FNab05952

antibody from FineTest Biotech
Targeting: OAS3
Provider product page for FNab05952
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab05952 - Provider product page
Provider
FineTest Biotech
Product name
OAS3 antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus(CHIKV), Dengue virus, Sindbis virus(SINV) and Semliki forest virus(SFV).
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
2'-5'-oligoadenylate synthetase 3,
100kDa
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
OAS3 protein structure - FNab05952 shown in red.