
Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution.
mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells.
Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents.
Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?
The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment.
Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice.
ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.
Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells.
Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells.
Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.
The miR-290-295 cluster suppresses autophagic cell death of melanoma cells.
Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells.
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity.
Involvement of the autophagy pathway in trafficking of Mycobacterium tuberculosis bacilli through cultured human type II epithelial cells.
Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis.
Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells.
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
Effect of dual inhibition of apoptosis and autophagy in prostate cancer.
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.
zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function.
Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.
Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases.
Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy.
Akt inactivation induces endoplasmic reticulum stress-independent autophagy in fibroblasts from patients with Pompe disease.
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen.
Suppression of autophagy exacerbates Mefloquine-mediated cell death.
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death.
A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen.
Characterization of biological responses of colorectal cancer cells to anticancer regimens.
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.
The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes.
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury.
Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells.
Modulation of pediatric brain tumor autophagy and chemosensitivity.
Autophagy regulates inflammation in adipocytes.
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
HMGB1 promotes drug resistance in osteosarcoma.
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.
Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.
Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.
Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response.
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.
Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.
NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans.
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis.
Autophagy links inflammasomes to atherosclerotic progression.
p53/HMGB1 complexes regulate autophagy and apoptosis.
Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin.
c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells.
Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy.
Autophagy-mediated chemosensitization by cysteamine in cancer cells.
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase.
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
Autophagy induction by tetrahydrobiopterin deficiency.
Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway.
Obligate role for ketone body oxidation in neonatal metabolic homeostasis.
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
Autophagy in term normal human placentas.
Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet.
High-mobility group box 1 is essential for mitochondrial quality control.
Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
Scratching beneath the surface: new insights into the functional properties of the lateral occipital area and parahippocampal place area.
Relieving autophagy and 4EBP1 from rapamycin resistance.
The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress.
Autophagosome precursor maturation requires homotypic fusion.
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries.
Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo.
Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis.
2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line.
Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A.
Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein.
Snapin deficiency is associated with developmental defects of the central nervous system.
Calcipotriol induces autophagy in HeLa cells and keratinocytes.
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.
Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy.
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury.
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes.
Melanized fungi in human disease.
Sodium 5,6-benzylidene-L-ascorbate induces oxidative stress, autophagy, and growth arrest in human colon cancer HT-29 cells.
GABARAPL1 (GEC1) associates with autophagic vesicles.
Induction of genuine autophagy by cationic lipids in mammalian cells.
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
The role of autophagy in follicular development and atresia in rat granulosa cells.
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
Laforin, the most common protein mutated in Lafora disease, regulates autophagy.
Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy.
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.
Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells.
Discovery and characterization of a mammalian amyloid disaggregation activity.
14-3-3Tau regulates Beclin 1 and is required for autophagy.
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy.
Autophagic clearance of aggregate-prone proteins associated with neurodegeneration.
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
Metabolic adaptations to interrupted glycosaminoglycan recycling.
Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells.
Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal.
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy.
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.
Exploring the human genome with functional maps.
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.
Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes.
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells.
Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol (Gln) induces cell death with more autophagosomes which is autophagy-independent.
The autophagy machinery is required to initiate hepatitis C virus replication.
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.
A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death.
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates.
Activation of antibacterial autophagy by NADPH oxidases.
Methods to investigate autophagy during starvation and regeneration in hydra.
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
A block of autophagy in lysosomal storage disorders.
The ARF tumor suppressor can promote the progression of some tumors.
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis.
Autophagy-mediated clearance of aggresomes is not a universal phenomenon.
The autophagy gene ATG5 plays an essential role in B lymphocyte development.
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.
Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M
Autophagy 2018;14(5):796-811
Autophagy 2018;14(5):796-811
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2).
Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, Liu JJ, Feng GK, Chen MS, Zeng YX, Deng R, Zhu XF
Autophagy 2018;14(4):671-684
Autophagy 2018;14(4):671-684
Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.
Yin Y, Li E, Sun G, Yan HQ, Foley LM, Andrzejczuk LA, Attarwala IY, Hitchens TK, Kiselyov K, Dixon CE, Sun D
Molecular neurobiology 2018 Mar;55(3):2454-2470
Molecular neurobiology 2018 Mar;55(3):2454-2470
Subcellular Localization and Functional Characterization of GII.4 Norovirus-Encoded NTPase.
Yen JB, Wei LH, Chen LW, Chen LY, Hung CH, Wang SS, Chang PJ
Journal of virology 2018 Mar 1;92(5)
Journal of virology 2018 Mar 1;92(5)
Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.
Wang X, Zhang X, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan;32(1):37-51
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan;32(1):37-51
Autophagy, Apoptosis, and Cell Proliferation in Exstrophy-Epispadias Complex.
Shabaninia M, Tourchi A, Di Carlo H, Gearhart JP
Urology 2018 Jan;111:157-161
Urology 2018 Jan;111:157-161
Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.
Zhang L, Gong H, Sun Q, Zhao R, Jia Y
Journal of agricultural and food chemistry 2018 Jan 17;66(2):540-550
Journal of agricultural and food chemistry 2018 Jan 17;66(2):540-550
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction.
Sun H, Krauss RM, Chang JT, Teng BB
Journal of lipid research 2018 Feb;59(2):207-223
Journal of lipid research 2018 Feb;59(2):207-223
N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis.
Zhang H, Su W, Ying Z, Chen Y, Zhou L, Li Y, Zhang J, Zhang L, Wang T
European journal of nutrition 2018 Feb;57(1):327-338
European journal of nutrition 2018 Feb;57(1):327-338
TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation.
Sun L, Meng Z, Zhu Y, Lu J, Li Z, Zhao Q, Huang Y, Jiang L, Yao X
Cell death and differentiation 2018 Feb;25(2):368-379
Cell death and differentiation 2018 Feb;25(2):368-379
Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection.
Jabir MS, Sulaiman GM, Taqi ZJ, Li D
Microbes and infection 2018 Feb;20(2):89-100
Microbes and infection 2018 Feb;20(2):89-100
In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.
Díaz-Casado ME, Rusanova I, Aranda P, Fernández-Ortiz M, Sayed RKA, Fernández-Gil BI, Hidalgo-Gutiérrez A, Escames G, López LC, Acuña-Castroviejo D
Zebrafish 2018 Feb;15(1):15-26
Zebrafish 2018 Feb;15(1):15-26
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Falcon B, Noad J, McMahon H, Randow F, Goedert M
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients.
Evans T, Kok WL, Cowan K, Hefford M, Anichtchik O
Brain research 2018 Feb 15;1681:1-13
Brain research 2018 Feb 15;1681:1-13
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.
Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G
Journal of pineal research 2018 Apr;64(3)
Journal of pineal research 2018 Apr;64(3)
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Zhang X, Wu WK, Xu W, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J
Theranostics 2017;7(11):2822-2836
Theranostics 2017;7(11):2822-2836
Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
André EA, Braatz EM, Liu JP, Zeitlin SO
Journal of Huntington's disease 2017;6(1):47-62
Journal of Huntington's disease 2017;6(1):47-62
Erratum to "Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis".
Matos L, Gouveia AM, Almeida H
Oxidative medicine and cellular longevity 2017;2017:9172085
Oxidative medicine and cellular longevity 2017;2017:9172085
Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes.
Huang W, Ao P, Li J, Wu T, Xu L, Deng Z, Chen W, Yin C, Cheng X
BioMed research international 2017;2017:6341919
BioMed research international 2017;2017:6341919
Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis.
Matos L, Gouveia AM, Almeida H
Oxidative medicine and cellular longevity 2017;2017:3793817
Oxidative medicine and cellular longevity 2017;2017:3793817
A Coupled Approach Utilizing Immunohistochemistry and Immunocytochemistry to Visualize Cellular Lipophagy.
Sathyanarayan A
Methods in molecular biology (Clifton, N.J.) 2017;1554:185-191
Methods in molecular biology (Clifton, N.J.) 2017;1554:185-191
NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.
Yang C, Cai CZ, Song JX, Tan JQ, Durairajan SSK, Iyaswamy A, Wu MY, Chen LL, Yue Z, Li M, Lu JH
Autophagy 2017;13(12):2028-2040
Autophagy 2017;13(12):2028-2040
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway.
Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, McDaniel ML, Remedi MS, Razani B, Urano F, Diwan A
Autophagy 2017;13(11):1952-1968
Autophagy 2017;13(11):1952-1968
Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy.
Song C, Mitter SK, Qi X, Beli E, Rao HV, Ding J, Ip CS, Gu H, Akin D, Dunn WA Jr, Bowes Rickman C, Lewin AS, Grant MB, Boulton ME
PloS one 2017;12(2):e0171940
PloS one 2017;12(2):e0171940
Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice.
Rogers RS, Tungtur S, Tanaka T, Nadeau LL, Badawi Y, Wang H, Ni HM, Ding WX, Nishimune H
Frontiers in neuroscience 2017;11:473
Frontiers in neuroscience 2017;11:473
Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death.
Lee KH, Lee SJ, Lee HJ, Choi GE, Jung YH, Kim DI, Gabr AA, Ryu JM, Han HJ
Frontiers in molecular neuroscience 2017;10:229
Frontiers in molecular neuroscience 2017;10:229
Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy.
Du C, Ren Y, Yao F, Duan J, Zhao H, Du Y, Xiao X, Duan H, Shi Y
The international journal of biochemistry & cell biology 2017 Sep;90:17-28
The international journal of biochemistry & cell biology 2017 Sep;90:17-28
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.
Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X
Journal of lipid research 2017 Sep;58(9):1808-1821
Journal of lipid research 2017 Sep;58(9):1808-1821
Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection.
Bisicchia E, Latini L, Cavallucci V, Sasso V, Nicolin V, Molinari M, D'Amelio M, Viscomi MT
Molecular neurobiology 2017 Sep;54(7):4896-4907
Molecular neurobiology 2017 Sep;54(7):4896-4907
Axonal dystrophy in the brain of mice with Sanfilippo syndrome.
Beard H, Hassiotis S, Gai WP, Parkinson-Lawrence E, Hopwood JJ, Hemsley KM
Experimental neurology 2017 Sep;295:243-255
Experimental neurology 2017 Sep;295:243-255
Multi-targeted therapy of everolimus in Kaposi's sarcoma associated herpes virus infected primary effusion lymphoma.
Mohanty S, Kumar A, Das P, Sahu SK, Choudhuri T
Apoptosis : an international journal on programmed cell death 2017 Sep;22(9):1098-1115
Apoptosis : an international journal on programmed cell death 2017 Sep;22(9):1098-1115
Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.
Kim YD, Jeong EI, Nah J, Yoo SM, Lee WJ, Kim Y, Moon S, Hong SH, Jung YK
Journal of neurochemistry 2017 Sep;142(5):734-746
Journal of neurochemistry 2017 Sep;142(5):734-746
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS.
Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T
Proceedings of the National Academy of Sciences of the United States of America 2017 Sep 26;114(39):E8294-E8303
Proceedings of the National Academy of Sciences of the United States of America 2017 Sep 26;114(39):E8294-E8303
Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms.
Mishra P, Dauphinee AN, Ward C, Sarkar S, Gunawardena AHLAN, Manjithaya R
Autophagy 2017 Sep 2;13(9):1556-1572
Autophagy 2017 Sep 2;13(9):1556-1572
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Zhang G, Liu Z, Ding H, Zhou Y, Doan HA, Sin KWT, Zhu ZJ, Flores R, Wen Y, Gong X, Liu Q, Li YP
Nature communications 2017 Sep 19;8(1):589
Nature communications 2017 Sep 19;8(1):589
Guanine nucleotide exchange factor -H1 promotes inflammatory cytokine production and intracellular mycobacterial elimination in macrophages.
Wang H, Wang J, Yang J, Yang X, He J, Wang R, Liu S, Zhou L, Ma L
Cell cycle (Georgetown, Tex.) 2017 Sep 17;16(18):1695-1704
Cell cycle (Georgetown, Tex.) 2017 Sep 17;16(18):1695-1704
Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells.
Lee WK, Probst S, Santoyo-Sánchez MP, Al-Hamdani W, Diebels I, von Sivers JK, Kerek E, Prenner EJ, Thévenod F
Archives of toxicology 2017 Oct;91(10):3225-3245
Archives of toxicology 2017 Oct;91(10):3225-3245
TFEB-mediated activation of the lysosome-autophagy system affects the transduction efficiency of adeno-associated virus 2.
Popp L, Gomez E, Orji W, Ho M, Suh J, Segatori L
Virology 2017 Oct;510:1-8
Virology 2017 Oct;510:1-8
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome.
Hein LK, Apaja PM, Hattersley K, Grose RH, Xie J, Proud CG, Sargeant TJ
Biochimica et biophysica acta. Molecular cell research 2017 Oct;1864(10):1554-1565
Biochimica et biophysica acta. Molecular cell research 2017 Oct;1864(10):1554-1565
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells.
Lee HJ, Jung YH, Choi GE, Ko SH, Lee SJ, Lee SH, Han HJ
Redox biology 2017 Oct;13:426-443
Redox biology 2017 Oct;13:426-443
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.
Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, Maystadt I, Füchtbauer A, Füchtbauer EM, Jablonka S, Blum R, Üçeyler N, Petri S, Kaltschmidt B, Jahn R, Kaltschmidt C, Sendtner M
Nature communications 2017 Oct 30;8(1):678
Nature communications 2017 Oct 30;8(1):678
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation.
Li X, Wu XQ, Deng R, Li DD, Tang J, Chen WD, Chen JH, Ji J, Jiao L, Jiang S, Yang F, Feng GK, Senthilkumar R, Yue F, Zhang HL, Wu RY, Yu Y, Xu XL, Mai J, Li ZL, Peng XD, Huang Y, Huang X, Ma NF, Tao Q, Zeng YX, Zhu XF
Nature communications 2017 Oct 27;8(1):1159
Nature communications 2017 Oct 27;8(1):1159
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.
Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ
Scientific reports 2017 Oct 2;7(1):12480
Scientific reports 2017 Oct 2;7(1):12480
MG-132 reduces virus release in Bovine herpesvirus-1 infection.
Fiorito F, Iovane V, Cantiello A, Marullo A, De Martino L, Iovane G
Scientific reports 2017 Oct 17;7(1):13306
Scientific reports 2017 Oct 17;7(1):13306
Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.
Zhou X, Yue GG, Chan AM, Tsui SK, Fung KP, Sun H, Pu J, Lau CB
Biochemical pharmacology 2017 Oct 15;142:58-70
Biochemical pharmacology 2017 Oct 15;142:58-70
Influence of endurance training on skeletal muscle mitophagy regulatory proteins in type 2 diabetic men.
Brinkmann C, Przyklenk A, Metten A, Schiffer T, Bloch W, Brixius K, Gehlert S
Endocrine research 2017 Nov;42(4):325-330
Endocrine research 2017 Nov;42(4):325-330
High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells.
Zhao XL, Lin Y, Jiang J, Tang Z, Yang S, Lu L, Liang Y, Liu X, Tan J, Hu XG, Niu Q, Fu WJ, Yan ZX, Guo DY, Ping YF, Wang JM, Zhang X, Kung HF, Bian XW, Yao XH
The Journal of pathology 2017 Nov;243(3):376-389
The Journal of pathology 2017 Nov;243(3):376-389
Sarsaparilla (Smilax Glabra Rhizome) Extract Activates Redox-Dependent ATM/ATR Pathway to Inhibit Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy.
She T, Feng J, Lian S, Li R, Zhao C, Song G, Luo J, Dawuti R, Cai S, Qu L, Shou C
Nutrition and cancer 2017 Nov-Dec;69(8):1281-1289
Nutrition and cancer 2017 Nov-Dec;69(8):1281-1289
Natural history of Helicobacter pylori VacA toxin in human gastric epithelium in vivo: vacuoles and beyond.
Necchi V, Sommi P, Vanoli A, Fiocca R, Ricci V, Solcia E
Scientific reports 2017 Nov 6;7(1):14526
Scientific reports 2017 Nov 6;7(1):14526
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death.
Granato M, Gilardini Montani MS, Santarelli R, D'Orazi G, Faggioni A, Cirone M
Journal of experimental & clinical cancer research : CR 2017 Nov 28;36(1):167
Journal of experimental & clinical cancer research : CR 2017 Nov 28;36(1):167
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D
The Journal of biological chemistry 2017 Nov 24;292(47):19209-19225
The Journal of biological chemistry 2017 Nov 24;292(47):19209-19225
miR-130a Deregulates PTEN and Stimulates Tumor Growth.
Wei H, Cui R, Bahr J, Zanesi N, Luo Z, Meng W, Liang G, Croce CM
Cancer research 2017 Nov 15;77(22):6168-6178
Cancer research 2017 Nov 15;77(22):6168-6178
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Ndoye A, Budina-Kolomets A, Kugel CH 3rd, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT
Cancer research 2017 Nov 1;77(21):5873-5885
Cancer research 2017 Nov 1;77(21):5873-5885
DJ-1 activates autophagy in the repression of cardiac hypertrophy.
Xue R, Jiang J, Dong B, Tan W, Sun Y, Zhao J, Chen Y, Dong Y, Liu C
Archives of biochemistry and biophysics 2017 Nov 1;633:124-132
Archives of biochemistry and biophysics 2017 Nov 1;633:124-132
Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle-Induced Liver Injury.
Zhu S, Zhang J, Zhang L, Ma W, Man N, Liu Y, Zhou W, Lin J, Wei P, Jin P, Zhang Y, Hu Y, Gu E, Lu X, Yang Z, Liu X, Bai L, Wen L
Advanced healthcare materials 2017 May;6(9)
Advanced healthcare materials 2017 May;6(9)
Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cells.
Riaz Ahmed KB, Kanduluru AK, Feng L, Fuchs PL, Huang P
International journal of oncology 2017 May;50(5):1482-1490
International journal of oncology 2017 May;50(5):1482-1490
HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition.
Foglio E, Puddighinu G, Germani A, Russo MA, Limana F
Journal of cellular physiology 2017 May;232(5):1135-1143
Journal of cellular physiology 2017 May;232(5):1135-1143
Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways.
Inoue T, Tanaka M, Masuda S, Ohue-Kitano R, Yamakage H, Muranaka K, Wada H, Kusakabe T, Shimatsu A, Hasegawa K, Satoh-Asahara N
Biochimica et biophysica acta. Molecular and cell biology of lipids 2017 May;1862(5):552-560
Biochimica et biophysica acta. Molecular and cell biology of lipids 2017 May;1862(5):552-560
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC
Nature 2017 May 4;545(7652):108-111
Nature 2017 May 4;545(7652):108-111
Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis.
Chen C, Lu Y, Siu HM, Guan J, Zhu L, Zhang S, Yue J, Zhang L
Molecules (Basel, Switzerland) 2017 May 27;22(6)
Molecules (Basel, Switzerland) 2017 May 27;22(6)
C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy.
Salcher S, Hermann M, Kiechl-Kohlendorfer U, Ausserlechner MJ, Obexer P
Molecular cancer 2017 May 25;16(1):95
Molecular cancer 2017 May 25;16(1):95
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.
Masuelli L, Benvenuto M, Di Stefano E, Mattera R, Fantini M, De Feudis G, De Smaele E, Tresoldi I, Giganti MG, Modesti A, Bei R
Oncotarget 2017 May 23;8(21):34405-34422
Oncotarget 2017 May 23;8(21):34405-34422
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme.
Wang L, Gundelach JH, Bram RJ
Cell death & disease 2017 May 18;8(5):e2807
Cell death & disease 2017 May 18;8(5):e2807
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.
Granato M, Rizzello C, Gilardini Montani MS, Cuomo L, Vitillo M, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M
The Journal of nutritional biochemistry 2017 Mar;41:124-136
The Journal of nutritional biochemistry 2017 Mar;41:124-136
Inflammation modulates LC3 expression in human preterm delivery.
Avagliano L, Massa V, Zullino S, Doi P, Marconi AM, Ferrazzi E, Bulfamante GP
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2017 Mar;30(6):698-704
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2017 Mar;30(6):698-704
Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.
Zhang S, Eitan E, Mattson MP
Journal of neurochemistry 2017 Mar;140(6):941-954
Journal of neurochemistry 2017 Mar;140(6):941-954
Roles of p62 in BDNF-dependent autophagy suppression and neuroprotection against mitochondrial dysfunction in rat cortical neurons.
Wu CL, Chen CH, Hwang CS, Chen SD, Hwang WC, Yang DI
Journal of neurochemistry 2017 Mar;140(6):845-861
Journal of neurochemistry 2017 Mar;140(6):845-861
Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells.
Yan C, Luo L, Guo CY, Goto S, Urata Y, Shao JH, Li TS
Cancer letters 2017 Mar 1;388:34-42
Cancer letters 2017 Mar 1;388:34-42
Glucocorticoids differentially regulate the innate immune responses of TLR4 and the cytosolic DNA sensing pathway.
Wang J, Wang R, Yang J, Yang X, Hu S, Wang H, Zhou C, Xiong W, Wen Q, Ma L
International immunopharmacology 2017 Jun;47:190-198
International immunopharmacology 2017 Jun;47:190-198
Loss of WDFY3 ameliorates severity of serum transfer-induced arthritis independently of autophagy.
Wu DJ, Adamopoulos IE
Cellular immunology 2017 Jun;316:61-69
Cellular immunology 2017 Jun;316:61-69
Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.
Xue R, Zeng J, Chen Y, Chen C, Tan W, Zhao J, Dong B, Sun Y, Dong Y, Liu C
Journal of cellular and molecular medicine 2017 Jun;21(6):1193-1205
Journal of cellular and molecular medicine 2017 Jun;21(6):1193-1205
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, Javaheri A, Crowley JR, Ballabio A, Schilling JD, Epelman S, Weihl CC, Diwan A, Fan D, Zayed MA, Razani B
Nature communications 2017 Jun 7;8:15750
Nature communications 2017 Jun 7;8:15750
Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer.
Li J, Song P, Zhu L, Aziz N, Zhou Q, Zhang Y, Xu W, Feng L, Chen D, Wang X, Jin H
Oncotarget 2017 Jun 27;8(26):42664-42672
Oncotarget 2017 Jun 27;8(26):42664-42672
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.
Peraro L, Zou Z, Makwana KM, Cummings AE, Ball HL, Yu H, Lin YS, Levine B, Kritzer JA
Journal of the American Chemical Society 2017 Jun 14;139(23):7792-7802
Journal of the American Chemical Society 2017 Jun 14;139(23):7792-7802
Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.
Liu YQ, Jia MQ, Xie ZH, Liu XF, Hui-Yang, Zheng XL, Yuan HQ, Bi JZ
Scientific reports 2017 Jun 13;7(1):3446
Scientific reports 2017 Jun 13;7(1):3446
AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.
Jang JE, Eom JI, Jeung HK, Cheong JW, Lee JY, Kim JS, Min YH
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2781-2794
Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 1;23(11):2781-2794
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease.
Nitschke F, Sullivan MA, Wang P, Zhao X, Chown EE, Perri AM, Israelian L, Juana-López L, Bovolenta P, Rodríguez de Córdoba S, Steup M, Minassian BA
EMBO molecular medicine 2017 Jul;9(7):906-917
EMBO molecular medicine 2017 Jul;9(7):906-917
Mechanisms of autophagy induction by sex steroids in bovine mammary epithelial cells.
Zielniok K, Sobolewska A, Gajewska M
Journal of molecular endocrinology 2017 Jul;59(1):29-48
Journal of molecular endocrinology 2017 Jul;59(1):29-48
The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae.
Ullah I, Ritchie ND, Evans TJ
Innate immunity 2017 Jul;23(5):413-423
Innate immunity 2017 Jul;23(5):413-423
Studying Autophagy in Zebrafish.
Mathai BJ, Meijer AH, Simonsen A
Cells 2017 Jul 9;6(3)
Cells 2017 Jul 9;6(3)
Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.
Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV
Scientific reports 2017 Jul 3;7(1):4543
Scientific reports 2017 Jul 3;7(1):4543
The role of ZKSCAN3 in the transcriptional regulation of autophagy.
Pan H, Yan Y, Liu C, Finkel T
Autophagy 2017 Jul 3;13(7):1235-1238
Autophagy 2017 Jul 3;13(7):1235-1238
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH
Autophagy 2017 Jul 3;13(7):1130-1144
Autophagy 2017 Jul 3;13(7):1130-1144
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY
Nature communications 2017 Jul 24;8(1):102
Nature communications 2017 Jul 24;8(1):102
Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy.
Cui D, Sun D, Wang X, Yi L, Kulikowicz E, Reyes M, Zhu J, Yang ZJ, Jiang W, Koehler RC
Cell death & disease 2017 Jul 13;8(7):e2919
Cell death & disease 2017 Jul 13;8(7):e2919
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A
EMBO molecular medicine 2017 Jan;9(1):112-132
EMBO molecular medicine 2017 Jan;9(1):112-132
Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells.
D'Eliseo D, Di Renzo L, Santoni A, Velotti F
Genes & cancer 2017 Jan;8(1-2):426-437
Genes & cancer 2017 Jan;8(1-2):426-437
mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells.
Park YS, Park JH, Ko J, Shin IC, Koh HC
Environmental toxicology 2017 Jan;32(1):109-121
Environmental toxicology 2017 Jan;32(1):109-121
Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice.
Li Y, Wang F, Luo Y
The Journal of surgical research 2017 Jan;207:181-189
The Journal of surgical research 2017 Jan;207:181-189
Peroxisomal protein PEX13 functions in selective autophagy.
Lee MY, Sumpter R Jr, Zou Z, Sirasanagandla S, Wei Y, Mishra P, Rosewich H, Crane DI, Levine B
EMBO reports 2017 Jan;18(1):48-60
EMBO reports 2017 Jan;18(1):48-60
Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells.
Xia J, Yu X, Song X, Li G, Mao X, Zhang Y
Molecular medicine reports 2017 Jan;15(1):488-494
Molecular medicine reports 2017 Jan;15(1):488-494
Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease.
Chen JL, David J, Cook-Spaeth D, Casey S, Cohen D, Selvendiran K, Bekaii-Saab T, Hays JL
Molecular cancer research : MCR 2017 Jan;15(1):26-34
Molecular cancer research : MCR 2017 Jan;15(1):26-34
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.
Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A
eLife 2017 Jan 17;6
eLife 2017 Jan 17;6
Relationships between mitochondrial DNA content, mitochondrial activity, and boar sperm motility.
Guo H, Gong Y, He B, Zhao R
Theriogenology 2017 Jan 1;87:276-283
Theriogenology 2017 Jan 1;87:276-283
SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway.
Ben Salem I, Boussabbeh M, Pires Da Silva J, Guilbert A, Bacha H, Abid-Essefi S, Lemaire C
Toxicology and applied pharmacology 2017 Jan 1;314:82-90
Toxicology and applied pharmacology 2017 Jan 1;314:82-90
Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes.
Kruse R, Pedersen AJ, Kristensen JM, Petersson SJ, Wojtaszewski JF, Højlund K
Clinical science (London, England : 1979) 2017 Jan 1;131(1):37-47
Clinical science (London, England : 1979) 2017 Jan 1;131(1):37-47
3D electron tomography of brain tissue unveils distinct Golgi structures that sequester cytoplasmic contents in neurons.
Fernandez-Fernandez MR, Ruiz-Garcia D, Martin-Solana E, Chichon FJ, Carrascosa JL, Fernandez JJ
Journal of cell science 2017 Jan 1;130(1):83-89
Journal of cell science 2017 Jan 1;130(1):83-89
Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death.
Panda PK, Behera B, Meher BR, Das DN, Mukhopadhyay S, Sinha N, Naik PP, Roy B, Das J, Paul S, Maiti TK, Agarwal R, Bhutia SK
Molecular carcinogenesis 2017 Feb;56(2):389-401
Molecular carcinogenesis 2017 Feb;56(2):389-401
Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress.
Hu DD, Mai JN, He LY, Li PQ, Chen WX, Yan JJ, Zhu WD, Deng L, Wei D, Liu DH, Yang SD, Yao ZB
Neurotoxicity research 2017 Feb;31(2):204-217
Neurotoxicity research 2017 Feb;31(2):204-217
Gambogic acid counteracts mutant p53 stability by inducing autophagy.
Foggetti G, Ottaggio L, Russo D, Monti P, Degan P, Fronza G, Menichini P
Biochimica et biophysica acta. Molecular cell research 2017 Feb;1864(2):382-392
Biochimica et biophysica acta. Molecular cell research 2017 Feb;1864(2):382-392
Persistency of Enlarged Autolysosomes Underscores Nanoparticle-Induced Autophagy in Hepatocytes.
Zhang JQ, Zhou W, Zhu SS, Lin J, Wei PF, Li FF, Jin PP, Yao H, Zhang YJ, Hu Y, Liu YM, Chen M, Li ZQ, Liu XS, Bai L, Wen LP
Small (Weinheim an der Bergstrasse, Germany) 2017 Feb;13(7)
Small (Weinheim an der Bergstrasse, Germany) 2017 Feb;13(7)
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS
Autophagy 2017 Feb;13(2):371-385
Autophagy 2017 Feb;13(2):371-385
Activating Autophagy by Aerobic Exercise in Mice.
Rocchi A, He C
Journal of visualized experiments : JoVE 2017 Feb 3;(120)
Journal of visualized experiments : JoVE 2017 Feb 3;(120)
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.
De Luca A, Carpanese D, Rapanotti MC, Viguria TM, Forgione MA, Rotili D, Fulci C, Iorio E, Quintieri L, Chimenti S, Bianchi L, Rosato A, Caccuri AM
Oncotarget 2017 Feb 28;8(9):15520-15538
Oncotarget 2017 Feb 28;8(9):15520-15538
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG
Nature communications 2017 Feb 15;8:14423
Nature communications 2017 Feb 15;8:14423
Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation.
Granato M, Gilardini Montani MS, Romeo MA, Santarelli R, Gonnella R, D'Orazi G, Faggioni A, Cirone M
Cellular signalling 2017 Dec;40:239-247
Cellular signalling 2017 Dec;40:239-247
Interleukin-6 downregulated vascular smooth muscle cell contractile proteins via ATG4B-mediated autophagy in thoracic aortic dissection.
An Z, Qiao F, Lu Q, Ma Y, Liu Y, Lu F, Xu Z
Heart and vessels 2017 Dec;32(12):1523-1535
Heart and vessels 2017 Dec;32(12):1523-1535
Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy.
Feng Y, Madungwe NB, da Cruz Junho CV, Bopassa JC
British journal of pharmacology 2017 Dec;174(23):4329-4344
British journal of pharmacology 2017 Dec;174(23):4329-4344
Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.
Hartupee J, Szalai GD, Wang W, Ma X, Diwan A, Mann DL
Circulation. Heart failure 2017 Dec;10(12)
Circulation. Heart failure 2017 Dec;10(12)
Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.
Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark GT, Ingelsson M, Bergström J, Roybon L, Erlandsson A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Dec 6;37(49):11835-11853
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Dec 6;37(49):11835-11853
Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.
Fiesel FC, James ED, Hudec R, Springer W
Oncotarget 2017 Dec 5;8(63):106233-106248
Oncotarget 2017 Dec 5;8(63):106233-106248
Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Wang H, Tian C, Sun J, Chen LN, Lv Y, Yang XD, Xiao K, Wang J, Chen C, Shi Q, Shao QX, Dong XP
Molecular neurobiology 2017 Aug;54(6):4401-4413
Molecular neurobiology 2017 Aug;54(6):4401-4413
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C
PLoS genetics 2017 Aug;13(8):e1006962
PLoS genetics 2017 Aug;13(8):e1006962
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN
eLife 2017 Aug 9;6
eLife 2017 Aug 9;6
Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
Bischoff FC, Werner A, John D, Boeckel JN, Melissari MT, Grote P, Glaser SF, Demolli S, Uchida S, Michalik KM, Meder B, Katus HA, Haas J, Chen W, Pullamsetti SS, Seeger W, Zeiher AM, Dimmeler S, Zehendner CM
Circulation research 2017 Aug 4;121(4):368-375
Circulation research 2017 Aug 4;121(4):368-375
MTOR controls genesis and autophagy of GABAergic interneurons during brain development.
Ka M, Smith AL, Kim WY
Autophagy 2017 Aug 3;13(8):1348-1363
Autophagy 2017 Aug 3;13(8):1348-1363
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.
Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC
The Journal of biological chemistry 2017 Aug 25;292(34):14050-14065
The Journal of biological chemistry 2017 Aug 25;292(34):14050-14065
TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma.
Lin TW, Chen MT, Lin LT, Huang PI, Lo WL, Yang YP, Lu KH, Chen YW, Chiou SH, Wu CW
Oncotarget 2017 Aug 22;8(34):56612-56625
Oncotarget 2017 Aug 22;8(34):56612-56625
Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells.
Ha S, Jeong SH, Yi K, Chung KM, Hong CJ, Kim SW, Kim EK, Yu SW
The Journal of biological chemistry 2017 Aug 18;292(33):13795-13808
The Journal of biological chemistry 2017 Aug 18;292(33):13795-13808
Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction.
Li L, Zviti R, Ha C, Wang ZV, Hill JA, Lin F
The Journal of biological chemistry 2017 Aug 18;292(33):13774-13783
The Journal of biological chemistry 2017 Aug 18;292(33):13774-13783
Accumulation of autophagosomes confers cytotoxicity.
Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S
The Journal of biological chemistry 2017 Aug 18;292(33):13599-13614
The Journal of biological chemistry 2017 Aug 18;292(33):13599-13614
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.
Gilardini Montani MS, Granato M, Santoni C, Del Porto P, Merendino N, D'Orazi G, Faggioni A, Cirone M
Cellular oncology (Dordrecht) 2017 Apr;40(2):167-180
Cellular oncology (Dordrecht) 2017 Apr;40(2):167-180
The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer.
Kong P, Zhu X, Geng Q, Xia L, Sun X, Chen Y, Li W, Zhou Z, Zhan Y, Xu D
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):1027-1037
Molecular therapy : the journal of the American Society of Gene Therapy 2017 Apr 5;25(4):1027-1037
Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages.
Wang J, Wang R, Wang H, Yang X, Yang J, Xiong W, Wen Q, Ma L
Scientific reports 2017 Apr 20;7(1):982
Scientific reports 2017 Apr 20;7(1):982
The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.
Tawo R, Pokrzywa W, Kevei É, Akyuz ME, Balaji V, Adrian S, Höhfeld J, Hoppe T
Cell 2017 Apr 20;169(3):470-482.e13
Cell 2017 Apr 20;169(3):470-482.e13
Measuring Autophagy in the Context of Cancer.
Morgan MJ, Thorburn A
Advances in experimental medicine and biology 2016;899:121-43
Advances in experimental medicine and biology 2016;899:121-43
MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole.
Teo WX, Kerr MC, Teasdale RD
Frontiers in cellular and infection microbiology 2016;6:91
Frontiers in cellular and infection microbiology 2016;6:91
Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway.
Lam T, Harmancey R, Vasquez H, Gilbert B, Patel N, Hariharan V, Lee A, Covey M, Taegtmeyer H
Cell death discovery 2016;2:16061
Cell death discovery 2016;2:16061
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Wilson CH, Nikolic A, Kentish SJ, Shalini S, Hatzinikolas G, Page AJ, Dorstyn L, Kumar S
Cell death discovery 2016;2:16009
Cell death discovery 2016;2:16009
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.
Chesser AS, Ganeshan V, Yang J, Johnson GV
Nutritional neuroscience 2016;19(1):21-31
Nutritional neuroscience 2016;19(1):21-31
Autophagy induced by a sulphamoylated estrone analogue contributes to its cytotoxic effect on breast cancer cells.
Verwey M, Nolte EM, Joubert AM, Theron AE
Cancer cell international 2016;16:91
Cancer cell international 2016;16:91
LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells.
Streeter A, Menzies FM, Rubinsztein DC
Methods in molecular biology (Clifton, N.J.) 2016;1303:161-70
Methods in molecular biology (Clifton, N.J.) 2016;1303:161-70
Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?
Zea AH, Stewart T, Ascani J, Tate DJ, Finkel-Jimenez B, Wilk A, Reiss K, Smoyer WE, Aviles DH
PloS one 2016;11(7):e0157907
PloS one 2016;11(7):e0157907
Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats.
Zhang X, Zhou Y, Xu M, Chen G
PloS one 2016;11(4):e0153505
PloS one 2016;11(4):e0153505
Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings.
Davis MA, Delaney JR, Patel CB, Storgard R, Stupack DG
Drug design, development and therapy 2016;10:1837-46
Drug design, development and therapy 2016;10:1837-46
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?
Seiler M, Bowen TS, Rolim N, Dieterlen MT, Werner S, Hoshi T, Fischer T, Mangner N, Linke A, Schuler G, Halle M, Wisloff U, Adams V
Circulation. Heart failure 2016 Sep;9(9)
Circulation. Heart failure 2016 Sep;9(9)
Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells.
Narasimhan PB, Bennuru S, Meng Z, Cotton RN, Elliott KR, Ganesan S, McDonald-Fleming R, Veenstra TD, Nutman TB, Tolouei Semnani R
Infection and immunity 2016 Sep;84(9):2463-72
Infection and immunity 2016 Sep;84(9):2463-72
Size, organization, and dynamics of soluble SQSTM1 and LC3-SQSTM1 complexes in living cells.
Kraft LJ, Dowler J, Manral P, Kenworthy AK
Autophagy 2016 Sep;12(9):1660-74
Autophagy 2016 Sep;12(9):1660-74
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.
Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV
Autophagy 2016 Sep;12(9):1631-46
Autophagy 2016 Sep;12(9):1631-46
Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids.
Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C
Autophagy 2016 Sep;12(9):1460-71
Autophagy 2016 Sep;12(9):1460-71
AMPK regulates autophagy by phosphorylating BECN1 at threonine 388.
Zhang D, Wang W, Sun X, Xu D, Wang C, Zhang Q, Wang H, Luo W, Chen Y, Chen H, Liu Z
Autophagy 2016 Sep;12(9):1447-59
Autophagy 2016 Sep;12(9):1447-59
Ammonium accumulation is a primary effect of 2-methylcitrate exposure in an in vitro model for brain damage in methylmalonic aciduria.
Cudré-Cung HP, Zavadakova P, do Vale-Pereira S, Remacle N, Henry H, Ivanisevic J, Tavel D, Braissant O, Ballhausen D
Molecular genetics and metabolism 2016 Sep;119(1-2):57-67
Molecular genetics and metabolism 2016 Sep;119(1-2):57-67
Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.
Urtasun R, Elizalde M, Azkona M, Latasa MU, García-Irigoyen O, Uriarte I, Fernández-Barrena MG, Vicent S, Alonso MM, Muntané J, Prieto J, Ávila MA, Berasain C
Oncogene 2016 Sep 8;35(36):4719-29
Oncogene 2016 Sep 8;35(36):4719-29
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.
White SH, McDermott MM, Sufit RL, Kosmac K, Bugg AW, Gonzalez-Freire M, Ferrucci L, Tian L, Zhao L, Gao Y, Kibbe MR, Criqui MH, Leeuwenburgh C, Peterson CA
Journal of translational medicine 2016 Sep 29;14(1):284
Journal of translational medicine 2016 Sep 29;14(1):284
The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes.
Gáspár R, Pipicz M, Hawchar F, Kovács D, Djirackor L, Görbe A, Varga ZV, Kiricsi M, Petrovski G, Gácser A, Csonka C, Csont T
Journal of molecular and cellular cardiology 2016 Oct;99:138-150
Journal of molecular and cellular cardiology 2016 Oct;99:138-150
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.
Granato M, Rizzello C, Romeo MA, Yadav S, Santarelli R, D'Orazi G, Faggioni A, Cirone M
The international journal of biochemistry & cell biology 2016 Oct;79:393-400
The international journal of biochemistry & cell biology 2016 Oct;79:393-400
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Duleh S, Wang X, Komirenko A, Margeta M
Acta neuropathologica communications 2016 Oct 31;4(1):115
Acta neuropathologica communications 2016 Oct 31;4(1):115
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.
Xie M, Yu Y, Kang R, Zhu S, Yang L, Zeng L, Sun X, Yang M, Billiar TR, Wang H, Cao L, Jiang J, Tang D
Nature communications 2016 Oct 25;7:13280
Nature communications 2016 Oct 25;7:13280
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S
The Journal of cell biology 2016 Oct 24;215(2):245-258
The Journal of cell biology 2016 Oct 24;215(2):245-258
MicroRNA expression profiling of Leishmania donovani-infected host cells uncovers the regulatory role of MIR30A-3p in host autophagy.
Singh AK, Pandey RK, Shaha C, Madhubala R
Autophagy 2016 Oct 2;12(10):1817-1831
Autophagy 2016 Oct 2;12(10):1817-1831
Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.
Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF
Oncotarget 2016 Oct 18;7(42):67919-67933
Oncotarget 2016 Oct 18;7(42):67919-67933
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Manzoni C, Mamais A, Roosen DA, Dihanich S, Soutar MP, Plun-Favreau H, Bandopadhyay R, Hardy J, Tooze SA, Cookson MR, Lewis PA
Scientific reports 2016 Oct 12;6:35106
Scientific reports 2016 Oct 12;6:35106
Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
Ren H, Guo H, Thakur A, Zhang S, Wang T, Liang Y, Shi P, Gao L, Liu F, Feng J, Chen T, Yang T, Shang D, Liu JJ, Xu F, Chen M
Oncotarget 2016 Oct 11;7(41):67277-67287
Oncotarget 2016 Oct 11;7(41):67277-67287
Regulation and role of ERK phosphorylation in glial cells following a nigrostriatal pathway injury.
Li D, Tong L, Kawano H, Liu N, Yan HJ, Zhao L, Li HP
Brain research 2016 Oct 1;1648(Pt A):90-100
Brain research 2016 Oct 1;1648(Pt A):90-100
Vitamin D-induced up-regulation of human keratinocyte cathelicidin anti-microbial peptide expression involves retinoid X receptor α.
Svensson D, Nebel D, Voss U, Ekblad E, Nilsson BO
Cell and tissue research 2016 Nov;366(2):353-362
Cell and tissue research 2016 Nov;366(2):353-362
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.
Kim DI, Lee KH, Gabr AA, Choi GE, Kim JS, Ko SH, Han HJ
Biochimica et biophysica acta 2016 Nov;1863(11):2820-2834
Biochimica et biophysica acta 2016 Nov;1863(11):2820-2834
Potential protective effects of autophagy activated in MPP+ treated astrocytes.
Shen C, Xian W, Zhou H, Chen L, Pei Z
Experimental and therapeutic medicine 2016 Nov;12(5):2803-2810
Experimental and therapeutic medicine 2016 Nov;12(5):2803-2810
Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism.
He L, Weber KJ, Diwan A, Schilling JD
Journal of leukocyte biology 2016 Nov;100(5):1113-1124
Journal of leukocyte biology 2016 Nov;100(5):1113-1124
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.
Wu CH, Chen HY, Wang CW, Shieh TM, Huang TC, Lin LC, Wang KL, Hsia SM
Oncotarget 2016 Nov 8;7(45):73432-73447
Oncotarget 2016 Nov 8;7(45):73432-73447
Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain.
Ahn JS, Ann EJ, Kim MY, Yoon JH, Lee HJ, Jo EH, Lee K, Lee JS, Park HS
Oncotarget 2016 Nov 29;7(48):79047-79063
Oncotarget 2016 Nov 29;7(48):79047-79063
LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.
Madjo U, Leymarie O, Frémont S, Kuster A, Nehlich M, Gallois-Montbrun S, Janvier K, Berlioz-Torrent C
Cell reports 2016 Nov 22;17(9):2221-2233
Cell reports 2016 Nov 22;17(9):2221-2233
Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice.
Choi YJ, Gurunathan S, Kim D, Jang HS, Park WJ, Cho SG, Park C, Song H, Seo HG, Kim JH
Oncotarget 2016 Nov 15;7(46):74658-74677
Oncotarget 2016 Nov 15;7(46):74658-74677
Autophagy-mediated clearance of ubiquitinated mutant huntingtin by graphene oxide.
Jin P, Wei P, Zhang Y, Lin J, Sha R, Hu Y, Zhang J, Zhou W, Yao H, Ren L, Yang JY, Liu Y, Wen L
Nanoscale 2016 Nov 10;8(44):18740-18750
Nanoscale 2016 Nov 10;8(44):18740-18750
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential.
Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM, Kota J
Oncotarget 2016 Nov 1;7(44):71635-71650
Oncotarget 2016 Nov 1;7(44):71635-71650
Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells.
Zhou YF, Wang QX, Zhou HY, Chen G
Acta pharmacologica Sinica 2016 May;37(5):580-8
Acta pharmacologica Sinica 2016 May;37(5):580-8
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
Developmental cell 2016 May 23;37(4):337-349
Developmental cell 2016 May 23;37(4):337-349
Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3.
Duan L, Yi M, Chen J, Li S, Chen W
Biochemical and biophysical research communications 2016 May 13;473(4):1229-1234
Biochemical and biophysical research communications 2016 May 13;473(4):1229-1234
The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer.
Hsuan SW, Chyau CC, Hung HY, Chen JH, Chou FP
European journal of nutrition 2016 Mar;55(2):491-503
European journal of nutrition 2016 Mar;55(2):491-503
Ramalin-Mediated Apoptosis Is Enhanced by Autophagy Inhibition in Human Breast Cancer Cells.
Lee E, Lee CG, Yim JH, Lee HK, Pyo S
Phytotherapy research : PTR 2016 Mar;30(3):426-38
Phytotherapy research : PTR 2016 Mar;30(3):426-38
Low-grade inflammatory polarization of monocytes impairs wound healing.
Yuan R, Geng S, Chen K, Diao N, Chu HW, Li L
The Journal of pathology 2016 Mar;238(4):571-83
The Journal of pathology 2016 Mar;238(4):571-83
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.
Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H
Nature immunology 2016 Mar;17(3):277-85
Nature immunology 2016 Mar;17(3):277-85
Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels.
Lopes VR, Loitto V, Audinot JN, Bayat N, Gutleb AC, Cristobal S
Journal of nanobiotechnology 2016 Mar 22;14:22
Journal of nanobiotechnology 2016 Mar 22;14:22
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Liu Y, Wang X, Wang J, Nie Y, Du H, Dai H, Wang J, Wang M, Chen S, Hei TK, Deng Z, Wu L, Xu A
Environmental science & technology 2016 Mar 15;50(6):3154-64
Environmental science & technology 2016 Mar 15;50(6):3154-64
Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress.
Wang Z, Du T, Dong X, Li Z, Wu G, Zhang R
International journal of oncology 2016 Jun;48(6):2558-66
International journal of oncology 2016 Jun;48(6):2558-66
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.
Fritzen AM, Frøsig C, Jeppesen J, Jensen TE, Lundsgaard AM, Serup AK, Schjerling P, Proud CG, Richter EA, Kiens B
Cellular signalling 2016 Jun;28(6):663-74
Cellular signalling 2016 Jun;28(6):663-74
Chaperone-like protein HYPK and its interacting partners augment autophagy.
Choudhury KR, Bucha S, Baksi S, Mukhopadhyay D, Bhattacharyya NP
European journal of cell biology 2016 Jun-Jul;95(6-7):182-94
European journal of cell biology 2016 Jun-Jul;95(6-7):182-94
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.
Bento CF, Ashkenazi A, Jimenez-Sanchez M, Rubinsztein DC
Nature communications 2016 Jun 9;7:11803
Nature communications 2016 Jun 9;7:11803
Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB.
Park SE, Yi HJ, Suh N, Park YY, Koh JY, Jeong SY, Cho DH, Kim CS, Hwang JJ
Oncotarget 2016 Jun 28;7(26):39796-39808
Oncotarget 2016 Jun 28;7(26):39796-39808
The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway.
Denaës T, Lodder J, Chobert MN, Ruiz I, Pawlotsky JM, Lotersztajn S, Teixeira-Clerc F
Scientific reports 2016 Jun 27;6:28806
Scientific reports 2016 Jun 27;6:28806
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
Choi MS, Kim HJ, Ham M, Choi DH, Lee TR, Shin DW
Scientific reports 2016 Jun 27;6:28476
Scientific reports 2016 Jun 27;6:28476
LAP-like process as an immune mechanism downstream of IFN-γ in control of the human malaria Plasmodium vivax liver stage.
Boonhok R, Rachaphaew N, Duangmanee A, Chobson P, Pattaradilokrat S, Utaisincharoen P, Sattabongkot J, Ponpuak M
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):E3519-28
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 21;113(25):E3519-28
Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway.
Song EJ, Lee SJ, Lim HS, Kim JS, Jang KK, Choi SH, Han HJ
Scientific reports 2016 Jun 2;6:27080
Scientific reports 2016 Jun 2;6:27080
Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction.
Livingston MJ, Ding HF, Huang S, Hill JA, Yin XM, Dong Z
Autophagy 2016 Jun 2;12(6):976-98
Autophagy 2016 Jun 2;12(6):976-98
Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway.
Wijdeven RH, Janssen H, Nahidiazar L, Janssen L, Jalink K, Berlin I, Neefjes J
Nature communications 2016 Jun 10;7:11808
Nature communications 2016 Jun 10;7:11808
Lanthanide co-doped paramagnetic spindle-like mesocrystals for imaging and autophagy induction.
Xu YJ, Lin J, Lu Y, Zhong SL, Wang L, Dong L, Wu YD, Peng J, Zhang L, Pan XF, Zhou W, Zhao Y, Wen LP, Yu SH
Nanoscale 2016 Jul 21;8(27):13399-406
Nanoscale 2016 Jul 21;8(27):13399-406
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ
The Journal of biological chemistry 2016 Jul 15;291(29):14939-53
The Journal of biological chemistry 2016 Jul 15;291(29):14939-53
Autophagy induced by exogenous bile acids is therapeutic in a model of α-1-AT deficiency liver disease.
Tang Y, Fickert P, Trauner M, Marcus N, Blomenkamp K, Teckman J
American journal of physiology. Gastrointestinal and liver physiology 2016 Jul 1;311(1):G156-65
American journal of physiology. Gastrointestinal and liver physiology 2016 Jul 1;311(1):G156-65
α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart.
Stotland A, Gottlieb RA
Journal of molecular and cellular cardiology 2016 Jan;90:53-8
Journal of molecular and cellular cardiology 2016 Jan;90:53-8
Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis.
Sorrell SL, Golder ZJ, Johnstone DB, Frankl FEK
Kidney international 2016 Jan;89(1):105-112
Kidney international 2016 Jan;89(1):105-112
Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy.
Zhang J, Zhou W, Lin J, Wei P, Zhang Y, Jin P, Chen M, Man N, Wen L
The international journal of biochemistry & cell biology 2016 Jan;70:76-81
The international journal of biochemistry & cell biology 2016 Jan;70:76-81
FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection.
Xu Y, Tian C, Sun J, Zhang J, Ren K, Fan XY, Wang K, Wang H, Yan YE, Chen C, Shi Q, Dong XP
Molecular neurobiology 2016 Jan;53(1):706-719
Molecular neurobiology 2016 Jan;53(1):706-719
Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720.
Zhang L, Ding K, Wang H, Wu Y, Xu J
Cellular and molecular neurobiology 2016 Jan;36(1):131-42
Cellular and molecular neurobiology 2016 Jan;36(1):131-42
Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer.
Masuda GO, Yashiro M, Kitayama K, Miki Y, Kasashima H, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Masaichi O, Hirakawa K
Anticancer research 2016 Jan;36(1):129-36
Anticancer research 2016 Jan;36(1):129-36
Hinokitiol induces autophagy in murine breast and colorectal cancer cells.
Wang WK, Lin ST, Chang WW, Liu LW, Li TY, Kuo CY, Hsieh JL, Lee CH
Environmental toxicology 2016 Jan;31(1):77-84
Environmental toxicology 2016 Jan;31(1):77-84
Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity.
Lin CL, Cheng YS, Li HH, Chiu PY, Chang YT, Ho YJ, Lai TJ
Experimental neurology 2016 Jan;275 Pt 1:84-98
Experimental neurology 2016 Jan;275 Pt 1:84-98
Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism.
Dangi A, Huang C, Tandon A, Stolz D, Wu T, Gandhi CR
Journal of cellular physiology 2016 Jan;231(1):94-105
Journal of cellular physiology 2016 Jan;231(1):94-105
Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells.
He B, Zhang N, Zhao R
Journal of cellular physiology 2016 Jan;231(1):233-42
Journal of cellular physiology 2016 Jan;231(1):233-42
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.
Gentry EG, Henderson BW, Arrant AE, Gearing M, Feng Y, Riddle NC, Herskowitz JH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 27;36(4):1316-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 27;36(4):1316-23
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.
Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L
Cell reports 2016 Jan 26;14(3):422-428
Cell reports 2016 Jan 26;14(3):422-428
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.
Tian T, Sun Y, Wu H, Pei J, Zhang J, Zhang Y, Wang L, Li B, Wang L, Shi J, Hu J, Fan C
Scientific reports 2016 Jan 21;6:19714
Scientific reports 2016 Jan 21;6:19714
Cell death and cell proliferation in human spina bifida.
Avagliano L, Doi P, Tosi D, Scagliotti V, Gualtieri A, Gaston-Massuet C, Pistocchi A, Gallina A, Marconi AM, Bulfamante G, Massa V
Birth defects research. Part A, Clinical and molecular teratology 2016 Feb;106(2):104-13
Birth defects research. Part A, Clinical and molecular teratology 2016 Feb;106(2):104-13
Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance.
Liu Y, Takahashi Y, Desai N, Zhang J, Serfass JM, Shi YG, Lynch CJ, Wang HG
Scientific reports 2016 Feb 9;6:20453
Scientific reports 2016 Feb 9;6:20453
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies FM, Rubinsztein DC
Nature communications 2016 Feb 3;7:10533
Nature communications 2016 Feb 3;7:10533
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis.
Button RW, Vincent JH, Strang CJ, Luo S
Oncotarget 2016 Feb 2;7(5):5157-75
Oncotarget 2016 Feb 2;7(5):5157-75
Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis.
Mukherjee R, Chakrabarti O
Journal of cell science 2016 Feb 15;129(4):757-73
Journal of cell science 2016 Feb 15;129(4):757-73
Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.
Fritzen AM, Madsen AB, Kleinert M, Treebak JT, Lundsgaard AM, Jensen TE, Richter EA, Wojtaszewski J, Kiens B, Frøsig C
The Journal of physiology 2016 Feb 1;594(3):745-61
The Journal of physiology 2016 Feb 1;594(3):745-61
Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation.
Musolino V, Palus S, Tschirner A, Drescher C, Gliozzi M, Carresi C, Vitale C, Muscoli C, Doehner W, von Haehling S, Anker SD, Mollace V, Springer J
Journal of cachexia, sarcopenia and muscle 2016 Dec;7(5):555-566
Journal of cachexia, sarcopenia and muscle 2016 Dec;7(5):555-566
WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation.
Feng Y, Zhao J, Hou H, Zhang H, Jiao Y, Wang J, Wang Y, Sun Y
Acta biochimica et biophysica Sinica 2016 Dec;48(12):1075-1084
Acta biochimica et biophysica Sinica 2016 Dec;48(12):1075-1084
Role of neutral ceramidase in colon cancer.
García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Dec;30(12):4159-4171
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Dec;30(12):4159-4171
Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial.
Castagnaro S, Pellegrini C, Pellegrini M, Chrisam M, Sabatelli P, Toni S, Grumati P, Ripamonti C, Pratelli L, Maraldi NM, Cocchi D, Righi V, Faldini C, Sandri M, Bonaldo P, Merlini L
Autophagy 2016 Dec;12(12):2484-2495
Autophagy 2016 Dec;12(12):2484-2495
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.
Bordi M, Berg MJ, Mohan PS, Peterhoff CM, Alldred MJ, Che S, Ginsberg SD, Nixon RA
Autophagy 2016 Dec;12(12):2467-2483
Autophagy 2016 Dec;12(12):2467-2483
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.
Santarelli R, Granato M, Pentassuglia G, Lacconi V, Gilardini Montani MS, Gonnella R, Tafani M, Torrisi MR, Faggioni A, Cirone M
Autophagy 2016 Dec;12(12):2311-2325
Autophagy 2016 Dec;12(12):2311-2325
CCT complex restricts neuropathogenic protein aggregation via autophagy.
Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC
Nature communications 2016 Dec 8;7:13821
Nature communications 2016 Dec 8;7:13821
Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect.
Hur JH, Park SY, Dall'Armi C, Lee JS, Di Paolo G, Lee HY, Yoon MS, Min DS, Choi CS
Scientific reports 2016 Dec 15;6:39170
Scientific reports 2016 Dec 15;6:39170
Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.
Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JH
Nucleic acids research 2016 Dec 15;44(22):10571-10587
Nucleic acids research 2016 Dec 15;44(22):10571-10587
Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
Jo YK, Park NY, Park SJ, Kim BG, Shin JH, Jo DS, Bae DJ, Suh YA, Chang JH, Lee EK, Kim SY, Kim JC, Cho DH
Oncotarget 2016 Aug 30;7(35):57186-57196
Oncotarget 2016 Aug 30;7(35):57186-57196
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC
Nature 2016 Aug 25;536(7617):479-83
Nature 2016 Aug 25;536(7617):479-83
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z, Li M
Autophagy 2016 Aug 2;12(8):1372-89
Autophagy 2016 Aug 2;12(8):1372-89
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.
Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J
Autophagy 2016 Aug 2;12(8):1340-54
Autophagy 2016 Aug 2;12(8):1340-54
Cocaine induces astrocytosis through ER stress-mediated activation of autophagy.
Periyasamy P, Guo ML, Buch S
Autophagy 2016 Aug 2;12(8):1310-29
Autophagy 2016 Aug 2;12(8):1310-29
TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.
Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R
Autophagy 2016 Aug 2;12(8):1240-58
Autophagy 2016 Aug 2;12(8):1240-58
Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation.
Parks A, Marceau F
Toxicology and applied pharmacology 2016 Aug 15;305:55-65
Toxicology and applied pharmacology 2016 Aug 15;305:55-65
Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes.
Zhao T, Hong Y, Li S, Li XJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Aug 10;36(32):8317-28
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Aug 10;36(32):8317-28
Nuclear LC3 Associates with Slowly Diffusing Complexes that Survey the Nucleolus.
Kraft LJ, Manral P, Dowler J, Kenworthy AK
Traffic (Copenhagen, Denmark) 2016 Apr;17(4):369-99
Traffic (Copenhagen, Denmark) 2016 Apr;17(4):369-99
Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance.
Cheong JW, Kim Y, Eom JI, Jeung HK, Min YH
Molecular medicine reports 2016 Apr;13(4):3433-40
Molecular medicine reports 2016 Apr;13(4):3433-40
Intracellular pH Modulates Autophagy and Mitophagy.
Berezhnov AV, Soutar MP, Fedotova EI, Frolova MS, Plun-Favreau H, Zinchenko VP, Abramov AY
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
The Journal of biological chemistry 2016 Apr 15;291(16):8701-8
Glutamine Modulates Macrophage Lipotoxicity.
He L, Weber KJ, Schilling JD
Nutrients 2016 Apr 12;8(4):215
Nutrients 2016 Apr 12;8(4):215
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M
Human molecular genetics 2016 Apr 1;25(7):1420-33
Human molecular genetics 2016 Apr 1;25(7):1420-33
Autophagy inhibition enhances sensitivity of endometrial carcinoma cells to paclitaxel.
Liu S, Li X
International journal of oncology 2015;46(6):2399-408
International journal of oncology 2015;46(6):2399-408
The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells.
Tsukahara T, Haniu H, Matsuda Y
BioResearch open access 2015;4(1):319-25
BioResearch open access 2015;4(1):319-25
Antiproliferative, Apoptotic, and Autophagic Activity of Ranibizumab, Bevacizumab, Pegaptanib, and Aflibercept on Fibroblasts: Implication for Choroidal Neovascularization.
Lytvynchuk L, Sergienko A, Lavrenchuk G, Petrovski G
Journal of ophthalmology 2015;2015:934963
Journal of ophthalmology 2015;2015:934963
Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury.
Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P, Diwan A
Autophagy 2015;11(9):1537-60
Autophagy 2015;11(9):1537-60
Cocaine-mediated microglial activation involves the ER stress-autophagy axis.
Guo ML, Liao K, Periyasamy P, Yang L, Cai Y, Callen SE, Buch S
Autophagy 2015;11(7):995-1009
Autophagy 2015;11(7):995-1009
Differential use of autophagy by primary dendritic cells specialized in cross-presentation.
Mintern JD, Macri C, Chin WJ, Panozza SE, Segura E, Patterson NL, Zeller P, Bourges D, Bedoui S, McMillan PJ, Idris A, Nowell CJ, Brown A, Radford KJ, Johnston AP, Villadangos JA
Autophagy 2015;11(6):906-17
Autophagy 2015;11(6):906-17
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
Kim Y, Kang YS, Lee NY, Kim KY, Hwang YJ, Kim HW, Rhyu IJ, Her S, Jung MK, Kim S, Lee CJ, Ko S, Kowall NW, Lee SB, Lee J, Ryu H
Autophagy 2015;11(5):796-811
Autophagy 2015;11(5):796-811
The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase.
Namkoong S, Lee KI, Lee JI, Park R, Lee EJ, Jang IS, Park J
Autophagy 2015;11(5):756-68
Autophagy 2015;11(5):756-68
Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J
Autophagy 2015;11(3):538-46
Autophagy 2015;11(3):538-46
The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.
Sanjurjo L, Amézaga N, Aran G, Naranjo-Gómez M, Arias L, Armengol C, Borràs FE, Sarrias MR
Autophagy 2015;11(3):487-502
Autophagy 2015;11(3):487-502
BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy.
Pedro JM, Wei Y, Sica V, Maiuri MC, Zou Z, Kroemer G, Levine B
Autophagy 2015;11(3):452-9
Autophagy 2015;11(3):452-9
ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells.
Chen JH, Zhang P, Chen WD, Li DD, Wu XQ, Deng R, Jiao L, Li X, Ji J, Feng GK, Zeng YX, Jiang JW, Zhu XF
Autophagy 2015;11(2):239-52
Autophagy 2015;11(2):239-52
Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy.
Yang M, Liu L, Xie M, Sun X, Yu Y, Kang R, Yang L, Zhu S, Cao L, Tang D
Autophagy 2015;11(2):214-24
Autophagy 2015;11(2):214-24
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Du TT, Wang L, Duan CL, Lu LL, Zhang JL, Gao G, Qiu XB, Wang XM, Yang H
Autophagy 2015;11(10):1803-20
Autophagy 2015;11(10):1803-20
TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model.
Yadav RK, Lee GH, Lee HY, Li B, Jung HE, Rashid HO, Choi MK, Yadav BK, Kim WH, Kim KW, Park BH, Kim W, Lee YC, Kim HR, Chae HJ
Autophagy 2015;11(10):1760-74
Autophagy 2015;11(10):1760-74
Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Jabir MS, Hopkins L, Ritchie ND, Ullah I, Bayes HK, Li D, Tourlomousis P, Lupton A, Puleston D, Simon AK, Bryant C, Evans TJ
Autophagy 2015;11(1):166-82
Autophagy 2015;11(1):166-82
Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines.
Koukourakis MI, Kalamida D, Giatromanolaki A, Zois CE, Sivridis E, Pouliliou S, Mitrakas A, Gatter KC, Harris AL
PloS one 2015;10(9):e0137675
PloS one 2015;10(9):e0137675
The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure.
Schiattarella GG, Cerulo G, De Pasquale V, Cocchiaro P, Paciello O, Avallone L, Belfiore MP, Iacobellis F, Di Napoli D, Magliulo F, Perrino C, Trimarco B, Esposito G, Di Natale P, Pavone LM
PloS one 2015;10(7):e0131662
PloS one 2015;10(7):e0131662
Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.
Lee HO, Mustafa A, Hudes GR, Kruger WD
PloS one 2015;10(7):e0131464
PloS one 2015;10(7):e0131464
Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.
Liu KE, Frazier WA
PloS one 2015;10(6):e0129667
PloS one 2015;10(6):e0129667
Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models.
Yakoub AM, Shukla D
PloS one 2015;10(4):e0124646
PloS one 2015;10(4):e0124646
Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells.
Kim ES, Shin JH, Park SJ, Jo YK, Kim JS, Kang IH, Nam JB, Chung DY, Cho Y, Lee EH, Chang JW, Cho DH
PloS one 2015;10(2):e0118190
PloS one 2015;10(2):e0118190
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury.
Chandrika BB, Yang C, Ou Y, Feng X, Muhoza D, Holmes AF, Theus S, Deshmukh S, Haun RS, Kaushal GP
PloS one 2015;10(10):e0140025
PloS one 2015;10(10):e0140025
Muscle LIM protein/CSRP3: a mechanosensor with a role in autophagy.
Rashid MM, Runci A, Polletta L, Carnevale I, Morgante E, Foglio E, Arcangeli T, Sansone L, Russo MA, Tafani M
Cell death discovery 2015;1:15014
Cell death discovery 2015;1:15014
AKT mediated glycolytic shift regulates autophagy in classically activated macrophages.
Matta SK, Kumar D
The international journal of biochemistry & cell biology 2015 Sep;66:121-33
The international journal of biochemistry & cell biology 2015 Sep;66:121-33
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.
Hrabeta J, Groh T, Khalil MA, Poljakova J, Adam V, Kizek R, Uhlik J, Doktorova H, Cerna T, Frei E, Stiborova M, Eckschlager T
International journal of oncology 2015 Sep;47(3):971-80
International journal of oncology 2015 Sep;47(3):971-80
Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy.
Li T, Sun KJ, Wang HD, Zhou ML, Ding K, Lu XY, Wei WT, Wang CX, Zhou XM
Neurochemical research 2015 Sep;40(9):1829-38
Neurochemical research 2015 Sep;40(9):1829-38
Pyruvate stimulates mitophagy via PINK1 stabilization.
Park S, Choi SG, Yoo SM, Nah J, Jeong E, Kim H, Jung YK
Cellular signalling 2015 Sep;27(9):1824-30
Cellular signalling 2015 Sep;27(9):1824-30
MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury.
Wang IK, Sun KT, Tsai TH, Chen CW, Chang SS, Yu TM, Yen TH, Lin FY, Huang CC, Li CY
Life sciences 2015 Sep 1;136:133-41
Life sciences 2015 Sep 1;136:133-41
Atg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma.
Xiong X, Wu M, Zhang H, Li J, Lu B, Guo Y, Zhou T, Guo H, Peng R, Li X, Tian Q, Wang Y
International journal of oncology 2015 Oct;47(4):1321-8
International journal of oncology 2015 Oct;47(4):1321-8
Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.
Herpin A, Englberger E, Zehner M, Wacker R, Gessler M, Schartl M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Oct;29(10):4145-61
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Oct;29(10):4145-61
Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.
Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA
Biochimica et biophysica acta 2015 Oct;1852(10 Pt A):2213-24
Biochimica et biophysica acta 2015 Oct;1852(10 Pt A):2213-24
The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.
Ngoh EN, Brugger HK, Monajemi M, Menzies SC, Hirschfeld AF, Del Bel KL, Jacobson K, Lavoie PM, Turvey SE, Sly LM
Genes and immunity 2015 Oct;16(7):452-61
Genes and immunity 2015 Oct;16(7):452-61
Multi-functionality and plasticity characterize epithelial cells in Hydra.
Buzgariu W, Al Haddad S, Tomczyk S, Wenger Y, Galliot B
Tissue barriers 2015 Oct-Dec;3(4):e1068908
Tissue barriers 2015 Oct-Dec;3(4):e1068908
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
Pellegrini C, Columbaro M, Capanni C, D'Apice MR, Cavallo C, Murdocca M, Lattanzi G, Squarzoni S
Oncotarget 2015 Oct 6;6(30):29914-28
Oncotarget 2015 Oct 6;6(30):29914-28
Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression.
Granato M, Gilardini Montani MS, Filardi M, Faggioni A, Cirone M
Oncotarget 2015 Oct 6;6(30):29543-54
Oncotarget 2015 Oct 6;6(30):29543-54
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Lin CW, Chen YS, Lin CC, Chen YJ, Lo GH, Lee PH, Kuo PL, Dai CY, Huang JF, Chung WL, Yu ML
Scientific reports 2015 Oct 30;5:15807
Scientific reports 2015 Oct 30;5:15807
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Pal I, Parida S, Prashanth Kumar BN, Banik P, Kumar Dey K, Chakraborty S, Bhutia SK, Mandal M
European journal of pharmacology 2015 Oct 15;765:217-27
European journal of pharmacology 2015 Oct 15;765:217-27
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer.
Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG
Oncotarget 2015 Oct 13;6(31):31104-18
Oncotarget 2015 Oct 13;6(31):31104-18
Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection.
Fan XY, Tian C, Wang H, Xu Y, Ren K, Zhang BY, Gao C, Shi Q, Meng G, Zhang LB, Zhao YJ, Shao QX, Dong XP
Scientific reports 2015 Oct 1;5:14728
Scientific reports 2015 Oct 1;5:14728
Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells.
Granato M, Chiozzi B, Filardi MR, Lotti LV, Di Renzo L, Faggioni A, Cirone M
Cancer letters 2015 Oct 1;366(2):191-7
Cancer letters 2015 Oct 1;366(2):191-7
BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide.
Chen CM, Syu JP, Way TD, Huang LJ, Kuo SC, Lin CT, Lin CL
International journal of molecular medicine 2015 Nov;36(5):1244-52
International journal of molecular medicine 2015 Nov;36(5):1244-52
Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis.
Zhang R, Li Y, Wang Z, Chen L, Dong X, Nie X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Nov;36(11):8585-92
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Nov;36(11):8585-92
Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages.
Chandra P, Ghanwat S, Matta SK, Yadav SS, Mehta M, Siddiqui Z, Singh A, Kumar D
Scientific reports 2015 Nov 6;5:16320
Scientific reports 2015 Nov 6;5:16320
Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.
Majumder P, Chakrabarti O
Cell death & disease 2015 Nov 5;6:e1970
Cell death & disease 2015 Nov 5;6:e1970
The activation of KSHV lytic cycle blocks autophagy in PEL cells.
Granato M, Santarelli R, Filardi M, Gonnella R, Farina A, Torrisi MR, Faggioni A, Cirone M
Autophagy 2015 Nov 2;11(11):1978-1986
Autophagy 2015 Nov 2;11(11):1978-1986
Pexophagy is induced by increasing peroxisomal reactive oxygen species in 1'10-phenanthroline-treated cells.
Jo DS, Bae DJ, Park SJ, Seo HM, Kim HB, Oh JS, Chang JW, Kim SY, Shin JW, Cho DH
Biochemical and biophysical research communications 2015 Nov 13;467(2):354-60
Biochemical and biophysical research communications 2015 Nov 13;467(2):354-60
Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway.
She T, Qu L, Wang L, Yang X, Xu S, Feng J, Gao Y, Zhao C, Han Y, Cai S, Shou C
Cancer prevention research (Philadelphia, Pa.) 2015 May;8(5):464-74
Cancer prevention research (Philadelphia, Pa.) 2015 May;8(5):464-74
NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
Roux C, Aligny C, Lesueur C, Girault V, Brunel V, Ramdani Y, Genty D, Driouich A, Laquerrière A, Marret S, Brasse-Lagnel C, Gonzalez BJ, Bekri S
Experimental neurology 2015 May;267:177-93
Experimental neurology 2015 May;267:177-93
Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death.
Chandler HL, Gervais KJ, Lutz EA, Curto EM, Matusow RB, Wilkie DA, Gemensky-Metzler AJ
Experimental eye research 2015 May;134:63-72
Experimental eye research 2015 May;134:63-72
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC
Nature chemical biology 2015 May;11(5):347-354
Nature chemical biology 2015 May;11(5):347-354
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism.
Gavilán E, Giráldez S, Sánchez-Aguayo I, Romero F, Ruano D, Daza P
Scientific reports 2015 May 5;5:10027
Scientific reports 2015 May 5;5:10027
Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth.
Sun T, Li X, Zhang P, Chen WD, Zhang HL, Li DD, Deng R, Qian XJ, Jiao L, Ji J, Li YT, Wu RY, Yu Y, Feng GK, Zhu XF
Nature communications 2015 May 26;6:7215
Nature communications 2015 May 26;6:7215
IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.
Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, Zhou X, Kuan PF, Pandey S, Chan KT, Jordan JL, Hao H, Frank JS, Hopkinson DA, Gibbs DC, Alldredge VD, Parrish E, Hanna SC, Berkowitz P, Rubenstein DS, Miller CR, Bear JE, Ollila DW, Sharpless NE, Conway K, Thomas NE
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 May 1;21(9):2167-76
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 May 1;21(9):2167-76
Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Johnson CE, Hunt DK, Wiltshire M, Herbert TP, Sampson JR, Errington RJ, Davies DM, Tee AR
Molecular oncology 2015 Mar;9(3):675-88
Molecular oncology 2015 Mar;9(3):675-88
Autophagy in zebrafish.
Varga M, Fodor E, Vellai T
Methods (San Diego, Calif.) 2015 Mar;75:172-80
Methods (San Diego, Calif.) 2015 Mar;75:172-80
A novel GBE1 mutation and features of polyglucosan bodies autophagy in adult polyglucosan body disease.
Sampaolo S, Esposito T, Gianfrancesco F, Napolitano F, Lombardi L, Lucà R, Roperto F, Di Iorio G
Neuromuscular disorders : NMD 2015 Mar;25(3):247-52
Neuromuscular disorders : NMD 2015 Mar;25(3):247-52
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.
Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, Ballabio A
Nature cell biology 2015 Mar;17(3):288-99
Nature cell biology 2015 Mar;17(3):288-99
Alteration of lysosome fusion and low-grade inflammation mediated by super-low-dose endotoxin.
Baker B, Geng S, Chen K, Diao N, Yuan R, Xu X, Dougherty S, Stephenson C, Xiong H, Chu HW, Li L
The Journal of biological chemistry 2015 Mar 6;290(10):6670-8
The Journal of biological chemistry 2015 Mar 6;290(10):6670-8
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.
Yue M, Hinkle KM, Davies P, Trushina E, Fiesel FC, Christenson TA, Schroeder AS, Zhang L, Bowles E, Behrouz B, Lincoln SJ, Beevers JE, Milnerwood AJ, Kurti A, McLean PJ, Fryer JD, Springer W, Dickson DW, Farrer MJ, Melrose HL
Neurobiology of disease 2015 Jun;78:172-95
Neurobiology of disease 2015 Jun;78:172-95
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Van Nostrand JL, Brisac A, Mello SS, Jacobs SB, Luong R, Attardi LD
Cancer discovery 2015 Jun;5(6):622-35
Cancer discovery 2015 Jun;5(6):622-35
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Baylor-Hopkins Center for Mendelian Genomics., Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK
Nature genetics 2015 Jun;47(6):654-60
Nature genetics 2015 Jun;47(6):654-60
Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway.
Yao J, Zheng K, Li C, Liu H, Shan X
Medical oncology (Northwood, London, England) 2015 Jun;32(6):610
Medical oncology (Northwood, London, England) 2015 Jun;32(6):610
Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle.
Tam BT, Pei XM, Yu AP, Sin TK, Leung KK, Au KK, Chong JT, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM
Acta physiologica (Oxford, England) 2015 Jun;214(2):221-36
Acta physiologica (Oxford, England) 2015 Jun;214(2):221-36
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gómez-Galán M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T
Nature neuroscience 2015 Jun;18(6):826-35
Nature neuroscience 2015 Jun;18(6):826-35
Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration.
Campbell GR, Rawat P, Bruckman RS, Spector SA
PLoS pathogens 2015 Jun;11(6):e1005018
PLoS pathogens 2015 Jun;11(6):e1005018
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CCY, Chang TY
Neurobiology of aging 2015 Jul;36(7):2248-2259
Neurobiology of aging 2015 Jul;36(7):2248-2259
Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway.
Li L, Wang X, Wang L, Qu L, Zhu X, Li M, Dang X, Li P, Gao Y, Peng Z, Pan L, Wan L
International journal of molecular medicine 2015 Jul;36(1):316-22
International journal of molecular medicine 2015 Jul;36(1):316-22
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells.
Shin JH, Bae DJ, Kim ES, Kim HB, Park SJ, Jo YK, Jo DS, Jo DG, Kim SY, Cho DH
Biomolecules & therapeutics 2015 Jul;23(4):327-32
Biomolecules & therapeutics 2015 Jul;23(4):327-32
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
Gonnella R, Granato M, Farina A, Santarelli R, Faggioni A, Cirone M
Biochimica et biophysica acta 2015 Jul;1853(7):1586-95
Biochimica et biophysica acta 2015 Jul;1853(7):1586-95
Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells.
Wu HM, Jiang ZF, Ding PS, Shao LJ, Liu RY
Scientific reports 2015 Jul 23;5:12291
Scientific reports 2015 Jul 23;5:12291
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA
Nucleic acids research 2015 Jan;43(2):943-59
Nucleic acids research 2015 Jan;43(2):943-59
mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.
Benhamron S, Pattanayak SP, Berger M, Tirosh B
Molecular and cellular biology 2015 Jan;35(1):153-66
Molecular and cellular biology 2015 Jan;35(1):153-66
Excessive autophagy induces the failure of trophoblast invasion and vasculature: possible relevance to the pathogenesis of preeclampsia.
Gao L, Qi HB, Kamana KC, Zhang XM, Zhang H, Baker PN
Journal of hypertension 2015 Jan;33(1):106-17
Journal of hypertension 2015 Jan;33(1):106-17
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death.
Liu S, Sarkar C, Dinizo M, Faden AI, Koh EY, Lipinski MM, Wu J
Cell death & disease 2015 Jan 8;6:e1582
Cell death & disease 2015 Jan 8;6:e1582
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
Raval KK, Tao R, White BE, De Lange WJ, Koonce CH, Yu J, Kishnani PS, Thomson JA, Mosher DF, Ralphe JC, Kamp TJ
The Journal of biological chemistry 2015 Jan 30;290(5):3121-36
The Journal of biological chemistry 2015 Jan 30;290(5):3121-36
Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia.
Yuan N, Song L, Lin W, Cao Y, Xu F, Liu S, Zhang A, Wang Z, Li X, Fang Y, Zhang H, Zhao W, Hu S, Wang J, Zhang S
Blood cancer journal 2015 Jan 23;5:e274
Blood cancer journal 2015 Jan 23;5:e274
Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis.
Weng Z, Luo Y, Yang X, Greenhaw JJ, Li H, Xie L, Mattes WB, Shi Q
Toxicology 2015 Jan 2;327:10-21
Toxicology 2015 Jan 2;327:10-21
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R
Cell 2015 Jan 15;160(1-2):62-73
Cell 2015 Jan 15;160(1-2):62-73
Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity.
Schloesser A, Campbell G, Glüer CC, Rimbach G, Huebbe P
Rejuvenation research 2015 Feb;18(1):30-9
Rejuvenation research 2015 Feb;18(1):30-9
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL
The Journal of clinical investigation 2015 Feb;125(2):521-38
The Journal of clinical investigation 2015 Feb;125(2):521-38
GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy.
Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K
Scientific reports 2015 Feb 9;5:8327
Scientific reports 2015 Feb 9;5:8327
Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1.
Campbell GR, Bruckman RS, Chu YL, Spector SA
The Journal of biological chemistry 2015 Feb 20;290(8):5028-40
The Journal of biological chemistry 2015 Feb 20;290(8):5028-40
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
Lin HH
Chemical research in toxicology 2015 Feb 16;28(2):202-15
Chemical research in toxicology 2015 Feb 16;28(2):202-15
Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine.
Clark O, Park I, Di Florio A, Cichon AC, Rustin S, Jugov R, Maeshima R, Stoker AW
Cancer letters 2015 Feb 1;357(1):316-327
Cancer letters 2015 Feb 1;357(1):316-327
Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.
Wei PF, Jin PP, Barui AK, Hu Y, Zhang L, Zhang JQ, Shi SS, Zhang HR, Lin J, Zhou W, Zhang YJ, Ruan RQ, Patra CR, Wen LP
Biomaterials 2015 Dec;73:160-74
Biomaterials 2015 Dec;73:160-74
Bakkenolide-IIIa Protects Against Cerebral Damage Via Inhibiting NF-κB Activation.
Jiang Q, Li RP, Tang Y, Wang YQ, Liu C, Guo ML
CNS neuroscience & therapeutics 2015 Dec;21(12):943-52
CNS neuroscience & therapeutics 2015 Dec;21(12):943-52
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C
Molecular cancer therapeutics 2015 Dec;14(12):2744-52
Molecular cancer therapeutics 2015 Dec;14(12):2744-52
Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.
Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C
Oncotarget 2015 Dec 8;6(39):41464-78
Oncotarget 2015 Dec 8;6(39):41464-78
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.
Keatinge M, Bui H, Menke A, Chen YC, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M, Trollope L, Payne T, McTighe A, Mortiboys H, de Jager S, Nuthall H, Kuo MS, Fleming A, Schapira AH, Renshaw SA, Highley JR, Chacinska A, Panula P, Burton EA, O'Neill MJ, Bandmann O
Human molecular genetics 2015 Dec 1;24(23):6640-52
Human molecular genetics 2015 Dec 1;24(23):6640-52
Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells.
Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS
Journal of lipid research 2015 Aug;56(8):1583-93
Journal of lipid research 2015 Aug;56(8):1583-93
Basal Autophagy Is Required for Herpes simplex Virus-2 Infection.
Yakoub AM, Shukla D
Scientific reports 2015 Aug 7;5:12985
Scientific reports 2015 Aug 7;5:12985
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Lee YH, Chen HY, Su LJ, Chueh PJ
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways.
Agarwal S, Tiwari SK, Seth B, Yadav A, Singh A, Mudawal A, Chauhan LK, Gupta SK, Choubey V, Tripathi A, Kumar A, Ray RS, Shukla S, Parmar D, Chaturvedi RK
The Journal of biological chemistry 2015 Aug 21;290(34):21163-84
The Journal of biological chemistry 2015 Aug 21;290(34):21163-84
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Moreau K, Ghislat G, Hochfeld W, Renna M, Zavodszky E, Runwal G, Puri C, Lee S, Siddiqi F, Menzies FM, Ravikumar B, Rubinsztein DC
Nature communications 2015 Aug 20;6:8045
Nature communications 2015 Aug 20;6:8045
LC3B globular structures correlate with survival in esophageal adenocarcinoma.
El-Mashed S, O'Donovan TR, Kay EW, Abdallah AR, Cathcart MC, O'Sullivan J, O'Grady A, Reynolds J, O'Reilly S, O'Sullivan GC, McKenna SL
BMC cancer 2015 Aug 12;15:582
BMC cancer 2015 Aug 12;15:582
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
Sun KT, Chen MY, Tu MG, Wang IK, Chang SS, Li CY
Bone 2015 Apr;73:145-53
Bone 2015 Apr;73:145-53
Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.
Maycotte P, Jones KL, Goodall ML, Thorburn J, Thorburn A
Molecular cancer research : MCR 2015 Apr;13(4):651-8
Molecular cancer research : MCR 2015 Apr;13(4):651-8
Autophagy stimulation abrogates herpes simplex virus-1 infection.
Yakoub AM, Shukla D
Scientific reports 2015 Apr 9;5:9730
Scientific reports 2015 Apr 9;5:9730
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.
Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 8;35(14):5724-42
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 8;35(14):5724-42
Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
Kommaddi RP, Jean-Charles PY, Shenoy SK
The Journal of biological chemistry 2015 Apr 3;290(14):8888-903
The Journal of biological chemistry 2015 Apr 3;290(14):8888-903
Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis.
Cabrera S, Maciel M, Herrera I, Nava T, Vergara F, Gaxiola M, López-Otín C, Selman M, Pardo A
Autophagy 2015 Apr 3;11(4):670-84
Autophagy 2015 Apr 3;11(4):670-84
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.
Wang S, Livingston MJ, Su Y, Dong Z
Autophagy 2015 Apr 3;11(4):607-16
Autophagy 2015 Apr 3;11(4):607-16
Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach.
Suarez G, Romero-Gallo J, Piazuelo MB, Wang G, Maier RJ, Forsberg LS, Azadi P, Gomez MA, Correa P, Peek RM Jr
Cancer research 2015 Apr 15;75(8):1749-59
Cancer research 2015 Apr 15;75(8):1749-59
Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation.
Hung KC, Huang HJ, Lin MW, Lei YP, Lin AM
PloS one 2014;9(3):e91074
PloS one 2014;9(3):e91074
Novel analogue of colchicine induces selective pro-death autophagy and necrosis in human cancer cells.
Larocque K, Ovadje P, Djurdjevic S, Mehdi M, Green J, Pandey S
PloS one 2014;9(1):e87064
PloS one 2014;9(1):e87064
Gambogenic acid kills lung cancer cells through aberrant autophagy.
Mei W, Dong C, Hui C, Bin L, Fenggen Y, Jingjing S, Cheng P, Meiling S, Yawen H, Xiaoshan W, Guanghui W, Zhiwu C, Qinglin L
PloS one 2014;9(1):e83604
PloS one 2014;9(1):e83604
High level of microtubule-associated protein light chain 3 predicts poor prognosis in resectable esophageal squamous cell carcinoma.
Hao CL, Li Y, Yang HX, Luo RZ, Zhang Y, Zhang MF, Cheng YF, Wang X
International journal of clinical and experimental pathology 2014;7(7):4213-21
International journal of clinical and experimental pathology 2014;7(7):4213-21
Targeting CREB inhibits radiation-induced neuroendocrine differentiation and increases radiation-induced cell death in prostate cancer cells.
Suarez CD, Deng X, Hu CD
American journal of cancer research 2014;4(6):850-61
American journal of cancer research 2014;4(6):850-61
Growth factor receptor-bound protein 2 promotes autophagic removal of amyloid-β protein precursor intracellular domain overload in neuronal cells.
Roy K, Raychaudhuri M, Chakrabarti O, Mukhopadhyay D
Journal of Alzheimer's disease : JAD 2014;38(4):881-95
Journal of Alzheimer's disease : JAD 2014;38(4):881-95
Melatonin inhibits mTOR-dependent autophagy during liver ischemia/reperfusion.
Kang JW, Cho HI, Lee SM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(1):23-36
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(1):23-36
Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures.
Zielniok K, Motyl T, Gajewska M
BioMed research international 2014;2014:382653
BioMed research international 2014;2014:382653
The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo.
Labouba I, Poisson A, Lafontaine J, Delvoye N, Gannon PO, Le Page C, Saad F, Mes-Masson AM
Cancer cell international 2014;14:67
Cancer cell international 2014;14:67
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury.
Sarkar C, Zhao Z, Aungst S, Sabirzhanov B, Faden AI, Lipinski MM
Autophagy 2014;10(12):2208-22
Autophagy 2014;10(12):2208-22
Inhibition of autophagy enhances the anticancer activity of silver nanoparticles.
Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang Y, Zheng F, Zhang J, Xu J, Hu Y, Wang Y, Li Y, Gu N, Wen L
Autophagy 2014;10(11):2006-20
Autophagy 2014;10(11):2006-20
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M
Autophagy 2014;10(11):1989-2005
Autophagy 2014;10(11):1989-2005
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Park S, Choi SG, Yoo SM, Son JH, Jung YK
Autophagy 2014;10(11):1906-20
Autophagy 2014;10(11):1906-20
Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
Lu Y, Dong S, Hao B, Li C, Zhu K, Guo W, Wang Q, Cheung KH, Wong CW, Wu WT, Markus H, Yue J
Autophagy 2014;10(11):1895-905
Autophagy 2014;10(11):1895-905
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.
Minoia M, Boncoraglio A, Vinet J, Morelli FF, Brunsting JF, Poletti A, Krom S, Reits E, Kampinga HH, Carra S
Autophagy 2014 Sep;10(9):1603-21
Autophagy 2014 Sep;10(9):1603-21
Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles.
Ligeon LA, Moreau K, Barois N, Bongiovanni A, Lacorre DA, Werkmeister E, Proux-Gillardeaux V, Galli T, Lafont F
Autophagy 2014 Sep;10(9):1588-602
Autophagy 2014 Sep;10(9):1588-602
Use of Shigella flexneri to study autophagy-cytoskeleton interactions.
Mazon Moya MJ, Colucci-Guyon E, Mostowy S
Journal of visualized experiments : JoVE 2014 Sep 9;(91):e51601
Journal of visualized experiments : JoVE 2014 Sep 9;(91):e51601
Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.
Shanware NP, Bray K, Eng CH, Wang F, Follettie M, Myers J, Fantin VR, Abraham RT
Nature communications 2014 Sep 25;5:4900
Nature communications 2014 Sep 25;5:4900
PICALM modulates autophagy activity and tau accumulation.
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC
Nature communications 2014 Sep 22;5:4998
Nature communications 2014 Sep 22;5:4998
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S
Molecular and cellular biology 2014 Sep 15;34(18):3435-49
Molecular and cellular biology 2014 Sep 15;34(18):3435-49
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy.
Lan YY, Londoño D, Bouley R, Rooney MS, Hacohen N
Cell reports 2014 Oct 9;9(1):180-192
Cell reports 2014 Oct 9;9(1):180-192
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.
Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K
Cell death & disease 2014 Oct 30;5:e1497
Cell death & disease 2014 Oct 30;5:e1497
Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.
McCabe KE, Bacos K, Lu D, Delaney JR, Axelrod J, Potter MD, Vamos M, Wong V, Cosford ND, Xiang R, Stupack DG
Cell death & disease 2014 Oct 30;5:e1496
Cell death & disease 2014 Oct 30;5:e1496
Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.
Liao CL, Chen CM, Chang YZ, Liu GY, Hung HC, Hsieh TY, Lin CL
Journal of agricultural and food chemistry 2014 Oct 29;62(43):10458-67
Journal of agricultural and food chemistry 2014 Oct 29;62(43):10458-67
In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.
Jiang P, Mukthavaram R, Chao Y, Nomura N, Bharati IS, Fogal V, Pastorino S, Teng D, Cong X, Pingle SC, Kapoor S, Shetty K, Aggrawal A, Vali S, Abbasi T, Chien S, Kesari S
British journal of cancer 2014 Oct 14;111(8):1562-71
British journal of cancer 2014 Oct 14;111(8):1562-71
Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent.
Morgan MJ, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte P, Thorburn A
Autophagy 2014 Oct 1;10(10):1814-26
Autophagy 2014 Oct 1;10(10):1814-26
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.
Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR
Autophagy 2014 Oct 1;10(10):1749-60
Autophagy 2014 Oct 1;10(10):1749-60
Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.
Granato M, Santarelli R, Farina A, Gonnella R, Lotti LV, Faggioni A, Cirone M
Journal of virology 2014 Nov;88(21):12715-26
Journal of virology 2014 Nov;88(21):12715-26
The autophagy/lysosome pathway is impaired in SCA7 patients and SCA7 knock-in mice.
Alves S, Cormier-Dequaire F, Marinello M, Marais T, Muriel MP, Beaumatin F, Charbonnier-Beaupel F, Tahiri K, Seilhean D, El Hachimi K, Ruberg M, Stevanin G, Barkats M, den Dunnen W, Priault M, Brice A, Durr A, Corvol JC, Sittler A
Acta neuropathologica 2014 Nov;128(5):705-22
Acta neuropathologica 2014 Nov;128(5):705-22
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Kao C, Chao A, Tsai CL, Chuang WC, Huang WP, Chen GC, Lin CY, Wang TH, Wang HS, Lai CH
Cell death & disease 2014 Nov 6;5:e1510
Cell death & disease 2014 Nov 6;5:e1510
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL
Molecular neurodegeneration 2014 Nov 28;9:54
Molecular neurodegeneration 2014 Nov 28;9:54
Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis.
Nogalska A, D'Agostino C, Engel WK, Askanas V
Neurobiology of disease 2014 May;65:93-101
Neurobiology of disease 2014 May;65:93-101
Size, stoichiometry, and organization of soluble LC3-associated complexes.
Kraft LJ, Nguyen TA, Vogel SS, Kenworthy AK
Autophagy 2014 May;10(5):861-77
Autophagy 2014 May;10(5):861-77
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA
Cell 2014 May 8;157(4):882-896
Cell 2014 May 8;157(4):882-896
Inhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro.
Kang M, Jeong CW, Ku JH, Kwak C, Kim HH
International journal of molecular sciences 2014 May 8;15(5):8106-21
International journal of molecular sciences 2014 May 8;15(5):8106-21
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Zavodszky E, Seaman MN, Moreau K, Jimenez-Sanchez M, Breusegem SY, Harbour ME, Rubinsztein DC
Nature communications 2014 May 13;5:3828
Nature communications 2014 May 13;5:3828
Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: heme oxygenase-1 as a possible regulator.
Yun N, Cho HI, Lee SM
Free radical biology & medicine 2014 Mar;68:168-77
Free radical biology & medicine 2014 Mar;68:168-77
The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.
Xia Q, Cai Y, Peng R, Wu G, Shi Y, Jiang W
International journal of oncology 2014 Mar;44(3):735-44
International journal of oncology 2014 Mar;44(3):735-44
Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway.
Lee CH, Lin ST, Liu JJ, Chang WW, Hsieh JL, Wang WK
Gene therapy 2014 Mar;21(3):309-16
Gene therapy 2014 Mar;21(3):309-16
Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation.
Pavlovic Z, Zhu L, Pereira L, Singh RK, Cornell RB, Bakovic M
The Journal of biological chemistry 2014 Mar 28;289(13):9053-64
The Journal of biological chemistry 2014 Mar 28;289(13):9053-64
Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.
Lin CJ, Chen TH, Yang LY, Shih CM
Cell death & disease 2014 Mar 27;5:e1147
Cell death & disease 2014 Mar 27;5:e1147
Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.
Frieboes HB, Huang JS, Yin WC, McNally LR
JOP : Journal of the pancreas 2014 Mar 10;15(2):189-97
JOP : Journal of the pancreas 2014 Mar 10;15(2):189-97
The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats.
Pötsch MS, Tschirner A, Palus S, von Haehling S, Doehner W, Beadle J, Coats AJ, Anker SD, Springer J
Journal of cachexia, sarcopenia and muscle 2014 Jun;5(2):149-58
Journal of cachexia, sarcopenia and muscle 2014 Jun;5(2):149-58
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.
Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS
Aging cell 2014 Jun;13(3):529-39
Aging cell 2014 Jun;13(3):529-39
Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.
Owen KA, Meyer CB, Bouton AH, Casanova JE
PLoS pathogens 2014 Jun;10(6):e1004159
PLoS pathogens 2014 Jun;10(6):e1004159
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J
Nature 2014 Jun 19;510(7505):397-401
Nature 2014 Jun 19;510(7505):397-401
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M
Nature 2014 Jun 19;510(7505):370-5
Nature 2014 Jun 19;510(7505):370-5
Hepatitis C virus present in the sera of infected patients interferes with the autophagic process of monocytes impairing their in-vitro differentiation into dendritic cells.
Granato M, Lacconi V, Peddis M, Di Renzo L, Valia S, Rivanera D, Antonelli G, Frati L, Faggioni A, Cirone M
Biochimica et biophysica acta 2014 Jul;1843(7):1348-55
Biochimica et biophysica acta 2014 Jul;1843(7):1348-55
Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10.
Ma D, Stokes K, Mahngar K, Domazet-Damjanov D, Sikorska M, Pandey S
Mitochondrion 2014 Jul;17:106-15
Mitochondrion 2014 Jul;17:106-15
Preferential estrogen receptor β ligands reduce Bcl-2 expression in hormone-resistant breast cancer cells to increase autophagy.
Ruddy SC, Lau R, Cabrita MA, McGregor C, McKay BC, Murphy LC, Wright JS, Durst T, Pratt MA
Molecular cancer therapeutics 2014 Jul;13(7):1882-93
Molecular cancer therapeutics 2014 Jul;13(7):1882-93
Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
Basu S, Rajakaruna S, Reyes B, Van Bockstaele E, Menko AS
Autophagy 2014 Jul;10(7):1193-211
Autophagy 2014 Jul;10(7):1193-211
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE, Atkin JD
Human molecular genetics 2014 Jul 1;23(13):3579-95
Human molecular genetics 2014 Jul 1;23(13):3579-95
Enteral leptin administration affects intestinal autophagy in suckling piglets.
Słupecka M, Woliński J, Gajewska M, Pierzynowski SG
Domestic animal endocrinology 2014 Jan;46:12-9
Domestic animal endocrinology 2014 Jan;46:12-9
Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods.
Wei PF, Zhang L, Nethi SK, Barui AK, Lin J, Zhou W, Shen Y, Man N, Zhang YJ, Xu J, Patra CR, Wen LP
Biomaterials 2014 Jan;35(3):899-907
Biomaterials 2014 Jan;35(3):899-907
Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet.
Raso GM, Simeoli R, Iacono A, Santoro A, Amero P, Paciello O, Russo R, D'Agostino G, Di Costanzo M, Canani RB, Calignano A, Meli R
The Journal of nutritional biochemistry 2014 Jan;25(1):81-90
The Journal of nutritional biochemistry 2014 Jan;25(1):81-90
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A
Nature cell biology 2014 Jan;16(1):47-54
Nature cell biology 2014 Jan;16(1):47-54
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP
Molecular cancer research : MCR 2014 Jan;12(1):48-57
Molecular cancer research : MCR 2014 Jan;12(1):48-57
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics.
Kang R, Tang D, Schapiro NE, Loux T, Livesey KM, Billiar TR, Wang H, Van Houten B, Lotze MT, Zeh HJ
Oncogene 2014 Jan 30;33(5):567-77
Oncogene 2014 Jan 30;33(5):567-77
Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.
Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S
Cancer research 2014 Jan 15;74(2):543-51
Cancer research 2014 Jan 15;74(2):543-51
De novo prion aggregates trigger autophagy in skeletal muscle.
Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ
Journal of virology 2014 Feb;88(4):2071-82
Journal of virology 2014 Feb;88(4):2071-82
Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.
Yazbeck VY, Li C, Grandis JR, Zang Y, Johnson DE
Oral oncology 2014 Feb;50(2):120-7
Oral oncology 2014 Feb;50(2):120-7
Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs.
Cho YH, Han KM, Kim D, Lee J, Lee SH, Choi KW, Kim J, Han YM
Stem cells (Dayton, Ohio) 2014 Feb;32(2):424-35
Stem cells (Dayton, Ohio) 2014 Feb;32(2):424-35
NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.
Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA
Cell 2014 Feb 27;156(5):1045-59
Cell 2014 Feb 27;156(5):1045-59
Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Polański R, Hodgkinson CL, Fusi A, Nonaka D, Priest L, Kelly P, Trapani F, Bishop PW, White A, Critchlow SE, Smith PD, Blackhall F, Dive C, Morrow CJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb 15;20(4):926-937
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Feb 15;20(4):926-937
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection.
Jabir MS, Ritchie ND, Li D, Bayes HK, Tourlomousis P, Puleston D, Lupton A, Hopkins L, Simon AK, Bryant C, Evans TJ
Cell host & microbe 2014 Feb 12;15(2):214-27
Cell host & microbe 2014 Feb 12;15(2):214-27
Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly.
Seguin SJ, Morelli FF, Vinet J, Amore D, De Biasi S, Poletti A, Rubinsztein DC, Carra S
Cell death and differentiation 2014 Dec;21(12):1838-51
Cell death and differentiation 2014 Dec;21(12):1838-51
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.
Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA
Brain : a journal of neurology 2014 Dec;137(Pt 12):3300-18
Brain : a journal of neurology 2014 Dec;137(Pt 12):3300-18
Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.
Cossette SM, Gastonguay AJ, Bao X, Lerch-Gaggl A, Zhong L, Harmann LM, Koceja C, Miao RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP, Ramchandran R
Biology open 2014 Dec 12;4(1):48-61
Biology open 2014 Dec 12;4(1):48-61
Antibody-derived in vivo imaging of tau pathology.
Krishnaswamy S, Lin Y, Rajamohamedsait WJ, Rajamohamedsait HB, Krishnamurthy P, Sigurdsson EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 10;34(50):16835-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 10;34(50):16835-50
Palmitic acid and oleic acid differentially regulate choline transporter-like 1 levels and glycerolipid metabolism in skeletal muscle cells.
Schenkel LC, Bakovic M
Lipids 2014 Aug;49(8):731-44
Lipids 2014 Aug;49(8):731-44
Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.
Zeng Y, Li S, Wu J, Chen W, Sun H, Peng W, Yu X, Yang X
Apoptosis : an international journal on programmed cell death 2014 Aug;19(8):1215-24
Apoptosis : an international journal on programmed cell death 2014 Aug;19(8):1215-24
YY1-MIR372-SQSTM1 regulatory axis in autophagy.
Feng L, Ma Y, Sun J, Shen Q, Liu L, Lu H, Wang F, Yue Y, Li J, Zhang S, Lin X, Chu J, Han W, Wang X, Jin H
Autophagy 2014 Aug;10(8):1442-53
Autophagy 2014 Aug;10(8):1442-53
Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma.
Barnard RA, Wittenburg LA, Amaravadi RK, Gustafson DL, Thorburn A, Thamm DH
Autophagy 2014 Aug;10(8):1415-25
Autophagy 2014 Aug;10(8):1415-25
Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A.
Yoon S, Han E, Choi YC, Kee H, Jeong Y, Yoon J, Baek K
Molecules and cells 2014 Apr;37(4):314-21
Molecules and cells 2014 Apr;37(4):314-21
Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.
Xu Y, Zhang J, Tian C, Ren K, Yan YE, Wang K, Wang H, Chen C, Wang J, Shi Q, Dong XP
Medical microbiology and immunology 2014 Apr;203(2):73-84
Medical microbiology and immunology 2014 Apr;203(2):73-84
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts.
Choi J, Jo M, Lee E, Kim HJ, Choi D
Molecular human reproduction 2014 Apr;20(4):309-17
Molecular human reproduction 2014 Apr;20(4):309-17
Alcohol-induced autophagy contributes to loss in skeletal muscle mass.
Thapaliya S, Runkana A, McMullen MR, Nagy LE, McDonald C, Naga Prasad SV, Dasarathy S
Autophagy 2014 Apr;10(4):677-90
Autophagy 2014 Apr;10(4):677-90
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
Ginet V, Puyal J, Rummel C, Aubry D, Breton C, Cloux AJ, Majjigapu SR, Sordat B, Vogel P, Bruzzone S, Nencioni A, Duchosal MA, Nahimana A
Autophagy 2014 Apr;10(4):603-17
Autophagy 2014 Apr;10(4):603-17
Autophagy is essential for cardiac morphogenesis during vertebrate development.
Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF
Autophagy 2014 Apr;10(4):572-87
Autophagy 2014 Apr;10(4):572-87
A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.
Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z
The Journal of biological chemistry 2014 Apr 25;289(17):12005-15
The Journal of biological chemistry 2014 Apr 25;289(17):12005-15
TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells.
Li BH, Yin YW, Liu Y, Pi Y, Guo L, Cao XJ, Gao CY, Zhang LL, Li JC
Cell death & disease 2014 Apr 17;5:e1182
Cell death & disease 2014 Apr 17;5:e1182
Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A
Cell reports 2014 Apr 10;7(1):45-52
Cell reports 2014 Apr 10;7(1):45-52
Autophagy, senescence, and apoptosis.
Goehe RW, Bristol ML, Wilson EN, Gewirtz DA
Methods in molecular biology (Clifton, N.J.) 2013;962:31-48
Methods in molecular biology (Clifton, N.J.) 2013;962:31-48
Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes.
Essick EE, Wilson RM, Pimentel DR, Shimano M, Baid S, Ouchi N, Sam F
PloS one 2013;8(7):e68697
PloS one 2013;8(7):e68697
Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Proenca CC, Stoehr N, Bernhard M, Seger S, Genoud C, Roscic A, Paganetti P, Liu S, Murphy LO, Kuhn R, Bouwmeester T, Galimberti I
PloS one 2013;8(7):e68357
PloS one 2013;8(7):e68357
Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.
Shin BH, Lim Y, Oh HJ, Park SM, Lee SK, Ahnn J, Kim DH, Song WK, Kwak TH, Park WJ
PloS one 2013;8(6):e64953
PloS one 2013;8(6):e64953
Insulin-stimulated degradation of apolipoprotein B100: roles of class II phosphatidylinositol-3-kinase and autophagy.
Andreo U, Guo L, Chirieac DV, Tuyama AC, Montenont E, Brodsky JL, Fisher EA
PloS one 2013;8(3):e57590
PloS one 2013;8(3):e57590
Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
Baldo B, Soylu R, Petersén A
PloS one 2013;8(12):e83050
PloS one 2013;8(12):e83050
The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma.
Lee YJ, Hah YJ, Kang YN, Kang KJ, Hwang JS, Chung WJ, Cho KB, Park KS, Kim ES, Seo HY, Kim MK, Park KG, Jang BK
PloS one 2013;8(11):e81540
PloS one 2013;8(11):e81540
Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation.
Jang BG, Choi BY, Kim JH, Kim MJ, Sohn M, Suh SW
PloS one 2013;8(10):e76466
PloS one 2013;8(10):e76466
Orientia tsutsugamushi subverts dendritic cell functions by escaping from autophagy and impairing their migration.
Choi JH, Cheong TC, Ha NY, Ko Y, Cho CH, Jeon JH, So I, Kim IK, Choi MS, Kim IS, Cho NH
PLoS neglected tropical diseases 2013;7(1):e1981
PLoS neglected tropical diseases 2013;7(1):e1981
Dopamine prevents lipid peroxidation-induced accumulation of toxic α-synuclein oligomers by preserving autophagy-lysosomal function.
Jiang P, Gan M, Yen SH
Frontiers in cellular neuroscience 2013;7:81
Frontiers in cellular neuroscience 2013;7:81
Spatiotemporally controlled induction of autophagy-mediated lysosome turnover.
Hung YH, Chen LM, Yang JY, Yang WY
Nature communications 2013;4:2111
Nature communications 2013;4:2111
Beading of the astrocytic processes (clasmatodendrosis) following head trauma is associated with protein degradation pathways.
Sakai K, Fukuda T, Iwadate K
Brain injury 2013;27(13-14):1692-7
Brain injury 2013;27(13-14):1692-7
Autophagy and human parturition: evaluation of LC3 expression in placenta from spontaneous or medically induced onset of labor.
Avagliano L, Virgili E, Garò C, Quadrelli F, Doi P, Samaja M, Bulfamante GP, Marconi AM
BioMed research international 2013;2013:689768
BioMed research international 2013;2013:689768
Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis.
Xu Y, Yuan J, Lipinski MM
Autophagy 2013 Sep;9(9):1418-30
Autophagy 2013 Sep;9(9):1418-30
Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.
Di X, Zhang G, Zhang Y, Takeda K, Rivera Rosado LA, Zhang B
Oncotarget 2013 Sep;4(9):1349-64
Oncotarget 2013 Sep;4(9):1349-64
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H
Nature neuroscience 2013 Sep;16(9):1257-65
Nature neuroscience 2013 Sep;16(9):1257-65
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation.
Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR
The Journal of investigative dermatology 2013 Sep;133(9):2247-54
The Journal of investigative dermatology 2013 Sep;133(9):2247-54
Diverse autophagosome membrane sources coalesce in recycling endosomes.
Puri C, Renna M, Bento CF, Moreau K, Rubinsztein DC
Cell 2013 Sep 12;154(6):1285-99
Cell 2013 Sep 12;154(6):1285-99
Glutathione peroxidase activity is neuroprotective in models of Huntington's disease.
Mason RP, Casu M, Butler N, Breda C, Campesan S, Clapp J, Green EW, Dhulkhed D, Kyriacou CP, Giorgini F
Nature genetics 2013 Oct;45(10):1249-54
Nature genetics 2013 Oct;45(10):1249-54
Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro.
Lou Z, Ren T, Peng X, Sun Y, Jiao G, Lu Q, Zhang S, Lu X, Guo W
The Journal of international medical research 2013 Oct;41(5):1505-19
The Journal of international medical research 2013 Oct;41(5):1505-19
Autophagy negatively regulates early axon growth in cortical neurons.
Ban BK, Jun MH, Ryu HH, Jang DJ, Ahmad ST, Lee JA
Molecular and cellular biology 2013 Oct;33(19):3907-19
Molecular and cellular biology 2013 Oct;33(19):3907-19
Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.
Fedorova LV, Tamirisa A, Kennedy DJ, Haller ST, Budnyy G, Shapiro JI, Malhotra D
BMC nephrology 2013 Oct 4;14:209
BMC nephrology 2013 Oct 4;14:209
Piperlongumine induces autophagy by targeting p38 signaling.
Wang Y, Wang JW, Xiao X, Shan Y, Xue B, Jiang G, He Q, Chen J, Xu HG, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX
Cell death & disease 2013 Oct 3;4:e824
Cell death & disease 2013 Oct 3;4:e824
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.
Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, McNiven MA
The Journal of cell biology 2013 Oct 28;203(2):315-26
The Journal of cell biology 2013 Oct 28;203(2):315-26
Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells.
Hou J, Han ZP, Jing YY, Yang X, Zhang SS, Sun K, Hao C, Meng Y, Yu FH, Liu XQ, Shi YF, Wu MC, Zhang L, Wei LX
Cell death & disease 2013 Oct 10;4:e844
Cell death & disease 2013 Oct 10;4:e844
Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment.
Song YJ, Zhang SS, Guo XL, Sun K, Han ZP, Li R, Zhao QD, Deng WJ, Xie XQ, Zhang JW, Wu MC, Wei LX
Cancer letters 2013 Oct 1;339(1):70-81
Cancer letters 2013 Oct 1;339(1):70-81
Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
Kim J, Kim TY, Cho KS, Kim HN, Koh JY
Neurobiology of disease 2013 Nov;59:80-5
Neurobiology of disease 2013 Nov;59:80-5
Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism.
Liu LL, Long ZJ, Wang LX, Zheng FM, Fang ZG, Yan M, Xu DF, Chen JJ, Wang SW, Lin DJ, Liu Q
Molecular cancer research : MCR 2013 Nov;11(11):1326-36
Molecular cancer research : MCR 2013 Nov;11(11):1326-36
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine MJ, Zerle J, Kara E, Taanman JW, Healy DG, Marti-Masso JF, Schapira AH, Plun-Favreau H, Tooze S, Hardy J, Bandopadhyay R, Lewis PA
Biochemical and biophysical research communications 2013 Nov 29;441(4):862-6
Biochemical and biophysical research communications 2013 Nov 29;441(4):862-6
Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology.
Gu J, Congdon EE, Sigurdsson EM
The Journal of biological chemistry 2013 Nov 15;288(46):33081-95
The Journal of biological chemistry 2013 Nov 15;288(46):33081-95
A proautophagic antiviral role for the cellular prion protein identified by infection with a herpes simplex virus 1 ICP34.5 mutant.
Korom M, Wylie KM, Wang H, Davis KL, Sangabathula MS, Delassus GS, Morrison LA
Journal of virology 2013 May;87(10):5882-94
Journal of virology 2013 May;87(10):5882-94
Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death.
Ambrosini G, Musi E, Ho AL, de Stanchina E, Schwartz GK
Molecular cancer therapeutics 2013 May;12(5):768-76
Molecular cancer therapeutics 2013 May;12(5):768-76
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Björklund A
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):E1817-26
Proceedings of the National Academy of Sciences of the United States of America 2013 May 7;110(19):E1817-26
Site-specific Mtm1 mutagenesis by an AAV-Cre vector reveals that myotubularin is essential in adult muscle.
Joubert R, Vignaud A, Le M, Moal C, Messaddeq N, Buj-Bello A
Human molecular genetics 2013 May 1;22(9):1856-66
Human molecular genetics 2013 May 1;22(9):1856-66
Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells.
Zhu S, Cao L, Yu Y, Yang L, Yang M, Liu K, Huang J, Kang R, Livesey KM, Tang D
Autophagy 2013 Mar;9(3):317-27
Autophagy 2013 Mar;9(3):317-27
Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells.
Gannon AM, Stämpfli MR, Foster WG
Biology of reproduction 2013 Mar;88(3):63
Biology of reproduction 2013 Mar;88(3):63
Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency.
Pastore N, Blomenkamp K, Annunziata F, Piccolo P, Mithbaokar P, Maria Sepe R, Vetrini F, Palmer D, Ng P, Polishchuk E, Iacobacci S, Polishchuk R, Teckman J, Ballabio A, Brunetti-Pierri N
EMBO molecular medicine 2013 Mar;5(3):397-412
EMBO molecular medicine 2013 Mar;5(3):397-412
Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy.
Chifenti B, Locci MT, Lazzeri G, Guagnozzi M, Dinucci D, Chiellini F, Filice ME, Salerno MG, Battini L
Clinical and experimental reproductive medicine 2013 Mar;40(1):33-7
Clinical and experimental reproductive medicine 2013 Mar;40(1):33-7
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA
The Journal of pharmacology and experimental therapeutics 2013 Mar;344(3):544-52
The Journal of pharmacology and experimental therapeutics 2013 Mar;344(3):544-52
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Magnaudeix A, Wilson CM, Page G, Bauvy C, Codogno P, Lévêque P, Labrousse F, Corre-Delage M, Yardin C, Terro F
Neurobiology of aging 2013 Mar;34(3):770-90
Neurobiology of aging 2013 Mar;34(3):770-90
Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells.
Cai Y, Wan Z, Sun T, Shi Y, Sun Y, Huang P, Li S, Jiang W
Oncology reports 2013 Mar;29(3):983-92
Oncology reports 2013 Mar;29(3):983-92
Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction.
Curtis S, Jones CJ, Garrod A, Hulme CH, Heazell AE
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Mar;26(4):339-46
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Mar;26(4):339-46
MDA5 localizes to stress granules, but this localization is not required for the induction of type I interferon.
Langereis MA, Feng Q, van Kuppeveld FJ
Journal of virology 2013 Jun;87(11):6314-25
Journal of virology 2013 Jun;87(11):6314-25
Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent.
Menvielle JP, Safini N, Tisminetzky SG, Skoko N
Molecular biotechnology 2013 Jun;54(2):711-20
Molecular biotechnology 2013 Jun;54(2):711-20
Composite fatty acid ether amides suppress growth of liver cancer cells in vitro and in an in vivo allograft mouse model.
Cao M, Prima V, Nelson D, Svetlov S
Cellular oncology (Dordrecht) 2013 Jun;36(3):247-57
Cellular oncology (Dordrecht) 2013 Jun;36(3):247-57
Effect of Immortalization-Upregulated Protein-2 (IMUP-2) on Cell Death of Trophoblast.
Jung R, Choi JH, Lee HJ, Kim JK, Kim GJ
Development & reproduction 2013 Jun;17(2):99-109
Development & reproduction 2013 Jun;17(2):99-109
Primary proteasome inhibition results in cardiac dysfunction.
Herrmann J, Wohlert C, Saguner AM, Flores A, Nesbitt LL, Chade A, Lerman LO, Lerman A
European journal of heart failure 2013 Jun;15(6):614-23
European journal of heart failure 2013 Jun;15(6):614-23
mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy.
Kim EJ, Jeong JH, Bae S, Kang S, Kim CH, Lim YB
Journal of cellular biochemistry 2013 Jun;114(6):1248-56
Journal of cellular biochemistry 2013 Jun;114(6):1248-56
UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts.
Lamore SD, Wondrak GT
Journal of photochemistry and photobiology. B, Biology 2013 Jun 5;123:1-12
Journal of photochemistry and photobiology. B, Biology 2013 Jun 5;123:1-12
Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.
Sun Y, Zamzow M, Ran H, Zhang W, Quinn B, Barnes S, Witte DP, Setchell KD, Williams MT, Vorhees CV, Grabowski GA
Human molecular genetics 2013 Jun 15;22(12):2435-50
Human molecular genetics 2013 Jun 15;22(12):2435-50
A sensitive and quantitative autolysosome probe for detecting autophagic activity in live and prestained fixed cells.
Chen JJ, Jing J, Chang H, Rong Y, Hai Y, Tang J, Zhang JL, Xu P
Autophagy 2013 Jun 1;9(6):894-904
Autophagy 2013 Jun 1;9(6):894-904
Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.
Li Y, Nie Y, Helou Y, Ding G, Feng B, Xu G, Salomon A, Xu H
Diabetes 2013 Jul;62(7):2396-409
Diabetes 2013 Jul;62(7):2396-409
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Granato M, Lacconi V, Peddis M, Lotti LV, Di Renzo L, Gonnella R, Santarelli R, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M
Cell death & disease 2013 Jul 18;4:e730
Cell death & disease 2013 Jul 18;4:e730
Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells.
Elschami M, Scherr M, Philippens B, Gerardy-Schahn R
European journal of cell biology 2013 Jan;92(1):21-9
European journal of cell biology 2013 Jan;92(1):21-9
Defective autophagy and mTORC1 signaling in myotubularin null mice.
Fetalvero KM, Yu Y, Goetschkes M, Liang G, Valdez RA, Gould T, Triantafellow E, Bergling S, Loureiro J, Eash J, Lin V, Porter JA, Finan PM, Walsh K, Yang Y, Mao X, Murphy LO
Molecular and cellular biology 2013 Jan;33(1):98-110
Molecular and cellular biology 2013 Jan;33(1):98-110
Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells.
Zhang XY, Wu XQ, Deng R, Sun T, Feng GK, Zhu XF
Cellular signalling 2013 Jan;25(1):150-8
Cellular signalling 2013 Jan;25(1):150-8
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N
Nature immunology 2013 Jan;14(1):61-71
Nature immunology 2013 Jan;14(1):61-71
Insufficient autophagy in idiopathic pulmonary fibrosis.
Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K
American journal of physiology. Lung cellular and molecular physiology 2013 Jan 1;304(1):L56-69
American journal of physiology. Lung cellular and molecular physiology 2013 Jan 1;304(1):L56-69
Active escape of Orientia tsutsugamushi from cellular autophagy.
Ko Y, Choi JH, Ha NY, Kim IS, Cho NH, Choi MS
Infection and immunity 2013 Feb;81(2):552-9
Infection and immunity 2013 Feb;81(2):552-9
Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins.
Chang YL, Wang TH, Chang SD, Chao AS, Hsieh PC, Wang CN
Prenatal diagnosis 2013 Feb;33(2):187-90
Prenatal diagnosis 2013 Feb;33(2):187-90
Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.
Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES
Cell death and differentiation 2013 Feb;20(2):259-69
Cell death and differentiation 2013 Feb;20(2):259-69
Autophagy is required for IL-2-mediated fibroblast growth.
Kang R, Tang D, Lotze MT, Zeh Iii HJ
Experimental cell research 2013 Feb 15;319(4):556-65
Experimental cell research 2013 Feb 15;319(4):556-65
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ
Toxicology and applied pharmacology 2013 Feb 15;267(1):113-24
Toxicology and applied pharmacology 2013 Feb 15;267(1):113-24
Inflammasome components coordinate autophagy and pyroptosis as macrophage responses to infection.
Byrne BG, Dubuisson JF, Joshi AD, Persson JJ, Swanson MS
mBio 2013 Feb 12;4(1):e00620-12
mBio 2013 Feb 12;4(1):e00620-12
Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?
Parajuli N, MacMillan-Crow LA
American journal of physiology. Renal physiology 2013 Feb 1;304(3):F257-67
American journal of physiology. Renal physiology 2013 Feb 1;304(3):F257-67
The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS quantum dots.
Chen L, Miao Y, Chen L, Jin P, Zha Y, Chai Y, Zheng F, Zhang Y, Zhou W, Zhang J, Wen L, Wang M
Biomaterials 2013 Dec;34(38):10172-81
Biomaterials 2013 Dec;34(38):10172-81
The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.
Chang J, Wang W, Zhang H, Hu Y, Wang M, Yin Z
International journal of molecular medicine 2013 Dec;32(6):1311-8
International journal of molecular medicine 2013 Dec;32(6):1311-8
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA
Biochimica et biophysica acta 2013 Dec;1833(12):2900-2910
Biochimica et biophysica acta 2013 Dec;1833(12):2900-2910
Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
Kruppa AJ, Ott S, Chandraratna DS, Irving JA, Page RM, Speretta E, Seto T, Camargo LM, Marciniak SJ, Lomas DA, Crowther DC
Biochimica et biophysica acta 2013 Dec;1832(12):2115-26
Biochimica et biophysica acta 2013 Dec;1832(12):2115-26
Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells.
Liuzzi JP, Yoo C
Biological trace element research 2013 Dec;156(1-3):350-6
Biological trace element research 2013 Dec;156(1-3):350-6
Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection.
Satori CP, Arriaga EA
Analytical chemistry 2013 Dec 3;85(23):11391-400
Analytical chemistry 2013 Dec 3;85(23):11391-400
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Liu Y, Shoji-Kawata S, Sumpter RM Jr, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death.
Alotaibi MR, Asnake B, Di X, Beckman MJ, Durrant D, Simoni D, Baruchello R, Lee RM, Schwartz EL, Gewirtz DA
Biochemical pharmacology 2013 Dec 15;86(12):1688-98
Biochemical pharmacology 2013 Dec 15;86(12):1688-98
The secretion of IL-1β and options for release.
Piccioli P, Rubartelli A
Seminars in immunology 2013 Dec 15;25(6):425-9
Seminars in immunology 2013 Dec 15;25(6):425-9
Autophagy mediates anti-melanogenic activity of 3'-ODI in B16F1 melanoma cells.
Kim ES, Shin JH, Seok SH, Kim JB, Chang H, Park SJ, Jo YK, Choi ES, Park JS, Yeom MH, Lim CS, Cho DH
Biochemical and biophysical research communications 2013 Dec 13;442(3-4):165-70
Biochemical and biophysical research communications 2013 Dec 13;442(3-4):165-70
Functional RIG-I-like receptors control the survival of mesenchymal stem cells.
Yang K, Wang J, Xiang AP, Zhan X, Wang Y, Wu M, Huang X
Cell death & disease 2013 Dec 12;4:e967
Cell death & disease 2013 Dec 12;4:e967
ARP101 inhibits α-MSH-stimulated melanogenesis by regulation of autophagy in melanocytes.
Kim ES, Jo YK, Park SJ, Chang H, Shin JH, Choi ES, Kim JB, Seok SH, Kim JS, Oh JS, Kim MH, Lee EH, Cho DH
FEBS letters 2013 Dec 11;587(24):3955-60
FEBS letters 2013 Dec 11;587(24):3955-60
Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.
Yang M, Cao L, Xie M, Yu Y, Kang R, Yang L, Zhao M, Tang D
Biochemical pharmacology 2013 Aug 1;86(3):410-8
Biochemical pharmacology 2013 Aug 1;86(3):410-8
Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling.
Kyrmizi I, Gresnigt MS, Akoumianaki T, Samonis G, Sidiropoulos P, Boumpas D, Netea MG, van de Veerdonk FL, Kontoyiannis DP, Chamilos G
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 1;191(3):1287-99
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 1;191(3):1287-99
Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution.
Elfrink HL, Zwart R, Baas F, Scheper W
Molecules and cells 2013 Apr;35(4):291-7
Molecules and cells 2013 Apr;35(4):291-7
mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells.
Cai Y, Xia Q, Su Q, Luo R, Sun Y, Shi Y, Jiang W
International journal of molecular medicine 2013 Apr;31(4):904-12
International journal of molecular medicine 2013 Apr;31(4):904-12
Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.
Han SG, Newsome B, Hennig B
Toxicology 2013 Apr 5;306:1-8
Toxicology 2013 Apr 5;306:1-8
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents.
Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C, Lasmézas CI
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 23;110(17):7044-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 23;110(17):7044-9
Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
Shi JM, Bai LL, Zhang DM, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC
Biochemical pharmacology 2013 Apr 1;85(7):913-26
Biochemical pharmacology 2013 Apr 1;85(7):913-26
Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
Park JH, Lee JE, Shin IC, Koh HC
Toxicology and applied pharmacology 2013 Apr 1;268(1):55-67
Toxicology and applied pharmacology 2013 Apr 1;268(1):55-67
Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?
Choudhury S, Kolukula VK, Preet A, Albanese C, Avantaggiati ML
Cell cycle (Georgetown, Tex.) 2013 Apr 1;12(7):1022-9
Cell cycle (Georgetown, Tex.) 2013 Apr 1;12(7):1022-9
The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment.
Li DD, Sun T, Wu XQ, Chen SP, Deng R, Jiang S, Feng GK, Pan JX, Zhang XS, Zeng YX, Zhu XF
PloS one 2012;7(9):e45058
PloS one 2012;7(9):e45058
Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice.
Zhang M, Jiang M, Bi Y, Zhu H, Zhou Z, Sha J
PloS one 2012;7(7):e41412
PloS one 2012;7(7):e41412
ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.
Ayna G, Krysko DV, Kaczmarek A, Petrovski G, Vandenabeele P, Fésüs L
PloS one 2012;7(6):e40069
PloS one 2012;7(6):e40069
Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells.
Lin CJ, Lee CC, Shih YL, Lin CH, Wang SH, Chen TH, Shih CM
PloS one 2012;7(6):e38706
PloS one 2012;7(6):e38706
Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells.
Hou H, Zhang Y, Huang Y, Yi Q, Lv L, Zhang T, Chen D, Hao Q, Shi Q
PloS one 2012;7(4):e35665
PloS one 2012;7(4):e35665
Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.
Shin JH, Park SJ, Kim ES, Jo YK, Hong J, Cho DH
Biological & pharmaceutical bulletin 2012;35(7):1069-75
Biological & pharmaceutical bulletin 2012;35(7):1069-75
The miR-290-295 cluster suppresses autophagic cell death of melanoma cells.
Chen Y, Liersch R, Detmar M
Scientific reports 2012;2:808
Scientific reports 2012;2:808
Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells.
Yang F, Chen WD, Deng R, Li DD, Wu KW, Feng GK, Li HJ, Zhu XF
Journal of pharmacological sciences 2012;119(3):214-20
Journal of pharmacological sciences 2012;119(3):214-20
Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity.
Jeong JK, Moon MH, Lee YJ, Seol JW, Park SY
Journal of pineal research 2012 Sep;53(2):138-46
Journal of pineal research 2012 Sep;53(2):138-46
Involvement of the autophagy pathway in trafficking of Mycobacterium tuberculosis bacilli through cultured human type II epithelial cells.
Fine KL, Metcalfe MG, White E, Virji M, Karls RK, Quinn FD
Cellular microbiology 2012 Sep;14(9):1402-14
Cellular microbiology 2012 Sep;14(9):1402-14
Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis.
Back JH, Zhu Y, Calabro A, Queenan C, Kim AS, Arbesman J, Kim AL
Photochemistry and photobiology 2012 Sep-Oct;88(5):1165-72
Photochemistry and photobiology 2012 Sep-Oct;88(5):1165-72
Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells.
Zhang G, Liu J, Zhang Y, Qu J, Xu L, Zheng H, Liu Y, Qu X
FEBS letters 2012 Sep 21;586(19):3104-10
FEBS letters 2012 Sep 21;586(19):3104-10
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
Wang IF, Guo BS, Liu YC, Wu CC, Yang CH, Tsai KJ, Shen CK
Proceedings of the National Academy of Sciences of the United States of America 2012 Sep 11;109(37):15024-9
Proceedings of the National Academy of Sciences of the United States of America 2012 Sep 11;109(37):15024-9
Effect of dual inhibition of apoptosis and autophagy in prostate cancer.
Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, DiPaola RS
The Prostate 2012 Sep 1;72(12):1374-81
The Prostate 2012 Sep 1;72(12):1374-81
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Krüger U, Wang Y, Kumar S, Mandelkow EM
Neurobiology of aging 2012 Oct;33(10):2291-305
Neurobiology of aging 2012 Oct;33(10):2291-305
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.
Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML
Oncotarget 2012 Oct;3(10):1220-35
Oncotarget 2012 Oct;3(10):1220-35
DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.
Gao H, Yang W, Qi Z, Lu L, Duan C, Zhao C, Yang H
Journal of molecular biology 2012 Oct 19;423(2):232-48
Journal of molecular biology 2012 Oct 19;423(2):232-48
zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function.
Herzog C, Yang C, Holmes A, Kaushal GP
American journal of physiology. Renal physiology 2012 Oct 15;303(8):F1239-50
American journal of physiology. Renal physiology 2012 Oct 15;303(8):F1239-50
Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.
Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 15;18(20):5639-49
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 15;18(20):5639-49
Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases.
Xu Y, Tian C, Wang SB, Xie WL, Guo Y, Zhang J, Shi Q, Chen C, Dong XP
Autophagy 2012 Nov;8(11):1604-20
Autophagy 2012 Nov;8(11):1604-20
Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy.
Liu X, Ye B, Miller S, Yuan H, Zhang H, Tian L, Nie J, Imae R, Arai H, Li Y, Cheng Z, Shi Y
Molecular and cellular biology 2012 Nov;32(21):4493-504
Molecular and cellular biology 2012 Nov;32(21):4493-504
Akt inactivation induces endoplasmic reticulum stress-independent autophagy in fibroblasts from patients with Pompe disease.
Nishiyama Y, Shimada Y, Yokoi T, Kobayashi H, Higuchi T, Eto Y, Ida H, Ohashi T
Molecular genetics and metabolism 2012 Nov;107(3):490-5
Molecular genetics and metabolism 2012 Nov;107(3):490-5
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE, Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ, Farrer MJ, Melrose HL
Molecular neurodegeneration 2012 May 30;7:25
Molecular neurodegeneration 2012 May 30;7:25
Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen.
Ma D, Collins J, Hudlicky T, Pandey S
Journal of visualized experiments : JoVE 2012 May 30;(63)
Journal of visualized experiments : JoVE 2012 May 30;(63)
Suppression of autophagy exacerbates Mefloquine-mediated cell death.
Shin JH, Park SJ, Jo YK, Kim ES, Kang H, Park JH, Lee EH, Cho DH
Neuroscience letters 2012 May 2;515(2):162-7
Neuroscience letters 2012 May 2;515(2):162-7
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM, Krasinskas A, Lotze MT, Zeh HJ 3rd
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):7031-6
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):7031-6
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death.
Ma X, Godar RJ, Liu H, Diwan A
Autophagy 2012 Mar;8(3):297-309
Autophagy 2012 Mar;8(3):297-309
A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen.
Ma D, Tremblay P, Mahngar K, Akbari-Asl P, Collins J, Hudlicky T, McNulty J, Pandey S
Investigational new drugs 2012 Jun;30(3):1012-27
Investigational new drugs 2012 Jun;30(3):1012-27
Characterization of biological responses of colorectal cancer cells to anticancer regimens.
Roh SA, Choi EY, Cho DH, Yoon YS, Kim TW, Kim YS, Kim JC
Journal of the Korean Surgical Society 2012 Jul;83(1):21-9
Journal of the Korean Surgical Society 2012 Jul;83(1):21-9
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.
Tang J, Deng R, Luo RZ, Shen GP, Cai MY, Du ZM, Jiang S, Yang MT, Fu JH, Zhu XF
Breast cancer research and treatment 2012 Jul;134(2):549-60
Breast cancer research and treatment 2012 Jul;134(2):549-60
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.
Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE
Molecular neurodegeneration 2012 Jul 29;7:36
Molecular neurodegeneration 2012 Jul 29;7:36
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.
Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, Wu MC, Wei LX
Cancer letters 2012 Jul 28;320(2):171-9
Cancer letters 2012 Jul 28;320(2):171-9
A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.
Homer CR, Kabi A, Marina-García N, Sreekumar A, Nesvizhskii AI, Nickerson KP, Chinnaiyan AM, Nuñez G, McDonald C
The Journal of biological chemistry 2012 Jul 20;287(30):25565-76
The Journal of biological chemistry 2012 Jul 20;287(30):25565-76
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY
Autophagy 2012 Jan;8(1):77-87
Autophagy 2012 Jan;8(1):77-87
β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.
Liu J, Hu XJ, Jin B, Qu XJ, Hou KZ, Liu YP
The Journal of pharmacy and pharmacology 2012 Jan;64(1):146-53
The Journal of pharmacy and pharmacology 2012 Jan;64(1):146-53
The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes.
Kim HN, Lee SJ, Koh JY
Neurochemistry international 2012 Jan;60(2):125-33
Neurochemistry international 2012 Jan;60(2):125-33
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury.
Sachdev U, Cui X, Hong G, Namkoong S, Karlsson JM, Baty CJ, Tzeng E
Journal of vascular surgery 2012 Jan;55(1):180-91
Journal of vascular surgery 2012 Jan;55(1):180-91
Melatonin protects against rotenone-induced cell injury via inhibition of Omi and Bax-mediated autophagy in Hela cells.
Zhou H, Chen J, Lu X, Shen C, Zeng J, Chen L, Pei Z
Journal of pineal research 2012 Jan;52(1):120-7
Journal of pineal research 2012 Jan;52(1):120-7
Modulation of pediatric brain tumor autophagy and chemosensitivity.
Levy JM, Thorburn A
Journal of neuro-oncology 2012 Jan;106(2):281-90
Journal of neuro-oncology 2012 Jan;106(2):281-90
Autophagy regulates inflammation in adipocytes.
Yoshizaki T, Kusunoki C, Kondo M, Yasuda M, Kume S, Morino K, Sekine O, Ugi S, Uzu T, Nishio Y, Kashiwagi A, Maegawa H
Biochemical and biophysical research communications 2012 Jan 6;417(1):352-7
Biochemical and biophysical research communications 2012 Jan 6;417(1):352-7
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, Gilpin C, Xiao G, Bassel-Duby R, Scherer PE, Levine B
Nature 2012 Jan 18;481(7382):511-5
Nature 2012 Jan 18;481(7382):511-5
HMGB1 promotes drug resistance in osteosarcoma.
Huang J, Ni J, Liu K, Yu Y, Xie M, Kang R, Vernon P, Cao L, Tang D
Cancer research 2012 Jan 1;72(1):230-8
Cancer research 2012 Jan 1;72(1):230-8
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.
Moreau K, Ravikumar B, Puri C, Rubinsztein DC
The Journal of cell biology 2012 Feb 20;196(4):483-96
The Journal of cell biology 2012 Feb 20;196(4):483-96
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy.
Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A
Autophagy 2012 Feb 1;8(2):200-12
Autophagy 2012 Feb 1;8(2):200-12
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.
Gagliostro V, Casas J, Caretti A, Abad JL, Tagliavacca L, Ghidoni R, Fabrias G, Signorelli P
The international journal of biochemistry & cell biology 2012 Dec;44(12):2135-43
The international journal of biochemistry & cell biology 2012 Dec;44(12):2135-43
Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.
Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J
The Journal of pathology 2012 Dec;228(4):448-58
The Journal of pathology 2012 Dec;228(4):448-58
Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.
Plötz M, Gillissen B, Hossini AM, Daniel PT, Eberle J
Cell death and differentiation 2012 Dec;19(12):1928-38
Cell death and differentiation 2012 Dec;19(12):1928-38
Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response.
Grossi V, Liuzzi M, Murzilli S, Martelli N, Napoli A, Ingravallo G, Del Rio A, Simone C
Cancer biology & therapy 2012 Dec;13(14):1471-81
Cancer biology & therapy 2012 Dec;13(14):1471-81
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Yu Y, Yang L, Zhao M, Zhu S, Kang R, Vernon P, Tang D, Cao L
Leukemia 2012 Aug;26(8):1752-60
Leukemia 2012 Aug;26(8):1752-60
Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.
Wang H, Ying Z, Wang G
The Journal of biological chemistry 2012 Aug 17;287(34):28576-85
The Journal of biological chemistry 2012 Aug 17;287(34):28576-85
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.
Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K
Oncoimmunology 2012 Aug 1;1(5):630-641
Oncoimmunology 2012 Aug 1;1(5):630-641
Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.
Kanai R, Zaupa C, Sgubin D, Antoszczyk SJ, Martuza RL, Wakimoto H, Rabkin SD
Journal of virology 2012 Apr;86(8):4420-31
Journal of virology 2012 Apr;86(8):4420-31
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.
Caramés B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M
Arthritis and rheumatism 2012 Apr;64(4):1182-92
Arthritis and rheumatism 2012 Apr;64(4):1182-92
NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans.
Juárez E, Carranza C, Hernández-Sánchez F, León-Contreras JC, Hernández-Pando R, Escobedo D, Torres M, Sada E
European journal of immunology 2012 Apr;42(4):880-9
European journal of immunology 2012 Apr;42(4):880-9
Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis.
Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, Sharma AK, Amin S, Hu CD, Zhang J, Kester M, Wang HG
The Journal of biological chemistry 2012 Apr 6;287(15):12455-68
The Journal of biological chemistry 2012 Apr 6;287(15):12455-68
Autophagy links inflammasomes to atherosclerotic progression.
Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF
Cell metabolism 2012 Apr 4;15(4):534-44
Cell metabolism 2012 Apr 4;15(4):534-44
p53/HMGB1 complexes regulate autophagy and apoptosis.
Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ 3rd, Li L, Lotze MT, Tang D
Cancer research 2012 Apr 15;72(8):1996-2005
Cancer research 2012 Apr 15;72(8):1996-2005
Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin.
Ma D, Tremblay P, Mahngar K, Collins J, Hudlicky T, Pandey S
PloS one 2011;6(12):e28780
PloS one 2011;6(12):e28780
c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells.
Sun T, Li D, Wang L, Xia L, Ma J, Guan Z, Feng G, Zhu X
Journal of translational medicine 2011 Sep 26;9:161
Journal of translational medicine 2011 Sep 26;9:161
Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.
Melton EM, Cerny RL, Watkins PA, DiRusso CC, Black PN
The Journal of biological chemistry 2011 Sep 2;286(35):30670-9
The Journal of biological chemistry 2011 Sep 2;286(35):30670-9
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.
Meng Q, Cai D
The Journal of biological chemistry 2011 Sep 16;286(37):32324-32
The Journal of biological chemistry 2011 Sep 16;286(37):32324-32
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy.
Xu CX, Zhao L, Yue P, Fang G, Tao H, Owonikoko TK, Ramalingam SS, Khuri FR, Sun SY
Cancer biology & therapy 2011 Sep 15;12(6):549-55
Cancer biology & therapy 2011 Sep 15;12(6):549-55
Autophagy-mediated chemosensitization by cysteamine in cancer cells.
Wan XM, Zheng F, Zhang L, Miao YY, Man N, Wen LP
International journal of cancer 2011 Sep 1;129(5):1087-95
International journal of cancer 2011 Sep 1;129(5):1087-95
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.
Kim YH, Rane A, Lussier S, Andersen JK
Journal of neuroscience research 2011 Oct;89(10):1666-75
Journal of neuroscience research 2011 Oct;89(10):1666-75
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
Qi Z, Yang W, Liu Y, Cui T, Gao H, Duan C, Lu L, Zhao C, Zhao H, Yang H
Neurochemistry international 2011 Oct;59(5):572-81
Neurochemistry international 2011 Oct;59(5):572-81
Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase.
Noh BK, Lee JK, Jun HJ, Lee JH, Jia Y, Hoang MH, Kim JW, Park KH, Lee SJ
Biochemical and biophysical research communications 2011 Oct 22;414(2):361-6
Biochemical and biophysical research communications 2011 Oct 22;414(2):361-6
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy.
Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I
Human molecular genetics 2011 Oct 1;20(19):3841-51
Human molecular genetics 2011 Oct 1;20(19):3841-51
Autophagy induction by tetrahydrobiopterin deficiency.
Kwak SS, Suk J, Choi JH, Yang S, Kim JW, Sohn S, Chung JH, Hong YH, Lee DH, Ahn JK, Min H, Fu YM, Meadows GG, Joe CO
Autophagy 2011 Nov;7(11):1323-34
Autophagy 2011 Nov;7(11):1323-34
Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.
Qiu W, Zhang J, Dekker MJ, Wang H, Huang J, Brumell JH, Adeli K
Hepatology (Baltimore, Md.) 2011 May;53(5):1515-25
Hepatology (Baltimore, Md.) 2011 May;53(5):1515-25
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
Zhang T, Yan W, Li Q, Fu J, Liu K, Jia W, Sun X, Liu X
Neurological research 2011 May;33(4):396-404
Neurological research 2011 May;33(4):396-404
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):795-808
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):795-808
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.
Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL
BMC cell biology 2011 May 5;12:17
BMC cell biology 2011 May 5;12:17
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB
Proceedings of the National Academy of Sciences of the United States of America 2011 May 24;108(21):8785-90
Proceedings of the National Academy of Sciences of the United States of America 2011 May 24;108(21):8785-90
Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway.
Waltz P, Carchman EH, Young AC, Rao J, Rosengart MR, Kaczorowski D, Zuckerbraun BS
Autophagy 2011 Mar;7(3):315-20
Autophagy 2011 Mar;7(3):315-20
Obligate role for ketone body oxidation in neonatal metabolic homeostasis.
Cotter DG, d'Avignon DA, Wentz AE, Weber ML, Crawford PA
The Journal of biological chemistry 2011 Mar 4;286(9):6902-10
The Journal of biological chemistry 2011 Mar 4;286(9):6902-10
Characterization of macroautophagic flux in vivo using a leupeptin-based assay.
Haspel J, Shaik RS, Ifedigbo E, Nakahira K, Dolinay T, Englert JA, Choi AM
Autophagy 2011 Jun;7(6):629-42
Autophagy 2011 Jun;7(6):629-42
Autophagy in term normal human placentas.
Signorelli P, Avagliano L, Virgili E, Gagliostro V, Doi P, Braidotti P, Bulfamante GP, Ghidoni R, Marconi AM
Placenta 2011 Jun;32(6):482-5
Placenta 2011 Jun;32(6):482-5
Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet.
Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA
American journal of physiology. Gastrointestinal and liver physiology 2011 Jun;300(6):G956-67
American journal of physiology. Gastrointestinal and liver physiology 2011 Jun;300(6):G956-67
High-mobility group box 1 is essential for mitochondrial quality control.
Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ 3rd, Lotze MT
Cell metabolism 2011 Jun 8;13(6):701-11
Cell metabolism 2011 Jun 8;13(6):701-11
Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
Park BH, Lee SB, Stolz DB, Lee YJ, Lee BC
The Journal of biological chemistry 2011 Jun 3;286(22):20087-99
The Journal of biological chemistry 2011 Jun 3;286(22):20087-99
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
Myeku N, Figueiredo-Pereira ME
The Journal of biological chemistry 2011 Jun 24;286(25):22426-40
The Journal of biological chemistry 2011 Jun 24;286(25):22426-40
Scratching beneath the surface: new insights into the functional properties of the lateral occipital area and parahippocampal place area.
Cant JS, Goodale MA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 1;31(22):8248-58
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 1;31(22):8248-58
Relieving autophagy and 4EBP1 from rapamycin resistance.
Nyfeler B, Bergman P, Triantafellow E, Wilson CJ, Zhu Y, Radetich B, Finan PM, Klionsky DJ, Murphy LO
Molecular and cellular biology 2011 Jul;31(14):2867-76
Molecular and cellular biology 2011 Jul;31(14):2867-76
The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress.
Broadley K, Larsen L, Herst PM, Smith RA, Berridge MV, McConnell MJ
Journal of cellular biochemistry 2011 Jul;112(7):1869-79
Journal of cellular biochemistry 2011 Jul;112(7):1869-79
Autophagosome precursor maturation requires homotypic fusion.
Moreau K, Ravikumar B, Renna M, Puri C, Rubinsztein DC
Cell 2011 Jul 22;146(2):303-17
Cell 2011 Jul 22;146(2):303-17
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.
Hsu HS, Huang PI, Chang YL, Tzao C, Chen YW, Shih HC, Hung SC, Chen YC, Tseng LM, Chiou SH
Cancer 2011 Jul 1;117(13):2970-85
Cancer 2011 Jul 1;117(13):2970-85
Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.
Takahashi Y, Meyerkord CL, Hori T, Runkle K, Fox TE, Kester M, Loughran TP, Wang HG
Autophagy 2011 Jan;7(1):61-73
Autophagy 2011 Jan;7(1):61-73
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA
Brain : a journal of neurology 2011 Jan;134(Pt 1):258-77
Brain : a journal of neurology 2011 Jan;134(Pt 1):258-77
Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries.
Xu B, Hua J, Zhang Y, Jiang X, Zhang H, Ma T, Zheng W, Sun R, Shen W, Sha J, Cooke HJ, Shi Q
PloS one 2011 Jan 6;6(1):e16046
PloS one 2011 Jan 6;6(1):e16046
Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo.
Narni-Mancinelli E, Soudja SM, Crozat K, Dalod M, Gounon P, Geissmann F, Lauvau G
PLoS pathogens 2011 Dec;7(12):e1002457
PLoS pathogens 2011 Dec;7(12):e1002457
Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis.
Higa A, Mulot A, Delom F, Bouchecareilh M, Nguyên DT, Boismenu D, Wise MJ, Chevet E
The Journal of biological chemistry 2011 Dec 30;286(52):44855-68
The Journal of biological chemistry 2011 Dec 30;286(52):44855-68
2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line.
Fiorito F, Ciarcia R, Granato GE, Marfe G, Iovane V, Florio S, De Martino L, Pagnini U
Toxicology 2011 Dec 18;290(2-3):258-70
Toxicology 2011 Dec 18;290(2-3):258-70
Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A.
Carmignac V, Svensson M, Körner Z, Elowsson L, Matsumura C, Gawlik KI, Allamand V, Durbeej M
Human molecular genetics 2011 Dec 15;20(24):4891-902
Human molecular genetics 2011 Dec 15;20(24):4891-902
Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
Molitoris JK, McColl KS, Swerdlow S, Matsuyama M, Lam M, Finkel TH, Matsuyama S, Distelhorst CW
The Journal of biological chemistry 2011 Aug 26;286(34):30181-9
The Journal of biological chemistry 2011 Aug 26;286(34):30181-9
Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein.
Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D
Autophagy 2011 Apr;7(4):401-11
Autophagy 2011 Apr;7(4):401-11
Snapin deficiency is associated with developmental defects of the central nervous system.
Zhou B, Zhu YB, Lin L, Cai Q, Sheng ZH
Bioscience reports 2011 Apr;31(2):151-8
Bioscience reports 2011 Apr;31(2):151-8
Calcipotriol induces autophagy in HeLa cells and keratinocytes.
Wang RC, Levine B
The Journal of investigative dermatology 2011 Apr;131(4):990-3
The Journal of investigative dermatology 2011 Apr;131(4):990-3
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.
Elgendy M, Sheridan C, Brumatti G, Martin SJ
Molecular cell 2011 Apr 8;42(1):23-35
Molecular cell 2011 Apr 8;42(1):23-35
Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy.
Lee SW, Song YS, Lee SY, Yoon YG, Lee SH, Park BS, Yun I, Choi H, Kim K, Chung WT, Yoo YH
PloS one 2011 Apr 29;6(4):e19163
PloS one 2011 Apr 29;6(4):e19163
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury.
Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr, Gottlieb RA, Przyklenk K
Circulation 2010 Sep 14;122(11 Suppl):S179-84
Circulation 2010 Sep 14;122(11 Suppl):S179-84
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes.
Harr MW, McColl KS, Zhong F, Molitoris JK, Distelhorst CW
Autophagy 2010 Oct;6(7):912-21
Autophagy 2010 Oct;6(7):912-21
Melanized fungi in human disease.
Revankar SG, Sutton DA
Clinical microbiology reviews 2010 Oct;23(4):884-928
Clinical microbiology reviews 2010 Oct;23(4):884-928
Sodium 5,6-benzylidene-L-ascorbate induces oxidative stress, autophagy, and growth arrest in human colon cancer HT-29 cells.
Cheung FW, Che CT, Sakagami H, Kochi M, Liu WK
Journal of cellular biochemistry 2010 Oct 1;111(2):412-24
Journal of cellular biochemistry 2010 Oct 1;111(2):412-24
GABARAPL1 (GEC1) associates with autophagic vesicles.
Chakrama FZ, Seguin-Py S, Le Grand JN, Fraichard A, Delage-Mourroux R, Despouy G, Perez V, Jouvenot M, Boyer-Guittaut M
Autophagy 2010 May;6(4):495-505
Autophagy 2010 May;6(4):495-505
Induction of genuine autophagy by cationic lipids in mammalian cells.
Man N, Chen Y, Zheng F, Zhou W, Wen LP
Autophagy 2010 May;6(4):449-54
Autophagy 2010 May;6(4):449-54
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP
The Journal of biological chemistry 2010 May 21;285(21):15714-23
The Journal of biological chemistry 2010 May 21;285(21):15714-23
Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway.
Zhou X, Wang L, Hasegawa H, Amin P, Han BX, Kaneko S, He Y, Wang F
Proceedings of the National Academy of Sciences of the United States of America 2010 May 18;107(20):9424-9
Proceedings of the National Academy of Sciences of the United States of America 2010 May 18;107(20):9424-9
The role of autophagy in follicular development and atresia in rat granulosa cells.
Choi JY, Jo MW, Lee EY, Yoon BK, Choi DS
Fertility and sterility 2010 May 15;93(8):2532-7
Fertility and sterility 2010 May 15;93(8):2532-7
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.
Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, Deckert M, Auberger P, Tanti JF, Bost F
Cancer research 2010 Mar 15;70(6):2465-75
Cancer research 2010 Mar 15;70(6):2465-75
Laforin, the most common protein mutated in Lafora disease, regulates autophagy.
Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, Boya P, Sanz P, de Córdoba SR, Knecht E, Rubinsztein DC
Human molecular genetics 2010 Jul 15;19(14):2867-76
Human molecular genetics 2010 Jul 15;19(14):2867-76
Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy.
Yuk JM, Shin DM, Song KS, Lim K, Kim KH, Lee SH, Kim JM, Lee JS, Paik TH, Kim JS, Jo EK
Autophagy 2010 Jan;6(1):46-60
Autophagy 2010 Jan;6(1):46-60
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.
Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM Jr, Gottlieb RA
American journal of physiology. Heart and circulatory physiology 2010 Feb;298(2):H570-9
American journal of physiology. Heart and circulatory physiology 2010 Feb;298(2):H570-9
Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells.
Li DD, Guo JF, Huang JJ, Wang LL, Deng R, Liu JN, Feng GK, Xiao DJ, Deng SZ, Zhang XS, Zhu XF
PloS one 2010 Aug 17;5(8):e12176
PloS one 2010 Aug 17;5(8):e12176
Discovery and characterization of a mammalian amyloid disaggregation activity.
Murray AN, Solomon JP, Wang YJ, Balch WE, Kelly JW
Protein science : a publication of the Protein Society 2010 Apr;19(4):836-46
Protein science : a publication of the Protein Society 2010 Apr;19(4):836-46
14-3-3Tau regulates Beclin 1 and is required for autophagy.
Wang B, Ling S, Lin WC
PloS one 2010 Apr 29;5(4):e10409
PloS one 2010 Apr 29;5(4):e10409
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy.
Eng CH, Yu K, Lucas J, White E, Abraham RT
Science signaling 2010 Apr 27;3(119):ra31
Science signaling 2010 Apr 27;3(119):ra31
Autophagic clearance of aggregate-prone proteins associated with neurodegeneration.
Sarkar S, Ravikumar B, Rubinsztein DC
Methods in enzymology 2009;453:83-110
Methods in enzymology 2009;453:83-110
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2928-41
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2928-41
Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression.
Davidson CD, Ali NF, Micsenyi MC, Stephney G, Renault S, Dobrenis K, Ory DS, Vanier MT, Walkley SU
PloS one 2009 Sep 11;4(9):e6951
PloS one 2009 Sep 11;4(9):e6951
Metabolic adaptations to interrupted glycosaminoglycan recycling.
Woloszynek JC, Kovacs A, Ohlemiller KK, Roberts M, Sands MS
The Journal of biological chemistry 2009 Oct 23;284(43):29684-91
The Journal of biological chemistry 2009 Oct 23;284(43):29684-91
Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells.
Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao L, Sun K, Shen F, Wu M, Wei L
Autophagy 2009 Nov;5(8):1131-44
Autophagy 2009 Nov;5(8):1131-44
Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal.
Zhang Q, Yang W, Man N, Zheng F, Shen Y, Sun K, Li Y, Wen LP
Autophagy 2009 Nov;5(8):1107-17
Autophagy 2009 Nov;5(8):1107-17
Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line.
Colosetti P, Puissant A, Robert G, Luciano F, Jacquel A, Gounon P, Cassuto JP, Auberger P
Autophagy 2009 Nov;5(8):1092-8
Autophagy 2009 Nov;5(8):1092-8
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy.
Shen S, Zhang P, Lovchik MA, Li Y, Tang L, Chen Z, Zeng R, Ma D, Yuan J, Yu Q
The Journal of cell biology 2009 May 18;185(4):629-39
The Journal of cell biology 2009 May 18;185(4):629-39
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.
Pacheco CD, Elrick MJ, Lieberman AP
Human molecular genetics 2009 Mar 1;18(5):956-65
Human molecular genetics 2009 Mar 1;18(5):956-65
Exploring the human genome with functional maps.
Huttenhower C, Haley EM, Hibbs MA, Dumeaux V, Barrett DR, Coller HA, Troyanskaya OG
Genome research 2009 Jun;19(6):1093-106
Genome research 2009 Jun;19(6):1093-106
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.
Young JE, Martinez RA, La Spada AR
The Journal of biological chemistry 2009 Jan 23;284(4):2363-73
The Journal of biological chemistry 2009 Jan 23;284(4):2363-73
Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes.
Panyasrivanit M, Khakpoor A, Wikan N, Smith DR
The Journal of general virology 2009 Feb;90(Pt 2):448-56
The Journal of general virology 2009 Feb;90(Pt 2):448-56
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
Yuan H, Perry CN, Huang C, Iwai-Kanai E, Carreira RS, Glembotski CC, Gottlieb RA
American journal of physiology. Heart and circulatory physiology 2009 Feb;296(2):H470-9
American journal of physiology. Heart and circulatory physiology 2009 Feb;296(2):H470-9
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells.
Li DD, Wang LL, Deng R, Tang J, Shen Y, Guo JF, Wang Y, Xia LP, Feng GK, Liu QQ, Huang WL, Zeng YX, Zhu XF
Oncogene 2009 Feb 12;28(6):886-98
Oncogene 2009 Feb 12;28(6):886-98
Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.
Tang D, Kang R, Xiao W, Zhang H, Lotze MT, Wang H, Xiao X
American journal of respiratory cell and molecular biology 2009 Dec;41(6):651-60
American journal of respiratory cell and molecular biology 2009 Dec;41(6):651-60
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Ferguson CJ, Lenk GM, Meisler MH
Human molecular genetics 2009 Dec 15;18(24):4868-78
Human molecular genetics 2009 Dec 15;18(24):4868-78
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.
Cao Y, Marks JD, Marks JW, Cheung LH, Kim S, Rosenblum MG
Cancer research 2009 Dec 1;69(23):8987-95
Cancer research 2009 Dec 1;69(23):8987-95
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY
Cancer research 2009 Dec 1;69(23):8967-76
Cancer research 2009 Dec 1;69(23):8967-76
1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol (Gln) induces cell death with more autophagosomes which is autophagy-independent.
Jahreiss L, Renna M, Bittman R, Arthur G, Rubinsztein DC
Autophagy 2009 Aug;5(6):835-46
Autophagy 2009 Aug;5(6):835-46
The autophagy machinery is required to initiate hepatitis C virus replication.
Dreux M, Gastaminza P, Wieland SF, Chisari FV
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 18;106(33):14046-51
Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 18;106(33):14046-51
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.
Fan S, Meng Q, Saha T, Sarkar FH, Rosen EM
Cancer research 2009 Aug 1;69(15):6083-91
Cancer research 2009 Aug 1;69(15):6083-91
A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death.
Samadder P, Bittman R, Byun HS, Arthur G
Biochemistry and cell biology = Biochimie et biologie cellulaire 2009 Apr;87(2):401-14
Biochemistry and cell biology = Biochimie et biologie cellulaire 2009 Apr;87(2):401-14
Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates.
Sarkar S, Korolchuk V, Renna M, Winslow A, Rubinsztein DC
Autophagy 2009 Apr;5(3):307-13
Autophagy 2009 Apr;5(3):307-13
Activation of antibacterial autophagy by NADPH oxidases.
Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH
Proceedings of the National Academy of Sciences of the United States of America 2009 Apr 14;106(15):6226-31
Proceedings of the National Academy of Sciences of the United States of America 2009 Apr 14;106(15):6226-31
Methods to investigate autophagy during starvation and regeneration in hydra.
Buzgariu W, Chera S, Galliot B
Methods in enzymology 2008;451:409-37
Methods in enzymology 2008;451:409-37
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Degtyarev M, De Mazière A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, Friedman LS, Lin K
The Journal of cell biology 2008 Oct 6;183(1):101-16
The Journal of cell biology 2008 Oct 6;183(1):101-16
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th
Nature 2008 Nov 13;456(7219):259-63
Nature 2008 Nov 13;456(7219):259-63
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC
Nature chemical biology 2008 May;4(5):295-305
Nature chemical biology 2008 May;4(5):295-305
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC
Human molecular genetics 2008 Jan 15;17(2):170-8
Human molecular genetics 2008 Jan 15;17(2):170-8
A block of autophagy in lysosomal storage disorders.
Settembre C, Fraldi A, Jahreiss L, Spampanato C, Venturi C, Medina D, de Pablo R, Tacchetti C, Rubinsztein DC, Ballabio A
Human molecular genetics 2008 Jan 1;17(1):119-29
Human molecular genetics 2008 Jan 1;17(1):119-29
The ARF tumor suppressor can promote the progression of some tumors.
Humbey O, Pimkina J, Zilfou JT, Jarnik M, Dominguez-Brauer C, Burgess DJ, Eischen CM, Murphy ME
Cancer research 2008 Dec 1;68(23):9608-13
Cancer research 2008 Dec 1;68(23):9608-13
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis.
Burdette DL, Yarbrough ML, Orvedahl A, Gilpin CJ, Orth K
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12497-502
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12497-502
Autophagy-mediated clearance of aggresomes is not a universal phenomenon.
Wong ES, Tan JM, Soong WE, Hussein K, Nukina N, Dawson VL, Dawson TM, Cuervo AM, Lim KL
Human molecular genetics 2008 Aug 15;17(16):2570-82
Human molecular genetics 2008 Aug 15;17(16):2570-82
The autophagy gene ATG5 plays an essential role in B lymphocyte development.
Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th
Autophagy 2008 Apr;4(3):309-14
Autophagy 2008 Apr;4(3):309-14
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
The Journal of biological chemistry 2008 Apr 18;283(16):10892-903
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.
Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T
The Journal of cell biology 2001 Feb 19;152(4):657-68
The Journal of cell biology 2001 Feb 19;152(4):657-68
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