CABT-RM157

antibody from Creative Diagnostics

Targeting: CALHM1 FAM26C

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM157

Provider

Creative Diagnostics

Product name

Mouse Anti-CALHM1 monoclonal antibody, clone 43D3

Antibody type

Monoclonal

Description

Calcium homeostasis modulator protein 1 is encoded by the CALHM1 gene in human. CALHM1 is a highly conserved N-glycosylated multi-pass transmembrane protein that is localized in both the cell membrane and endoplasmic reticulum membrane. It serves as a non-selective channel permeable to many ionic species, with relative permeabilities following the sequence Ca2+:Na+:K+:Cl-. It is predominantly expressed in adult brain and is specifically expressed in circumvallate taste bud cells. In type II taste bud cells, it plays a central role in sweet, bitter, and umami taste perception by inducing ATP release from the cell. It is shown to be localized to points of contact between the receptor cells and sensory nerve fibers. In neurons, CALHM1 plays an important role in Ca2+ homeostasis and flux through the membrane, especially in response to low extracellular Ca2+ and is activated by a decrease in extracellular Ca2+ levels. CALHM1 is reported to trigger the activation of MEK1/2, RSK1/2/3 and MSK1 that are upstream and downstream effectors of ERK1/2 signaling and pharmacological inhibition of CALHM1 permeability is reported to block the effect of CALHM1 on the MEK, ERK, RSK and MSK signaling cascade.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG