FNab05249

antibody from FineTest Biotech
Targeting: MMS19 CIAO4, hMMS19, MET18, MMS19L
Provider product page for FNab05249
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab05249 - Provider product page
Provider
FineTest Biotech
Product name
MMS19 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
MMS19 nucleotide excision repair ho
molog
Epitope
IgG2a
Isotype
IgG
Antibody clone number
6H1
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
MMS19 protein structure - FNab05249 shown in red.