CABT-RM177

antibody from Creative Diagnostics

Targeting: ARL6IP5 DERP11, GTRAP3-18, HSPC127, JWA, PRAF3, Yip6b

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-RM177

Provider

Creative Diagnostics

Product name

Mouse Anti-ARL6IP5 monoclonal antibody, clone 078D4

Antibody type

Monoclonal

Description

PRA1 family protein 3 is encoded by the ARL6IP5 gene in human. JWA is a multi-pass membrane protein that also exists in a soluble form in the cytoplasm. It exists as either as a homodimer or as a heterodimer with ARL6IP1. Its homo or heterodimerization requires amino acids sequence 103-117 and another sequence (aa 136-188) is required for its targeting to the endoplasmic reticulum membrane. Its levels are reported to be up-regulated upon induced differentiation and during heat stress. JWA expression is dependent upon generation of intracellular reactive oxygen species (ROS) and it protects cells against ROS-associated DNA damage. JWA serves as a repair protein by regulating base excision repair. It can also serve as a tumor suppressor that can regulate tumor angiogenesis by suppressing the activity of matrix metalloproteinase and inhibiting invasion via focal adhesion kinase. JWA is also known to regulate cancer cells differentiation and apoptosis induced by multiple chemicals. However, its levels are relatively lower in many types of tumors. JWA is shown to sensitize p-glycoprotein-mediated drug resistance to etoposide, a topoisomerase II inhibitor.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG