Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- AF534 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal uPAR Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse uPAR in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human uPAR is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references A Virus-Derived Immune Modulating Serpin Accelerates Wound Closure with Improved Collagen Remodeling.
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.
Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.
Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System.
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease.
Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes.
Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression.
Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke.
Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model.
Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.
Zhang L, Yaron JR, Tafoya AM, Wallace SE, Kilbourne J, Haydel S, Rege K, McFadden G, Lucas AR
Journal of clinical medicine 2019 Oct 4;8(10)
Journal of clinical medicine 2019 Oct 4;8(10)
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.
Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E
Journal of neuroinflammation 2019 Dec 6;16(1):257
Journal of neuroinflammation 2019 Dec 6;16(1):257
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.
Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J
The Journal of clinical investigation 2019 Apr 2;129(5):1946-1959
The Journal of clinical investigation 2019 Apr 2;129(5):1946-1959
Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.
Magnussen SN, Hadler-Olsen E, Costea DE, Berg E, Jacobsen CC, Mortensen B, Salo T, Martinez-Zubiaurre I, Winberg JO, Uhlin-Hansen L, Svineng G
BMC cancer 2017 May 19;17(1):350
BMC cancer 2017 May 19;17(1):350
Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System.
Merino P, Diaz A, Jeanneret V, Wu F, Torre E, Cheng L, Yepes M
The Journal of biological chemistry 2017 Feb 17;292(7):2741-2753
The Journal of biological chemistry 2017 Feb 17;292(7):2741-2753
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease.
Spinale JM, Mariani LH, Kapoor S, Zhang J, Weyant R, Song PX, Wong HN, Troost JP, Gadegbeku CA, Gipson DS, Kretzler M, Nihalani D, Holzman LB, Nephrotic Syndrome Study Network
Kidney international 2015 Mar;87(3):564-74
Kidney international 2015 Mar;87(3):564-74
Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR) and concomitant activation of gelatinolytic enzymes.
Magnussen S, Hadler-Olsen E, Latysheva N, Pirila E, Steigen SE, Hanes R, Salo T, Winberg JO, Uhlin-Hansen L, Svineng G
PloS one 2014;9(8):e105929
PloS one 2014;9(8):e105929
Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression.
Yang J, Duh EJ, Caldwell RB, Behzadian MA
Investigative ophthalmology & visual science 2010 Jun;51(6):3273-80
Investigative ophthalmology & visual science 2010 Jun;51(6):3273-80
Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke.
Nagai N, Okada K, Kawao N, Ishida C, Ueshima S, Collen D, Matsuo O
Neuroscience letters 2008 Feb 13;432(1):46-9
Neuroscience letters 2008 Feb 13;432(1):46-9
Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model.
Das A, Boyd N, Jones TR, Talarico N, McGuire PG
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Dec;122(12):1844-9
Archives of ophthalmology (Chicago, Ill. : 1960) 2004 Dec;122(12):1844-9
Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.
Zhang G, Cai X, López-Guisa JM, Collins SJ, Eddy AA
Journal of the American Society of Nephrology : JASN 2004 Aug;15(8):2090-102
Journal of the American Society of Nephrology : JASN 2004 Aug;15(8):2090-102
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- uPAR in Mouse Kidney. uPAR in Mouse Kidney.