Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 16473-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Aquaporin 4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Aquaporin 4 antibody (Cat. #16473-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats.
Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion.
Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats.
Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.
Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis.
Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP/PS1-transgenic mice.
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Mesenchymal Stem Cells Attenuated Blood-Brain Barrier Disruption via Downregulation of Aquaporin-4 Expression in EAE Mice.
Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte.
Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems.
Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat model.
Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion.
Higher expression levels of aquaporin (AQP)1 and AQP5 in the lungs of arid-desert living Lepus yarkandensis.
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation.
Higher Expression Levels of Aquaporin Family of Proteins in the Kidneys of Arid-Desert Living Lepus yarkandensis.
Protective effect of 4-Methoxy benzyl alcohol on the neurovascular unit after cerebral ischemia reperfusion injury.
Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis.
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice.
Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.
Severe white matter astrocytopathy in CADASIL.
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
2-(2-Benzofuranyl)-2-Imidazoline Mediates Neuroprotection by Regulating the Neurovascular Unit Integrity in a Rat Model of Focal Cerebral Ischemia.
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats.
Role of vasodilator-stimulated phosphoprotein in human cytomegalovirus-induced hyperpermeability of human endothelial cells.
A novel IL-1RA-PEP fusion protein with enhanced brain penetration ameliorates cerebral ischemia-reperfusion injury by inhibition of oxidative stress and neuroinflammation.
Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report.
Protective Effect of 4-Methoxy Benzyl Alcohol on the Blood-Brain Barrier after Cerebral Ischemia Reperfusion Injury.
Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.
Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion.
PROTECTIVE EFFECTS OF ETHYL ACETATE EXTRACTION FROM GASTRODIA ELATA BLUME ON BLOOD-BRAIN BARRIER IN FOCAL CEREBRAL ISCHEMIA REPERFUSION.
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.
Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury.
NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy.
Visualization of inflammation and demyelination in 2D2 transgenic mice with rodent MRI.
Liu K, Zhu J, Chang Y, Lin Z, Shi Z, Li X, Chen X, Lin C, Pan S, Huang K
JCI insight 2021 Sep 8;6(17)
JCI insight 2021 Sep 8;6(17)
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Ma X, Qin C, Chen M, Yu HH, Chu YH, Chen TJ, Bosco DB, Wu LJ, Bu BT, Wang W, Tian DS
Journal of neuroinflammation 2021 Sep 15;18(1):201
Journal of neuroinflammation 2021 Sep 15;18(1):201
Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats.
Xing C, Zhou Y, Xu H, Ding M, Zhang Y, Zhang M, Hu M, Huang X, Song L
Neuroscience research 2021 Oct;171:124-132
Neuroscience research 2021 Oct;171:124-132
Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion.
Cao J, Yao D, Li R, Guo X, Hao J, Xie M, Li J, Pan D, Luo X, Yu Z, Wang M, Wang W
Neuroscience bulletin 2021 Oct 27;
Neuroscience bulletin 2021 Oct 27;
Effects of cannabinoid (CBD) on blood brain barrier permeability after brain injury in rats.
Jiang H, Li H, Cao Y, Zhang R, Zhou L, Zhou Y, Zeng X, Wu J, Wu D, Wu D, Guo X, Li X, Wu H, Li P
Brain research 2021 Oct 1;1768:147586
Brain research 2021 Oct 1;1768:147586
Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats.
Zhan YA, Qiu XL, Wang XZ, Zhao N, Qian KJ
Neural regeneration research 2021 Jul;16(7):1288-1293
Neural regeneration research 2021 Jul;16(7):1288-1293
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.
Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR
bioRxiv : the preprint server for biology 2021 Jan 18;
bioRxiv : the preprint server for biology 2021 Jan 18;
Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis.
Jiang Q, Dong X, Hu D, Chen L, Luo Y
Bioengineered 2021 Dec;12(1):9021-9030
Bioengineered 2021 Dec;12(1):9021-9030
Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP/PS1-transgenic mice.
Quan W, Luo Q, Hao W, Tomic I, Furihata T, Schulz-Schäffer W, Menger MD, Fassbender K, Liu Y
Glia 2021 Aug;69(8):1987-2005
Glia 2021 Aug;69(8):1987-2005
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W
Frontiers in cell and developmental biology 2020;8:598020
Frontiers in cell and developmental biology 2020;8:598020
Mesenchymal Stem Cells Attenuated Blood-Brain Barrier Disruption via Downregulation of Aquaporin-4 Expression in EAE Mice.
Liu Y, Ma Y, Du B, Wang Y, Yang GY, Bi X
Molecular neurobiology 2020 Sep;57(9):3891-3901
Molecular neurobiology 2020 Sep;57(9):3891-3901
Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte.
Liu M, Xu Z, Wang L, Zhang L, Liu Y, Cao J, Fu Q, Liu Y, Li H, Lou J, Hou W, Mi W, Ma Y
Journal of neuroinflammation 2020 Sep 11;17(1):270
Journal of neuroinflammation 2020 Sep 11;17(1):270
Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems.
Liu X, Hao J, Yao E, Cao J, Zheng X, Yao D, Zhang C, Li J, Pan D, Luo X, Wang M, Wang W
Brain, behavior, and immunity 2020 Oct;89:357-370
Brain, behavior, and immunity 2020 Oct;89:357-370
Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat model.
Guan Y, Li L, Chen J, Lu H
Experimental and therapeutic medicine 2020 Mar;19(3):2029-2036
Experimental and therapeutic medicine 2020 Mar;19(3):2029-2036
Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion.
Wang H, Chen H, Jin J, Liu Q, Zhong D, Li G
Life sciences 2020 Jun 15;251:117638
Life sciences 2020 Jun 15;251:117638
Higher expression levels of aquaporin (AQP)1 and AQP5 in the lungs of arid-desert living Lepus yarkandensis.
Zhang J, Li S, Liu J, Li L, Deng F, Baikeli B, Li L, Ma X, Liu G
Journal of animal physiology and animal nutrition 2020 Jul;104(4):1186-1195
Journal of animal physiology and animal nutrition 2020 Jul;104(4):1186-1195
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation.
Shimizu M, Okuno T, Kinoshita M, Sumi H, Fujimura H, Yamashita K, Sugimoto T, Sakakibara S, Sakakibara K, Koda T, Tada S, Ishikura T, Murata H, Beppu S, Shiraishi N, Sugiyama Y, Nakatsuji Y, Kumanogoh A, Mochizuki H
Scientific reports 2020 Aug 6;10(1):13274
Scientific reports 2020 Aug 6;10(1):13274
Higher Expression Levels of Aquaporin Family of Proteins in the Kidneys of Arid-Desert Living Lepus yarkandensis.
Zhang J, Li S, Deng F, Baikeli B, Huang S, Wang B, Liu G
Frontiers in physiology 2019;10:1172
Frontiers in physiology 2019;10:1172
Protective effect of 4-Methoxy benzyl alcohol on the neurovascular unit after cerebral ischemia reperfusion injury.
He F, Dai R, Zhou X, Li X, Song X, Yan H, Meng Q, Yang C, Lin Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109260
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109260
Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis.
Zhang J, Li S, Deng F, Baikeli B, Yu W, Liu G
Scientific reports 2019 Nov 12;9(1):16639
Scientific reports 2019 Nov 12;9(1):16639
PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.
Huang B, Miao H, Yuan Y, Qiu F, Liu X, Liu Z, Zhang H, Zhao Q, Wang M, Dong H, Zhang Z
International journal of molecular medicine 2019 May;43(5):1979-1990
International journal of molecular medicine 2019 May;43(5):1979-1990
Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice.
Fang Y, Tian Y, Huang Q, Wan Y, Xu L, Wang W, Pan D, Zhu S, Xie M
Journal of neuroinflammation 2019 May 9;16(1):96
Journal of neuroinflammation 2019 May 9;16(1):96
Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.
Cotzomi E, Stathopoulos P, Lee CS, Ritchie AM, Soltys JN, Delmotte FR, Oe T, Sng J, Jiang R, Ma AK, Vander Heiden JA, Kleinstein SH, Levy M, Bennett JL, Meffre E, O'Connor KC
Brain : a journal of neurology 2019 Jun 1;142(6):1598-1615
Brain : a journal of neurology 2019 Jun 1;142(6):1598-1615
Severe white matter astrocytopathy in CADASIL.
Hase Y, Chen A, Bates LL, Craggs LJL, Yamamoto Y, Gemmell E, Oakley AE, Korolchuk VI, Kalaria RN
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):832-843
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):832-843
TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types.
Khalfallah Y, Kuta R, Grasmuck C, Prat A, Durham HD, Vande Velde C
Scientific reports 2018 May 15;8(1):7551
Scientific reports 2018 May 15;8(1):7551
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
Li M, Tian X, An R, Yang M, Zhang Q, Xiang F, Liu H, Wang Y, Xu L, Dong Z
Neurochemical research 2018 Jun;43(6):1283-1296
Neurochemical research 2018 Jun;43(6):1283-1296
2-(2-Benzofuranyl)-2-Imidazoline Mediates Neuroprotection by Regulating the Neurovascular Unit Integrity in a Rat Model of Focal Cerebral Ischemia.
Zhang Z, Zhang L, Chen J, Cao Y, Qu M, Lin X, Han Z, Ji X
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018 Jun;27(6):1481-1489
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018 Jun;27(6):1481-1489
Aquaporin 4 Silencing Aggravates Hydrocephalus Induced by Injection of Autologous Blood in Rats.
Guo J, Mi X, Zhan R, Li M, Wei L, Sun J
Medical science monitor : international medical journal of experimental and clinical research 2018 Jun 20;24:4204-4212
Medical science monitor : international medical journal of experimental and clinical research 2018 Jun 20;24:4204-4212
Role of vasodilator-stimulated phosphoprotein in human cytomegalovirus-induced hyperpermeability of human endothelial cells.
Tian Y, He Y, Zhang L, Zhang J, Xu L, Ma Y, Xu X, Wei L
Experimental and therapeutic medicine 2018 Aug;16(2):1295-1303
Experimental and therapeutic medicine 2018 Aug;16(2):1295-1303
A novel IL-1RA-PEP fusion protein with enhanced brain penetration ameliorates cerebral ischemia-reperfusion injury by inhibition of oxidative stress and neuroinflammation.
Zhang DD, Zou MJ, Zhang YT, Fu WL, Xu T, Wang JX, Xia WR, Huang ZG, Gan XD, Zhu XM, Xu DG
Experimental neurology 2017 Nov;297:1-13
Experimental neurology 2017 Nov;297:1-13
Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report.
Shepard MJ, Padmanaban V, Edwards NA, Chittiboina P, Ray-Chaudhury A, Heiss JD
World neurosurgery 2017 Nov;107:1046.e1-1046.e7
World neurosurgery 2017 Nov;107:1046.e1-1046.e7
Protective Effect of 4-Methoxy Benzyl Alcohol on the Blood-Brain Barrier after Cerebral Ischemia Reperfusion Injury.
He F, Duan X, Dai R, Li Y, Lin Q
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jun;26(6):1258-1265
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jun;26(6):1258-1265
Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.
Zhou Y, Huang X, Zhao T, Qiao M, Zhao X, Zhao M, Xu L, Zhao Y, Wu L, Wu K, Chen R, Fan M, Zhu L
Brain, behavior, and immunity 2017 Aug;64:266-275
Brain, behavior, and immunity 2017 Aug;64:266-275
Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion.
Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K, Kalaria RN
Journal of neuroinflammation 2017 Apr 11;14(1):81
Journal of neuroinflammation 2017 Apr 11;14(1):81
PROTECTIVE EFFECTS OF ETHYL ACETATE EXTRACTION FROM GASTRODIA ELATA BLUME ON BLOOD-BRAIN BARRIER IN FOCAL CEREBRAL ISCHEMIA REPERFUSION.
He F, Duan X, Dai R, Wang W, Yang C, Lin Q
African journal of traditional, complementary, and alternative medicines : AJTCAM 2016;13(4):199-209
African journal of traditional, complementary, and alternative medicines : AJTCAM 2016;13(4):199-209
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.
Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJ, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O'Brien JT, Horsburgh K, Ihara M, Kalaria RN
Brain : a journal of neurology 2016 Jan;139(Pt 1):242-58
Brain : a journal of neurology 2016 Jan;139(Pt 1):242-58
Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury.
Zhang C, Chen J, Lu H
Molecular medicine reports 2015 Nov;12(5):7351-7
Molecular medicine reports 2015 Nov;12(5):7351-7
NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy.
Pecorelli A, Natrella F, Belmonte G, Miracco C, Cervellati F, Ciccoli L, Mariottini A, Rocchi R, Vatti G, Bua A, Canitano R, Hayek J, Forman HJ, Valacchi G
Biochimica et biophysica acta 2015 Mar;1852(3):507-19
Biochimica et biophysica acta 2015 Mar;1852(3):507-19
Visualization of inflammation and demyelination in 2D2 transgenic mice with rodent MRI.
Bell JC, Liu Q, Gan Y, Liu Q, Liu Y, Shi FD, Turner GH
Journal of neuroimmunology 2013 Nov 15;264(1-2):35-40
Journal of neuroimmunology 2013 Nov 15;264(1-2):35-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SKOV-3 cells were subjected to SDS PAGE followed by western blot with 16473-1-AP(AQP4 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16473-1-AP(AQP4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Aquaporin 4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Aquaporin 4. This antibody recognizes human,mouse,rat antigen. The Aquaporin 4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.