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antibody from Invitrogen Antibodies
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [875]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Other assay [23]
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- Product number
- MN1020 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MN1020 recognizes a phosphatase-senstive epitope on PHF-Tau. No cross reactivity with normal Tau has been observed. The epitope of this antibody contains the phosphorylated Ser202 (4,5) residue (numbering according to human Tau40). MN1020 detects PHF-tau (Ser202/Thr205)a which has a predicted molecular weight of approximately 79 kDa. This product is a Low Endotoxin formulation. Purity is >95% as determined by SDS-PAGE.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- AT8
- Vial size
- 100 µg
- Concentration
- 0.2 mg/mL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.
Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank.
Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.
Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.
Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis.
A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging.
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.
Long-Term Sequelae of COVID-19 in Experimental Mice.
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.
Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease.
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Tau deposition patterns are associated with functional connectivity in primary tauopathies.
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy.
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology.
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.
Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures.
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Synaptosome microRNAs regulate synapse functions in Alzheimer's disease.
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy.
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
High altitude is associated with pTau deposition, neuroinflammation, and myelin loss.
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.
Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies.
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.
Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.
Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease.
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor.
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease.
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia.
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies.
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.
Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.
Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.
Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.
Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.
Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders.
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways.
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.
Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue.
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
Phosphorylated tau interactome in the human Alzheimer's disease brain.
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants.
Reductive stress promotes protein aggregation and impairs neurogenesis.
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Reproductive status impact on tau phosphorylation induced by chronic stress.
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes.
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia.
Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission.
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures.
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing.
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.
Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology.
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
β-amyloid and tau pathology in the aging feline brain.
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.
Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Distribution patterns of tau pathology in progressive supranuclear palsy.
Fyn Kinase Controls Tau Aggregation In Vivo.
Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion.
Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease.
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation.
Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells.
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy.
Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling.
BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.
Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.
Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease.
Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological Specimens.
Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.
Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes.
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model.
Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin.
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia.
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN.
Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults.
Early-life exposure to high-fat diet influences brain health in aging mice.
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice.
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.
A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.
In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model.
Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.
Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Modulatory Effects of a Novel Cyclized Peptide in Reducing the Expression of Markers Linked to Alzheimer's Disease.
Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.
Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology.
Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.
A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.
Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities.
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.
Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Estimation of amyloid distribution by [(18)F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition.
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.
Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment.
Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease.
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Different tau species lead to heterogeneous tau pathology propagation and misfolding.
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment.
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Effects of treadmill exercise on PI3K/AKT/GSK-3β pathway and tau protein in high-fat diet-fed rats.
Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients.
Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.
Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model.
Phosphorylation of different tau sites during progression of Alzheimer's disease.
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
iPSC-derived familial Alzheimer's PSEN2 (N141I) cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.
Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser(422) containing epitope on pathological tau.
A Multidisciplinary Approach Reveals an Age-Dependent Expression of a Novel Bioactive Peptide, Already Involved in Neurodegeneration, in the Postnatal Rat Forebrain.
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
A transcriptomic atlas of aged human microglia.
Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer's disease in wild-type, C57BL/6 mice.
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.
A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau.
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.
Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.
A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.
A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.
Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.
Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
A Novel Ex Vivo Model to Investigate the Underlying Mechanisms in Alzheimer's Disease.
Adrenomedullin Contributes to Age-Related Memory Loss in Mice and Is Elevated in Aging Human Brains.
The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.
Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea.
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model.
Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1-42) synaptotoxicity.
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Tau-positive nuclear indentations in P301S tauopathy mice.
Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Tau association with synaptic vesicles causes presynaptic dysfunction.
Development of [(11)C]/[(3)H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury.
Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.
Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.
Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies.
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.
Cryo-EM structures of tau filaments from Alzheimer's disease.
Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration.
Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model.
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice.
Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.
A Single Neonatal Exposure to BMAA in a Rat Model Produces Neuropathology Consistent with Neurodegenerative Diseases.
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.
Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring.
Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Early neurovascular dysfunction in a transgenic rat model of Alzheimer's disease.
Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.
Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease.
Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease.
Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction.
Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.
Late running is not too late against Alzheimer's pathology.
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study.
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.
Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.
Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.
TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment.
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.
Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway.
Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury.
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.
Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.
Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.
Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains.
Neuronal activity enhances tau propagation and tau pathology in vivo.
Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series.
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.
Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia.
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.
High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.
Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease.
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.
Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease.
Dexmedetomidine directly increases tau phosphorylation.
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study.
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus.
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.
Role of Liver X Receptor in AD Pathophysiology.
Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease.
Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse.
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus.
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Isolation and characterization of antibody fragments selective for toxic oligomeric tau.
Aneuploidy in Lewy body diseases.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices.
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
A 3D human neural cell culture system for modeling Alzheimer's disease.
Reelin protects against amyloid β toxicity in vivo.
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.
Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.
Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase.
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury.
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
The domestic cat as a natural animal model of Alzheimer's disease.
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-β pathology.
Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology.
Array tomography for the detection of non-dilated, injured axons in traumatic brain injury.
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
Piericidin A aggravates Tau pathology in P301S transgenic mice.
A lifespan observation of a novel mouse model: in vivo evidence supports aβ oligomer hypothesis.
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Distribution of pathology in frontal variant Alzheimer's disease.
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
PICALM modulates autophagy activity and tau accumulation.
Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates.
Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models.
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
The problem of axonal injury in the brains of veterans with histories of blast exposure.
CDK5 activator protein p25 preferentially binds and activates GSK3β.
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
REST and stress resistance in ageing and Alzheimer's disease.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage.
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Two cases of multinodular and vacuolating neuronal tumour.
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Visualizing the microtubule-associated protein tau in the nucleus.
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.
Ubiquilin 2 is not associated with tau pathology.
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PINCH in the cellular stress response to tau-hyperphosphorylation.
Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
Pericyte loss influences Alzheimer-like neurodegeneration in mice.
Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration.
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Making the diagnosis of frontotemporal lobar degeneration.
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
Clinical correlates in an experimental model of repetitive mild brain injury.
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins.
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
Brainstem aminergic nuclei and late-life depressive symptoms.
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease.
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.
Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress.
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Hyperphosphorylated tau in young and middle-aged subjects.
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Dystrophic neurites express C9orf72 in Alzheimer's disease brains.
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Frontal cortex neuropathology in dementia pugilistica.
Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.
Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
Microglial pathology in Down syndrome.
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Rapidly progressive diffuse Lewy body disease.
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Protein aggregation in the aging retina.
WNT signaling in activated microglia is proinflammatory.
Propofol directly increases tau phosphorylation.
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
The pathological process underlying Alzheimer's disease in individuals under thirty.
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Clinical correlates of similar pathologies in parkinsonian syndromes.
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
αB-crystallin negative astrocytic inclusions.
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Regulation of tau pathology by the microglial fractalkine receptor.
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation.
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease.
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
Caspase activation precedes and leads to tangles.
Hyposmia in progressive supranuclear palsy.
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Altered subcellular distribution of c-Abl in Alzheimer's disease.
Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Transmission and spreading of tauopathy in transgenic mouse brain.
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
Tremor on smiling.
Bell's palsy preceding Parkinson's disease: a case-control study.
Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature.
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition.
Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells.
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
TDP-43 pathology in familial British dementia.
Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
A new function of microtubule-associated protein tau: involvement in chromosome stability.
MAPT S305I mutation: implications for argyrophilic grain disease.
Tauopathy with paired helical filaments in an aged chimpanzee.
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.
Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease.
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Interleukin-1 mediates Alzheimer and Lewy body pathologies.
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons.
Astrocytic degeneration relates to the severity of disease in frontotemporal dementia.
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease.
Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type.
Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.
Senejani AG, Maghsoudlou J, El-Zohiry D, Gaur G, Wawrzeniak K, Caravaglia C, Khatri VA, MacDonald A, Sapi E
Journal of Alzheimer's disease : JAD 2022;85(2):889-903
Journal of Alzheimer's disease : JAD 2022;85(2):889-903
Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank.
McCann H, Bahar AY, Burkhardt K, Gardner AJ, Halliday GM, Iverson GL, Shepherd CE
Brain communications 2022;4(4):fcac189
Brain communications 2022;4(4):fcac189
Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.
Tejada Moreno JA, Villegas Lanau A, Madrigal Zapata L, Baena Pineda AY, Velez Hernandez J, Campo Nieto O, Soto Ospina A, Araque Marín P, Rishishwar L, Norris ET, Chande AT, Jordan IK, Bedoya Berrio G
PloS one 2022;17(7):e0269955
PloS one 2022;17(7):e0269955
Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.
Mate V, Smolek T, Kazmerova ZV, Jadhav S, Brezovakova V, Jurkanin B, Uhrinova I, Basheer N, Zilka N, Katina S, Novak P
Frontiers in aging neuroscience 2022;14:935973
Frontiers in aging neuroscience 2022;14:935973
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.
Jiang J, Yang C, Ai JQ, Zhang QL, Cai XL, Tu T, Wan L, Wang XS, Wang H, Pan A, Manavis J, Gai WP, Che C, Tu E, Wang XP, Li ZY, Yan XX
Frontiers in aging neuroscience 2022;14:926904
Frontiers in aging neuroscience 2022;14:926904
Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis.
Lopez-Toledo G, Silva-Lucero MD, Herrera-Díaz J, García DE, Arias-Montaño JA, Cardenas-Aguayo MD
Frontiers in aging neuroscience 2022;14:921573
Frontiers in aging neuroscience 2022;14:921573
A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging.
Parekh P, Mu Q, Badachhape A, Bhavane R, Srivastava M, Devkota L, Sun X, Bhandari P, Eriksen JL, Tanifum E, Ghaghada K, Annapragada A
Theranostics 2022;12(12):5504-5521
Theranostics 2022;12(12):5504-5521
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.
Sepulveda-Falla D, Sanchez JS, Almeida MC, Boassa D, Acosta-Uribe J, Vila-Castelar C, Ramirez-Gomez L, Baena A, Aguillon D, Villalba-Moreno ND, Littau JL, Villegas A, Beach TG, White CL 3rd, Ellisman M, Krasemann S, Glatzel M, Johnson KA, Sperling RA, Reiman EM, Arboleda-Velasquez JF, Kosik KS, Lopera F, Quiroz YT
Acta neuropathologica 2022 Sep;144(3):589-601
Acta neuropathologica 2022 Sep;144(3):589-601
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.
Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY
Molecular neurodegeneration 2022 Sep 2;17(1):58
Molecular neurodegeneration 2022 Sep 2;17(1):58
Long-Term Sequelae of COVID-19 in Experimental Mice.
Paidas MJ, Cosio DS, Ali S, Kenyon NS, Jayakumar AR
Molecular neurobiology 2022 Oct;59(10):5970-5986
Molecular neurobiology 2022 Oct;59(10):5970-5986
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.
Xu S, Yang P, Qian K, Li Y, Guo Q, Wang P, Meng R, Wu J, Cao J, Cheng Y, Xu M, Zhang Q
Bioactive materials 2022 May;11:300-316
Bioactive materials 2022 May;11:300-316
Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease.
Fagan SG, Bechet S, Dev KK
Molecular neurobiology 2022 Mar;59(3):1882-1895
Molecular neurobiology 2022 Mar;59(3):1882-1895
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.
Liu AJ, Lusk JB, Ervin J, Burke J, O'Brien R, Wang SJ
Acta neuropathologica communications 2022 Mar 3;10(1):27
Acta neuropathologica communications 2022 Mar 3;10(1):27
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Marengo L, Armbrust F, Schoenherr C, Storck SE, Schmitt U, Zampar S, Wirths O, Altmeppen H, Glatzel M, Kaether C, Weggen S, Becker-Pauly C, Pietrzik CU
Cellular and molecular life sciences : CMLS 2022 Mar 2;79(3):168
Cellular and molecular life sciences : CMLS 2022 Mar 2;79(3):168
Tau deposition patterns are associated with functional connectivity in primary tauopathies.
Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M
Nature communications 2022 Mar 15;13(1):1362
Nature communications 2022 Mar 15;13(1):1362
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.
Vagenknecht P, Luzgin A, Ono M, Ji B, Higuchi M, Noain D, Maschio CA, Sobek J, Chen Z, Konietzko U, Gerez JA, Riek R, Razansky D, Klohs J, Nitsch RM, Dean-Ben XL, Ni R
European journal of nuclear medicine and molecular imaging 2022 Jun;49(7):2137-2152
European journal of nuclear medicine and molecular imaging 2022 Jun;49(7):2137-2152
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.
Suzuki C, Yamaguchi J, Sanada T, Oliva Trejo JA, Kakuta S, Shibata M, Tanida I, Uchiyama Y
Scientific reports 2022 Jul 8;12(1):11662
Scientific reports 2022 Jul 8;12(1):11662
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A
Brain : a journal of neurology 2022 Jul 29;145(7):2486-2506
Brain : a journal of neurology 2022 Jul 29;145(7):2486-2506
Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy.
Hendrickx JO, Adams C, Sieben A, Laukens K, Van Dam D, De Meyer GRY
Biomedicines 2022 Jul 22;10(8)
Biomedicines 2022 Jul 22;10(8)
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH, Fang EF
Nature biomedical engineering 2022 Jan;6(1):76-93
Nature biomedical engineering 2022 Jan;6(1):76-93
Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology.
Smith AM, Davey K, Tsartsalis S, Khozoie C, Fancy N, Tang SS, Liaptsi E, Weinert M, McGarry A, Muirhead RCJ, Gentleman S, Owen DR, Matthews PM
Acta neuropathologica 2022 Jan;143(1):75-91
Acta neuropathologica 2022 Jan;143(1):75-91
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
Manos JD, Preiss CN, Venkat N, Tamm J, Reinhardt P, Kwon T, Wu J, Winter AD, Jahn TR, Yanamandra K, Titterton K, Karran E, Langlois X
iScience 2022 Jan 21;25(1):103658
iScience 2022 Jan 21;25(1):103658
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.
Muñoz-Castro C, Noori A, Magdamo CG, Li Z, Marks JD, Frosch MP, Das S, Hyman BT, Serrano-Pozo A
Journal of neuroinflammation 2022 Feb 2;19(1):30
Journal of neuroinflammation 2022 Feb 2;19(1):30
Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures.
Kazim SF, Sharma A, Saroja SR, Seo JH, Larson CS, Ramakrishnan A, Wang M, Blitzer RD, Shen L, Peña CJ, Crary JF, Shimoda LA, Zhang B, Nestler EJ, Pereira AC
Biological psychiatry 2022 Feb 15;91(4):346-358
Biological psychiatry 2022 Feb 15;91(4):346-358
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Walker JM, Kazempour Dehkordi S, Fracassi A, Vanschoiack A, Pavenko A, Taglialatela G, Woltjer R, Richardson TE, Zare H, Orr ME
Acta neuropathologica communications 2022 Feb 14;10(1):23
Acta neuropathologica communications 2022 Feb 14;10(1):23
Synaptosome microRNAs regulate synapse functions in Alzheimer's disease.
Kumar S, Orlov E, Gowda P, Bose C, Swerdlow RH, Lahiri DK, Reddy PH
NPJ genomic medicine 2022 Aug 8;7(1):47
NPJ genomic medicine 2022 Aug 8;7(1):47
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.
Wander CM, Tsujimoto THM, Ervin JF, Wang C, Maranto SM, Bhat V, Dallmeier JD, Wang SJ, Lin FC, Scott WK, Holtzman DM, Cohen TJ
Acta neuropathologica communications 2022 Aug 8;10(1):110
Acta neuropathologica communications 2022 Aug 8;10(1):110
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy.
Kindler D, Maschio C, Ni R, Zerbi V, Razansky D, Klohs J
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2022 Apr;42(4):686-693
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2022 Apr;42(4):686-693
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Danis C, Dupré E, Zejneli O, Caillierez R, Arrial A, Bégard S, Mortelecque J, Eddarkaoui S, Loyens A, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Buée L, Landrieu I
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1484-1499
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1484-1499
High altitude is associated with pTau deposition, neuroinflammation, and myelin loss.
Iacono D, Murphy EK, Sherman PM, Chapapas H, Cerqueira B, Christensen C, Perl DP, Sladky J
Scientific reports 2022 Apr 27;12(1):6839
Scientific reports 2022 Apr 27;12(1):6839
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
Permanne B, Sand A, Ousson S, Nény M, Hantson J, Schubert R, Wiessner C, Quattropani A, Beher D
ACS chemical neuroscience 2022 Apr 20;13(8):1296-1314
ACS chemical neuroscience 2022 Apr 20;13(8):1296-1314
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.
Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, Kraemer BC, Liachko NF
Disease models & mechanisms 2022 Apr 1;15(4)
Disease models & mechanisms 2022 Apr 1;15(4)
Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.
Soto-Mercado V, Mendivil-Perez M, Jimenez-Del-Rio M, Velez-Pardo C
Journal of Alzheimer's disease : JAD 2021;82(s1):S359-S378
Journal of Alzheimer's disease : JAD 2021;82(s1):S359-S378
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Stojakovic A, Chang SY, Nesbitt J, Pichurin NP, Ostroot MA, Aikawa T, Kanekiyo T, Trushina E
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Omoluabi T, Torraville SE, Maziar A, Ghosh A, Power KD, Reinhardt C, Harley CW, Yuan Q
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies.
Pitera AP, Hartnell IJ, Scullard L, Williamson KL, Boche D, O'Connor V, Deinhardt K
Journal of Alzheimer's disease reports 2021;5(1):855-869
Journal of Alzheimer's disease reports 2021;5(1):855-869
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.
Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, Saido TC, Trojanowski JQ, Zhang MR, Suhara T, Higuchi M, Sahara N
Brain communications 2021;3(1):fcab011
Brain communications 2021;3(1):fcab011
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM
Frontiers in neuroscience 2021;15:785276
Frontiers in neuroscience 2021;15:785276
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Filippone A, Smith T, Pratico D
Journal of inflammation research 2021;14:7455-7465
Journal of inflammation research 2021;14:7455-7465
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Ba L, Huang L, He Z, Deng S, Xie Y, Zhang M, Jacob C, Antonecchia E, Liu Y, Xiao W, Xie Q, Huang Z, Yi C, D'Ascenzo N, Ding F
Frontiers in aging neuroscience 2021;13:759983
Frontiers in aging neuroscience 2021;13:759983
Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.
Raha AA, Ghaffari SD, Henderson J, Chakraborty S, Allinson K, Friedland RP, Holland A, Zaman SH, Mukaetova-Ladinska EB, Raha-Chowdhury R
Frontiers in aging neuroscience 2021;13:653591
Frontiers in aging neuroscience 2021;13:653591
Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.
Miguel JC, Perez SE, Malek-Ahmadi M, Mufson EJ
Frontiers in aging neuroscience 2021;13:645334
Frontiers in aging neuroscience 2021;13:645334
Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease.
Liu XC, Qi XH, Fang H, Zhou KQ, Wang QS, Chen GH
Frontiers in aging neuroscience 2021;13:639318
Frontiers in aging neuroscience 2021;13:639318
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
Ahmad F, Mein H, Jing Y, Zhang H, Liu P
International journal of molecular sciences 2021 Sep 8;22(18)
International journal of molecular sciences 2021 Sep 8;22(18)
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Pérez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser SA, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M
Molecular psychiatry 2021 Oct;26(10):5733-5750
Molecular psychiatry 2021 Oct;26(10):5733-5750
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.
Sato H, Takado Y, Toyoda S, Tsukamoto-Yasui M, Minatohara K, Takuwa H, Urushihata T, Takahashi M, Shimojo M, Ono M, Maeda J, Orihara A, Sahara N, Aoki I, Karakawa S, Isokawa M, Kawasaki N, Kawasaki M, Ueno S, Kanda M, Nishimura M, Suzuki K, Mitsui A, Nagao K, Kitamura A, Higuchi M
Science advances 2021 Oct 22;7(43):eabd5046
Science advances 2021 Oct 22;7(43):eabd5046
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies.
Vega AR, Chkheidze R, Jarmale V, Shang P, Foong C, Diamond MI, White CL 3rd, Rajaram S
Acta neuropathologica communications 2021 Oct 21;9(1):170
Acta neuropathologica communications 2021 Oct 21;9(1):170
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Chambraud B, Daguinot C, Guillemeau K, Genet M, Dounane O, Meduri G, Poüs C, Baulieu EE, Giustiniani J
Autophagy 2021 Nov;17(11):3491-3510
Autophagy 2021 Nov;17(11):3491-3510
Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor.
Chiocchetti R, Hitrec T, Giancola F, Sadeghinezhad J, Squarcio F, Galiazzo G, Piscitiello E, De Silva M, Cerri M, Amici R, Luppi M
Cell and tissue research 2021 May;384(2):287-299
Cell and tissue research 2021 May;384(2):287-299
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.
Waller R, Narramore R, Simpson JE, Heath PR, Verma N, Tinsley M, Barnes JR, Haris HT, Henderson FE, Matthews FE, Richardson CD, Brayne C, Ince PG, Kalaria RN, Wharton SB, CFAS
Brain pathology (Zurich, Switzerland) 2021 May;31(3):e12928
Brain pathology (Zurich, Switzerland) 2021 May;31(3):e12928
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z
eLife 2021 May 21;10
eLife 2021 May 21;10
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R
Neuron 2021 May 19;109(10):1675-1691.e9
Neuron 2021 May 19;109(10):1675-1691.e9
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM
Cell 2021 May 13;184(10):2696-2714.e25
Cell 2021 May 13;184(10):2696-2714.e25
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi RE, Zhang Y, Quan Q, Xie Z
Communications biology 2021 May 12;4(1):560
Communications biology 2021 May 12;4(1):560
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease.
Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, Amadoro G
Acta neuropathologica communications 2021 Mar 9;9(1):38
Acta neuropathologica communications 2021 Mar 9;9(1):38
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Xia F, Ha Y, Shi S, Li Y, Li S, Luisi J, Kayed R, Motamedi M, Liu H, Zhang W
Acta neuropathologica communications 2021 Mar 24;9(1):51
Acta neuropathologica communications 2021 Mar 24;9(1):51
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA
Acta neuropathologica communications 2021 Mar 12;9(1):41
Acta neuropathologica communications 2021 Mar 12;9(1):41
Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Guennewig B, Lim J, Marshall L, McCorkindale AN, Paasila PJ, Patrick E, Kril JJ, Halliday GM, Cooper AA, Sutherland GT
Scientific reports 2021 Mar 1;11(1):4865
Scientific reports 2021 Mar 1;11(1):4865
Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia.
Mol MO, Wong TH, Melhem S, Basu S, Viscusi R, Galjart N, Rozemuller AJM, Fallini C, Landers JE, Kaat LD, Seelaar H, van Rooij JGJ, van Swieten JC
Neurology. Genetics 2021 Jun;7(3):e596
Neurology. Genetics 2021 Jun;7(3):e596
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
Cornblath EJ, Li HL, Changolkar L, Zhang B, Brown HJ, Gathagan RJ, Olufemi MF, Trojanowski JQ, Bassett DS, Lee VMY, Henderson MX
Science advances 2021 Jun;7(24)
Science advances 2021 Jun;7(24)
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.
Zhang J, Wu N, Wang S, Yao Z, Xiao F, Lu J, Chen B
Aging cell 2021 Jun;20(6):e13380
Aging cell 2021 Jun;20(6):e13380
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, Wang X, Liu E, Ye J, Yu H, Gao Y, He T, Jiang T, Sun F, Su J, Song G, Peng W, Yang Y, Wang JZ
Clinical and translational medicine 2021 Jun;11(6):e428
Clinical and translational medicine 2021 Jun;11(6):e428
Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.
Dickson JR, Yoon H, Frosch MP, Hyman BT
Journal of neuropathology and experimental neurology 2021 Jun 4;80(6):530-540
Journal of neuropathology and experimental neurology 2021 Jun 4;80(6):530-540
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N
Acta neuropathologica communications 2021 Jun 29;9(1):118
Acta neuropathologica communications 2021 Jun 29;9(1):118
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Raha-Chowdhury R, Raha AA, Henderson J, Ghaffari SD, Grigorova M, Beresford-Webb J, Allinson K, Chakraborty S, Holland A, Zaman SH
Journal of clinical medicine 2021 Jun 29;10(13)
Journal of clinical medicine 2021 Jun 29;10(13)
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K
Nature communications 2021 Jun 2;12(1):3291
Nature communications 2021 Jun 2;12(1):3291
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
Takamura R, Mizuta K, Sekine Y, Islam T, Saito T, Sato M, Ohkura M, Nakai J, Ohshima T, Saido TC, Hayashi Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Jun 16;41(24):5315-5329
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Jun 16;41(24):5315-5329
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
Journal of neuroinflammation 2021 Jun 11;18(1):131
Journal of neuroinflammation 2021 Jun 11;18(1):131
Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.
Cores Á, Abril S, Michalska P, Duarte P, Olives AI, Martín MA, Villacampa M, León R, Menéndez JC
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) 2021 Jul;31(4):e12914
Brain pathology (Zurich, Switzerland) 2021 Jul;31(4):e12914
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
Wang ZH, Xia Y, Liu P, Liu X, Edgington-Mitchell L, Lei K, Yu SP, Wang XC, Ye K
Progress in neurobiology 2021 Jul;202:102032
Progress in neurobiology 2021 Jul;202:102032
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.
Xu Y, Propson NE, Du S, Xiong W, Zheng H
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 6;118(27)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 6;118(27)
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE
Molecular neurodegeneration 2021 Jul 2;16(1):46
Molecular neurodegeneration 2021 Jul 2;16(1):46
Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies.
Abey A, Davies D, Goldsbury C, Buckland M, Valenzuela M, Duncan T
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):144-162
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):144-162
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Reimer L, Betzer C, Kofoed RH, Volbracht C, Fog K, Kurhade C, Nilsson E, Överby AK, Jensen PH
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):103-119
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):103-119
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, Zhang YW
Cell death and differentiation 2021 Jan;28(1):337-348
Cell death and differentiation 2021 Jan;28(1):337-348
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.
Zuliani I, Lanzillotta C, Tramutola A, Francioso A, Pagnotta S, Barone E, Perluigi M, Di Domenico F
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jan;18(1):340-363
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jan;18(1):340-363
Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.
Na H, Tian H, Zhang Z, Li Q, Yang JB, Mcparland L, Gan Q, Qiu WQ
American journal of Alzheimer's disease and other dementias 2021 Jan-Dec;36:15333175211012867
American journal of Alzheimer's disease and other dementias 2021 Jan-Dec;36:15333175211012867
Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.
Choi YB, Dunn-Meynell AA, Marchese M, Blumberg BM, Gaindh D, Dowling PC, Lu W
Alzheimer's research & therapy 2021 Jan 27;13(1):32
Alzheimer's research & therapy 2021 Jan 27;13(1):32
Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.
Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF
Journal of neuropathology and experimental neurology 2021 Jan 20;80(2):102-111
Journal of neuropathology and experimental neurology 2021 Jan 20;80(2):102-111
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.
Shin J, Park S, Lee H, Kim Y
Scientific reports 2021 Jan 15;11(1):1617
Scientific reports 2021 Jan 15;11(1):1617
Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.
Kang S, Kim J, Chang KA
Scientific reports 2021 Jan 14;11(1):1334
Scientific reports 2021 Jan 14;11(1):1334
Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains.
Jankovska N, Olejar T, Matej R
International journal of molecular sciences 2021 Feb 20;22(4)
International journal of molecular sciences 2021 Feb 20;22(4)
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC
The Journal of clinical investigation 2021 Feb 15;131(4)
The Journal of clinical investigation 2021 Feb 15;131(4)
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T
Brain : a journal of neurology 2021 Feb 12;144(1):288-309
Brain : a journal of neurology 2021 Feb 12;144(1):288-309
Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.
Walker CK, Greathouse KM, Boros BD, Poovey EH, Clearman KR, Ramdas R, Muhammad HM, Herskowitz JH
Neuroscience 2021 Feb 10;455:195-211
Neuroscience 2021 Feb 10;455:195-211
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.
de Pablo-Fernández E, Courtney R, Rockliffe A, Gentleman S, Holton JL, Warner TT
Neuropathology and applied neurobiology 2021 Dec;47(7):1080-1091
Neuropathology and applied neurobiology 2021 Dec;47(7):1080-1091
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME
Nature aging 2021 Dec;1(12):1107-1116
Nature aging 2021 Dec;1(12):1107-1116
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
Bettencourt C, Miki Y, Piras IS, de Silva R, Foti SC, Talboom JS, Revesz T, Lashley T, Balazs R, Viré E, Warner TT, Huentelman MJ, Holton JL
Neuropathology and applied neurobiology 2021 Aug;47(5):640-652
Neuropathology and applied neurobiology 2021 Aug;47(5):640-652
Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders.
Sundermann EE, Bondi MW, Campbell LM, Gouaux B, Moore RC, Soontornniyomkij V, Moore DJ
The Journal of infectious diseases 2021 Aug 2;224(3):435-442
The Journal of infectious diseases 2021 Aug 2;224(3):435-442
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU
Nature communications 2021 Aug 11;12(1):4863
Nature communications 2021 Aug 11;12(1):4863
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64
Acta neuropathologica communications 2021 Apr 8;9(1):64
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira ST, De Felice FG
Translational psychiatry 2021 Apr 28;11(1):251
Translational psychiatry 2021 Apr 28;11(1):251
Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.
Gao Y, Zheng J, Jiang T, Pi G, Sun F, Xiong R, Wang W, Wu D, Li S, Lei H, Yu H, Zhou Q, Yang Y, Zhang H, Wang JZ
Frontiers in cell and developmental biology 2020;8:633725
Frontiers in cell and developmental biology 2020;8:633725
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, Lee VM, Takahashi R, Suhara T, Higuchi M, Inoue H
NPJ vaccines 2020;5(1):28
NPJ vaccines 2020;5(1):28
Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways.
Colas J, Chessel N, Ouared A, Gruz-Gibelli E, Marin P, Herrmann FR, Savioz A
Neural plasticity 2020;2020:9369815
Neural plasticity 2020;2020:9369815
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.
Neddens J, Daurer M, Flunkert S, Beutl K, Loeffler T, Walker L, Attems J, Hutter-Paier B
PloS one 2020;15(7):e0235543
PloS one 2020;15(7):e0235543
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
Yadikar H, Torres I, Aiello G, Kurup M, Yang Z, Lin F, Kobeissy F, Yost R, Wang KK
PloS one 2020;15(7):e0224952
PloS one 2020;15(7):e0224952
Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.
Soto-Mercado V, Mendivil-Perez M, Velez-Pardo C, Lopera F, Jimenez-Del-Rio M
PloS one 2020;15(5):e0221669
PloS one 2020;15(5):e0221669
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.
LeBlang CJ, Medalla M, Nicoletti NW, Hays EC, Zhao J, Shattuck J, Cruz AL, Wolozin B, Luebke JI
Frontiers in neuroscience 2020;14:285
Frontiers in neuroscience 2020;14:285
Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue.
Alsema AM, Jiang Q, Kracht L, Gerrits E, Dubbelaar ML, Miedema A, Brouwer N, Hol EM, Middeldorp J, van Dijk R, Woodbury M, Wachter A, Xi S, Möller T, Biber KP, Kooistra SM, Boddeke EWGM, Eggen BJL
Frontiers in molecular neuroscience 2020;13:134
Frontiers in molecular neuroscience 2020;13:134
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Ye J, Yin Y, Yin Y, Zhang H, Wan H, Wang L, Zuo Y, Gao D, Li M, Li J, Liu Y, Ke D, Wang JZ
Aging cell 2020 Sep;19(9):e13209
Aging cell 2020 Sep;19(9):e13209
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.
Yu Y, Yang Y, Tan H, Boukhali M, Khatri A, Yu Y, Hua F, Liu L, Li M, Yang G, Dong Y, Zhang Y, Haas W, Xie Z
Anesthesiology 2020 Sep;133(3):595-610
Anesthesiology 2020 Sep;133(3):595-610
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
Katsikoudi A, Ficulle E, Cavallini A, Sharman G, Guyot A, Zagnoni M, Eastwood BJ, Hutton M, Bose S
The Journal of biological chemistry 2020 Sep 11;295(37):13079-13093
The Journal of biological chemistry 2020 Sep 11;295(37):13079-13093
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
Roda AR, Montoliu-Gaya L, Serra-Mir G, Villegas S
International journal of molecular sciences 2020 Sep 10;21(18)
International journal of molecular sciences 2020 Sep 10;21(18)
Phosphorylated tau interactome in the human Alzheimer's disease brain.
Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M, Safar J, Ueberheide B, Wisniewski T
Brain : a journal of neurology 2020 Sep 1;143(9):2803-2817
Brain : a journal of neurology 2020 Sep 1;143(9):2803-2817
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Ni R, Chen Z, Gerez JA, Shi G, Zhou Q, Riek R, Nilsson KPR, Razansky D, Klohs J
Biomedical optics express 2020 Sep 1;11(9):4989-5002
Biomedical optics express 2020 Sep 1;11(9):4989-5002
Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants.
Venkataraman L, He P, Schulz P, Sierks MR
Neurobiology of aging 2020 Oct;94:7-14
Neurobiology of aging 2020 Oct;94:7-14
Reductive stress promotes protein aggregation and impairs neurogenesis.
S Narasimhan KK, Devarajan A, Karan G, Sundaram S, Wang Q, van Groen T, Monte FD, Rajasekaran NS
Redox biology 2020 Oct;37:101739
Redox biology 2020 Oct;37:101739
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.
Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT
Acta neuropathologica communications 2020 Oct 19;8(1):168
Acta neuropathologica communications 2020 Oct 19;8(1):168
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Murphy EK, Iacono D, Pan H, Grimes JB, Parks S, Raiciulescu S, Leonessa F, Perl DP
Scientific reports 2020 Oct 15;10(1):17446
Scientific reports 2020 Oct 15;10(1):17446
Reproductive status impact on tau phosphorylation induced by chronic stress.
Muñoz-Mayorga D, Rissman RA, Morales T
Neurobiology of stress 2020 Nov;13:100241
Neurobiology of stress 2020 Nov;13:100241
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Chiu CC, Weng YH, Huang YZ, Chen RS, Liu YC, Yeh TH, Lu CS, Lin YW, Chen YJ, Hsu CC, Chiu CH, Wang YT, Chen WS, Liu SY, Wang HL
Cell death & disease 2020 Nov 30;11(11):1018
Cell death & disease 2020 Nov 30;11(11):1018
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF
Acta neuropathologica communications 2020 Nov 23;8(1):200
Acta neuropathologica communications 2020 Nov 23;8(1):200
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G
Nature communications 2020 Nov 2;11(1):5540
Nature communications 2020 Nov 2;11(1):5540
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes.
Giarratana AO, Zheng C, Reddi S, Teng SL, Berger D, Adler D, Sullivan P, Thakker-Varia S, Alder J
Scientific reports 2020 Nov 16;10(1):19919
Scientific reports 2020 Nov 16;10(1):19919
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, Kaipainen S, Takalo M, Svobodová H, Leppänen L, Kemiläinen B, Ryhänen S, Kuulasmaa T, Rahunen E, Juutinen S, Mäkinen P, Miettinen P, Rauramaa T, Pihlajamäki J, Haapasalo A, Leinonen V, Tanila H, Hiltunen M
Molecular neurodegeneration 2020 Nov 10;15(1):66
Molecular neurodegeneration 2020 Nov 10;15(1):66
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
van Olst L, Verhaege D, Franssen M, Kamermans A, Roucourt B, Carmans S, Ytebrouck E, van der Pol SMA, Wever D, Popovic M, Vandenbroucke RE, Sobrino T, Schouten M, de Vries HE
Neurobiology of aging 2020 May;89:89-98
Neurobiology of aging 2020 May;89:89-98
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.
Bourdenx M, Nioche A, Dovero S, Arotcarena ML, Camus S, Porras G, Thiolat ML, Rougier NP, Prigent A, Aubert P, Bohic S, Sandt C, Laferrière F, Doudnikoff E, Kruse N, Mollenhauer B, Novello S, Morari M, Leste-Lasserre T, Damas IT, Goillandeau M, Perier C, Estrada C, Garcia-Carrillo N, Recasens A, Vaikath NN, El-Agnaf OMA, Herrero MT, Derkinderen P, Vila M, Obeso JA, Dehay B, Bezard E
Science advances 2020 May;6(20):eaaz9165
Science advances 2020 May;6(20):eaaz9165
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
Puangmalai N, Bhatt N, Montalbano M, Sengupta U, Gaikwad S, Ventura F, McAllen S, Ellsworth A, Garcia S, Kayed R
Cell death & disease 2020 May 4;11(5):314
Cell death & disease 2020 May 4;11(5):314
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu E, Park CM, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS
Nature communications 2020 May 12;11(1):2358
Nature communications 2020 May 12;11(1):2358
Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia.
Shafei R, Woollacott IOC, Mummery CJ, Bocchetta M, Guerreiro R, Bras J, Warren JD, Lashley T, Jaunmuktane Z, Rohrer JD
Neurobiology of aging 2020 Mar;87:141.e15-141.e20
Neurobiology of aging 2020 Mar;87:141.e15-141.e20
Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission.
Zheng J, Li HL, Tian N, Liu F, Wang L, Yin Y, Yue L, Ma L, Wan Y, Wang JZ
Cell stem cell 2020 Mar 5;26(3):331-345.e6
Cell stem cell 2020 Mar 5;26(3):331-345.e6
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
Crowe A, Henderson MJ, Anderson J, Titus SA, Zakharov A, Simeonov A, Buist A, Delay C, Moechars D, Trojanowski JQ, Lee VM, Brunden KR
The Journal of biological chemistry 2020 Mar 20;295(12):4001-4013
The Journal of biological chemistry 2020 Mar 20;295(12):4001-4013
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.
García-Arriaza J, Marín MQ, Merchán-Rubira J, Mascaraque SM, Medina M, Ávila J, Hernández F, Esteban M
Vaccines 2020 Mar 13;8(1)
Vaccines 2020 Mar 13;8(1)
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
Bevan-Jones WR, Cope TE, Jones PS, Kaalund SS, Passamonti L, Allinson K, Green O, Hong YT, Fryer TD, Arnold R, Coles JP, Aigbirhio FI, Larner AJ, Patterson K, O'Brien JT, Rowe JB
Brain : a journal of neurology 2020 Mar 1;143(3):1010-1026
Brain : a journal of neurology 2020 Mar 1;143(3):1010-1026
Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures.
Liaudanskaya V, Chung JY, Mizzoni C, Rouleau N, Berk AN, Wu L, Turner JA, Georgakoudi I, Whalen MJ, Nieland TJF, Kaplan DL
Advanced healthcare materials 2020 Jun;9(12):e2000122
Advanced healthcare materials 2020 Jun;9(12):e2000122
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J
International journal of molecular sciences 2020 Jun 25;21(12)
International journal of molecular sciences 2020 Jun 25;21(12)
Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing.
Ghosh A, Mizuno K, Tiwari SS, Proitsi P, Gomez Perez-Nievas B, Glennon E, Martinez-Nunez RT, Giese KP
Translational psychiatry 2020 Jun 16;10(1):192
Translational psychiatry 2020 Jun 16;10(1):192
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.
Pontecorvo MJ, Keene CD, Beach TG, Montine TJ, Arora AK, Devous MD Sr, Navitsky M, Kennedy I, Joshi AD, Lu M, Serrano GE, Sue LI, Intorcia AJ, Rose SE, Wilson A, Hellstern L, Coleman N, Flitter M, Aldea P, Fleisher AS, Mintun MA, Siderowf A
EJNMMI research 2020 Jun 15;10(1):65
EJNMMI research 2020 Jun 15;10(1):65
Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology.
Das R, Balmik AA, Chinnathambi S
International journal of biological macromolecules 2020 Jun 1;152:30-39
International journal of biological macromolecules 2020 Jun 1;152:30-39
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.
Miki Y, Foti SC, Hansen D, Strand KM, Asi YT, Tsushima E, Jaunmuktane Z, Lees AJ, Warner TT, Quinn N, Ling H, Holton JL
Brain : a journal of neurology 2020 Jun 1;143(6):1798-1810
Brain : a journal of neurology 2020 Jun 1;143(6):1798-1810
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Chen C, Ahn EH, Kang SS, Liu X, Alam A, Ye K
Science advances 2020 Jul;6(31):eaba0466
Science advances 2020 Jul;6(31):eaba0466
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Yang M, Lian N, Yu Y, Wang Y, Xie K, Yu Y
Molecular medicine reports 2020 Jul;22(1):445-453
Molecular medicine reports 2020 Jul;22(1):445-453
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF
Scientific reports 2020 Jul 30;10(1):12827
Scientific reports 2020 Jul 30;10(1):12827
The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.
Wander CM, Tseng JH, Song S, Al Housseiny HA, Tart DS, Ajit A, Ian Shih YY, Lobrovich R, Song J, Meeker RB, Irwin DJ, Cohen TJ
iScience 2020 Jul 24;23(7):101255
iScience 2020 Jul 24;23(7):101255
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
Nam E, Lee YB, Moon C, Chang KA
International journal of molecular sciences 2020 Jul 15;21(14)
International journal of molecular sciences 2020 Jul 15;21(14)
Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.
Eckenweber F, Medina-Luque J, Blume T, Sacher C, Biechele G, Wind K, Deussing M, Briel N, Lindner S, Boening G, von Ungern-Sternberg B, Unterrainer M, Albert NL, Zwergal A, Levin J, Bartenstein P, Cumming P, Rominger A, Höglinger GU, Herms J, Brendel M
Journal of neuroinflammation 2020 Jul 13;17(1):208
Journal of neuroinflammation 2020 Jul 13;17(1):208
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, Nussbaum-Krammer C
The Journal of biological chemistry 2020 Jul 10;295(28):9676-9690
The Journal of biological chemistry 2020 Jul 10;295(28):9676-9690
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM
Acta neuropathologica communications 2020 Jul 1;8(1):96
Acta neuropathologica communications 2020 Jul 1;8(1):96
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Ahn EH, Kang SS, Liu X, Chen G, Zhang Z, Chandrasekharan B, Alam AM, Neish AS, Cao X, Ye K
Cell research 2020 Jan;30(1):70-87
Cell research 2020 Jan;30(1):70-87
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
Fan Q, He W, Gayen M, Benoit MR, Luo X, Hu X, Yan R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jan 29;40(5):1133-1144
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jan 29;40(5):1133-1144
β-amyloid and tau pathology in the aging feline brain.
Fiock KL, Smith JD, Crary JF, Hefti MM
The Journal of comparative neurology 2020 Jan 1;528(1):108-113
The Journal of comparative neurology 2020 Jan 1;528(1):108-113
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Guarascio R, Salih D, Yasvoina M, Edwards FA, Cheetham ME, van der Spuy J
Human molecular genetics 2020 Jan 1;29(1):80-96
Human molecular genetics 2020 Jan 1;29(1):80-96
Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Wong TH, Seelaar H, Melhem S, Rozemuller AJM, van Swieten JC
Neurobiology of aging 2020 Feb;86:201.e9-201.e14
Neurobiology of aging 2020 Feb;86:201.e9-201.e14
Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.
Ornelas AS, Adler CH, Serrano GE, Curry JR, Shill HA, Kopyov O, Beach TG
Parkinsonism & related disorders 2020 Feb;71:36-39
Parkinsonism & related disorders 2020 Feb;71:36-39
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X, Wu H, Kong W
Journal of neuroinflammation 2020 Feb 24;17(1):72
Journal of neuroinflammation 2020 Feb 24;17(1):72
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Iacono D, Lee P, Edlow BL, Gray N, Fischl B, Kenney K, Lew HL, Lozanoff S, Liacouras P, Lichtenberger J, Dams-O'Connor K, Cifu D, Hinds SR, Perl DP
Journal of neuropathology and experimental neurology 2020 Feb 1;79(2):144-162
Journal of neuropathology and experimental neurology 2020 Feb 1;79(2):144-162
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.
Cao Q, Wang W, Williams JB, Yang F, Wang ZJ, Yan Z
Science advances 2020 Dec;6(50)
Science advances 2020 Dec;6(50)
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.
Wen X, An P, Li H, Zhou Z, Sun Y, Wang J, Ma L, Lu B
Neuroscience bulletin 2020 Dec;36(12):1414-1428
Neuroscience bulletin 2020 Dec;36(12):1414-1428
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.
Sandberg A, Ling H, Gearing M, Dombroski B, Cantwell L, R'Bibo L, Levey A, Schellenberg GD, Hardy J, Wood N, Fernius J, Nyström S, Svensson S, Thor S, Hammarström P, Revesz T, Mok KY
Neurobiology of disease 2020 Dec;146:105079
Neurobiology of disease 2020 Dec;146:105079
Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.
Guo X, Liu Y, Morgan D, Zhao LR
Aging and disease 2020 Dec;11(6):1423-1443
Aging and disease 2020 Dec;11(6):1423-1443
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Wu Z, Liu X, Cheng L, Ye K
Cell death & disease 2020 Dec 12;11(12):1058
Cell death & disease 2020 Dec 12;11(12):1058
Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.
Vanan S, Zeng X, Chia SY, Varnäs K, Jiang M, Zhang K, Saw WT, Padmanabhan P, Yu WP, Zhou ZD, Halldin C, Gulyás B, Tan EK, Zeng L
Molecular brain 2020 Dec 1;13(1):164
Molecular brain 2020 Dec 1;13(1):164
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Hou TY, Zhou Y, Zhu LS, Wang X, Pang P, Wang DQ, Liuyang ZY, Man H, Lu Y, Zhu LQ, Liu D
Journal of neurochemistry 2020 Aug;154(4):441-457
Journal of neurochemistry 2020 Aug;154(4):441-457
Distribution patterns of tau pathology in progressive supranuclear palsy.
Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU
Acta neuropathologica 2020 Aug;140(2):99-119
Acta neuropathologica 2020 Aug;140(2):99-119
Fyn Kinase Controls Tau Aggregation In Vivo.
Briner A, Götz J, Polanco JC
Cell reports 2020 Aug 18;32(7):108045
Cell reports 2020 Aug 18;32(7):108045
Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion.
Mankhong S, Kim S, Moon S, Lee KH, Jeon HE, Hwang BH, Beak JW, Joa KL, Kang JH
International journal of molecular sciences 2020 Aug 14;21(16)
International journal of molecular sciences 2020 Aug 14;21(16)
Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.
Koller EJ, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz PE, Ryu D, Golde TE, Sullivan PM, Lewis J, Borchelt DR, Chakrabarty P
Molecular neurobiology 2020 Apr;57(4):1986-2001
Molecular neurobiology 2020 Apr;57(4):1986-2001
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Apr 22;40(17):3491-3501
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Apr 22;40(17):3491-3501
Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease.
Töpperwien M, van der Meer F, Stadelmann C, Salditt T
NeuroImage 2020 Apr 15;210:116523
NeuroImage 2020 Apr 15;210:116523
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI
Journal of neuropathology and experimental neurology 2020 Apr 1;79(4):407-418
Journal of neuropathology and experimental neurology 2020 Apr 1;79(4):407-418
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Regalado-Reyes M, Furcila D, Hernández F, Ávila J, DeFelipe J, León-Espinosa G
Journal of Alzheimer's disease : JAD 2019;69(1):277-288
Journal of Alzheimer's disease : JAD 2019;69(1):277-288
Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.
Reed MJ, Damodarasamy M, Pathan JL, Chan CK, Spiekerman C, Wight TN, Banks WA, Day AJ, Vernon RB, Keene CD
Journal of Alzheimer's disease : JAD 2019;67(1):91-102
Journal of Alzheimer's disease : JAD 2019;67(1):91-102
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
Maphis NM, Peabody J, Crossey E, Jiang S, Jamaleddin Ahmad FA, Alvarez M, Mansoor SK, Yaney A, Yang Y, Sillerud LO, Wilson CM, Selwyn R, Brigman JL, Cannon JL, Peabody DS, Chackerian B, Bhaskar K
NPJ vaccines 2019;4:26
NPJ vaccines 2019;4:26
Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
Liu Y, Cao L, Zhang X, Liang Y, Xu Y, Zhu C
Neural plasticity 2019;2019:4168472
Neural plasticity 2019;2019:4168472
Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation.
Scarpelli EM, Trinh VY, Tashnim Z, Krans JL, Keller LC, Colodner KJ
PloS one 2019;14(12):e0226380
PloS one 2019;14(12):e0226380
Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.
Furcila D, Domínguez-Álvaro M, DeFelipe J, Alonso-Nanclares L
Frontiers in neuroanatomy 2019;13:99
Frontiers in neuroanatomy 2019;13:99
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Bullmann T, Feneberg E, Kretzschmann TP, Ogunlade V, Holzer M, Arendt T
Frontiers in neuroanatomy 2019;13:69
Frontiers in neuroanatomy 2019;13:69
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL
Frontiers in cellular neuroscience 2019;13:399
Frontiers in cellular neuroscience 2019;13:399
Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells.
Deng L, Pushpitha K, Joseph C, Gupta V, Rajput R, Chitranshi N, Dheer Y, Amirkhani A, Kamath K, Pascovici D, Wu JX, Salekdeh GH, Haynes PA, Graham SL, Gupta VK, Mirzaei M
Frontiers in molecular neuroscience 2019;12:24
Frontiers in molecular neuroscience 2019;12:24
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
Miao J, Shi R, Li L, Chen F, Zhou Y, Tung YC, Hu W, Gong CX, Iqbal K, Liu F
Frontiers in aging neuroscience 2019;11:34
Frontiers in aging neuroscience 2019;11:34
In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy.
Dunn-Meynell AA, Dowling P, Marchese M, Rodriguez E, Blumberg B, Choi YB, Gaindh D, Lu W
Frontiers in aging neuroscience 2019;11:252
Frontiers in aging neuroscience 2019;11:252
Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling.
Wan W, Cao L, Kalionis B, Murthi P, Xia S, Guan Y
Frontiers in neurology 2019;10:607
Frontiers in neurology 2019;10:607
BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.
Giarratana AO, Teng S, Reddi S, Zheng C, Adler D, Thakker-Varia S, Alder J
Frontiers in neurology 2019;10:1175
Frontiers in neurology 2019;10:1175
Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, Berndt M, Schmitt-Willich H, Darmency V, Gabellieri E, Boudou C, Juergens T, Varisco Y, Vokali E, Hickman DT, Tamagnan G, Pfeifer A, Dinkelborg L, Muhs A, Stephens A
European journal of nuclear medicine and molecular imaging 2019 Sep;46(10):2178-2189
European journal of nuclear medicine and molecular imaging 2019 Sep;46(10):2178-2189
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S
Molecular psychiatry 2019 Sep;24(9):1383-1397
Molecular psychiatry 2019 Sep;24(9):1383-1397
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Gary C, Lam S, Hérard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP, French Neuropathology Network, Brouillet E, Buée L, Comoy EE, Pifferi F, Picq JL, Dhenain M
Acta neuropathologica communications 2019 Sep 4;7(1):126
Acta neuropathologica communications 2019 Sep 4;7(1):126
Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.
Bonds JA, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Oct 23;39(43):8576-8583
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Oct 23;39(43):8576-8583
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J, NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Di Meco A, Li JG, Barrero C, Merali S, Praticò D
Molecular psychiatry 2019 Nov;24(11):1696-1706
Molecular psychiatry 2019 Nov;24(11):1696-1706
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
Ajit D, Trzeciakiewicz H, Tseng JH, Wander CM, Chen Y, Ajit A, King DP, Cohen TJ
The Journal of biological chemistry 2019 Nov 8;294(45):16698-16711
The Journal of biological chemistry 2019 Nov 8;294(45):16698-16711
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Henderson MX, Sengupta M, Trojanowski JQ, Lee VMY
Acta neuropathologica communications 2019 Nov 16;7(1):183
Acta neuropathologica communications 2019 Nov 16;7(1):183
Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.
Muhire G, Iulita MF, Vallerand D, Youwakim J, Gratuze M, Petry FR, Planel E, Ferland G, Girouard H
Journal of the American Heart Association 2019 May 7;8(9):e011630
Journal of the American Heart Association 2019 May 7;8(9):e011630
Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease.
Libard S, Alafuzoff I
Acta neuropathologica communications 2019 May 29;7(1):98
Acta neuropathologica communications 2019 May 29;7(1):98
Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological Specimens.
Middelveen MJ, Filush KR, Bandoski C, Kasliwala RS, Melillo A, Stricker RB, Sapi E
Healthcare (Basel, Switzerland) 2019 May 17;7(2)
Healthcare (Basel, Switzerland) 2019 May 17;7(2)
Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.
Munger EL, Edler MK, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Sherwood CC, Raghanti MA
The Journal of comparative neurology 2019 May 1;527(7):1179-1195
The Journal of comparative neurology 2019 May 1;527(7):1179-1195
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.
Perez SE, Miguel JC, He B, Malek-Ahmadi M, Abrahamson EE, Ikonomovic MD, Lott I, Doran E, Alldred MJ, Ginsberg SD, Mufson EJ
Acta neuropathologica 2019 Mar;137(3):413-436
Acta neuropathologica 2019 Mar;137(3):413-436
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.
Zhang Y, Wu F, Iqbal K, Gong CX, Hu W, Liu F
Scientific reports 2019 Mar 7;9(1):3789
Scientific reports 2019 Mar 7;9(1):3789
Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes.
Andersson CR, Falsig J, Stavenhagen JB, Christensen S, Kartberg F, Rosenqvist N, Finsen B, Pedersen JT
Scientific reports 2019 Mar 15;9(1):4658
Scientific reports 2019 Mar 15;9(1):4658
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
Gangolli M, Benetatos J, Esparza TJ, Fountain EM, Seneviratne S, Brody DL
Journal of neurotrauma 2019 Mar 1;36(5):735-755
Journal of neurotrauma 2019 Mar 1;36(5):735-755
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model.
Paula PC, Angelica Maria SG, Luis CH, Gloria Patricia CG
Molecules (Basel, Switzerland) 2019 Jun 20;24(12)
Molecules (Basel, Switzerland) 2019 Jun 20;24(12)
Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin.
Walker DG, Lue LF, Beach TG, Tooyama I
Cells 2019 Jul 23;8(7)
Cells 2019 Jul 23;8(7)
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.
Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M
Scientific reports 2019 Jul 22;9(1):10591
Scientific reports 2019 Jul 22;9(1):10591
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K
Cell reports 2019 Jul 16;28(3):655-669.e5
Cell reports 2019 Jul 16;28(3):655-669.e5
Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.
Lee JY, Kim MJ, Thomas S, Oorschot V, Ramm G, Aui PM, Sekine Y, Deliyanti D, Wilkinson-Berka J, Niego B, Harvey AR, Theotokis P, McLean C, Strittmatter SM, Petratos S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5562-5580
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5562-5580
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
Evans HT, Benetatos J, van Roijen M, Bodea LG, Götz J
The EMBO journal 2019 Jul 1;38(13):e101174
The EMBO journal 2019 Jul 1;38(13):e101174
Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia.
Iacono D, Geraci-Erck M, Peng H, Rabin ML, Kurlan R
Parkinsonism & related disorders 2019 Jan;58:63-69
Parkinsonism & related disorders 2019 Jan;58:63-69
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH
Nature medicine 2019 Jan;25(1):152-164
Nature medicine 2019 Jan;25(1):152-164
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Nam WH, Choi YP
Prion 2019 Jan;13(1):1-12
Prion 2019 Jan;13(1):1-12
Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.
Harrison IF, Whitaker R, Bertelli PM, O'Callaghan JM, Csincsik L, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O'Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I
Acta neuropathologica communications 2019 Jan 7;7(1):4
Acta neuropathologica communications 2019 Jan 7;7(1):4
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA
Cell reports 2019 Jan 29;26(5):1112-1127.e9
Cell reports 2019 Jan 29;26(5):1112-1127.e9
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Paonessa F, Evans LD, Solanki R, Larrieu D, Wray S, Hardy J, Jackson SP, Livesey FJ
Cell reports 2019 Jan 15;26(3):582-593.e5
Cell reports 2019 Jan 15;26(3):582-593.e5
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Belfiore R, Rodin A, Ferreira E, Velazquez R, Branca C, Caccamo A, Oddo S
Aging cell 2019 Feb;18(1):e12873
Aging cell 2019 Feb;18(1):e12873
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
Christensen KR, Beach TG, Serrano GE, Kanaan NM
Acta neuropathologica communications 2019 Feb 28;7(1):29
Acta neuropathologica communications 2019 Feb 28;7(1):29
TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN.
Rossor AM, Jaunmuktane Z, Rossor MN, Hoti G, Reilly MM
Neurology 2019 Feb 26;92(9):e951-e956
Neurology 2019 Feb 26;92(9):e951-e956
Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults.
Soontornniyomkij V, Moore DJ, Gouaux B, Soontornniyomkij B, Sinsheimer JS, Levine AJ
Journal of neurovirology 2019 Dec;25(6):741-753
Journal of neurovirology 2019 Dec;25(6):741-753
Early-life exposure to high-fat diet influences brain health in aging mice.
Di Meco A, Praticò D
Aging cell 2019 Dec;18(6):e13040
Aging cell 2019 Dec;18(6):e13040
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice.
Young ML, Franklin JL
Molecular and cellular neurosciences 2019 Dec;101:103409
Molecular and cellular neurosciences 2019 Dec;101:103409
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Mendsaikhan A, Tooyama I, Bellier JP, Serrano GE, Sue LI, Lue LF, Beach TG, Walker DG
Acta neuropathologica communications 2019 Dec 21;7(1):215
Acta neuropathologica communications 2019 Dec 21;7(1):215
Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.
Hesse R, Hurtado ML, Jackson RJ, Eaton SL, Herrmann AG, Colom-Cadena M, Tzioras M, King D, Rose J, Tulloch J, McKenzie CA, Smith C, Henstridge CM, Lamont D, Wishart TM, Spires-Jones TL
Acta neuropathologica communications 2019 Dec 20;7(1):214
Acta neuropathologica communications 2019 Dec 20;7(1):214
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, Zhu L, Qiao Y, Sun Q, Qin W, Zhao Q, Jia J, Wei C
Aging cell 2019 Aug;18(4):e12978
Aging cell 2019 Aug;18(4):e12978
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW
Nature communications 2019 Aug 29;10(1):3885
Nature communications 2019 Aug 29;10(1):3885
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW
Nature 2019 Apr;568(7752):420-423
Nature 2019 Apr;568(7752):420-423
Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.
Yang Q, Chen K, Zhang H, Zhang W, Gong C, Zhang Q, Liu P, Sun T, Xu Y, Qian X, Qiu W, Ma C
Neuroscience bulletin 2019 Apr;35(2):193-204
Neuroscience bulletin 2019 Apr;35(2):193-204
A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.
Humphreys CA, Jansen MA, Muñoz Maniega S, González-Castro V, Pernet C, Deary IJ, Al-Shahi Salman R, Wardlaw JM, Smith C
International journal of stroke : official journal of the International Stroke Society 2019 Apr;14(3):310-320
International journal of stroke : official journal of the International Stroke Society 2019 Apr;14(3):310-320
In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model.
Marinković P, Blumenstock S, Goltstein PM, Korzhova V, Peters F, Knebl A, Herms J
Brain : a journal of neurology 2019 Apr 1;142(4):1051-1062
Brain : a journal of neurology 2019 Apr 1;142(4):1051-1062
Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.
Bartolotti N, Disouky A, Kalinski A, Elmann A, Lazarov O
Journal of Alzheimer's disease : JAD 2018;66(4):1425-1435
Journal of Alzheimer's disease : JAD 2018;66(4):1425-1435
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Hu W, Tung YC, Zhang Y, Liu F, Iqbal K
Journal of Alzheimer's disease : JAD 2018;64(3):709-722
Journal of Alzheimer's disease : JAD 2018;64(3):709-722
A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.
Furcila D, DeFelipe J, Alonso-Nanclares L
Journal of Alzheimer's disease : JAD 2018;64(2):417-435
Journal of Alzheimer's disease : JAD 2018;64(2):417-435
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Yan T, Wang L, Gao J, Siedlak SL, Huntley ML, Termsarasab P, Perry G, Chen SG, Wang X
Journal of Alzheimer's disease : JAD 2018;63(1):157-165
Journal of Alzheimer's disease : JAD 2018;63(1):157-165
Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.
Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA
Journal of Alzheimer's disease : JAD 2018;61(3):1201-1219
Journal of Alzheimer's disease : JAD 2018;61(3):1201-1219
Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.
Flanagan ME, Larson EB, Walker RL, Keene CD, Postupna N, Cholerton B, Sonnen JA, Dublin S, Crane PK, Montine TJ
Journal of Alzheimer's disease : JAD 2018;61(2):653-662
Journal of Alzheimer's disease : JAD 2018;61(2):653-662
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina C, Navarro V, Sanchez-Varo R, Jimenez S, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Muñoz-Castro C, Gutierrez A, Vitorica J, Vizuete M
Frontiers in cellular neuroscience 2018;12:421
Frontiers in cellular neuroscience 2018;12:421
Modulatory Effects of a Novel Cyclized Peptide in Reducing the Expression of Markers Linked to Alzheimer's Disease.
Brai E, Simon F, Cogoni A, Greenfield SA
Frontiers in neuroscience 2018;12:362
Frontiers in neuroscience 2018;12:362
Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.
Kang S, Ha S, Park H, Nam E, Suh WH, Suh YH, Chang KA
Frontiers in behavioral neuroscience 2018;12:273
Frontiers in behavioral neuroscience 2018;12:273
Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology.
Andrés-Benito P, Delgado-Morales R, Ferrer I
Frontiers in cellular neuroscience 2018;12:131
Frontiers in cellular neuroscience 2018;12:131
Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.
Rodriguez L, Mdzomba JB, Joly S, Boudreau-Laprise M, Planel E, Pernet V
Frontiers in molecular neuroscience 2018;11:293
Frontiers in molecular neuroscience 2018;11:293
A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.
Lippi SLP, Smith ML, Flinn JM
Frontiers in aging neuroscience 2018;10:382
Frontiers in aging neuroscience 2018;10:382
Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities.
Nie S, Tan Y, Zhang Z, Chen G, Xiong J, Hu D, Ye K, Zhang Y, Cao X, Chen L, Zhang Z
Frontiers in aging neuroscience 2018;10:303
Frontiers in aging neuroscience 2018;10:303
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.
Zhou Y, Shi J, Chu D, Hu W, Guan Z, Gong CX, Iqbal K, Liu F
Frontiers in aging neuroscience 2018;10:27
Frontiers in aging neuroscience 2018;10:27
Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.
Foidl BM, Humpel C
Frontiers in aging neuroscience 2018;10:113
Frontiers in aging neuroscience 2018;10:113
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R, Crowther RA, Ghetti B, Scheres SHW, Goedert M
Nature 2018 Sep;561(7721):137-140
Nature 2018 Sep;561(7721):137-140
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ
Nature 2018 Oct;562(7728):578-582
Nature 2018 Oct;562(7728):578-582
Estimation of amyloid distribution by [(18)F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition.
Thal DR, Beach TG, Zanette M, Lilja J, Heurling K, Chakrabarty A, Ismail A, Farrar G, Buckley C, Smith APL
Acta neuropathologica 2018 Oct;136(4):557-567
Acta neuropathologica 2018 Oct;136(4):557-567
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, Caselli RJ, Sanchez-Contreras MY, Rademakers R, Murray ME, Koga S, Dickson DW, Ross OA, Bu G
Nature communications 2018 Oct 22;9(1):4388
Nature communications 2018 Oct 22;9(1):4388
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.
Brekk OR, Moskites A, Isacson O, Hallett PJ
Scientific reports 2018 Oct 12;8(1):15207
Scientific reports 2018 Oct 12;8(1):15207
Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment.
Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ
Acta neuropathologica communications 2018 Oct 1;6(1):103
Acta neuropathologica communications 2018 Oct 1;6(1):103
Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease.
Keyvani K, Münster Y, Kurapati NK, Rubach S, Schönborn A, Kocakavuk E, Karout M, Hammesfahr P, Wang YC, Hermann DM, Teuber-Hanselmann S, Herring A
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):947-964
Brain pathology (Zurich, Switzerland) 2018 Nov;28(6):947-964
Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.
Courade JP, Angers R, Mairet-Coello G, Pacico N, Tyson K, Lightwood D, Munro R, McMillan D, Griffin R, Baker T, Starkie D, Nan R, Westwood M, Mushikiwabo ML, Jung S, Odede G, Sweeney B, Popplewell A, Burgess G, Downey P, Citron M
Acta neuropathologica 2018 Nov;136(5):729-745
Acta neuropathologica 2018 Nov;136(5):729-745
Different tau species lead to heterogeneous tau pathology propagation and misfolding.
Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L
Acta neuropathologica communications 2018 Nov 29;6(1):132
Acta neuropathologica communications 2018 Nov 29;6(1):132
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
Zhu Y, Zhan G, Fenik P, Brandes M, Bell P, Francois N, Shulman K, Veasey S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 28;38(48):10255-10270
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 28;38(48):10255-10270
Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.
Mente K, Edwards NA, Urbano D, Ray-Chaudhury A, Iacono D, Alho ATDL, Alho EJL, Amaro E Jr,, Horovitz SG, Hallett M
Movement disorders : official journal of the Movement Disorder Society 2018 May;33(5):827-834
Movement disorders : official journal of the Movement Disorder Society 2018 May;33(5):827-834
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y
Nature medicine 2018 May;24(5):647-657
Nature medicine 2018 May;24(5):647-657
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 May;14(5):680-691
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 May;14(5):680-691
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.
Jaunmuktane Z, Quaegebeur A, Taipa R, Viana-Baptista M, Barbosa R, Koriath C, Sciot R, Mead S, Brandner S
Acta neuropathologica 2018 May;135(5):671-679
Acta neuropathologica 2018 May;135(5):671-679
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Huang C, Irwin MG, Wong GTC, Chang RCC
Journal of neuroinflammation 2018 May 17;15(1):147
Journal of neuroinflammation 2018 May 17;15(1):147
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment.
Stoffel W, Jenke B, Schmidt-Soltau I, Binczek E, Brodesser S, Hammels I
Cell death & disease 2018 May 1;9(5):507
Cell death & disease 2018 May 1;9(5):507
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.
Abu Hamdeh S, Shevchenko G, Mi J, Musunuri S, Bergquist J, Marklund N
Scientific reports 2018 May 1;8(1):6807
Scientific reports 2018 May 1;8(1):6807
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Schapansky J, Khasnavis S, DeAndrade MP, Nardozzi JD, Falkson SR, Boyd JD, Sanderson JB, Bartels T, Melrose HL, LaVoie MJ
Neurobiology of disease 2018 Mar;111:26-35
Neurobiology of disease 2018 Mar;111:26-35
Effects of treadmill exercise on PI3K/AKT/GSK-3β pathway and tau protein in high-fat diet-fed rats.
Jeong JH, Kang EB
Journal of exercise nutrition & biochemistry 2018 Mar 30;22(1):9-14
Journal of exercise nutrition & biochemistry 2018 Mar 30;22(1):9-14
Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients.
Domínguez-Álvaro M, Montero-Crespo M, Blazquez-Llorca L, Insausti R, DeFelipe J, Alonso-Nanclares L
Acta neuropathologica communications 2018 Mar 2;6(1):20
Acta neuropathologica communications 2018 Mar 2;6(1):20
Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.
Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM
Nature communications 2018 Mar 14;9(1):1066
Nature communications 2018 Mar 14;9(1):1066
Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model.
Grimaldi A, Brighi C, Peruzzi G, Ragozzino D, Bonanni V, Limatola C, Ruocco G, Di Angelantonio S
Cell death & disease 2018 Jun 7;9(6):685
Cell death & disease 2018 Jun 7;9(6):685
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B
Acta neuropathologica communications 2018 Jun 29;6(1):52
Acta neuropathologica communications 2018 Jun 29;6(1):52
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH
Neuron 2018 Jun 27;98(6):1141-1154.e7
Neuron 2018 Jun 27;98(6):1141-1154.e7
iPSC-derived familial Alzheimer's PSEN2 (N141I) cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.
Moreno CL, Della Guardia L, Shnyder V, Ortiz-Virumbrales M, Kruglikov I, Zhang B, Schadt EE, Tanzi RE, Noggle S, Buettner C, Gandy S
Molecular neurodegeneration 2018 Jun 26;13(1):33
Molecular neurodegeneration 2018 Jun 26;13(1):33
Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.
Chatterjee M, Del Campo M, Morrema THJ, de Waal M, van der Flier WM, Hoozemans JJM, Teunissen CE
Alzheimer's research & therapy 2018 Jun 1;10(1):52
Alzheimer's research & therapy 2018 Jun 1;10(1):52
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.
Park J, Wetzel I, Marriott I, Dréau D, D'Avanzo C, Kim DY, Tanzi RE, Cho H
Nature neuroscience 2018 Jul;21(7):941-951
Nature neuroscience 2018 Jul;21(7):941-951
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser(422) containing epitope on pathological tau.
van Ameijde J, Crespo R, Janson R, Juraszek J, Siregar B, Verveen H, Sprengers I, Nahar T, Hoozemans JJ, Steinbacher S, Willems R, Delbroek L, Borgers M, Dockx K, Van Kolen K, Mercken M, Pascual G, Koudstaal W, Apetri A
Acta neuropathologica communications 2018 Jul 12;6(1):59
Acta neuropathologica communications 2018 Jul 12;6(1):59
A Multidisciplinary Approach Reveals an Age-Dependent Expression of a Novel Bioactive Peptide, Already Involved in Neurodegeneration, in the Postnatal Rat Forebrain.
Ferrati G, Brai E, Stuart S, Marino C, Greenfield SA
Brain sciences 2018 Jul 10;8(7)
Brain sciences 2018 Jul 10;8(7)
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B
Nature neuroscience 2018 Jan;21(1):72-80
Nature neuroscience 2018 Jan;21(1):72-80
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):74-92
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):74-92
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
Bardai FH, Wang L, Mutreja Y, Yenjerla M, Gamblin TC, Feany MB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):108-119
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):108-119
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S, Gillingwater TH, Abrahams S, Spires-Jones TL
Acta neuropathologica 2018 Feb;135(2):213-226
Acta neuropathologica 2018 Feb;135(2):213-226
A transcriptomic atlas of aged human microglia.
Olah M, Patrick E, Villani AC, Xu J, White CC, Ryan KJ, Piehowski P, Kapasi A, Nejad P, Cimpean M, Connor S, Yung CJ, Frangieh M, McHenry A, Elyaman W, Petyuk V, Schneider JA, Bennett DA, De Jager PL, Bradshaw EM
Nature communications 2018 Feb 7;9(1):539
Nature communications 2018 Feb 7;9(1):539
Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer's disease in wild-type, C57BL/6 mice.
Torres L, Robinson SA, Kim DG, Yan A, Cleland TA, Bynoe MS
Journal of neuroinflammation 2018 Feb 23;15(1):57
Journal of neuroinflammation 2018 Feb 23;15(1):57
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI
The Journal of biological chemistry 2018 Feb 2;293(5):1781-1793
The Journal of biological chemistry 2018 Feb 2;293(5):1781-1793
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.
Youssef P, Chami B, Lim J, Middleton T, Sutherland GT, Witting PK
Scientific reports 2018 Aug 1;8(1):11553
Scientific reports 2018 Aug 1;8(1):11553
A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau.
Valachova B, Brezovakova V, Bugos O, Jadhav S, Smolek T, Novak P, Zilka N
The Journal of comparative neurology 2018 Aug 1;526(11):1777-1789
The Journal of comparative neurology 2018 Aug 1;526(11):1777-1789
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Cuadrado A, Kügler S, Lastres-Becker I
Redox biology 2018 Apr;14:522-534
Redox biology 2018 Apr;14:522-534
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK
Nature communications 2018 Apr 16;9(1):1479
Nature communications 2018 Apr 16;9(1):1479
Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.
Todd KL, Brighton T, Norton ES, Schick S, Elkins W, Pletnikova O, Fortinsky RH, Troncoso JC, Molfese PJ, Resnick SM, Conover JC, Alzheimer’s Disease Neuroimaging Initiative
Frontiers in aging neuroscience 2017;9:445
Frontiers in aging neuroscience 2017;9:445
Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.
Ferguson SA, Mouzon BC, Lynch C, Lungmus C, Morin A, Crynen G, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F
Frontiers in aging neuroscience 2017;9:416
Frontiers in aging neuroscience 2017;9:416
A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.
Yang Z, Kuboyama T, Tohda C
Frontiers in pharmacology 2017;8:340
Frontiers in pharmacology 2017;8:340
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.
Leino M, Popova SN, Alafuzoff I
Journal of Alzheimer's disease : JAD 2017;59(1):43-56
Journal of Alzheimer's disease : JAD 2017;59(1):43-56
A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.
Hashimoto H, Kawabe T, Fukuda T, Kusakabe M
Neuro-degenerative diseases 2017;17(4-5):181-198
Neuro-degenerative diseases 2017;17(4-5):181-198
Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.
Blanken AE, Hurtz S, Zarow C, Biado K, Honarpisheh H, Somme J, Brook J, Tung S, Kraft E, Lo D, Ng DW, Vinters HV, Apostolova LG
NeuroImage. Clinical 2017;15:56-61
NeuroImage. Clinical 2017;15:56-61
Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.
Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G
PloS one 2017;12(8):e0182844
PloS one 2017;12(8):e0182844
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
Ibáñez-Salazar A, Bañuelos-Hernández B, Rodríguez-Leyva I, Chi-Ahumada E, Monreal-Escalante E, Jiménez-Capdeville ME, Rosales-Mendoza S
Frontiers in neuroscience 2017;11:495
Frontiers in neuroscience 2017;11:495
A Novel Ex Vivo Model to Investigate the Underlying Mechanisms in Alzheimer's Disease.
Brai E, Stuart S, Badin AS, Greenfield SA
Frontiers in cellular neuroscience 2017;11:291
Frontiers in cellular neuroscience 2017;11:291
Adrenomedullin Contributes to Age-Related Memory Loss in Mice and Is Elevated in Aging Human Brains.
Larrayoz IM, Ferrero H, Martisova E, Gil-Bea FJ, Ramírez MJ, Martínez A
Frontiers in molecular neuroscience 2017;10:384
Frontiers in molecular neuroscience 2017;10:384
The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.
Di Primio C, Quercioli V, Siano G, Rovere M, Kovacech B, Novak M, Cattaneo A
Frontiers in molecular neuroscience 2017;10:210
Frontiers in molecular neuroscience 2017;10:210
Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea.
Lee KH, Seo SW, Lim TS, Kim EJ, Kim BC, Kim Y, Lee HW, Jeon JP, Shim SM, Na DL, Huh GY, Lee MC, Suh YL
Yonsei medical journal 2017 Sep;58(5):1055-1060
Yonsei medical journal 2017 Sep;58(5):1055-1060
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M
Scientific reports 2017 Sep 18;7(1):11771
Scientific reports 2017 Sep 18;7(1):11771
Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model.
Mardini F, Tang JX, Li JC, Arroliga MJ, Eckenhoff RG, Eckenhoff MF
British journal of anaesthesia 2017 Sep 1;119(3):472-480
British journal of anaesthesia 2017 Sep 1;119(3):472-480
Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1-42) synaptotoxicity.
Qu X, Yuan FN, Corona C, Pasini S, Pero ME, Gundersen GG, Shelanski ML, Bartolini F
The Journal of cell biology 2017 Oct 2;216(10):3161-3178
The Journal of cell biology 2017 Oct 2;216(10):3161-3178
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL
Scientific reports 2017 Oct 19;7(1):13556
Scientific reports 2017 Oct 19;7(1):13556
Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.
Yan Z, Liao H, Chen H, Deng S, Jia Y, Deng C, Lin J, Ge J, Zhuo Y
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5434-5443
Investigative ophthalmology & visual science 2017 Oct 1;58(12):5434-5443
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME
Acta neuropathologica 2017 Nov;134(5):769-788
Acta neuropathologica 2017 Nov;134(5):769-788
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D
The Journal of biological chemistry 2017 Nov 24;292(47):19209-19225
The Journal of biological chemistry 2017 Nov 24;292(47):19209-19225
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Cisbani G, Maxan A, Kordower JH, Planel E, Freeman TB, Cicchetti F
Brain : a journal of neurology 2017 Nov 1;140(11):2982-2992
Brain : a journal of neurology 2017 Nov 1;140(11):2982-2992
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Chanu SI, Sarkar S
Molecular neurobiology 2017 May;54(4):2706-2719
Molecular neurobiology 2017 May;54(4):2706-2719
Tau-positive nuclear indentations in P301S tauopathy mice.
Fernández-Nogales M, Santos-Galindo M, Merchán-Rubira J, Hoozemans JJM, Rábano A, Ferrer I, Avila J, Hernández F, Lucas JJ
Brain pathology (Zurich, Switzerland) 2017 May;27(3):314-322
Brain pathology (Zurich, Switzerland) 2017 May;27(3):314-322
Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.
Yoshida K, Hata Y, Kinoshita K, Takashima S, Tanaka K, Nishida N
Acta neuropathologica 2017 May;133(5):809-823
Acta neuropathologica 2017 May;133(5):809-823
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM, Alzheimer’s Disease Neuroimaging Initiative
Acta neuropathologica 2017 May;133(5):785-807
Acta neuropathologica 2017 May;133(5):785-807
Tau association with synaptic vesicles causes presynaptic dysfunction.
Zhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, De Wit J, Verstreken P
Nature communications 2017 May 11;8:15295
Nature communications 2017 May 11;8:15295
Development of [(11)C]/[(3)H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.
Stepanov V, Svedberg M, Jia Z, Krasikova R, Lemoine L, Okamura N, Furumoto S, Mitsios N, Mulder J, Långström B, Nordberg A, Halldin C
Nuclear medicine and biology 2017 Mar;46:50-53
Nuclear medicine and biology 2017 Mar;46:50-53
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, Bäumer V, Engelborghs S, De Bleecker J, Baets J, Gelpi E, Rojas-García R, Clarimón J, Lleó A, Diehl-Schmid J, Alexopoulos P, Perneczky R, Synofzik M, Just J, Schöls L, Graff C, Thonberg H, Borroni B, Padovani A, Jordanova A, Sarafov S, Tournev I, de Mendonça A, Miltenberger-Miltényi G, Simões do Couto F, Ramirez A, Jessen F, Heneka MT, Gómez-Tortosa E, Danek A, Cras P, Vandenberghe R, De Jonghe P, De Deyn PP, Sleegers K, Cruts M, Van Broeckhoven C, Goeman J, Nuytten D, Smets K, Robberecht W, Damme PV, Bleecker J, Santens P, Dermaut B, Versijpt J, Michotte A, Ivanoiu A, Deryck O, Bergmans B, Delbeck J, Bruyland M, Willems C, Salmon E, Pastor P, Ortega-Cubero S, Benussi L, Ghidoni R, Binetti G, Hernández I, Boada M, Ruiz A, Sorbi S, Nacmias B, Bagnoli S, Sorbi S, Sanchez-Valle R, Llado A, Santana I, Rosário Almeida M, Frisoni GB, Maetzler W, Matej R, Fraidakis MJ, Kovacs GG, Fabrizi GM, Testi S
Human mutation 2017 Mar;38(3):297-309
Human mutation 2017 Mar;38(3):297-309
Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury.
Acosta SA, Tajiri N, Sanberg PR, Kaneko Y, Borlongan CV
Journal of cellular physiology 2017 Mar;232(3):665-677
Journal of cellular physiology 2017 Mar;232(3):665-677
Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.
Shively SB, Edgerton SL, Iacono D, Purohit DP, Qu BX, Haroutunian V, Davis KL, Diaz-Arrastia R, Perl DP
Acta neuropathologica 2017 Mar;133(3):353-366
Acta neuropathologica 2017 Mar;133(3):353-366
Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.
Ling H, Morris HR, Neal JW, Lees AJ, Hardy J, Holton JL, Revesz T, Williams DD
Acta neuropathologica 2017 Mar;133(3):337-352
Acta neuropathologica 2017 Mar;133(3):337-352
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, Hardy J, Leroy K, Brion JP, Vanderhaeghen P, De Strooper B
Neuron 2017 Mar 8;93(5):1066-1081.e8
Neuron 2017 Mar 8;93(5):1066-1081.e8
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K
Nature communications 2017 Mar 27;8:14740
Nature communications 2017 Mar 27;8:14740
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 22;37(12):3181-3191
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 22;37(12):3181-3191
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Trzeciakiewicz H, Tseng JH, Wander CM, Madden V, Tripathy A, Yuan CX, Cohen TJ
Scientific reports 2017 Mar 13;7:44102
Scientific reports 2017 Mar 13;7:44102
Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA
Neurobiology of aging 2017 Jun;54:59-70
Neurobiology of aging 2017 Jun;54:59-70
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.
Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B
Molecular psychiatry 2017 Jun;22(6):874-883
Molecular psychiatry 2017 Jun;22(6):874-883
Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.
Kobayashi S, Tanaka T, Soeda Y, Almeida OFX, Takashima A
EBioMedicine 2017 Jun;20:120-126
EBioMedicine 2017 Jun;20:120-126
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S
The American journal of pathology 2017 Jun;187(6):1399-1412
The American journal of pathology 2017 Jun;187(6):1399-1412
Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.
Zhu H, Xue X, Wang E, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ
Neuropharmacology 2017 Jun;119:170-181
Neuropharmacology 2017 Jun;119:170-181
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies.
Querol-Vilaseca M, Colom-Cadena M, Pegueroles J, San Martín-Paniello C, Clarimon J, Belbin O, Fortea J, Lleó A
Journal of neuroinflammation 2017 Jun 9;14(1):118
Journal of neuroinflammation 2017 Jun 9;14(1):118
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G
eLife 2017 Jun 26;6
eLife 2017 Jun 26;6
Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.
Kim E, Sakata K, Liao FF
PLoS genetics 2017 Jul;13(7):e1006849
PLoS genetics 2017 Jul;13(7):e1006849
Cryo-EM structures of tau filaments from Alzheimer's disease.
Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW
Nature 2017 Jul 13;547(7662):185-190
Nature 2017 Jul 13;547(7662):185-190
Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration.
Hennessy E, Gormley S, Lopez-Rodriguez AB, Murray C, Murray C, Cunningham C
Brain, behavior, and immunity 2017 Jan;59:233-244
Brain, behavior, and immunity 2017 Jan;59:233-244
Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model.
Park TS, Ryu YK, Park HY, Kim JY, Go J, Noh JR, Kim YH, Hwang JH, Choi DH, Oh WK, Lee CH, Kim KS
International journal of molecular medicine 2017 Jan;39(1):21-30
International journal of molecular medicine 2017 Jan;39(1):21-30
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.
Braak H, Ludolph AC, Neumann M, Ravits J, Del Tredici K
Acta neuropathologica 2017 Jan;133(1):79-90
Acta neuropathologica 2017 Jan;133(1):79-90
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice.
Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):598-609
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):598-609
Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.
Jayakumar AR, Tong XY, Shamaladevi N, Barcelona S, Gaidosh G, Agarwal A, Norenberg MD
Journal of neurochemistry 2017 Feb;140(4):645-661
Journal of neurochemistry 2017 Feb;140(4):645-661
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE
Neuron 2017 Feb 8;93(3):533-541.e5
Neuron 2017 Feb 8;93(3):533-541.e5
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.
Lauretti E, Praticò D
Scientific reports 2017 Dec 7;7(1):17134
Scientific reports 2017 Dec 7;7(1):17134
A Single Neonatal Exposure to BMAA in a Rat Model Produces Neuropathology Consistent with Neurodegenerative Diseases.
Scott LL, Downing TG
Toxins 2017 Dec 29;10(1)
Toxins 2017 Dec 29;10(1)
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL
Stem cell reports 2017 Dec 12;9(6):1868-1884
Stem cell reports 2017 Dec 12;9(6):1868-1884
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
Lauretti E, Iuliano L, Praticò D
Annals of clinical and translational neurology 2017 Aug;4(8):564-574
Annals of clinical and translational neurology 2017 Aug;4(8):564-574
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.
Tseng JH, Xie L, Song S, Xie Y, Allen L, Ajit D, Hong JS, Chen X, Meeker RB, Cohen TJ
Cell reports 2017 Aug 29;20(9):2169-2183
Cell reports 2017 Aug 29;20(9):2169-2183
Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring.
Ramos-Rodriguez JJ, Sanchez-Sotano D, Doblas-Marquez A, Infante-Garcia C, Lubian-Lopez S, Garcia-Alloza M
Molecular neurodegeneration 2017 Aug 2;12(1):57
Molecular neurodegeneration 2017 Aug 2;12(1):57
Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.
Postupna N, Latimer CS, Larson EB, Sherfield E, Paladin J, Shively CA, Jorgensen MJ, Andrews RN, Kaplan JR, Crane PK, Montine KS, Craft S, Keene CD, Montine TJ
The American journal of pathology 2017 Apr;187(4):884-895
The American journal of pathology 2017 Apr;187(4):884-895
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J
Aging cell 2017 Apr;16(2):377-386
Aging cell 2017 Apr;16(2):377-386
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Li JG, Barrero C, Merali S, Praticò D
Scientific reports 2017 Apr 6;7:46002
Scientific reports 2017 Apr 6;7:46002
Early neurovascular dysfunction in a transgenic rat model of Alzheimer's disease.
Joo IL, Lai AY, Bazzigaluppi P, Koletar MM, Dorr A, Brown ME, Thomason LA, Sled JG, McLaurin J, Stefanovic B
Scientific reports 2017 Apr 12;7:46427
Scientific reports 2017 Apr 12;7:46427
Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.
Chen X, Wagener JF, Ghribi O, Geiger JD
Frontiers in aging neuroscience 2016;8:129
Frontiers in aging neuroscience 2016;8:129
Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease.
Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H, Davis S
Journal of Alzheimer's disease : JAD 2016;51(4):1157-73
Journal of Alzheimer's disease : JAD 2016;51(4):1157-73
Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease.
Rábano A, Cuadros R, Merino-Serráis P, Rodal I, Benavides-Piccione R, Gómez E, Medina M, DeFelipe J, Avila J
Methods in molecular biology (Clifton, N.J.) 2016;1303:143-60
Methods in molecular biology (Clifton, N.J.) 2016;1303:143-60
Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction.
Yetman MJ, Fowler SW, Jankowsky JL
PloS one 2016;11(4):e0153724
PloS one 2016;11(4):e0153724
Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.
Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG
PloS one 2016;11(3):e0151615
PloS one 2016;11(3):e0151615
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH, Gilead S, Nadeem M, Dodiya HB, Shoaga S, Mufson EJ, Tsubery H, Krishnan R, Wright J, Solomon B, Fisher R, Gannon KS
Alzheimer's & dementia (New York, N. Y.) 2016 Sep;2(3):141-155
Alzheimer's & dementia (New York, N. Y.) 2016 Sep;2(3):141-155
Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.
Mansuroglu Z, Benhelli-Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, Delattre L, Loyens A, Talahari S, Bégard S, Nesslany F, Colin M, Souès S, Lefebvre B, Buée L, Galas MC, Bonnefoy E
Scientific reports 2016 Sep 8;6:33047
Scientific reports 2016 Sep 8;6:33047
Late running is not too late against Alzheimer's pathology.
Herring A, Münster Y, Metzdorf J, Bolczek B, Krüssel S, Krieter D, Yavuz I, Karim F, Roggendorf C, Stang A, Wang Y, Hermann DM, Teuber-Hanselmann S, Keyvani K
Neurobiology of disease 2016 Oct;94:44-54
Neurobiology of disease 2016 Oct;94:44-54
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, Ndjim M, Vergara C, Belkouch M, Potier MC, Duyckaerts C, Brion JP
Neurobiology of disease 2016 Oct;94:32-43
Neurobiology of disease 2016 Oct;94:32-43
Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ
Aging cell 2016 Oct;15(5):924-39
Aging cell 2016 Oct;15(5):924-39
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M
Aging cell 2016 Oct;15(5):914-23
Aging cell 2016 Oct;15(5):914-23
Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study.
Plowey ED, Ziskin JL
Acta neuropathologica communications 2016 Oct 28;4(1):114
Acta neuropathologica communications 2016 Oct 28;4(1):114
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A
Autophagy 2016 Oct 2;12(10):1902-1916
Autophagy 2016 Oct 2;12(10):1902-1916
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H
EMBO molecular medicine 2016 May;8(5):458-65
EMBO molecular medicine 2016 May;8(5):458-65
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
Merlini M, Wanner D, Nitsch RM
Acta neuropathologica 2016 May;131(5):737-52
Acta neuropathologica 2016 May;131(5):737-52
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.
Villaseñor R, Ozmen L, Messaddeq N, Grüninger F, Loetscher H, Keller A, Betsholtz C, Freskgård PO, Collin L
Scientific reports 2016 May 6;6:25658
Scientific reports 2016 May 6;6:25658
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J
Neuron 2016 May 18;90(4):724-39
Neuron 2016 May 18;90(4):724-39
Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases.
Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ
Journal of neuropathology and experimental neurology 2016 Mar;75(3):256-62
Journal of neuropathology and experimental neurology 2016 Mar;75(3):256-62
Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
Perez SE, Sherwood CC, Cranfield MR, Erwin JM, Mudakikwa A, Hof PR, Mufson EJ
Neurobiology of aging 2016 Mar;39:195-201
Neurobiology of aging 2016 Mar;39:195-201
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Di Meco A, Joshi YB, Lauretti E, Praticò D
Molecular psychiatry 2016 Mar;21(3):403-10
Molecular psychiatry 2016 Mar;21(3):403-10
Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.
Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP
The American journal of pathology 2016 Mar;186(3):552-67
The American journal of pathology 2016 Mar;186(3):552-67
Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
Peng Y, Kim MJ, Hullinger R, O'Riordan KJ, Burger C, Pehar M, Puglielli L
Brain : a journal of neurology 2016 Mar;139(Pt 3):937-52
Brain : a journal of neurology 2016 Mar;139(Pt 3):937-52
Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.
Sabogal-Guáqueta AM, Osorio E, Cardona-Gómez GP
Neuropharmacology 2016 Mar;102:111-20
Neuropharmacology 2016 Mar;102:111-20
TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.
Wang H, Wang R, Carrera I, Xu S, Lakshmana MK
eNeuro 2016 Mar-Apr;3(2)
eNeuro 2016 Mar-Apr;3(2)
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L
Scientific reports 2016 Mar 4;6:22685
Scientific reports 2016 Mar 4;6:22685
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A
Acta neuropathologica communications 2016 Mar 2;4:22
Acta neuropathologica communications 2016 Mar 2;4:22
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
Smolek T, Madari A, Farbakova J, Kandrac O, Jadhav S, Cente M, Brezovakova V, Novak M, Zilka N
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.
Garcia-Ratés S, Morrill P, Tu H, Pottiez G, Badin AS, Tormo-Garcia C, Heffner C, Coen CW, Greenfield SA
Neuropharmacology 2016 Jun;105:487-499
Neuropharmacology 2016 Jun;105:487-499
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Jiang T, Zhang YD, Chen Q, Gao Q, Zhu XC, Zhou JS, Shi JQ, Lu H, Tan L, Yu JT
Neuropharmacology 2016 Jun;105:196-206
Neuropharmacology 2016 Jun;105:196-206
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L
Molecular neurodegeneration 2016 Jun 29;11(1):47
Molecular neurodegeneration 2016 Jun 29;11(1):47
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M
Acta neuropathologica communications 2016 Jun 23;4(1):63
Acta neuropathologica communications 2016 Jun 23;4(1):63
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Polanco JC, Scicluna BJ, Hill AF, Götz J
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment.
Watamura N, Toba J, Yoshii A, Nikkuni M, Ohshima T
Journal of neuroscience research 2016 Jan;94(1):15-26
Journal of neuroscience research 2016 Jan;94(1):15-26
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.
Tapia-Rojas C, Aranguiz F, Varela-Nallar L, Inestrosa NC
Brain pathology (Zurich, Switzerland) 2016 Jan;26(1):62-74
Brain pathology (Zurich, Switzerland) 2016 Jan;26(1):62-74
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Rosenberger AF, Morrema TH, Gerritsen WH, van Haastert ES, Snkhchyan H, Hilhorst R, Rozemuller AJ, Scheltens P, van der Vies SM, Hoozemans JJ
Journal of neuroinflammation 2016 Jan 6;13:4
Journal of neuroinflammation 2016 Jan 6;13:4
Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.
Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 13;36(2):561-76
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 13;36(2):561-76
Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway.
Liu HS, Shi HL, Huang F, Peterson KE, Wu H, Lan YY, Zhang BB, He YX, Woods T, Du M, Wu XJ, Wang ZT
Scientific reports 2016 Jan 11;6:19137
Scientific reports 2016 Jan 11;6:19137
Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury.
Pamphlett R, Kum Jew S
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2016 Feb;29(1):171-5
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2016 Feb;29(1):171-5
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.
Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, Trojanowski JQ, Vinters HV, Zhou XH, Hyman BT
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Feb;12(2):164-169
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Feb;12(2):164-169
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP
Neuroscience 2016 Feb 19;315:162-74
Neuroscience 2016 Feb 19;315:162-74
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, Zahel J, Sanchez-Mendoza E, Wang Y, Hermann DM, Arzberger T, Teuber-Hanselmann S, Keyvani K
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Dec;12(12):1273-1287
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Dec;12(12):1273-1287
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 27;113(52):15120-15125
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 27;113(52):15120-15125
Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.
Ikonomovic MD, Buckley CJ, Heurling K, Sherwin P, Jones PA, Zanette M, Mathis CA, Klunk WE, Chakrabarty A, Ironside J, Ismail A, Smith C, Thal DR, Beach TG, Farrar G, Smith AP
Acta neuropathologica communications 2016 Dec 12;4(1):130
Acta neuropathologica communications 2016 Dec 12;4(1):130
Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.
Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N
Cell death & disease 2016 Dec 1;7(12):e2499
Cell death & disease 2016 Dec 1;7(12):e2499
Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.
Adams SL, Tilton K, Kozubek JA, Seshadri S, Delalle I
Journal of neuropathology and experimental neurology 2016 Aug;75(8):779-790
Journal of neuropathology and experimental neurology 2016 Aug;75(8):779-790
Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains.
Nagamine S, Yamazaki T, Makioka K, Fujita Y, Ikeda M, Takatama M, Okamoto K, Yokoo H, Ikeda Y
Neuropathology : official journal of the Japanese Society of Neuropathology 2016 Aug;36(4):333-45
Neuropathology : official journal of the Japanese Society of Neuropathology 2016 Aug;36(4):333-45
Neuronal activity enhances tau propagation and tau pathology in vivo.
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE
Nature neuroscience 2016 Aug;19(8):1085-92
Nature neuroscience 2016 Aug;19(8):1085-92
Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series.
Shively SB, Horkayne-Szakaly I, Jones RV, Kelly JP, Armstrong RC, Perl DP
The Lancet. Neurology 2016 Aug;15(9):944-953
The Lancet. Neurology 2016 Aug;15(9):944-953
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A, Scearce-Levie K, Ayalon G
Cell reports 2016 Aug 9;16(6):1690-1700
Cell reports 2016 Aug 9;16(6):1690-1700
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
Acta neuropathologica communications 2016 Aug 26;4(1):91
Acta neuropathologica communications 2016 Aug 26;4(1):91
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.
Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE
Cell chemical biology 2016 Aug 18;23(8):992-1001
Cell chemical biology 2016 Aug 18;23(8):992-1001
Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia.
Pratt D, Mente K, Rahimpour S, Edwards NA, Tinaz S, Berman BD, Hallett M, Ray-Chaudhury A
Acta neuropathologica communications 2016 Aug 17;4(1):85
Acta neuropathologica communications 2016 Aug 17;4(1):85
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E
Neurobiology of disease 2016 Apr;88:55-65
Neurobiology of disease 2016 Apr;88:55-65
Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.
Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD
Neuropathology : official journal of the Japanese Society of Neuropathology 2016 Apr;36(2):135-45
Neuropathology : official journal of the Japanese Society of Neuropathology 2016 Apr;36(2):135-45
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L
EMBO reports 2016 Apr;17(4):530-51
EMBO reports 2016 Apr;17(4):530-51
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Vasconcelos B, Stancu IC, Buist A, Bird M, Wang P, Vanoosthuyse A, Van Kolen K, Verheyen A, Kienlen-Campard P, Octave JN, Baatsen P, Moechars D, Dewachter I
Acta neuropathologica 2016 Apr;131(4):549-69
Acta neuropathologica 2016 Apr;131(4):549-69
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Van der Jeugd A, Vermaercke B, Halliday GM, Staufenbiel M, Götz J
Neurobiology of learning and memory 2016 Apr;130:34-43
Neurobiology of learning and memory 2016 Apr;130:34-43
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H
Acta neuropathologica communications 2016 Apr 4;4:36
Acta neuropathologica communications 2016 Apr 4;4:36
High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.
Bouvier DS, Jones EV, Quesseveur G, Davoli MA, A Ferreira T, Quirion R, Mechawar N, Murai KK
Scientific reports 2016 Apr 19;6:24544
Scientific reports 2016 Apr 19;6:24544
Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease.
Garza-Manero S, Arias C, Bermúdez-Rattoni F, Vaca L, Zepeda A
Frontiers in cellular neuroscience 2015;9:53
Frontiers in cellular neuroscience 2015;9:53
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP
Frontiers in cellular neuroscience 2015;9:498
Frontiers in cellular neuroscience 2015;9:498
Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.
Iacono D, Geraci-Erck M, Peng H, Rabin ML, Kurlan R
Tremor and other hyperkinetic movements (New York, N.Y.) 2015;5
Tremor and other hyperkinetic movements (New York, N.Y.) 2015;5
Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease.
Pamphlett R, Kum Jew S
Journal of Alzheimer's disease : JAD 2015;45(2):437-47
Journal of Alzheimer's disease : JAD 2015;45(2):437-47
Dexmedetomidine directly increases tau phosphorylation.
Huang C, Ho YS, Ng OT, Irwin MG, Chang RC, Wong GT
Journal of Alzheimer's disease : JAD 2015;44(3):839-50
Journal of Alzheimer's disease : JAD 2015;44(3):839-50
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study.
Krudop WA, Bosman S, Geurts JJ, Sikkes SA, Verwey NA, Stek ML, Scheltens P, Rozemuller AJ, Pijnenburg YA
Dementia and geriatric cognitive disorders 2015;40(3-4):121-9
Dementia and geriatric cognitive disorders 2015;40(3-4):121-9
Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus.
Du LY, Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML
PloS one 2015;10(8):e0135499
PloS one 2015;10(8):e0135499
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
Eggers SD, Horn AK, Roeber S, Härtig W, Nair G, Reich DS, Leigh RJ
PloS one 2015;10(7):e0132075
PloS one 2015;10(7):e0132075
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.
Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M
PloS one 2015;10(5):e0125614
PloS one 2015;10(5):e0125614
Role of Liver X Receptor in AD Pathophysiology.
Sandoval-Hernández AG, Buitrago L, Moreno H, Cardona-Gómez GP, Arboleda G
PloS one 2015;10(12):e0145467
PloS one 2015;10(12):e0145467
Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease.
Zeineh MM, Chen Y, Kitzler HH, Hammond R, Vogel H, Rutt BK
Neurobiology of aging 2015 Sep;36(9):2483-500
Neurobiology of aging 2015 Sep;36(9):2483-500
Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.
Sun LH, Ban T, Liu CD, Chen QX, Wang X, Yan ML, Hu XL, Su XL, Bao YN, Sun LL, Zhao LJ, Pei SC, Jiang XM, Zong DK, Ai J
Journal of neurochemistry 2015 Sep;134(6):1139-51
Journal of neurochemistry 2015 Sep;134(6):1139-51
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Kim JM, Kim SS, Lee YD
Neuroreport 2015 Sep 9;26(13):767-72
Neuroreport 2015 Sep 9;26(13):767-72
Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse.
Henstridge CM, Jackson RJ, Kim JM, Herrmann AG, Wright AK, Harris SE, Bastin ME, Starr JM, Wardlaw J, Gillingwater TH, Smith C, McKenzie CA, Cox SR, Deary IJ, Spires-Jones TL
Acta neuropathologica communications 2015 Sep 4;3:53
Acta neuropathologica communications 2015 Sep 4;3:53
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.
Sottejeau Y, Bretteville A, Cantrelle FX, Malmanche N, Demiaute F, Mendes T, Delay C, Alves Dos Alves H, Flaig A, Davies P, Dourlen P, Dermaut B, Laporte J, Amouyel P, Lippens G, Chapuis J, Landrieu I, Lambert JC
Acta neuropathologica communications 2015 Sep 23;3:58
Acta neuropathologica communications 2015 Sep 23;3:58
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI
Journal of neuroscience research 2015 Oct;93(10):1567-80
Journal of neuroscience research 2015 Oct;93(10):1567-80
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R, Lefebvre B, Bonnefoy E, Buée L, Galas MC
Neurobiology of disease 2015 Oct;82:540-551
Neurobiology of disease 2015 Oct;82:540-551
At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.
Reis R, Hennessy E, Murray C, Griffin ÉW, Cunningham C
Neuropathology and applied neurobiology 2015 Oct;41(6):780-97
Neuropathology and applied neurobiology 2015 Oct;41(6):780-97
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L
Nature medicine 2015 Oct;21(10):1154-62
Nature medicine 2015 Oct;21(10):1154-62
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.
Chauhan S, Ahmed Z, Bradfute SB, Arko-Mensah J, Mandell MA, Won Choi S, Kimura T, Blanchet F, Waller A, Mudd MH, Jiang S, Sklar L, Timmins GS, Maphis N, Bhaskar K, Piguet V, Deretic V
Nature communications 2015 Oct 27;6:8620
Nature communications 2015 Oct 27;6:8620
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM
Molecular neurodegeneration 2015 Oct 26;10:55
Molecular neurodegeneration 2015 Oct 26;10:55
Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T
Nature neuroscience 2015 Nov;18(11):1584-93
Nature neuroscience 2015 Nov;18(11):1584-93
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR
Acta neuropathologica 2015 Nov;130(5):633-42
Acta neuropathologica 2015 Nov;130(5):633-42
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M
Acta neuropathologica 2015 Nov;130(5):619-31
Acta neuropathologica 2015 Nov;130(5):619-31
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Hunt JB Jr, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, Sandusky LA, Gordon MN, Morgan D, Lee DC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Nov 4;35(44):14842-60
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Nov 4;35(44):14842-60
Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus.
Elobeid A, Laurell K, Cesarini KG, Alafuzoff I
Journal of neuropathology and experimental neurology 2015 May;74(5):470-9
Journal of neuropathology and experimental neurology 2015 May;74(5):470-9
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.
Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers JC
Experimental neurology 2015 May;267:219-29
Experimental neurology 2015 May;267:219-29
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Li R, Xu DE, Ma T
Neuroscience 2015 May 21;294:14-20
Neuroscience 2015 May 21;294:14-20
Isolation and characterization of antibody fragments selective for toxic oligomeric tau.
Tian H, Davidowitz E, Lopez P, He P, Schulz P, Moe J, Sierks MR
Neurobiology of aging 2015 Mar;36(3):1342-55
Neurobiology of aging 2015 Mar;36(3):1342-55
Aneuploidy in Lewy body diseases.
Yang Y, Shepherd C, Halliday G
Neurobiology of aging 2015 Mar;36(3):1253-60
Neurobiology of aging 2015 Mar;36(3):1253-60
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT
The Journal of experimental medicine 2015 Mar 9;212(3):287-95
The Journal of experimental medicine 2015 Mar 9;212(3):287-95
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, Wang X, Hyde L, Hess JF, Parker EM, Zhang L
Molecular neurodegeneration 2015 Mar 26;10:14
Molecular neurodegeneration 2015 Mar 26;10:14
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.
Leinenga G, Götz J
Science translational medicine 2015 Mar 11;7(278):278ra33
Science translational medicine 2015 Mar 11;7(278):278ra33
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
Sabogal-Guáqueta AM, Muñoz-Manco JI, Ramírez-Pineda JR, Lamprea-Rodriguez M, Osorio E, Cardona-Gómez GP
Neuropharmacology 2015 Jun;93:134-45
Neuropharmacology 2015 Jun;93:134-45
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, Lamb BT, Bhaskar K
Brain : a journal of neurology 2015 Jun;138(Pt 6):1738-55
Brain : a journal of neurology 2015 Jun;138(Pt 6):1738-55
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM
Scientific reports 2015 Jun 9;5:11161
Scientific reports 2015 Jun 9;5:11161
TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices.
Lue LF, Schmitz CT, Serrano G, Sue LI, Beach TG, Walker DG
Brain pathology (Zurich, Switzerland) 2015 Jul;25(4):469-80
Brain pathology (Zurich, Switzerland) 2015 Jul;25(4):469-80
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.
Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MK, Lee JH, Chen C, Ballard C, Hortobágyi T, Francis PT
Brain pathology (Zurich, Switzerland) 2015 Jul;25(4):401-8
Brain pathology (Zurich, Switzerland) 2015 Jul;25(4):401-8
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
Filipcik P, Cente M, Zilka N, Smolek T, Hanes J, Kucerak J, Opattova A, Kovacech B, Novak M
Biochimica et biophysica acta 2015 Jul;1852(7):1219-29
Biochimica et biophysica acta 2015 Jul;1852(7):1219-29
A 3D human neural cell culture system for modeling Alzheimer's disease.
Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY
Nature protocols 2015 Jul;10(7):985-1006
Nature protocols 2015 Jul;10(7):985-1006
Reelin protects against amyloid β toxicity in vivo.
Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J
Science signaling 2015 Jul 7;8(384):ra67
Science signaling 2015 Jul 7;8(384):ra67
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia.
Ziskin JL, Greicius MD, Zhu W, Okumu AN, Adams CM, Plowey ED
Acta neuropathologica communications 2015 Jul 10;3:43
Acta neuropathologica communications 2015 Jul 10;3:43
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM
Journal of neurochemistry 2015 Jan;132(1):135-45
Journal of neurochemistry 2015 Jan;132(1):135-45
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.
Spilsbury A, Miwa S, Attems J, Saretzki G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 28;35(4):1659-74
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jan 28;35(4):1659-74
Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.
Postupna N, Keene CD, Crane PK, Gonzalez-Cuyar LF, Sonnen JA, Hewitt J, Rice S, Howard K, Montine KS, Larson EB, Montine TJ
Journal of neuropathology and experimental neurology 2015 Feb;74(2):100-9
Journal of neuropathology and experimental neurology 2015 Feb;74(2):100-9
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Lauretti E, Di Meco A, Chu J, Praticò D
Neurobiology of aging 2015 Feb;36(2):812-20
Neurobiology of aging 2015 Feb;36(2):812-20
Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.
Apostolova LG, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, Honarpisheh H, Blanken AE, Brook J, Tung S, Lo D, Ng D, Alger JR, Vinters HV, Bocchetta M, Duvernoy H, Jack CR Jr, Frisoni GB, EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Feb;11(2):139-50
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Feb;11(2):139-50
Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase.
Lauretti E, Praticò D
Aging cell 2015 Dec;14(6):1067-74
Aging cell 2015 Dec;14(6):1067-74
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Schwab AJ, Ebert AD
Stem cell reports 2015 Dec 8;5(6):1039-1052
Stem cell reports 2015 Dec 8;5(6):1039-1052
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A
Molecular brain 2015 Dec 4;8(1):82
Molecular brain 2015 Dec 4;8(1):82
Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury.
Gyoneva S, Kim D, Katsumoto A, Kokiko-Cochran ON, Lamb BT, Ransohoff RM
Journal of neuroinflammation 2015 Dec 3;12:228
Journal of neuroinflammation 2015 Dec 3;12:228
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, Ripova D
Journal of neuroimmunology 2015 Dec 15;289:121-9
Journal of neuroimmunology 2015 Dec 15;289:121-9
The domestic cat as a natural animal model of Alzheimer's disease.
Chambers JK, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, Tomiyama T, Une Y, Nakayama H
Acta neuropathologica communications 2015 Dec 10;3:78
Acta neuropathologica communications 2015 Dec 10;3:78
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, Bennett DA, Fernandez-Gomez FJ, Sergeant N, Buée L, Tremblay MÈ, Calon F, Hébert SS
Human molecular genetics 2015 Dec 1;24(23):6721-35
Human molecular genetics 2015 Dec 1;24(23):6721-35
[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-β pathology.
Thal DR, Beach TG, Zanette M, Heurling K, Chakrabarty A, Ismail A, Smith AP, Buckley C
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Aug;11(8):975-85
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 Aug;11(8):975-85
Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.
Walker DG, Whetzel AM, Lue LF
Neuroscience 2015 Aug 27;302:121-37
Neuroscience 2015 Aug 27;302:121-37
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Lee IS, Jung K, Kim IS, Lee H, Kim M, Yun S, Hwang K, Shin JE, Park KI
Molecular neurodegeneration 2015 Aug 21;10:38
Molecular neurodegeneration 2015 Aug 21;10:38
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology.
Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ
Journal of neuropathology and experimental neurology 2015 Apr;74(4):345-58
Journal of neuropathology and experimental neurology 2015 Apr;74(4):345-58
Array tomography for the detection of non-dilated, injured axons in traumatic brain injury.
Bennett RE, Brody DL
Journal of neuroscience methods 2015 Apr 30;245:25-36
Journal of neuroscience methods 2015 Apr 30;245:25-36
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger JJ, Zerbinatti C
PloS one 2014;9(7):e103187
PloS one 2014;9(7):e103187
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E
PloS one 2014;9(5):e94251
PloS one 2014;9(5):e94251
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
Kim HJ, Chang KA, Ha TY, Kim J, Ha S, Shin KY, Moon C, Nacken W, Kim HS, Suh YH
PloS one 2014;9(2):e88924
PloS one 2014;9(2):e88924
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Höllerhage M, Deck R, De Andrade A, Respondek G, Xu H, Rösler TW, Salama M, Carlsson T, Yamada ES, Gad El Hak SA, Goedert M, Oertel WH, Höglinger GU
PloS one 2014;9(12):e113557
PloS one 2014;9(12):e113557
A lifespan observation of a novel mouse model: in vivo evidence supports aβ oligomer hypothesis.
Zhang Y, Lu L, Jia J, Jia L, Geula C, Pei J, Xu Z, Qin W, Liu R, Li D, Pan N
PloS one 2014;9(1):e85885
PloS one 2014;9(1):e85885
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Xia D, Götz J
Frontiers in molecular neuroscience 2014;7:40
Frontiers in molecular neuroscience 2014;7:40
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Castro-Alvarez JF, Uribe-Arias SA, Kosik KS, Cardona-Gómez GP
Frontiers in aging neuroscience 2014;6:243
Frontiers in aging neuroscience 2014;6:243
The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.
Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M
Surgical neurology international 2014;5:184
Surgical neurology international 2014;5:184
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Lin L, Yang SS, Chu J, Wang L, Ning LN, Zhang T, Jiang Q, Tian Q, Wang JZ
Journal of Alzheimer's disease : JAD 2014;41(4):1149-63
Journal of Alzheimer's disease : JAD 2014;41(4):1149-63
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Dalby NO, Volbracht C, Helboe L, Larsen PH, Jensen HS, Egebjerg J, Elvang AB
Journal of Alzheimer's disease : JAD 2014;40(2):429-42
Journal of Alzheimer's disease : JAD 2014;40(2):429-42
Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.
Murray PS, Kirkwood CM, Gray MC, Fish KN, Ikonomovic MD, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Sweet RA
Journal of Alzheimer's disease : JAD 2014;39(4):759-73
Journal of Alzheimer's disease : JAD 2014;39(4):759-73
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Tooyama I
Journal of Alzheimer's disease : JAD 2014;39(3):617-31
Journal of Alzheimer's disease : JAD 2014;39(3):617-31
Distribution of pathology in frontal variant Alzheimer's disease.
Blennerhassett R, Lillo P, Halliday GM, Hodges JR, Kril JJ
Journal of Alzheimer's disease : JAD 2014;39(1):63-70
Journal of Alzheimer's disease : JAD 2014;39(1):63-70
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L
Annals of neurology 2014 Sep;76(3):443-56
Annals of neurology 2014 Sep;76(3):443-56
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H
EMBO molecular medicine 2014 Sep;6(9):1142-60
EMBO molecular medicine 2014 Sep;6(9):1142-60
Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
van der Zee J, Van Langenhove T, Kovacs GG, Dillen L, Deschamps W, Engelborghs S, Matěj R, Vandenbulcke M, Sieben A, Dermaut B, Smets K, Van Damme P, Merlin C, Laureys A, Van Den Broeck M, Mattheijssens M, Peeters K, Benussi L, Binetti G, Ghidoni R, Borroni B, Padovani A, Archetti S, Pastor P, Razquin C, Ortega-Cubero S, Hernández I, Boada M, Ruiz A, de Mendonça A, Miltenberger-Miltényi G, do Couto FS, Sorbi S, Nacmias B, Bagnoli S, Graff C, Chiang HH, Thonberg H, Perneczky R, Diehl-Schmid J, Alexopoulos P, Frisoni GB, Bonvicini C, Synofzik M, Maetzler W, vom Hagen JM, Schöls L, Haack TB, Strom TM, Prokisch H, Dols-Icardo O, Clarimón J, Lleó A, Santana I, Almeida MR, Santiago B, Heneka MT, Jessen F, Ramirez A, Sanchez-Valle R, Llado A, Gelpi E, Sarafov S, Tournev I, Jordanova A, Parobkova E, Fabrizi GM, Testi S, Salmon E, Ströbel T, Santens P, Robberecht W, De Jonghe P, Martin JJ, Cras P, Vandenberghe R, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C
Acta neuropathologica 2014 Sep;128(3):397-410
Acta neuropathologica 2014 Sep;128(3):397-410
PICALM modulates autophagy activity and tau accumulation.
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC
Nature communications 2014 Sep 22;5:4998
Nature communications 2014 Sep 22;5:4998
Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
Lee S, Xu G, Jay TR, Bhatta S, Kim KW, Jung S, Landreth GE, Ransohoff RM, Lamb BT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Sep 10;34(37):12538-46
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Sep 10;34(37):12538-46
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Jiang T, Yu JT, Zhu XC, Zhang QQ, Cao L, Wang HF, Tan MS, Gao Q, Qin H, Zhang YD, Tan L
Neuropharmacology 2014 Oct;85:121-30
Neuropharmacology 2014 Oct;85:121-30
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.
Collin L, Bohrmann B, Göpfert U, Oroszlan-Szovik K, Ozmen L, Grüninger F
Brain : a journal of neurology 2014 Oct;137(Pt 10):2834-46
Brain : a journal of neurology 2014 Oct;137(Pt 10):2834-46
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 8;34(41):13629-43
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 8;34(41):13629-43
Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates.
Thomzig A, Wagenführ K, Daus ML, Joncic M, Schulz-Schaeffer WJ, Thanheiser M, Mielke M, Beekes M
Acta neuropathologica communications 2014 Oct 25;2:151
Acta neuropathologica communications 2014 Oct 25;2:151
Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Köhler C, Dinekov M, Götz J
Neurobiology of disease 2014 Nov;71:169-79
Neurobiology of disease 2014 Nov;71:169-79
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models.
Hohsfield LA, Daschil N, Orädd G, Strömberg I, Humpel C
Molecular and cellular neurosciences 2014 Nov;63:83-95
Molecular and cellular neurosciences 2014 Nov;63:83-95
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE
Acta neuropathologica 2014 Nov;128(5):679-89
Acta neuropathologica 2014 Nov;128(5):679-89
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL
Molecular neurodegeneration 2014 Nov 28;9:54
Molecular neurodegeneration 2014 Nov 28;9:54
The problem of axonal injury in the brains of veterans with histories of blast exposure.
Ryu J, Horkayne-Szakaly I, Xu L, Pletnikova O, Leri F, Eberhart C, Troncoso JC, Koliatsos VE
Acta neuropathologica communications 2014 Nov 25;2:153
Acta neuropathologica communications 2014 Nov 25;2:153
CDK5 activator protein p25 preferentially binds and activates GSK3β.
Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup K, Zhang J
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11;111(45):E4887-95
Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11;111(45):E4887-95
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.
Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH
Journal of neuropathology and experimental neurology 2014 May;73(5):467-73
Journal of neuropathology and experimental neurology 2014 May;73(5):467-73
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Huang XT, Qian ZM, He X, Gong Q, Wu KC, Jiang LR, Lu LN, Zhu ZJ, Zhang HY, Yung WH, Ke Y
Neurobiology of aging 2014 May;35(5):1045-54
Neurobiology of aging 2014 May;35(5):1045-54
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, Fukuda Y, Nakai Y, Uchida T, Sato E, Tanemura K
FEBS letters 2014 May 29;588(11):2003-8
FEBS letters 2014 May 29;588(11):2003-8
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R
Acta neuropathologica communications 2014 May 29;2:56
Acta neuropathologica communications 2014 May 29;2:56
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, Rugarli EI
The EMBO journal 2014 May 2;33(9):1011-26
The EMBO journal 2014 May 2;33(9):1011-26
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Shilling D, Müller M, Takano H, Mak DO, Abel T, Coulter DA, Foskett JK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU
Experimental neurology 2014 Mar;253:113-25
Experimental neurology 2014 Mar;253:113-25
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM
The American journal of pathology 2014 Mar;184(3):819-26
The American journal of pathology 2014 Mar;184(3):819-26
REST and stress resistance in ageing and Alzheimer's disease.
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA
Nature 2014 Mar 27;507(7493):448-54
Nature 2014 Mar 27;507(7493):448-54
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Li JG, Chu J, Barrero C, Merali S, Praticò D
Annals of neurology 2014 Jun;75(6):851-63
Annals of neurology 2014 Jun;75(6):851-63
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Orr ME, Salinas A, Buffenstein R, Oddo S
Neurobiology of aging 2014 Jun;35(6):1233-42
Neurobiology of aging 2014 Jun;35(6):1233-42
Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage.
Dye JA, Rees G, Yang I, Vespa PM, Martin NA, Vinters HV
Neuropathology : official journal of the Japanese Society of Neuropathology 2014 Jun;34(3):253-60
Neuropathology : official journal of the Japanese Society of Neuropathology 2014 Jun;34(3):253-60
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
Stancu IC, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, Haylani LE, Couturier J, Schakman O, Gailly P, Pierrot N, Kienlen-Campard P, Octave JN, Dewachter I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2620-31
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2620-31
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Pan JJ, Lee M, Honig LS, Vonsattel JP, Faust PL, Louis ED
Parkinsonism & related disorders 2014 Jun;20(6):655-8
Parkinsonism & related disorders 2014 Jun;20(6):655-8
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV
Biochimica et biophysica acta 2014 Jun;1838(6):1680-92
Biochimica et biophysica acta 2014 Jun;1838(6):1680-92
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Pehar M, Ko MH, Li M, Scrable H, Puglielli L
Aging cell 2014 Jun;13(3):449-56
Aging cell 2014 Jun;13(3):449-56
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
García-Mesa Y, Pareja-Galeano H, Bonet-Costa V, Revilla S, Gómez-Cabrera MC, Gambini J, Giménez-Llort L, Cristòfol R, Viña J, Sanfeliu C
Psychoneuroendocrinology 2014 Jul;45:154-66
Psychoneuroendocrinology 2014 Jul;45:154-66
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F
The European journal of neuroscience 2014 Jul;40(2):2442-53
The European journal of neuroscience 2014 Jul;40(2):2442-53
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G
Journal of neurochemistry 2014 Jul;130(1):115-25
Journal of neurochemistry 2014 Jul;130(1):115-25
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D
Vaccines 2014 Jul 29;2(3):601-23
Vaccines 2014 Jul 29;2(3):601-23
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG
Journal of neurochemistry 2014 Jan;128(1):162-72
Journal of neurochemistry 2014 Jan;128(1):162-72
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L
Acta neuropathologica communications 2014 Jan 30;2:14
Acta neuropathologica communications 2014 Jan 30;2:14
Two cases of multinodular and vacuolating neuronal tumour.
Bodi I, Curran O, Selway R, Elwes R, Burrone J, Laxton R, Al-Sarraj S, Honavar M
Acta neuropathologica communications 2014 Jan 20;2:7
Acta neuropathologica communications 2014 Jan 20;2:7
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM
Neurobiology of disease 2014 Feb;62:407-15
Neurobiology of disease 2014 Feb;62:407-15
Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.
Mizukami K, Abrahamson EE, Mi Z, Ishikawa M, Watanabe K, Kinoshita S, Asada T, Ikonomovic MD
Neuropathology : official journal of the Japanese Society of Neuropathology 2014 Feb;34(1):11-8
Neuropathology : official journal of the Japanese Society of Neuropathology 2014 Feb;34(1):11-8
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM
The American journal of pathology 2014 Feb;184(2):520-9
The American journal of pathology 2014 Feb;184(2):520-9
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 3;34(49):16180-93
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 3;34(49):16180-93
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice.
Serrano FG, Tapia-Rojas C, Carvajal FJ, Hancke J, Cerpa W, Inestrosa NC
Molecular neurodegeneration 2014 Dec 18;9:61
Molecular neurodegeneration 2014 Dec 18;9:61
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.
Chare L, Hodges JR, Leyton CE, McGinley C, Tan RH, Kril JJ, Halliday GM
Journal of neurology, neurosurgery, and psychiatry 2014 Aug;85(8):865-70
Journal of neurology, neurosurgery, and psychiatry 2014 Aug;85(8):865-70
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Fernández-Nogales M, Cabrera JR, Santos-Galindo M, Hoozemans JJ, Ferrer I, Rozemuller AJ, Hernández F, Avila J, Lucas JJ
Nature medicine 2014 Aug;20(8):881-5
Nature medicine 2014 Aug;20(8):881-5
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H
Neuropharmacology 2014 Apr;79:307-13
Neuropharmacology 2014 Apr;79:307-13
Visualizing the microtubule-associated protein tau in the nucleus.
Lu J, Li T, He R, Bartlett PF, Götz J
Science China. Life sciences 2014 Apr;57(4):422-31
Science China. Life sciences 2014 Apr;57(4):422-31
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer CJ
Journal of anatomy 2014 Apr;224(4):377-91
Journal of anatomy 2014 Apr;224(4):377-91
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.
Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ
Molecular neurodegeneration 2014 Apr 28;9:15
Molecular neurodegeneration 2014 Apr 28;9:15
Ubiquilin 2 is not associated with tau pathology.
Nölle A, van Haastert ES, Zwart R, Hoozemans JJ, Scheper W
PloS one 2013;8(9):e76598
PloS one 2013;8(9):e76598
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E
PloS one 2013;8(7):e68722
PloS one 2013;8(7):e68722
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT
PloS one 2013;8(5):e62459
PloS one 2013;8(5):e62459
PINCH in the cellular stress response to tau-hyperphosphorylation.
Ozdemir AY, Rom I, Kovalevich J, Yen W, Adiga R, Dave RS, Langford D
PloS one 2013;8(3):e58232
PloS one 2013;8(3):e58232
Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.
Ramos-Rodriguez JJ, Molina-Gil S, Rey-Brea R, Berrocoso E, Garcia-Alloza M
PloS one 2013;8(11):e79947
PloS one 2013;8(11):e79947
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, Ixart G, Maurice T, Givalois L
PloS one 2013;8(1):e53117
PloS one 2013;8(1):e53117
Pericyte loss influences Alzheimer-like neurodegeneration in mice.
Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV
Nature communications 2013;4:2932
Nature communications 2013;4:2932
Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration.
Popova SN, Alafuzoff I
Journal of Alzheimer's disease : JAD 2013;37(3):603-10
Journal of Alzheimer's disease : JAD 2013;37(3):603-10
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Levarska L, Zilka N, Jadhav S, Neradil P, Novak M
Journal of Alzheimer's disease : JAD 2013;37(3):569-77
Journal of Alzheimer's disease : JAD 2013;37(3):569-77
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M
Journal of Alzheimer's disease : JAD 2013;37(1):217-32
Journal of Alzheimer's disease : JAD 2013;37(1):217-32
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
Manczak M, Reddy PH
Journal of Alzheimer's disease : JAD 2013;36(2):285-95
Journal of Alzheimer's disease : JAD 2013;36(2):285-95
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A
Journal of Alzheimer's disease : JAD 2013;33(2):357-71
Journal of Alzheimer's disease : JAD 2013;33(2):357-71
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Neuro-degenerative diseases 2013;11(4):194-205
Neuro-degenerative diseases 2013;11(4):194-205
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
Chen RJ, Chang WW, Lin YC, Cheng PL, Chen YR
ACS chemical neuroscience 2013 Sep 18;4(9):1287-96
ACS chemical neuroscience 2013 Sep 18;4(9):1287-96
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN
Biological psychiatry 2013 Sep 1;74(5):357-66
Biological psychiatry 2013 Sep 1;74(5):357-66
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
Anumala UR, Gu J, Lo Monte F, Kramer T, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Schön C, Mall G, Hilger I, Czech C, Herms J, Schmidt B
Bioorganic & medicinal chemistry 2013 Sep 1;21(17):5139-44
Bioorganic & medicinal chemistry 2013 Sep 1;21(17):5139-44
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Hensley K, Gabbita SP, Venkova K, Hristov A, Johnson MF, Eslami P, Harris-White ME
Journal of neuropathology and experimental neurology 2013 Oct;72(10):955-69
Journal of neuropathology and experimental neurology 2013 Oct;72(10):955-69
Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.
Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS
Journal of neuropathology and experimental neurology 2013 Nov;72(11):1009-15
Journal of neuropathology and experimental neurology 2013 Nov;72(11):1009-15
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Josephs KA, Dickson DW, Murray ME, Senjem ML, Parisi JE, Petersen RC, Jack CR Jr, Whitwell JL
Brain and language 2013 Nov;127(2):127-34
Brain and language 2013 Nov;127(2):127-34
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Acta neuropathologica communications 2013 Nov 12;1:73
Acta neuropathologica communications 2013 Nov 12;1:73
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Zufferey V, Vallet PG, Moeri M, Moulin-Sallanon M, Piotton F, Marin P, Savioz A
Brain research bulletin 2013 May;94:17-22
Brain research bulletin 2013 May;94:17-22
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D
Diabetes 2013 May;62(5):1681-8
Diabetes 2013 May;62(5):1681-8
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Köhler C, Dinekov M, Götz J
Neurobiology of aging 2013 May;34(5):1369-79
Neurobiology of aging 2013 May;34(5):1369-79
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Wu TH, Lu YN, Chuang CL, Wu CL, Chiang AS, Krantz DE, Chang HY
Acta neuropathologica 2013 May;125(5):711-25
Acta neuropathologica 2013 May;125(5):711-25
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 15;33(20):8891-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 15;33(20):8891-7
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
Feldengut S, Del Tredici K, Braak H
Journal of neuroscience methods 2013 May 15;215(2):241-4
Journal of neuroscience methods 2013 May 15;215(2):241-4
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
Colom-Cadena M, Gelpi E, Martí MJ, Charif S, Dols-Icardo O, Blesa R, Clarimón J, Lleó A
Neurobiology of aging 2013 Mar;34(3):936-42
Neurobiology of aging 2013 Mar;34(3):936-42
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Magnaudeix A, Wilson CM, Page G, Bauvy C, Codogno P, Lévêque P, Labrousse F, Corre-Delage M, Yardin C, Terro F
Neurobiology of aging 2013 Mar;34(3):770-90
Neurobiology of aging 2013 Mar;34(3):770-90
Making the diagnosis of frontotemporal lobar degeneration.
Bigio EH
Archives of pathology & laboratory medicine 2013 Mar;137(3):314-25
Archives of pathology & laboratory medicine 2013 Mar;137(3):314-25
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
Gu J, Anumala UR, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Mall G, Hilger I, Czech C, Schmidt B
ChemMedChem 2013 Jun;8(6):891-7
ChemMedChem 2013 Jun;8(6):891-7
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Nash KR, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D
Neurobiology of aging 2013 Jun;34(6):1540-8
Neurobiology of aging 2013 Jun;34(6):1540-8
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
Barros-Miñones L, Martín-de-Saavedra D, Perez-Alvarez S, Orejana L, Suquía V, Goñi-Allo B, Hervias I, López MG, Jordan J, Aguirre N, Puerta E
Biochimica et biophysica acta 2013 Jun;1832(6):705-17
Biochimica et biophysica acta 2013 Jun;1832(6):705-17
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, DeWitt DS, Kayed R
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
Clinical correlates in an experimental model of repetitive mild brain injury.
Mannix R, Meehan WP, Mandeville J, Grant PE, Gray T, Berglass J, Zhang J, Bryant J, Rezaie S, Chung JY, Peters NV, Lee C, Tien LW, Kaplan DL, Feany M, Whalen M
Annals of neurology 2013 Jul;74(1):65-75
Annals of neurology 2013 Jul;74(1):65-75
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M
Molecular therapy : the journal of the American Society of Gene Therapy 2013 Jul;21(7):1358-68
Molecular therapy : the journal of the American Society of Gene Therapy 2013 Jul;21(7):1358-68
Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins.
Hurley MJ, Brandon B, Gentleman SM, Dexter DT
Brain : a journal of neurology 2013 Jul;136(Pt 7):2077-97
Brain : a journal of neurology 2013 Jul;136(Pt 7):2077-97
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, Petrucelli L, Sahara N, Dickson DW, Giasson B, Lewis J
Acta neuropathologica 2013 Jul;126(1):39-50
Acta neuropathologica 2013 Jul;126(1):39-50
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
Alonso E, Vale C, Vieytes MR, Botana LM
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Braak H, Thal DR, Matschke J, Ghebremedhin E, Del Tredici K
Neurobiology of aging 2013 Jan;34(1):286-97
Neurobiology of aging 2013 Jan;34(1):286-97
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M
The Journal of nutritional biochemistry 2013 Jan;24(1):360-70
The Journal of nutritional biochemistry 2013 Jan;24(1):360-70
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Choi SH, Aid S, Caracciolo L, Minami SS, Niikura T, Matsuoka Y, Turner RS, Mattson MP, Bosetti F
Journal of neurochemistry 2013 Jan;124(1):59-68
Journal of neurochemistry 2013 Jan;124(1):59-68
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
Sundaram JR, Poore CP, Sulaimee NH, Pareek T, Asad AB, Rajkumar R, Cheong WF, Wenk MR, Dawe GS, Chuang KH, Pant HC, Kesavapany S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 2;33(1):334-43
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 2;33(1):334-43
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
Manaye KF, Mouton PR, Xu G, Drew A, Lei DL, Sharma Y, Rebeck GW, Turner S
Age (Dordrecht, Netherlands) 2013 Feb;35(1):139-47
Age (Dordrecht, Netherlands) 2013 Feb;35(1):139-47
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Cancino GI, Miller FD, Kaplan DR
Neurobiology of aging 2013 Feb;34(2):387-99
Neurobiology of aging 2013 Feb;34(2):387-99
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Pirker S, Perju-Dumbrava L, Kovacs GG, Traub-Weidinger T, Asenbaum S, Pirker W
Parkinsonism & related disorders 2013 Feb;19(2):222-6
Parkinsonism & related disorders 2013 Feb;19(2):222-6
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Morcinek K, Köhler C, Götz J, Schröder H
Brain research 2013 Feb 25;1497:73-84
Brain research 2013 Feb 25;1497:73-84
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
López-Menéndez C, Gamir-Morralla A, Jurado-Arjona J, Higuero AM, Campanero MR, Ferrer I, Hernández F, Ávila J, Díaz-Guerra M, Iglesias T
Human molecular genetics 2013 Feb 1;22(3):466-82
Human molecular genetics 2013 Feb 1;22(3):466-82
Brainstem aminergic nuclei and late-life depressive symptoms.
Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA
JAMA psychiatry 2013 Dec;70(12):1320-8
JAMA psychiatry 2013 Dec;70(12):1320-8
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J
Acta neuropathologica communications 2013 Dec 17;1:82
Acta neuropathologica communications 2013 Dec 17;1:82
Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).
Perez SE, Raghanti MA, Hof PR, Kramer L, Ikonomovic MD, Lacor PN, Erwin JM, Sherwood CC, Mufson EJ
The Journal of comparative neurology 2013 Dec 15;521(18):4318-38
The Journal of comparative neurology 2013 Dec 15;521(18):4318-38
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Lahmy V, Meunier J, Malmström S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Aug;38(9):1706-23
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Aug;38(9):1706-23
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Geekiyanage H, Upadhye A, Chan C
Neurobiology of aging 2013 Aug;34(8):2037-51
Neurobiology of aging 2013 Aug;34(8):2037-51
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis.
Dobson-Stone C, Luty AA, Thompson EM, Blumbergs P, Brooks WS, Short CL, Field CD, Panegyres PK, Hecker J, Solski JA, Blair IP, Fullerton JM, Halliday GM, Schofield PR, Kwok JB
Acta neuropathologica 2013 Apr;125(4):523-33
Acta neuropathologica 2013 Apr;125(4):523-33
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD
Aging cell 2013 Apr;12(2):257-68
Aging cell 2013 Apr;12(2):257-68
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM
Cell death & disease 2013 Apr 25;4(4):e608
Cell death & disease 2013 Apr 25;4(4):e608
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke HS, Jordan SD, Rugarli EI, Langer T
PLoS genetics 2012;8(11):e1003021
PLoS genetics 2012;8(11):e1003021
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L
PloS one 2012;7(9):e45881
PloS one 2012;7(9):e45881
Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.
Mewes A, Franke H, Singer D
PloS one 2012;7(9):e45017
PloS one 2012;7(9):e45017
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Castello NA, Green KN, LaFerla FM
PloS one 2012;7(8):e39566
PloS one 2012;7(8):e39566
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Julien C, Marcouiller F, Bretteville A, El Khoury NB, Baillargeon J, Hébert SS, Planel E
PloS one 2012;7(6):e40020
PloS one 2012;7(6):e40020
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
Capsoni S, Marinelli S, Ceci M, Vignone D, Amato G, Malerba F, Paoletti F, Meli G, Viegi A, Pavone F, Cattaneo A
PloS one 2012;7(5):e37555
PloS one 2012;7(5):e37555
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Herzig MC, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, Danner S, Vidotto N, Stauffer D, Barske C, Mayer F, Schmid P, Rovelli G, van der Putten PH, Shimshek DR
PloS one 2012;7(5):e36581
PloS one 2012;7(5):e36581
Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease.
Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, Zhou Y, Dai J
PloS one 2012;7(3):e33722
PloS one 2012;7(3):e33722
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM
PloS one 2012;7(2):e31993
PloS one 2012;7(2):e31993
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
Caesar I, Jonson M, Nilsson KP, Thor S, Hammarström P
PloS one 2012;7(2):e31424
PloS one 2012;7(2):e31424
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J
PloS one 2012;7(12):e53547
PloS one 2012;7(12):e53547
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
Chambers JK, Uchida K, Harada T, Tsuboi M, Sato M, Kubo M, Kawaguchi H, Miyoshi N, Tsujimoto H, Nakayama H
PloS one 2012;7(10):e46452
PloS one 2012;7(10):e46452
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one 2012;7(1):e30834
PloS one 2012;7(1):e30834
Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.
Sarnat H, Flores-Sarnat L, Crino P, Hader W, Bello-Espinosa L
Folia neuropathologica 2012;50(4):330-45
Folia neuropathologica 2012;50(4):330-45
Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.
Sarnat H, Flores-Sarnat L, Crino P, Hader W, Bello-Espinosa L
Folia neuropathologica 2012;50(4):330-45
Folia neuropathologica 2012;50(4):330-45
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Joshi YB, Chu J, Praticò D
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Clausen A, Xu X, Bi X, Baudry M
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, Duyckaerts C, Chambraud B, Baulieu EE
Journal of Alzheimer's disease : JAD 2012;29(2):471-83
Journal of Alzheimer's disease : JAD 2012;29(2):471-83
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Venkataramani V, Wirths O, Budka H, Härtig W, Kovacs GG, Bayer TA
Journal of Alzheimer's disease : JAD 2012;29(2):361-71
Journal of Alzheimer's disease : JAD 2012;29(2):361-71
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Cuadrado-Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A
Journal of Alzheimer's disease : JAD 2012;28(3):567-78
Journal of Alzheimer's disease : JAD 2012;28(3):567-78
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Antonell A, Gelpi E, Sánchez-Valle R, Martínez R, Molinuevo JL, Lladó A
Journal of Alzheimer's disease : JAD 2012;28(2):303-8
Journal of Alzheimer's disease : JAD 2012;28(2):303-8
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, Beal MF, Dumont M
Journal of Alzheimer's disease : JAD 2012;28(1):173-82
Journal of Alzheimer's disease : JAD 2012;28(1):173-82
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Bretteville A, Marcouiller F, Julien C, El Khoury NB, Petry FR, Poitras I, Mouginot D, Lévesque G, Hébert SS, Planel E
Scientific reports 2012;2:480
Scientific reports 2012;2:480
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Soontornniyomkij V, Soontornniyomkij B, Moore DJ, Gouaux B, Masliah E, Tung S, Vinters HV, Grant I, Achim CL
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):579-90
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):579-90
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A
Molecular neurodegeneration 2012 Sep 21;7:48
Molecular neurodegeneration 2012 Sep 21;7:48
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Britschgi M, Takeda-Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss-Coray T
Journal of neuroinflammation 2012 Sep 18;9:220
Journal of neuroinflammation 2012 Sep 18;9:220
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Krüger U, Wang Y, Kumar S, Mandelkow EM
Neurobiology of aging 2012 Oct;33(10):2291-305
Neurobiology of aging 2012 Oct;33(10):2291-305
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
Woehrer A, Laszlo L, Finsterer J, Stöllberger C, Furtner J, Rinner W, Molnar K, Budka H, Kovacs GG
Acta neuropathologica 2012 Oct;124(4):583-91
Acta neuropathologica 2012 Oct;124(4):583-91
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CB
Neuroscience letters 2012 Oct 24;528(2):104-9
Neuroscience letters 2012 Oct 24;528(2):104-9
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, Bittner T, Hölzer J, Heyny-von Haußen R, Mall G, Goetschy V, Czech C, Knust H, Berger R, Herms J, Hilger I, Schmidt B
Journal of medicinal chemistry 2012 Nov 8;55(21):9170-80
Journal of medicinal chemistry 2012 Nov 8;55(21):9170-80
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
Hong Y, Chan CB, Kwon IS, Li X, Song M, Lee HP, Liu X, Sompol P, Jin P, Lee HG, Yu SP, Ye K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17262-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17262-72
Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.
Soontornniyomkij V, Moore DJ, Gouaux B, Soontornniyomkij B, Tatro ET, Umlauf A, Masliah E, Levine AJ, Singer EJ, Vinters HV, Gelman BB, Morgello S, Cherner M, Grant I, Achim CL
AIDS (London, England) 2012 Nov 28;26(18):2327-35
AIDS (London, England) 2012 Nov 28;26(18):2327-35
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Molecular neurodegeneration 2012 Nov 22;7:59
Molecular neurodegeneration 2012 Nov 22;7:59
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L
Current Alzheimer research 2012 May;9(4):397-405
Current Alzheimer research 2012 May;9(4):397-405
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L
Current Alzheimer research 2012 May;9(4):397-405
Current Alzheimer research 2012 May;9(4):397-405
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Kantarci K, Yang C, Schneider JA, Senjem ML, Reyes DA, Lowe VJ, Barnes LL, Aggarwal NT, Bennett DA, Smith GE, Petersen RC, Jack CR Jr, Boeve BF
Neurobiology of aging 2012 May;33(5):878-85
Neurobiology of aging 2012 May;33(5):878-85
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):1946-59
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):1946-59
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Orejana L, Barros-Miñones L, Jordán J, Puerta E, Aguirre N
Neurobiology of aging 2012 Mar;33(3):625.e11-20
Neurobiology of aging 2012 Mar;33(3):625.e11-20
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, Bae JS
Neurobiology of aging 2012 Mar;33(3):588-602
Neurobiology of aging 2012 Mar;33(3):588-602
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Stefanits H, Budka H, Kovacs GG
Acta neuropathologica 2012 Mar;123(3):449-52
Acta neuropathologica 2012 Mar;123(3):449-52
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M
Acta neuropathologica 2012 Mar;123(3):381-94
Acta neuropathologica 2012 Mar;123(3):381-94
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
García-Mesa Y, Giménez-Llort L, López LC, Venegas C, Cristòfol R, Escames G, Acuña-Castroviejo D, Sanfeliu C
Neurobiology of aging 2012 Jun;33(6):1124.e13-29
Neurobiology of aging 2012 Jun;33(6):1124.e13-29
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T
Neurotoxicology 2012 Jun;33(3):370-83
Neurotoxicology 2012 Jun;33(3):370-83
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Kapas I, Majtenyi K, Törö K, Keller E, Voigtländer T, Kovacs GG
Metabolic brain disease 2012 Jun;27(2):231-5
Metabolic brain disease 2012 Jun;27(2):231-5
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Fine JM, Baillargeon AM, Renner DB, Hoerster NS, Tokarev J, Colton S, Pelleg A, Andrews A, Sparley KA, Krogh KM, Frey WH, Hanson LR
Experimental brain research 2012 Jun;219(3):381-90
Experimental brain research 2012 Jun;219(3):381-90
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Petratos S, Ozturk E, Azari MF, Kenny R, Lee JY, Magee KA, Harvey AR, McDonald C, Taghian K, Moussa L, Mun Aui P, Siatskas C, Litwak S, Fehlings MG, Strittmatter SM, Bernard CC
Brain : a journal of neurology 2012 Jun;135(Pt 6):1794-818
Brain : a journal of neurology 2012 Jun;135(Pt 6):1794-818
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM
Acta neuropathologica 2012 Jun;123(6):787-805
Acta neuropathologica 2012 Jun;123(6):787-805
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M
Neurobiology of aging 2012 Jul;33(7):1448-56
Neurobiology of aging 2012 Jul;33(7):1448-56
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Ksiezak-Reding H, Ho L, Santa-Maria I, Diaz-Ruiz C, Wang J, Pasinetti GM
Neurobiology of aging 2012 Jul;33(7):1427-39
Neurobiology of aging 2012 Jul;33(7):1427-39
Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress.
Filipcik P, Novak P, Mravec B, Ondicova K, Krajciova G, Novak M, Kvetnansky R
Cellular and molecular neurobiology 2012 Jul;32(5):837-45
Cellular and molecular neurobiology 2012 Jul;32(5):837-45
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Morawski M, Brückner G, Jäger C, Seeger G, Matthews RT, Arendt T
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):547-61
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):547-61
Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.
Postupna N, Rose SE, Bird TD, Gonzalez-Cuyar LF, Sonnen JA, Larson EB, Keene CD, Montine TJ
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):472-84
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):472-84
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Piccardo P, Cervenak J, Yakovleva O, Gregori L, Pomeroy K, Cook A, Muhammad FS, Seuberlich T, Cervenakova L, Asher DM
Journal of comparative pathology 2012 Jul;147(1):84-93
Journal of comparative pathology 2012 Jul;147(1):84-93
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Wang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Mustroph ML, King MA, Klein RL, Ramirez JJ
Behavioural brain research 2012 Jul 15;233(1):141-8
Behavioural brain research 2012 Jul 15;233(1):141-8
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Wilhelmus MM, de Jager M, Rozemuller AJ, Brevé J, Bol JG, Eckert RL, Drukarch B
The Journal of pathology 2012 Jan;226(1):132-42
The Journal of pathology 2012 Jan;226(1):132-42
Hyperphosphorylated tau in young and middle-aged subjects.
Elobeid A, Soininen H, Alafuzoff I
Acta neuropathologica 2012 Jan;123(1):97-104
Acta neuropathologica 2012 Jan;123(1):97-104
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A
Acta neuropathologica 2012 Jan;123(1):53-70
Acta neuropathologica 2012 Jan;123(1):53-70
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.
Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ, Zhu LQ
Journal of neurochemistry 2012 Jan;120(1):157-64
Journal of neurochemistry 2012 Jan;120(1):157-64
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
Sundaram JR, Chan ES, Poore CP, Pareek TK, Cheong WF, Shui G, Tang N, Low CM, Wenk MR, Kesavapany S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):1020-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):1020-34
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
Li L, Zhang ZF, Holscher C, Gao C, Jiang YH, Liu YZ
European journal of pharmacology 2012 Jan 15;674(2-3):280-6
European journal of pharmacology 2012 Jan 15;674(2-3):280-6
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Hartikainen PH, Pikkarainen M, Hänninen T, Soininen H, Alafuzoff I
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Feb;32(1):60-8
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Feb;32(1):60-8
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Perez SE, Getova DP, He B, Counts SE, Geula C, Desire L, Coutadeur S, Peillon H, Ginsberg SD, Mufson EJ
The American journal of pathology 2012 Feb;180(2):526-40
The American journal of pathology 2012 Feb;180(2):526-40
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Attur S
Acta biologica Hungarica 2012 Dec;63(4):411-25
Acta biologica Hungarica 2012 Dec;63(4):411-25
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Schauer TH, Lochner M, Kovacs GG
Journal of neural transmission (Vienna, Austria : 1996) 2012 Dec;119(12):1545-9
Journal of neural transmission (Vienna, Austria : 1996) 2012 Dec;119(12):1545-9
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF
The Journal of experimental medicine 2012 Dec 17;209(13):2501-13
The Journal of experimental medicine 2012 Dec 17;209(13):2501-13
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
Yokota T, Akatsu H, Miyauchi T, Heese K
FEBS letters 2012 Dec 14;586(24):4357-61
FEBS letters 2012 Dec 14;586(24):4357-61
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, Calingasan NY, Yang L, Tampellini D, Starkov AA, Chan RB, Di Paolo G, Pujol A, Beal MF
Human molecular genetics 2012 Dec 1;21(23):5091-105
Human molecular genetics 2012 Dec 1;21(23):5091-105
Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
Ndung'u M, Härtig W, Wegner F, Mwenda JM, Low RW, Akinyemi RO, Kalaria RN
Neuropathology and applied neurobiology 2012 Aug;38(5):487-99
Neuropathology and applied neurobiology 2012 Aug;38(5):487-99
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Gerhauser I, Wohlsein P, Ernst H, Germann PG, Baumgärtner W
Neurobiology of aging 2012 Aug;33(8):1716-9
Neurobiology of aging 2012 Aug;33(8):1716-9
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM
The American journal of pathology 2012 Aug;181(2):616-25
The American journal of pathology 2012 Aug;181(2):616-25
Dystrophic neurites express C9orf72 in Alzheimer's disease brains.
Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K
Alzheimer's research & therapy 2012 Aug 16;4(4):33
Alzheimer's research & therapy 2012 Aug 16;4(4):33
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Martinez-Saez E, Gelpi E, Rey MJ, Ferrer I, Ribalta T, Botta-Orfila T, Nos C, Yagüe J, Sanchez-Valle R
Neuropathology and applied neurobiology 2012 Apr;38(2):153-61
Neuropathology and applied neurobiology 2012 Apr;38(2):153-61
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K
Neuropathology and applied neurobiology 2012 Apr;38(2):132-41
Neuropathology and applied neurobiology 2012 Apr;38(2):132-41
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK
Neurobiology of aging 2012 Apr;33(4):828.e31-44
Neurobiology of aging 2012 Apr;33(4):828.e31-44
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW
Neurobiology of aging 2012 Apr;33(4):825.e15-24
Neurobiology of aging 2012 Apr;33(4):825.e15-24
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
Rodriguez-Diehl R, Rey MJ, Gironell A, Martinez-Saez E, Ferrer I, Sánchez-Valle R, Jagüe J, Nos C, Gelpi E
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Apr;32(2):158-63
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Apr;32(2):158-63
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ
The Journal of pathology 2012 Apr;226(5):693-702
The Journal of pathology 2012 Apr;226(5):693-702
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE
The Journal of clinical investigation 2012 Apr;122(4):1316-38
The Journal of clinical investigation 2012 Apr;122(4):1316-38
Frontal cortex neuropathology in dementia pugilistica.
Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.
Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD
PloS one 2011;6(8):e24293
PloS one 2011;6(8):e24293
Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.
Whiteman IT, Minamide LS, Goh de L, Bamburg JR, Goldsbury C
PloS one 2011;6(6):e20878
PloS one 2011;6(6):e20878
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Maarouf CL, Daugs ID, Kokjohn TA, Walker DG, Hunter JM, Kruchowsky JC, Woltjer R, Kaye J, Castaño EM, Sabbagh MN, Beach TG, Roher AE
PloS one 2011;6(11):e27291
PloS one 2011;6(11):e27291
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
Silva DF, Esteves AR, Arduino DM, Oliveira CR, Cardoso SM
Journal of Alzheimer's disease : JAD 2011;26(3):565-81
Journal of Alzheimer's disease : JAD 2011;26(3):565-81
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.
Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, Canu N, Benussi L, Ghidoni R, Forloni G, Borsello T
Journal of Alzheimer's disease : JAD 2011;26(2):315-29
Journal of Alzheimer's disease : JAD 2011;26(2):315-29
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.
Li L, Cheung T, Chen J, Herrup K
International journal of Alzheimer's disease 2011;2011:171464
International journal of Alzheimer's disease 2011;2011:171464
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
Ferreira A, Bigio EH
Molecular medicine (Cambridge, Mass.) 2011;17(7-8):676-85
Molecular medicine (Cambridge, Mass.) 2011;17(7-8):676-85
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Copenhaver PF, Anekonda TS, Musashe D, Robinson KM, Ramaker JM, Swanson TL, Wadsworth TL, Kretzschmar D, Woltjer RL, Quinn JF
Disease models & mechanisms 2011 Sep;4(5):634-48
Disease models & mechanisms 2011 Sep;4(5):634-48
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Hagen MC, Murrell JR, Delisle MB, Andermann E, Andermann F, Guiot MC, Ghetti B
Brain pathology (Zurich, Switzerland) 2011 Sep;21(5):575-82
Brain pathology (Zurich, Switzerland) 2011 Sep;21(5):575-82
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M
The Journal of biological chemistry 2011 Sep 30;286(39):34457-67
The Journal of biological chemistry 2011 Sep 30;286(39):34457-67
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L
The Journal of biological chemistry 2011 Sep 16;286(37):32713-22
The Journal of biological chemistry 2011 Sep 16;286(37):32713-22
Microglial pathology in Down syndrome.
Xue QS, Streit WJ
Acta neuropathologica 2011 Oct;122(4):455-66
Acta neuropathologica 2011 Oct;122(4):455-66
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Emmer KL, Waxman EA, Covy JP, Giasson BI
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E
The EMBO journal 2011 Oct 18;30(23):4825-37
The EMBO journal 2011 Oct 18;30(23):4825-37
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Braak H, Thal DR, Ghebremedhin E, Del Tredici K
Journal of neuropathology and experimental neurology 2011 Nov;70(11):960-9
Journal of neuropathology and experimental neurology 2011 Nov;70(11):960-9
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
McMillan PJ, Kraemer BC, Robinson L, Leverenz JB, Raskind M, Schellenberg G
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, Yang L, Starkov AA, Beal F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Nov;25(11):4063-72
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Nov;25(11):4063-72
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
Wilhelmus MM, Bol JG, Van Haastert ES, Rozemuller AJ, Bu G, Drukarch B, Hoozemans JJ
The American journal of pathology 2011 Nov;179(5):2152-6
The American journal of pathology 2011 Nov;179(5):2152-6
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Green KN, Khashwji H, Estrada T, Laferla FM
Annals of neurology 2011 May;69(5):831-44
Annals of neurology 2011 May;69(5):831-44
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Braak H, Thal DR, Del Tredici K
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):809-19
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):809-19
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, Pradat PF, Le Forestier N, LeGuern E, Dubois B, Meininger V, Brice A, Hauw JJ, Duyckaerts C
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):753-64
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):753-64
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
Waxman EA, Giasson BI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 25;31(21):7604-18
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 25;31(21):7604-18
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
Rusina R, Kovacs GG, Fiala J, Hort J, Ridzoň P, Holmerová I, Ströbel T, Matěj R
BMC neurology 2011 May 10;11:50
BMC neurology 2011 May 10;11:50
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL
Human molecular genetics 2011 May 1;20(9):1820-33
Human molecular genetics 2011 May 1;20(9):1820-33
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S
Journal of molecular neuroscience : MN 2011 Mar;43(3):326-32
Journal of molecular neuroscience : MN 2011 Mar;43(3):326-32
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
The Journal of biological chemistry 2011 Mar 4;286(9):7619-28
The Journal of biological chemistry 2011 Mar 4;286(9):7619-28
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
Talbot K, Louneva N, Cohen JW, Kazi H, Blake DJ, Arnold SE
PloS one 2011 Mar 1;6(3):e16886
PloS one 2011 Mar 1;6(3):e16886
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Nunes A, Pressey SN, Cooper JD, Soriano S
Neurobiology of disease 2011 Jun;42(3):349-59
Neurobiology of disease 2011 Jun;42(3):349-59
Rapidly progressive diffuse Lewy body disease.
Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, Rey MJ, Martí MJ, Graus F, Tolosa E
Movement disorders : official journal of the Movement Disorder Society 2011 Jun;26(7):1316-23
Movement disorders : official journal of the Movement Disorder Society 2011 Jun;26(7):1316-23
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Castro-Alvarez JF, Gutierrez-Vargas J, Darnaudéry M, Cardona-Gómez GP
Behavioral neuroscience 2011 Jun;125(3):465-72
Behavioral neuroscience 2011 Jun;125(3):465-72
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Tran HT, LaFerla FM, Holtzman DM, Brody DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG
Journal of neuropathology and experimental neurology 2011 Jul;70(7):578-87
Journal of neuropathology and experimental neurology 2011 Jul;70(7):578-87
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Goodwin JE, Zhang J, Gonzalez D, Albinsson S, Geller DS
Journal of hypertension 2011 Jul;29(7):1347-56
Journal of hypertension 2011 Jul;29(7):1347-56
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Sepulveda-Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, Garcia G, Zea J, Gomez-Mancilla B, Ferrer I, Lopera F, Glatzel M
Brain pathology (Zurich, Switzerland) 2011 Jul;21(4):452-63
Brain pathology (Zurich, Switzerland) 2011 Jul;21(4):452-63
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A
Behavioural brain research 2011 Jul 7;220(2):338-43
Behavioural brain research 2011 Jul 7;220(2):338-43
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Engmann O, Hortobágyi T, Thompson AJ, Guadagno J, Troakes C, Soriano S, Al-Sarraj S, Kim Y, Giese KP
Biological psychiatry 2011 Jul 15;70(2):159-68
Biological psychiatry 2011 Jul 15;70(2):159-68
Protein aggregation in the aging retina.
Leger F, Fernagut PO, Canron MH, Léoni S, Vital C, Tison F, Bezard E, Vital A
Journal of neuropathology and experimental neurology 2011 Jan;70(1):63-8
Journal of neuropathology and experimental neurology 2011 Jan;70(1):63-8
WNT signaling in activated microglia is proinflammatory.
Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T, Schulte G
Glia 2011 Jan;59(1):119-31
Glia 2011 Jan;59(1):119-31
Propofol directly increases tau phosphorylation.
Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E
PloS one 2011 Jan 31;6(1):e16648
PloS one 2011 Jan 31;6(1):e16648
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
Dusonchet J, Kochubey O, Stafa K, Young SM Jr, Zufferey R, Moore DJ, Schneider BL, Aebischer P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jan 19;31(3):907-12
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jan 19;31(3):907-12
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Stieler JT, Bullmann T, Kohl F, Tøien Ø, Brückner MK, Härtig W, Barnes BM, Arendt T
PloS one 2011 Jan 18;6(1):e14530
PloS one 2011 Jan 18;6(1):e14530
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ
Journal of neuroinflammation 2011 Jan 15;8(1):4
Journal of neuroinflammation 2011 Jan 15;8(1):4
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J
Annals of neurology 2011 Feb;69(2):248-56
Annals of neurology 2011 Feb;69(2):248-56
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
Perez SE, He B, Muhammad N, Oh KJ, Fahnestock M, Ikonomovic MD, Mufson EJ
Neurobiology of disease 2011 Feb;41(2):338-52
Neurobiology of disease 2011 Feb;41(2):338-52
The pathological process underlying Alzheimer's disease in individuals under thirty.
Braak H, Del Tredici K
Acta neuropathologica 2011 Feb;121(2):171-81
Acta neuropathologica 2011 Feb;121(2):171-81
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1688-92
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1688-92
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 16;31(7):2511-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 16;31(7):2511-25
Clinical correlates of similar pathologies in parkinsonian syndromes.
Song YJ, Huang Y, Halliday GM
Movement disorders : official journal of the Movement Disorder Society 2011 Feb 15;26(3):499-506
Movement disorders : official journal of the Movement Disorder Society 2011 Feb 15;26(3):499-506
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
To AW, Ribe EM, Chuang TT, Schroeder JE, Lovestone S
PloS one 2011 Feb 10;6(2):e16991
PloS one 2011 Feb 10;6(2):e16991
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X
Laboratory investigation; a journal of technical methods and pathology 2011 Dec;91(12):1777-86
Laboratory investigation; a journal of technical methods and pathology 2011 Dec;91(12):1777-86
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM
Neurochemistry international 2011 Dec;59(7):1056-65
Neurochemistry international 2011 Dec;59(7):1056-65
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
Cuadrado-Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez-Roldán JM, García-Barroso C, Franco R, Aguirre N, García-Osta A
British journal of pharmacology 2011 Dec;164(8):2029-41
British journal of pharmacology 2011 Dec;164(8):2029-41
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Ambegaokar SS, Jackson GR
Human molecular genetics 2011 Dec 15;20(24):4947-77
Human molecular genetics 2011 Dec 15;20(24):4947-77
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Panaite PA, Kielar M, Kraftsik R, Gourdon G, Kuntzer T, Barakat-Walter I
Journal of neuropathology and experimental neurology 2011 Aug;70(8):678-85
Journal of neuropathology and experimental neurology 2011 Aug;70(8):678-85
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, Grosjean ME, Demeyer D, Obriot H, Brion I, Barbot B, Galas MC, Staels B, Humez S, Sergeant N, Schraen-Maschke S, Muhr-Tailleux A, Hamdane M, Buée L, Blum D
Neurobiology of disease 2011 Aug;43(2):486-94
Neurobiology of disease 2011 Aug;43(2):486-94
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
Hall EC 2nd, Lee SY, Mairuae N, Simmons Z, Connor JR
Neurobiology of aging 2011 Aug;32(8):1409-19
Neurobiology of aging 2011 Aug;32(8):1409-19
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Kovacs GG, Molnár K, László L, Ströbel T, Botond G, Hönigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H
Acta neuropathologica 2011 Aug;122(2):205-22
Acta neuropathologica 2011 Aug;122(2):205-22
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
Glöckner F, Meske V, Lütjohann D, Ohm TG
Journal of neuropathology and experimental neurology 2011 Apr;70(4):292-301
Journal of neuropathology and experimental neurology 2011 Apr;70(4):292-301
αB-crystallin negative astrocytic inclusions.
Barnett BP, Bressler J, Chen T, Hutchins GM, Crain BJ, Kaufmann WE
Brain & development 2011 Apr;33(4):349-52
Brain & development 2011 Apr;33(4):349-52
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
Sparks DL, Ziolkowski C, Lawmaster T, Martin T
International journal of Alzheimer's disease 2011 Apr 17;2011:987023
International journal of Alzheimer's disease 2011 Apr 17;2011:987023
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Blazquez-Llorca L, Garcia-Marin V, Defelipe J
Frontiers in neuroanatomy 2010;4:20
Frontiers in neuroanatomy 2010;4:20
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Chen X, Wagener JF, Morgan DH, Hui L, Ghribi O, Geiger JD
Journal of Alzheimer's disease : JAD 2010;22(4):1289-303
Journal of Alzheimer's disease : JAD 2010;22(4):1289-303
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G
Journal of Alzheimer's disease : JAD 2010;19(4):1155-67
Journal of Alzheimer's disease : JAD 2010;19(4):1155-67
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Liu XA, Liao K, Liu R, Wang HH, Zhang Y, Zhang Q, Wang Q, Li HL, Tian Q, Wang JZ
Journal of Alzheimer's disease : JAD 2010;19(3):953-62
Journal of Alzheimer's disease : JAD 2010;19(3):953-62
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.
Fujimura RK, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson DW, Roos BA, Howard GA, Perez-Stable C
Journal of Alzheimer's disease : JAD 2010;19(1):97-109
Journal of Alzheimer's disease : JAD 2010;19(1):97-109
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C
Neurobiology of disease 2010 Sep;39(3):265-71
Neurobiology of disease 2010 Sep;39(3):265-71
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ
The European journal of neuroscience 2010 Sep;32(6):905-20
The European journal of neuroscience 2010 Sep;32(6):905-20
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Ambegaokar SS, Jackson GR
Genetics 2010 Sep;186(1):435-42
Genetics 2010 Sep;186(1):435-42
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG
The Journal of biological chemistry 2010 Sep 3;285(36):27737-44
The Journal of biological chemistry 2010 Sep 3;285(36):27737-44
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Minami SS, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, Rebeck GW, Prendergast JS, Dealwis C, Wetzel R, Bosetti F, Matsuoka Y, Hoe HS, Turner RS
Journal of neuroinflammation 2010 Sep 28;7:57
Journal of neuroinflammation 2010 Sep 28;7:57
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L
Neuron 2010 Sep 23;67(6):953-66
Neuron 2010 Sep 23;67(6):953-66
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
Morawski M, Brückner G, Jäger C, Seeger G, Arendt T
Neuroscience 2010 Sep 1;169(3):1347-63
Neuroscience 2010 Sep 1;169(3):1347-63
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Bertrand J, Sénéchal P, Zummo-Soucy M, Plouffe V, Leclerc N
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Van Nostrand WE, Xu F, Rozemuller AJ, Colton CA
Stroke 2010 Oct;41(10 Suppl):S135-8
Stroke 2010 Oct;41(10 Suppl):S135-8
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
Bhaskar K, Hobbs GA, Yen SH, Lee G
Neuropathology and applied neurobiology 2010 Oct;36(6):462-77
Neuropathology and applied neurobiology 2010 Oct;36(6):462-77
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM
The American journal of pathology 2010 Oct;177(4):1977-88
The American journal of pathology 2010 Oct;177(4):1977-88
Regulation of tau pathology by the microglial fractalkine receptor.
Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT
Neuron 2010 Oct 6;68(1):19-31
Neuron 2010 Oct 6;68(1):19-31
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J, Hara H
PloS one 2010 Oct 18;5(10):e13447
PloS one 2010 Oct 18;5(10):e13447
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT
The American journal of pathology 2010 Nov;177(5):2549-62
The American journal of pathology 2010 Nov;177(5):2549-62
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M
Brain : a journal of neurology 2010 Nov;133(11):3323-35
Brain : a journal of neurology 2010 Nov;133(11):3323-35
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I
Acta neuropathologica 2010 Nov;120(5):605-21
Acta neuropathologica 2010 Nov;120(5):605-21
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Rosario ER, Carroll J, Pike CJ
Brain research 2010 Nov 4;1359:281-90
Brain research 2010 Nov 4;1359:281-90
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 3;30(44):14915-24
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 3;30(44):14915-24
PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation.
Roltsch E, Holcomb L, Young KA, Marks A, Zimmer DB
Journal of neuroinflammation 2010 Nov 16;7:78
Journal of neuroinflammation 2010 Nov 16;7:78
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J
PloS one 2010 Nov 16;5(11):e15477
PloS one 2010 Nov 16;5(11):e15477
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Höftberger R, Fink S, Aboul-Enein F, Botond G, Olah J, Berki T, Ovadi J, Lassmann H, Budka H, Kovacs GG
Glia 2010 Nov 15;58(15):1847-57
Glia 2010 Nov 15;58(15):1847-57
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.
Berg I, Nilsson KP, Thor S, Hammarström P
Nature protocols 2010 May;5(5):935-44
Nature protocols 2010 May;5(5):935-44
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM
Cellular and molecular neurobiology 2010 May;30(4):577-90
Cellular and molecular neurobiology 2010 May;30(4):577-90
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ
Experimental & molecular medicine 2010 May 31;42(5):386-94
Experimental & molecular medicine 2010 May 31;42(5):386-94
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
Fang H, Zhang LF, Meng FT, Du X, Zhou JN
Neuroscience letters 2010 May 3;474(3):173-177
Neuroscience letters 2010 May 3;474(3):173-177
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Dickstein DL, Brautigam H, Stockton SD Jr, Schmeidler J, Hof PR
Brain structure & function 2010 Mar;214(2-3):161-79
Brain structure & function 2010 Mar;214(2-3):161-79
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.
Ma JF, Huang Y, Chen SD, Halliday G
Neuropathology and applied neurobiology 2010 Jun;36(4):312-9
Neuropathology and applied neurobiology 2010 Jun;36(4):312-9
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Escribano L, Simón AM, Gimeno E, Cuadrado-Tejedor M, López de Maturana R, García-Osta A, Ricobaraza A, Pérez-Mediavilla A, Del Río J, Frechilla D
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Jun;35(7):1593-604
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Jun;35(7):1593-604
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Khan TK, Alkon DL
Neurobiology of aging 2010 Jun;31(6):889-900
Neurobiology of aging 2010 Jun;31(6):889-900
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Carroll JC, Rosario ER, Villamagna A, Pike CJ
Endocrinology 2010 Jun;151(6):2713-22
Endocrinology 2010 Jun;151(6):2713-22
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H
Acta neuropathologica 2010 Jun;119(6):703-13
Acta neuropathologica 2010 Jun;119(6):703-13
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Bertrand J, Plouffe V, Sénéchal P, Leclerc N
Neuroscience 2010 Jun 30;168(2):323-34
Neuroscience 2010 Jun 30;168(2):323-34
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM
The American journal of pathology 2010 Jul;177(1):300-10
The American journal of pathology 2010 Jul;177(1):300-10
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
Braak H, Ludolph A, Thal DR, Del Tredici K
Acta neuropathologica 2010 Jul;120(1):67-74
Acta neuropathologica 2010 Jul;120(1):67-74
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle MB, Maurage CA, Blum D, Buée L, Frébourg T, Campion D, Lecourtois M
Brain research 2010 Jul 23;1345:182-9
Brain research 2010 Jul 23;1345:182-9
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB
PLoS genetics 2010 Jul 15;6(7):e1001026
PLoS genetics 2010 Jul 15;6(7):e1001026
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Härtig W, Kacza J, Paulke BR, Grosche J, Bauer U, Hoffmann A, Elsinghorst PW, Gütschow M
The European journal of neuroscience 2010 Jan;31(1):99-109
The European journal of neuroscience 2010 Jan;31(1):99-109
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Lecanu L, Rammouz G, McCourty A, Sidahmed EK, Greeson J, Papadopoulos V
Neuroscience 2010 Jan 20;165(2):427-35
Neuroscience 2010 Jan 20;165(2):427-35
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG, Reichmann H, Funk RH
PloS one 2010 Jan 19;5(1):e8762
PloS one 2010 Jan 19;5(1):e8762
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS
Stem cells (Dayton, Ohio) 2010 Feb;28(2):329-43
Stem cells (Dayton, Ohio) 2010 Feb;28(2):329-43
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM
The American journal of pathology 2010 Feb;176(2):870-80
The American journal of pathology 2010 Feb;176(2):870-80
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J
PloS one 2010 Feb 2;5(2):e9002
PloS one 2010 Feb 2;5(2):e9002
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ
Neuropathology : official journal of the Japanese Society of Neuropathology 2010 Dec;30(6):574-9
Neuropathology : official journal of the Japanese Society of Neuropathology 2010 Dec;30(6):574-9
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Loy CT, McCusker E, Kril JJ, Kwok JB, Brooks WS, McCann H, Isaacs AM, Halliday GM
Brain : a journal of neurology 2010 Dec;133(Pt 12):e158; author reply e159
Brain : a journal of neurology 2010 Dec;133(Pt 12):e158; author reply e159
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
Boutajangout A, Quartermain D, Sigurdsson EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 8;30(49):16559-66
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 8;30(49):16559-66
DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease.
Chen J, Cohen ML, Lerner AJ, Yang Y, Herrup K
Molecular neurodegeneration 2010 Dec 20;5:60
Molecular neurodegeneration 2010 Dec 20;5:60
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Colodner KJ, Feany MB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Pretnar-Oblak J, Zaletel M, Hajnsek TM, Meglic B, Hocevar-Boltezar I, Popovic M
Journal of neurology, neurosurgery, and psychiatry 2010 Aug;81(8):847-9
Journal of neurology, neurosurgery, and psychiatry 2010 Aug;81(8):847-9
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J
Brain research 2010 Aug 6;1347:179-85
Brain research 2010 Aug 6;1347:179-85
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Caltagarone J, Hamilton RL, Murdoch G, Jing Z, DeFranco DB, Bowser R
Journal of neuropathology and experimental neurology 2010 Apr;69(4):356-71
Journal of neuropathology and experimental neurology 2010 Apr;69(4):356-71
Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L
The Journal of endocrinology 2010 Apr;205(1):25-36
The Journal of endocrinology 2010 Apr;205(1):25-36
Caspase activation precedes and leads to tangles.
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT
Nature 2010 Apr 22;464(7292):1201-4
Nature 2010 Apr 22;464(7292):1201-4
Hyposmia in progressive supranuclear palsy.
Silveira-Moriyama L, Hughes G, Church A, Ayling H, Williams DR, Petrie A, Holton J, Revesz T, Kingsbury A, Morris HR, Burn DJ, Lees AJ
Movement disorders : official journal of the Movement Disorder Society 2010 Apr 15;25(5):570-7
Movement disorders : official journal of the Movement Disorder Society 2010 Apr 15;25(5):570-7
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Campos-Peña V, Tapia-Ramírez J, Sánchez-Torres C, Meraz-Rios MA
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Altered subcellular distribution of c-Abl in Alzheimer's disease.
Jing Z, Caltagarone J, Bowser R
Journal of Alzheimer's disease : JAD 2009;17(2):409-22
Journal of Alzheimer's disease : JAD 2009;17(2):409-22
Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.
Filipcik P, Cente M, Krajciova G, Vanicky I, Novak M
Cellular and molecular neurobiology 2009 Sep;29(6-7):895-900
Cellular and molecular neurobiology 2009 Sep;29(6-7):895-900
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Nogalska A, Terracciano C, D'Agostino C, King Engel W, Askanas V
Acta neuropathologica 2009 Sep;118(3):407-13
Acta neuropathologica 2009 Sep;118(3):407-13
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Kovacs GG, Murrell JR, Horvath S, Haraszti L, Majtenyi K, Molnar MJ, Budka H, Ghetti B, Spina S
Movement disorders : official journal of the Movement Disorder Society 2009 Sep 15;24(12):1843-7
Movement disorders : official journal of the Movement Disorder Society 2009 Sep 15;24(12):1843-7
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
McConnell GC, Rees HD, Levey AI, Gutekunst CA, Gross RE, Bellamkonda RV
Journal of neural engineering 2009 Oct;6(5):056003
Journal of neural engineering 2009 Oct;6(5):056003
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Wilhelmus MM, Grunberg SC, Bol JG, van Dam AM, Hoozemans JJ, Rozemuller AJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
van Eersel J, Bi M, Ke YD, Hodges JR, Xuereb JH, Gregory GC, Halliday GM, Götz J, Kril JJ, Ittner LM
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Tang J, LeGros RP, Louneva N, Yeh L, Cohen JW, Hahn CG, Blake DJ, Arnold SE, Talbot K
Human molecular genetics 2009 Oct 15;18(20):3851-63
Human molecular genetics 2009 Oct 15;18(20):3851-63
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
Whiteman IT, Gervasio OL, Cullen KM, Guillemin GJ, Jeong EV, Witting PK, Antao ST, Minamide LS, Bamburg JR, Goldsbury C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Oct 14;29(41):12994-3005
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Oct 14;29(41):12994-3005
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS
Brain : a journal of neurology 2009 May;132(Pt 5):1324-34
Brain : a journal of neurology 2009 May;132(Pt 5):1324-34
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N
Neuroscience letters 2009 May 22;455(3):191-4
Neuroscience letters 2009 May 22;455(3):191-4
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Ricobaraza A, Cuadrado-Tejedor M, Pérez-Mediavilla A, Frechilla D, Del Río J, García-Osta A
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 Jun;34(7):1721-32
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 Jun;34(7):1721-32
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Kim HS, Sul D, Lim JY, Lee D, Joo SS, Hwang KW, Park SY
Bioscience, biotechnology, and biochemistry 2009 Jul;73(7):1685-9
Bioscience, biotechnology, and biochemistry 2009 Jul;73(7):1685-9
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CC, Shaw PJ, Grierson AJ
Journal of neurochemistry 2009 Jul;110(1):34-44
Journal of neurochemistry 2009 Jul;110(1):34-44
Transmission and spreading of tauopathy in transgenic mouse brain.
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M
Nature cell biology 2009 Jul;11(7):909-13
Nature cell biology 2009 Jul;11(7):909-13
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N
FEBS letters 2009 Jul 7;583(13):2194-200
FEBS letters 2009 Jul 7;583(13):2194-200
Tremor on smiling.
Schwingenschuh P, Cordivari C, Czerny J, Esposito M, Bhatia KP
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1542-5
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1542-5
Bell's palsy preceding Parkinson's disease: a case-control study.
Savica R, Bower JH, Maraganore DM, Grossardt BR, Rocca WA
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1530-3
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1530-3
Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature.
Kraoua I, Stirnemann J, Ribeiro MJ, Rouaud T, Verin M, Annic A, Rose C, Defebvre L, Réménieras L, Schüpbach M, Belmatoug N, Vidailhet M, Sedel F
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1524-30
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1524-30
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Halliday G, Herrero MT, Murphy K, McCann H, Ros-Bernal F, Barcia C, Mori H, Blesa FJ, Obeso JA
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1519-23
Movement disorders : official journal of the Movement Disorder Society 2009 Jul 30;24(10):1519-23
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
Vidal R, Barbeito AG, Miravalle L, Ghetti B
Brain pathology (Zurich, Switzerland) 2009 Jan;19(1):58-68
Brain pathology (Zurich, Switzerland) 2009 Jan;19(1):58-68
2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.
Sul D, Kim HS, Cho EK, Lee M, Kim HS, Jung WW, Hwang KW, Park SY
Toxicology 2009 Jan 8;255(1-2):65-71
Toxicology 2009 Jan 8;255(1-2):65-71
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA
Brain research 2009 Jan 16;1249:244-50
Brain research 2009 Jan 16;1249:244-50
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Chatterjee S, Sang TK, Lawless GM, Jackson GR
Human molecular genetics 2009 Jan 1;18(1):164-77
Human molecular genetics 2009 Jan 1;18(1):164-77
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Sul D, Kim HS, Lee D, Joo SS, Hwang KW, Park SY
Life sciences 2009 Feb 27;84(9-10):257-62
Life sciences 2009 Feb 27;84(9-10):257-62
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Greco SJ, Sarkar S, Johnston JM, Tezapsidis N
Biochemical and biophysical research communications 2009 Feb 27;380(1):98-104
Biochemical and biophysical research communications 2009 Feb 27;380(1):98-104
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition.
Heffron DS, Landreth GE, Samuels IS, Mandell JW
The American journal of pathology 2009 Dec;175(6):2586-99
The American journal of pathology 2009 Dec;175(6):2586-99
Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells.
Pandey NR, Sultan K, Twomey E, Sparks DL
Neuroscience 2009 Dec 29;164(4):1744-53
Neuroscience 2009 Dec 29;164(4):1744-53
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2595-604
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2595-604
TDP-43 pathology in familial British dementia.
Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL
Acta neuropathologica 2009 Aug;118(2):303-11
Acta neuropathologica 2009 Aug;118(2):303-11
Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies.
Leem YH, Lim HJ, Shim SB, Cho JY, Kim BS, Han PL
Journal of neuroscience research 2009 Aug 15;87(11):2561-70
Journal of neuroscience research 2009 Aug 15;87(11):2561-70
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG
Aging 2009 Apr;1(4):382-8
Aging 2009 Apr;1(4):382-8
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
Schrag M, Sharma S, Brown-Borg H, Ghribi O
Hippocampus 2008;18(3):239-44
Hippocampus 2008;18(3):239-44
The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.
Kanungo J, Zheng YL, Amin ND, Pant HC
Journal of neurochemistry 2008 Sep;106(5):2236-48
Journal of neurochemistry 2008 Sep;106(5):2236-48
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Laporte V, Ait-Ghezala G, Volmar CH, Ganey C, Ganey N, Wood M, Mullan M
Brain research 2008 Sep 22;1231:132-42
Brain research 2008 Sep 22;1231:132-42
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 26;28(48):12798-807
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 26;28(48):12798-807
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
Patil S, Balu D, Melrose J, Chan C
BMC research notes 2008 Jun 4;1:20
BMC research notes 2008 Jun 4;1:20
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D, Tagliavini F
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
MAPT S305I mutation: implications for argyrophilic grain disease.
Kovacs GG, Pittman A, Revesz T, Luk C, Lees A, Kiss E, Tariska P, Laszlo L, Molnár K, Molnar MJ, Tolnay M, de Silva R
Acta neuropathologica 2008 Jul;116(1):103-18
Acta neuropathologica 2008 Jul;116(1):103-18
Tauopathy with paired helical filaments in an aged chimpanzee.
Rosen RF, Farberg AS, Gearing M, Dooyema J, Long PM, Anderson DC, Davis-Turak J, Coppola G, Geschwind DH, Paré JF, Duong TQ, Hopkins WD, Preuss TM, Walker LC
The Journal of comparative neurology 2008 Jul 20;509(3):259-70
The Journal of comparative neurology 2008 Jul 20;509(3):259-70
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Huang Y, Song YJ, Murphy K, Holton JL, Lashley T, Revesz T, Gai WP, Halliday GM
Acta neuropathologica 2008 Dec;116(6):639-46
Acta neuropathologica 2008 Dec;116(6):639-46
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13805-14
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13805-14
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
Park SY, Kim HS, Cho EK, Kwon BY, Phark S, Hwang KW, Sul D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008 Aug;46(8):2881-7
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008 Aug;46(8):2881-7
Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.
Hu M, Waring JF, Gopalakrishnan M, Li J
Journal of neurochemistry 2008 Aug;106(3):1371-7
Journal of neurochemistry 2008 Aug;106(3):1371-7
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.
Luty AA, Kwok JB, Thompson EM, Blumbergs P, Brooks WS, Loy CT, Dobson-Stone C, Panegyres PK, Hecker J, Nicholson GA, Halliday GM, Schofield PR
BMC neurology 2008 Aug 29;8:32
BMC neurology 2008 Aug 29;8:32
Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Bai F, Xi JH, Andley UP
Molecular vision 2007 Sep 6;13:1589-600
Molecular vision 2007 Sep 6;13:1589-600
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 28;27(48):13357-65
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Nov 28;27(48):13357-65
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
Gelpi E, Preusser M, Bauer G, Budka H
Forensic science international 2007 May 24;168(2-3):177-82
Forensic science international 2007 May 24;168(2-3):177-82
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Magaki S, Raghavan R, Mueller C, Oberg KC, Vinters HV, Kirsch WM
Neuroscience letters 2007 May 11;418(1):72-6
Neuroscience letters 2007 May 11;418(1):72-6
Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease.
Zhu HY, Guo HF, Hou HL, Liu YJ, Sheng SL, Zhou JN
Human pathology 2007 Mar;38(3):426-34
Human pathology 2007 Mar;38(3):426-34
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Papapetropoulos S, Mash DC
Journal of neural transmission (Vienna, Austria : 1996) 2007 Mar;114(3):341-5
Journal of neural transmission (Vienna, Austria : 1996) 2007 Mar;114(3):341-5
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Mar 21;27(12):3090-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Mar 21;27(12):3090-7
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G
Journal of neuropathology and experimental neurology 2007 Jun;66(6):525-32
Journal of neuropathology and experimental neurology 2007 Jun;66(6):525-32
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R
Journal of neurochemistry 2007 Jun;101(5):1303-15
Journal of neurochemistry 2007 Jun;101(5):1303-15
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
Rissman RA, Lee KF, Vale W, Sawchenko PE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Jun 13;27(24):6552-62
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Jun 13;27(24):6552-62
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Papapetropoulos S, Mash DC
Parkinsonism & related disorders 2007 Jul;13(5):308-11
Parkinsonism & related disorders 2007 Jul;13(5):308-11
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Sikorska B, Papierz W, Preusser M, Liberski PP, Budka H
Neuropathology and applied neurobiology 2007 Feb;33(1):126-9
Neuropathology and applied neurobiology 2007 Feb;33(1):126-9
Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.
Saturno G, Pesenti M, Cavazzoli C, Rossi A, Giusti AM, Gierke B, Pawlak M, Venturi M
Toxicologic pathology 2007 Dec;35(7):972-83
Toxicologic pathology 2007 Dec;35(7):972-83
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM
Journal of neurochemistry 2007 Aug;102(4):1053-63
Journal of neurochemistry 2007 Aug;102(4):1053-63
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Ikonomovic MD, Abrahamson EE, Isanski BA, Debnath ML, Mathis CA, Dekosky ST, Klunk WE
Methods in enzymology 2006;412:123-44
Methods in enzymology 2006;412:123-44
Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.
Lagalwar S, Guillozet-Bongaarts AL, Berry RW, Binder LI
Journal of neuropathology and experimental neurology 2006 May;65(5):455-64
Journal of neuropathology and experimental neurology 2006 May;65(5):455-64
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Blain JF, Sullivan PM, Poirier J
Neurobiology of disease 2006 Mar;21(3):505-14
Neurobiology of disease 2006 Mar;21(3):505-14
Interleukin-1 mediates Alzheimer and Lewy body pathologies.
Griffin WS, Liu L, Li Y, Mrak RE, Barger SW
Journal of neuroinflammation 2006 Mar 16;3:5
Journal of neuroinflammation 2006 Mar 16;3:5
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Arranz R, Patiño C
Journal of structural biology 2006 Jan;153(1):42-54
Journal of structural biology 2006 Jan;153(1):42-54
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Lee HG, Ueda M, Zhu X, Perry G, Smith MA
Journal of neuroscience research 2006 Dec;84(8):1856-61
Journal of neuroscience research 2006 Dec;84(8):1856-61
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, Arbustini E, Palladini G, Diegoli M, Genovese E, Ferrari G, Coverlizza S, Merlini G
Annals of neurology 2005 Oct;58(4):639-44
Annals of neurology 2005 Oct;58(4):639-44
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Klos KJ, Josephs KA, Parisi JE, Dickson DW
Movement disorders : official journal of the Movement Disorder Society 2005 Nov;20(11):1515-20
Movement disorders : official journal of the Movement Disorder Society 2005 Nov;20(11):1515-20
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, Howng SL, Wang CH
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, Howng SL, Wang CH
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Wang YJ, Chen GH, Hu XY, Lu YP, Zhou JN, Liu RY
Brain research 2005 Jan 7;1031(1):101-8
Brain research 2005 Jan 7;1031(1):101-8
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons.
Patil S, Chan C
Neuroscience letters 2005 Aug 26;384(3):288-93
Neuroscience letters 2005 Aug 26;384(3):288-93
Astrocytic degeneration relates to the severity of disease in frontotemporal dementia.
Broe M, Kril J, Halliday GM
Brain : a journal of neurology 2004 Oct;127(Pt 10):2214-20
Brain : a journal of neurology 2004 Oct;127(Pt 10):2214-20
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.
Takahashi S, Kulkarni AB
Journal of neurochemistry 2004 Mar;88(5):1295-304
Journal of neurochemistry 2004 Mar;88(5):1295-304
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Mesulam M, Shaw P, Mash D, Weintraub S
Annals of neurology 2004 Jun;55(6):815-28
Annals of neurology 2004 Jun;55(6):815-28
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
Shimura H, Schwartz D, Gygi SP, Kosik KS
The Journal of biological chemistry 2004 Feb 6;279(6):4869-76
The Journal of biological chemistry 2004 Feb 6;279(6):4869-76
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Vidal R, Ghetti B, Takao M, Brefel-Courbon C, Uro-Coste E, Glazier BS, Siani V, Benson MD, Calvas P, Miravalle L, Rascol O, Delisle MB
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Vidal R, Ghetti B, Takao M, Brefel-Courbon C, Uro-Coste E, Glazier BS, Siani V, Benson MD, Calvas P, Miravalle L, Rascol O, Delisle MB
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA
Acta neuropathologica 2004 Apr;107(4):365-71
Acta neuropathologica 2004 Apr;107(4):365-71
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
Shimura H, Miura-Shimura Y, Kosik KS
The Journal of biological chemistry 2004 Apr 23;279(17):17957-62
The Journal of biological chemistry 2004 Apr 23;279(17):17957-62
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.
Takahashi S, Saito T, Hisanaga S, Pant HC, Kulkarni AB
The Journal of biological chemistry 2003 Mar 21;278(12):10506-15
The Journal of biological chemistry 2003 Mar 21;278(12):10506-15
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.
Schofield E, Kersaitis C, Shepherd CE, Kril JJ, Halliday GM
Brain : a journal of neurology 2003 Apr;126(Pt 4):827-40
Brain : a journal of neurology 2003 Apr;126(Pt 4):827-40
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.
Schofield E, Kersaitis C, Shepherd CE, Kril JJ, Halliday GM
Brain : a journal of neurology 2003 Apr;126(Pt 4):827-40
Brain : a journal of neurology 2003 Apr;126(Pt 4):827-40
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
Agarwal-Mawal A, Qureshi HY, Cafferty PW, Yuan Z, Han D, Lin R, Paudel HK
The Journal of biological chemistry 2003 Apr 11;278(15):12722-8
The Journal of biological chemistry 2003 Apr 11;278(15):12722-8
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease.
Cottrell DA, Borthwick GM, Johnson MA, Ince PG, Turnbull DM
Neuropathology and applied neurobiology 2002 Oct;28(5):390-6
Neuropathology and applied neurobiology 2002 Oct;28(5):390-6
Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type.
Forno LS, Langston JW, Herrick MK, Wilson JD, Murayama S
Acta neuropathologica 2002 Jun;103(6):599-606
Acta neuropathologica 2002 Jun;103(6):599-606
Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.
Cottrell DA, Blakely EL, Johnson MA, Ince PG, Borthwick GM, Turnbull DM
Neurobiology of aging 2001 Mar-Apr;22(2):265-72
Neurobiology of aging 2001 Mar-Apr;22(2):265-72
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.
Rapoport M, Ferreira A
Journal of neurochemistry 2000 Jan;74(1):125-33
Journal of neurochemistry 2000 Jan;74(1):125-33
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot was performed using Anti-Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) and a 60kDa band corresponding to Phospho-Tau (Ser202, Thr205) was observed across cell line tested and increased upon Retinoic acid and the successive Okadaic acid treatments. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Retinoic acid (10 uM for 8 days) (Lane 2), SH-SY5Y differentiated with retinoic acid and treated with Okadaic acid (100 nM for 6 hours) (Lane 3) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:5000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using SuperSignal™ West Dura Extended Duration Substrate (Product # 34076).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
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- Immunofluorescence analysis of Phospho-Tau (Ser202, Thr205) was performed using 70% confluent log phase SH-SY5Y Retinoic acid 100 nM, 8 days. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8) (Product # MN1020) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766), (1:2000), for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b:Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing Plasma membrane and cytoskeleton localization. Panel e represents untreated cells showing faint signal Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.
Supportive validation
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- Fig. 5 Stereological assessments of brain pathology and integrity. Representative images of microglial (CD68; a + b ), phosphorylated-tau ( c + d ), TDP-43 ( e + f ), ubiquitin ( g + h ) and alpha-synuclein ( i + j ) staining in the hippocampus (CA1) from LBC1936 ( a , c , e , g , i ) and AD ( b , d , f , h , j ) brains. Large scale bar = 50 mum, insert scale bars = 10 mum. k Histogram showing neuronal densities in eight cortical regions from the LBC1936 (black bars) and AD (grey bars) brains. l Histogram showing microglial densities (CD68-positive cells) in eight cortical regions from the LBC1936 and AD brains. m Histogram of cortical thickness measurements from eight cortical regions in the LBC1936 and AD brains
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- Fig. 2 Tau phosphorylation precludes the BIN1-Tau interaction in vitro . a . Tau-F5 fragment phosphorylation analysis after in vitro phosphorylation by CDK2/CycA3 kinase. Representative immunoblots using various antibodies against phosphorylation epitopes in Tau. The total amount of Tau-F5 was revealed by the phosphorylation-independent antibody Tau5. The significant shift in molecular weight observed in CDK2/CycA3-treated samples indicates Tau hyperphosphorylation. In contrast to other antibodies, the Tau-1 antibody binds to various non-phosphorylated Tau sites; the signal thus decreases when Tau is hyperphosphorylated [ 31 ]. b . 2D [ 1 H, 15 N] HSQC spectra of 125 muM 15 N CDK-phosphorylated Tau-F5[165-245] free in solution (gray) and with a 1 molar amount of GST-BIN1/SH3 (red, superimposed): Overlaid details of 2D [ 1 H, 15 N] HSQC spectra presented in Additional file 6 . c . 2D [ 1 H, 15 N] HSQC spectra of 60 muM 15 N CDK-phosphorylated 2N4R Tau free in solution (gray) and with a 2 molar amount of GST-BIN1/SH3 (blue, superimposed): Overlaid details of full spectra presented in Additional file 7
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- Figure 3 In vitro biochemical interaction between PTK2B and Tau. ( a ) Pull down of PTK2B with GST, GST-Tau1N4R and GST-Tau2N4R protein constructs. Upper panel: detection of PTK2B in the pull down extract by western blotting. Lower panel: corresponding Coomassie blue gel used as loading control of GST constructs. ( b ) Pull down of Tau1N4R and Tau2N4R with GST and GST-PTK2B protein constructs. Upper panel: detection of Tau (arrows) in the pull down extract by western blotting (an unspecific band is labeled with a star, MW, molecular weight). Lower panel: corresponding Coomassie blue gel used as loading control of GST constructs. As the GST-PTK2B constructs were difficult to produce and visualize with Coomassie blue staining (arrows), we checked the GST-PTK2B construct through detection of PTK2B by western blotting (middle panel). All results shown in panels ( a and b ) are representative of three independent experiments. ( c ) Western blotting analysis of Tau phosphorylation in different Fak conditions in the Drosophila eye. Actin is used as a loading control ( n =2-4). ( d ) Images and quantification of fly eyes co-expressing the 2N4R Tau isoform and a mCD8::GFP construct used as control or wild-type Fak or mutant Fak Y430F (scale bar 0.1 mm).
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- Figure 7 Tau pathology in pericyte-deficient APP sw/0 Pdgfrbeta +/- mice. ( a - f ) Representative cortex and hippocampus sections stained with antibodies against p-tau (Thr231) ( a ), quantification of p-tau (Thr231)-positive neurons ( b ), p-tau (Ser202/Thr205, AT8) ( c ), quantification of AT8-positive neurons ( d ), caspase-cleaved tau ( e ) and an early pathological tau marker MC1 ( f ) in 9-month-old APP sw/0 Pdgfrbeta +/- mice and age-matched APP sw/0 Pdgfrbeta +/+ littermates. In a , c , e , f , scale bar, 25 mum. CA1 and CA3 denote hippocampal regions. In b , d , values are means+-s.e.m., n =5 mice per group. P
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- Figure 8. Inhibition of MT dynamics causes tau hyperphosphorylation and spine loss though tau. (A and B) WB analysis of Glu and acetylated (Acety) tubulin (A) as well as phosphorylated (AT8 and pS262) and total (tau-46) tau levels (B) in hippocampal neurons (7 DIV) incubated with 10 nM taxol for 3 h. (C) Quantification of normalized AT8 and pS262 against control levels in taxol-treated neurons. (D) WB analysis of total tau (tau-C) and tubulin (DM1A) levels in cortical neurons (7 DIV) treated with 10 nM taxol for 3 h. Aliquots of soluble (S) and MT pellet (P) fractions are shown. (E) Representative images from time-lapse recordings of NIH3T3 cells cotransfected with human 2N4R WT or S262A tau-GFP and RFP-tubulin before and 10 min after 10 nM taxol. Dashed lines indicate cell peripheries. Bar, 20 um. (F) Quantification of background-subtracted MT-bound WT tau, S262A tau, and MT intensity after taxol treatment. (G and H) Representative images (G) and quantification (H) of spine density and morphology of hippocampal neurons (21 DIV) treated with vehicle control, Abeta, or taxol for the indicated times +- washout (w/o). (I and J) Representative images (I) and quantification (J) of spine density and morphology of hippocampal neurons (21 DIV) from WT and tau-KO mice treated with vehicle control, Abeta, or taxol for the indicated times. Bars, 2 um. Gray asterisks in J compare Abeta- or taxol-treated KO neurons to KO control neurons. Data are shown as means +- SEM. *, P < 0.5; **,
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- Figure 3 Aggregates Are Comprised of Cytoskeletal Proteins (A) LRRK2 G2019S aggregates were positive (indicated by arrows) for betaIII tubulin (green) and peripherin (red), tau (green), MAP2 (red), and LRRK2 (green). Aggregates were generally negative (indicated by arrowheads) for SNCA and ubiquitin (green). (B-D) LRRK2 G2019S sensory neuron cultures display significantly increased levels of (B and C) tau and (B and D) phospho-tau by western blot and densitometry. * p < 0.01 by ANOVA; n = 6 independent experiments. The scale bar represents 50 mum. See also Figure S3 .
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- Fig. 5 Cytoskeletal pathology in young PS1/APP hippocampus. a Quantitative Western blotting using AT8 antibody in the hippocampus of 6-month-old PS1/APP and WT mice; PS1/APP mice had significantly higher AT8 levels than to age-matched WT mice ( n = 6, p < 0.05). b The presence of AT8-positive structures around plaques ( asterisk ) was observed from 4 months of age. c1 - c4 and d1 - d4. Double-label immunofluorescence confocal laser microscopy of APP ( green ) and AT8 ( red ) in 6-month-old transgenic mice showing the presence of phospho-tau in some APP-positive dystrophic neurites. e Immunohistochemistry for cofilin revealed the presence of actin-cofilin rods around plaques ( asterisk ) from 4 months of age. A higher magnification detail of a rod is shown in the inset . f1 - f3 Confocal laser microscopy with double APP/cofilin labeling revealed the presence of cofilin within some APP-positive neurites. g Quantitative Western blotting for heavy chain kinesin-1 and dynein in 6-month-old PS1/APP and WT mice hippocampus. PS1/APP mice were found to have significantly lower kinesin-1 and dynein levels than age-matched WT mice ( n = 8, p < 0.05). Scale bars b 100 mum, c1 - c3 5 mum, c4 2.5 mum, d1 - d3 7.5 mum, d4 2.5 mum, e 50 mum ( inset 7 mum), f1 - f3 7.5 mum
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- Figure 2 Diet-induced HHcy in brain affects tau phosphorylation and pathology A. Brain cortex homogenates from h-tau mice receiving the low folate and B vitamins diet (DIET) or chow diet controls (CTR) from 4 to 12 months of age were assayed by HPLC for levels of Hcy, SAM, SAH, and the ratio SAM/SAH calculated (*p
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- Figure 1 Tau acetylation modulates tau phosphorylation at specific epitopes. (a-c ) Immunoblot analysis and quantification using the indicated tau antibodies for (a ) cells expressing WT tau-T40 and either an active form of CBP or a catalytically inactive form of CBP (CBP-LD), ( b ) cells co- expressing tau-T40 (WT, DeltaKK, 4KQ, or 4KR) and tau modifying enzymes, and ( c ) cells expressing tau-T40 (WT, DeltaKK, 2KQ, 4KQ, or 4KR) and treated with control (DMSO) or okadaic acid (OA), where indicated. Solid black arrows highlight the ~75 kDa phospho-tau species that is reduced upon acetylation. Statistical significance was assessed using a student t-test (****p < 0.0001). Cropped images from full size immunoblots are provided in panels a-c. Full-length immunoblots are presented in Supplementary Fig. S1 . ( d ) Immunofluorescence microscopy of primary cortical neurons expressing WT-tau-GFP (left) or 4KQ-tau-GFP (right) detecting phosphorylated tau (AT8). White arrows identify transfected neurons. Scale bar, 50 um.
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- Figure 2 Both HMW-tau and LMW-tau are selectively hyperphosphorylated in AD brain. (A) AD and control human brain homogenates were analyzed by western blots developed with the indicated site-specific and phosphorylation dependent anti-tau antibodies. (B,C) Blots were analyzed by densitometry. The levels of hyperphosphorylated HMW-tau (B) and LMW-tau (C) are shown as scattered dots with mean +- SD. ** p < 0.01; *** p < 0.001; **** p < 0.0001.
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- Fig. 2 Tau is hyperphosphorylated in fimbria of the hippocampus in 3xTg-AD mice after r-mTBI. A) Representative images showing immunohistochemical staining of sagittal brain sections with antibodies PHF-1, AT8 (pSer 202 /pThr 205 ) or anti-pThr 212 -tau. Fimbria showed easily visible PHF-1 immunoreactivity, and quantification revealed significantly more immunoreactivity in r-mTBI group than sham control group. No staining was detected by AT8 or anti-pThr 212 -tau. No primary antibody control for PHF-1 staining exhibited no staining. B) Immunofluorescence staining with anti-pSer 396 -tau. Immunoreactivity was mostly seen in fimbria, though subiculum also showed sparse staining. In addition, quantification which was performed by using images taken with a 20x objective lens showed more immunoreactivity in fimbria in r-mTBI group than in sham controls. Data are expressed as scattered dot plots with mean+-SEM ( n = 6-7 mice/group) and analyzed with unpaired Student t test. Scale bar = 500 mu m (A), 50 mu m (insert and B).
