Tissue expression
Cell line expression
Protein structure
COX11
Cytochrome c oxidase copper chaperone COX11COX11P
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
Top validated antibodies |
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Proteintech Group | 11498-1-AP | 3 references | Polyclonal |
WB
EL
IP
IHC |
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Invitrogen Antibodies | 11498-1-AP | Polyclonal |
WB
IP
IHC
OA |
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NovoPro Bioscience Inc. | 109483 | Polyclonal |
WB
EL
IP
IHC |
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Cusabio Biotech Co., Ltd | CSB-PA007193 | Polyclonal |
WB
EL
ICC
IHC |
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Biorbyt | orb673274 | Polyclonal |
WB
EL
ICC
IHC |
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