FNab09784

antibody from FineTest Biotech

Targeting: MAP3K3 MAPKKK3, MEKK3

Western blot

ELISA

Immunohistochemistry

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Validation data

Product number: FNab09784 - Provider product page
Provider: FineTest Biotech
Product name: MAP3K3 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: mitogen-activated protein kinase ki nase kinase 3
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

MAP3K3 protein structure - FNab09784 shown in red.