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LearnPAB3865
antibody from Abnova Corporation
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- PAB3865 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB3865, RRID:AB_1577784
- Product name
- MAPT polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of MAPT.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Nitration of tau protein is linked to neurodegeneration in tauopathies.
Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes.
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ
The American journal of pathology 2003 Sep;163(3):1021-31
The American journal of pathology 2003 Sep;163(3):1021-31
Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes.
Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Nov 19;23(33):10662-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Nov 19;23(33):10662-71
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 19;100(17):10032-7
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 19;100(17):10032-7
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of MAPT (arrow) using MAPT polyclonal antibody (Cat # PAB3865).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAPT gene (Lane 2).
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MAPT polyclonal antibody (Cat # PAB3865) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
