Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10157-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10157-1-AP, RRID:AB_514025
- Product name
- TUSC4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TUSC4 antibody (Cat. #10157-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway.
NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer.
High expression of NPRL2 is linked to poor prognosis in patients with prostate cancer.
Downregulation of nitrogen permease regulator like-2 activates PDK1-AKT1 and contributes to the malignant growth of glioma cells.
TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Zhao X, Jiang L, Hu D, Tang Y, Zhao G, Du X, Luo S, Tang W
Experimental cell research 2021 Jun 15;403(2):112614
Experimental cell research 2021 Jun 15;403(2):112614
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
Tang Y, Jiang L, Zhao X, Hu D, Zhao G, Luo S, Du X, Tang W
Cell biology international 2021 Dec;45(12):2510-2520
Cell biology international 2021 Dec;45(12):2510-2520
NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway.
Luo S, Shao L, Chen Z, Hu D, Jiang L, Tang W
Experimental cell research 2020 May 15;390(2):111981
Experimental cell research 2020 May 15;390(2):111981
NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer.
Chen Z, Jiang Q, Zhu P, Chen Y, Xie X, Du Z, Jiang L, Tang W
The Prostate 2019 Jan;79(1):44-53
The Prostate 2019 Jan;79(1):44-53
High expression of NPRL2 is linked to poor prognosis in patients with prostate cancer.
Chen Z, Luo S, Chen Y, Xie X, Du Z, Jiang L
Human pathology 2018 Jun;76:141-148
Human pathology 2018 Jun;76:141-148
Downregulation of nitrogen permease regulator like-2 activates PDK1-AKT1 and contributes to the malignant growth of glioma cells.
Huang N, Cheng S, Mi X, Tian Q, Huang Q, Wang F, Xu Z, Xie Z, Chen J, Cheng Y
Molecular carcinogenesis 2016 Nov;55(11):1613-1626
Molecular carcinogenesis 2016 Nov;55(11):1613-1626
TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.
Peng Y, Dai H, Wang E, Lin CC, Mo W, Peng G, Lin SY
Cancer research 2015 Jan 15;75(2):378-86
Cancer research 2015 Jan 15;75(2):378-86
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N
Cancer science 2008 Sep;99(9):1827-34
Cancer science 2008 Sep;99(9):1827-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 10157-1-AP(NPR2L,TUSC4 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TUSC4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TUSC4. This antibody recognizes human,mouse,rat antigen. The TUSC4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.