Antibody data
- Antibody Data
- Antigen structure
- References [133]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10829-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10829-1-AP, RRID:AB_2232989
- Product name
- HMGB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HMGB1 antibody (Cat. #10829-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors.
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling.
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis.
Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Methionine enkephalin (MENK) suppresses lung cancer by regulating the Bcl-2/Bax/caspase-3 signaling pathway and enhancing natural killer cell-driven tumor immunity.
Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events.
miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1.
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells.
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.
Impact of perioperative high mobility group box chromosomal protein 1 expression on long-term outcomes in patients with esophageal squamous cell carcinoma.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Pannexin1 Channel Inhibitor (10panx) Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting RIP3 Expression and Inflammatory Response in Rats.
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling.
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Neuroprotective Effect of Dioscin on the Aging Brain.
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis.
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.
HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single-center experience.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization.
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.
Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium.
Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae.
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury.
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Potent effects of dioscin against obesity in mice.
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Potent effects of dioscin against liver fibrosis.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
miR-200c inhibits metastasis of breast cancer cells by targeting HMGB1.
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells.
RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.
RAGE signaling significantly impacts tumorigenesis and hepatic tumor growth in murine models of colorectal carcinoma.
The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines.
HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells.
Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.
Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.
Jia S, He D, Liang X, Cheng P, Liu J, Chen M, Wang C, Zhang H, Meng C
Molecular medicine reports 2022 Jan;25(1)
Molecular medicine reports 2022 Jan;25(1)
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors.
Zhu L, Hu S, Chen Q, Zhang H, Fu J, Zhou Y, Bai Y, Pan Y, Shao C
International journal of biological sciences 2021;17(4):926-941
International journal of biological sciences 2021;17(4):926-941
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Yu H, He B, Han X, Yan T
Open life sciences 2021;16(1):845-855
Open life sciences 2021;16(1):845-855
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling.
Guo Q, Qu H, Zhang H, Zhong X
Drug design, development and therapy 2021;15:4559-4574
Drug design, development and therapy 2021;15:4559-4574
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Huang Y, Zhang G, Zhu Q, Wu X, Wu L
Cancer management and research 2021;13:7399-7409
Cancer management and research 2021;13:7399-7409
HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis.
Huang J, Chen X, Lv Y
Frontiers in endocrinology 2021;12:616696
Frontiers in endocrinology 2021;12:616696
Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.
Ren J, Zhou J, Liu H, Jiao X, Cao Y, Xu Z, Kang Y, Xue P
Theranostics 2021;11(19):9470-9491
Theranostics 2021;11(19):9470-9491
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Methionine enkephalin (MENK) suppresses lung cancer by regulating the Bcl-2/Bax/caspase-3 signaling pathway and enhancing natural killer cell-driven tumor immunity.
Zhang S, Liu N, Ma M, Huang H, Handley M, Bai X, Shan F
International immunopharmacology 2021 Sep;98:107837
International immunopharmacology 2021 Sep;98:107837
Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.
Yang B, Peng F, Zhang Y, Wang X, Wang S, Zheng Y, Zhang J, Zeng Y, Wang N, Peng C, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153628
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153628
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks BW, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S
Toxicology 2021 Sep;461:152901
Toxicology 2021 Sep;461:152901
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
Wang K, Xiao X, Jiang M, Li J, Zhou J, Yuan Y
Small (Weinheim an der Bergstrasse, Germany) 2021 Sep;17(36):e2102610
Small (Weinheim an der Bergstrasse, Germany) 2021 Sep;17(36):e2102610
Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.
Luo L, Qin B, Jiang M, Xie L, Luo Z, Guo X, Zhang J, Li X, Zhu C, Du Y, Peng L, You J
Journal of nanobiotechnology 2021 Sep 30;19(1):297
Journal of nanobiotechnology 2021 Sep 30;19(1):297
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Chen A, Yang F, Kuang J, Xiong Y, Mi BB, Zhou Y, Hu JJ, Song SJ, Wan T, Wan ZZ, Huang HY, Li XR, Song W, Qiu WX
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
Jin F, Qi J, Liu D, You Y, Shu G, Du Y, Wang J, Xu X, Ying X, Ji J, Du Y
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Qiu C, Wang M, Yu W, Rong Z, Zheng HS, Sun T, Liu SB, Zhao MG, Wu YM
Molecular neurobiology 2021 Oct;58(10):5272-5288
Molecular neurobiology 2021 Oct;58(10):5272-5288
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Kong L, Ma Y, Wang Z, Liu N, Ma G, Liu C, Shi R, Du G
International immunopharmacology 2021 May;94:107507
International immunopharmacology 2021 May;94:107507
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
Zhang K, Liu D, Zhao J, Shi S, He X, Da P, You Y, You B
Cell death & disease 2021 May 28;12(6):554
Cell death & disease 2021 May 28;12(6):554
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Feng L, Liang L, Zhang S, Yang J, Yue Y, Zhang X
Autophagy 2021 May 24;:1-20
Autophagy 2021 May 24;:1-20
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Kawahara I, Goto K, Nakashima C, Kido A, Tanaka Y, Luo Y, Kuniyasu H
International journal of molecular sciences 2021 May 13;22(10)
International journal of molecular sciences 2021 May 13;22(10)
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events.
Imano H, Kato R, Ijiri Y, Hayashi T
Toxicology in vitro : an international journal published in association with BIBRA 2021 Mar;71:105063
Toxicology in vitro : an international journal published in association with BIBRA 2021 Mar;71:105063
miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1.
Feng XE
Cancer biotherapy & radiopharmaceuticals 2021 Mar;36(2):189-201
Cancer biotherapy & radiopharmaceuticals 2021 Mar;36(2):189-201
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Liu N, Liu C, Yang Y, Ma G, Wei G, Liu S, Kong L, Du G
Pharmacological research 2021 Jul;169:105650
Pharmacological research 2021 Jul;169:105650
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Yu C, Lei Z, Li X, Huang LH, Li ZQ, Zhu HW, Han D, Huang H, Yu X
Biochemical genetics 2021 Jul 29;
Biochemical genetics 2021 Jul 29;
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Huang Y, Guan Z, Dai X, Shen Y, Wei Q, Ren L, Jiang J, Xiao Z, Jiang Y, Liu D, Huang Z, Xu X, Luo Y, Zhao C
Nature communications 2021 Jul 14;12(1):4310
Nature communications 2021 Jul 14;12(1):4310
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target.
Liu L, Zhang J, Zhang X, Cheng P, Liu L, Huang Q, Liu H, Ren S, Wei P, Wang C, Dou C, Chen L, Liu X, Zhang H, Chen M
Journal of molecular medicine (Berlin, Germany) 2021 Jan;99(1):107-118
Journal of molecular medicine (Berlin, Germany) 2021 Jan;99(1):107-118
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Qiu C, Yang LD, Yu W, Tian DD, Gao MR, Wang WJ, Li XB, Wu YM, Wang M
Metabolic brain disease 2021 Feb;36(2):273-283
Metabolic brain disease 2021 Feb;36(2):273-283
Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
Li Y, Guo Z, Zhang G, Tian X, Li Q, Luo Z
Immunology letters 2021 Dec;240:149-158
Immunology letters 2021 Dec;240:149-158
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
Wang B, Ji D, Xing W, Li F, Huang Z, Zheng W, Xue J, Zhu Y, Yang X
Cartilage 2021 Dec;13(2_suppl):592S-603S
Cartilage 2021 Dec;13(2_suppl):592S-603S
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2021 Aug 24;
Inflammation 2021 Aug 24;
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.
Wang Z, Chen L, Ma Y, Li X, Hu A, Wang H, Wang W, Li X, Tian B, Dong J
Journal of nanobiotechnology 2021 Aug 12;19(1):243
Journal of nanobiotechnology 2021 Aug 12;19(1):243
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, Kc R, Chen K, Jin Z, Liu J, Zhang M
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Wu H, Ma K, Na X
The Journal of toxicological sciences 2020;45(7):373-390
The Journal of toxicological sciences 2020;45(7):373-390
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680
The Journal of toxicological sciences 2020;45(11):673-680
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
Wang S, Sun Y, Bai Y, Zhou N, Chen N, Miller EJ, Zhang Y, Li W
Mediators of inflammation 2020;2020:8094347
Mediators of inflammation 2020;2020:8094347
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, Yu E, Zhang H, Wang Z, Shen J, Zhuge Q, Huang L
Oxidative medicine and cellular longevity 2020;2020:7879629
Oxidative medicine and cellular longevity 2020;2020:7879629
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
Fan QL, Wang JW, Zhang SL, Liu T, Zhao J, You SP
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, Duan Y, Li K, Liu K, Peng C
BioMed research international 2020;2020:1860637
BioMed research international 2020;2020:1860637
Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells.
Song Y, Zou X, Zhang D, Liu S, Duan Z, Liu L
Journal of Cancer 2020;11(13):3893-3902
Journal of Cancer 2020;11(13):3893-3902
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, Qian X
Frontiers in pharmacology 2020;11:776
Frontiers in pharmacology 2020;11:776
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H
Journal of cellular and molecular medicine 2020 Sep;24(18):10356-10366
Journal of cellular and molecular medicine 2020 Sep;24(18):10356-10366
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.
Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF, Wang XY, Li X, Wu SX, Zhang GL
Journal of neuroinflammation 2020 Oct 9;17(1):295
Journal of neuroinflammation 2020 Oct 9;17(1):295
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Jin Z, Sun J, Song Z, Chen K, Nicolas YSM, Kc R, Ma Q, Liu J, Zhang M
NPJ Regenerative medicine 2020 Oct 30;5(1):19
NPJ Regenerative medicine 2020 Oct 30;5(1):19
Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.
Wilkinson ML, Abramova E, Guo C, Gow JG, Murray A, Koudelka A, Cechova V, Freeman BA, Gow AJ
Toxicology and applied pharmacology 2020 Nov 15;407:115236
Toxicology and applied pharmacology 2020 Nov 15;407:115236
Impact of perioperative high mobility group box chromosomal protein 1 expression on long-term outcomes in patients with esophageal squamous cell carcinoma.
Tsujimoto H, Horiguchi H, Takahata R, Ono S, Yaguchi Y, Nomura S, Ito N, Harada M, Nagata H, Ishibashi Y, Kouzu K, Tsuchiya S, Itazaki Y, Fujishima S, Kishi Y, Ueno H
Journal of gastroenterology and hepatology 2020 May;35(5):788-794
Journal of gastroenterology and hepatology 2020 May;35(5):788-794
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
Jiang B, Xue M, Xu D, Song Y, Zhu S
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Wang D, Zhou M, Wang Y, Sun S
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Pannexin1 Channel Inhibitor (10panx) Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting RIP3 Expression and Inflammatory Response in Rats.
Wei R, Bao W, He F, Meng F, Liang H, Luo B
Neuroscience 2020 Jun 15;437:23-33
Neuroscience 2020 Jun 15;437:23-33
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
Jin F, Qi J, Zhu M, Liu D, You Y, Shu G, Du Y, Wang J, Yu H, Sun M, Xu X, Shen Q, Ying X, Ji J, Du Y
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Ying C, Ying L, Yanxia L, Le W, Lili C
Acta histochemica 2020 Feb;122(2):151485
Acta histochemica 2020 Feb;122(2):151485
Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.
Luo XQ, Duan JX, Yang HH, Zhang CY, Sun CC, Guan XX, Xiong JB, Zu C, Tao JH, Zhou Y, Guan CX
Journal of cellular physiology 2020 Dec;235(12):9910-9921
Journal of cellular physiology 2020 Dec;235(12):9910-9921
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Lin CH, Chen HY, Wei KC
Cells 2020 Dec 3;9(12)
Cells 2020 Dec 3;9(12)
Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.
Wang B, Huang X, Pan X, Zhang T, Hou C, Su WJ, Liu LL, Li JM, Wang YX
Brain, behavior, and immunity 2020 Aug;88:132-143
Brain, behavior, and immunity 2020 Aug;88:132-143
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, Zhao Y, Wang Z, Zhang N, Yao J
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.
Ye Y, Zhao L, Li Q, Xi C, Li Y, Li Z
Thoracic cancer 2020 Aug;11(8):2196-2208
Thoracic cancer 2020 Aug;11(8):2196-2208
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Ge X, Meng X, Fei D, Kang K, Wang Q, Zhao M
3 Biotech 2020 Aug;10(8):369
3 Biotech 2020 Aug;10(8):369
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Zhong X, Xiao Q, Liu Z, Wang W, Lai CH, Yang W, Yue P, Ye Q, Xiao J
Molecular medicine reports 2019 Sep;20(3):2101-2110
Molecular medicine reports 2019 Sep;20(3):2101-2110
Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling.
Liu ZZ, Weng HB, Zhang LJ, Pan LY, Sun W, Chen HX, Chen MY, Zeng T, Zhang YY, Chen DF, Li H
Chinese journal of natural medicines 2019 Sep;17(9):641-649
Chinese journal of natural medicines 2019 Sep;17(9):641-649
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, Ni B, Cheng H, You H
European journal of pharmacology 2019 Sep 15;859:172481
European journal of pharmacology 2019 Sep 15;859:172481
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
Wu ZL, Wang J
Experimental lung research 2019 Oct;45(8):236-244
Experimental lung research 2019 Oct;45(8):236-244
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Ma Y, Zhang Z, Chen R, Shi R, Zeng P, Chen R, Leng Y, Chen AF
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Hua S, Ma M, Fei X, Zhang Y, Gong F, Fang M
International immunopharmacology 2019 Mar;68:145-155
International immunopharmacology 2019 Mar;68:145-155
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis.
Cao Y, Liu X, Guo SW
Scientific reports 2019 Jun 25;9(1):9272
Scientific reports 2019 Jun 25;9(1):9272
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Zhou J, Yang Y, Gan T, Li Y, Hu F, Hao N, Yuan B, Chen Y, Zhang M
Oncology letters 2019 Jul;18(1):181-188
Oncology letters 2019 Jul;18(1):181-188
Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.
Feng Y, Weng H, Ling L, Zeng T, Zhang Y, Chen D, Li H
International journal of biological macromolecules 2019 Jul 1;132:1001-1011
International journal of biological macromolecules 2019 Jul 1;132:1001-1011
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Chen J, Jiang Z, Zhou X, Sun X, Cao J, Liu Y, Wang X
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.
Balan I, Beattie MC, O'Buckley TK, Aurelian L, Morrow AL
Scientific reports 2019 Feb 4;9(1):1220
Scientific reports 2019 Feb 4;9(1):1220
HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.
Dai M, Xiao R, Cai L, Ge T, Zhu L, Hu Q
American journal of physiology. Cell physiology 2019 Feb 1;316(2):C175-C185
American journal of physiology. Cell physiology 2019 Feb 1;316(2):C175-C185
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Wang N, Yang B, Muhetaer G, Wang S, Zheng Y, Lu J, Li M, Zhang F, Situ H, Lin Y, Wang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer.
Nishiguchi Y, Oue N, Fujiwara-Tani R, Sasaki T, Ohmori H, Kishi S, Mori S, Mori T, Ikeda N, Matsumoto S, Wakatsuki K, Luo Y, Yasui W, Sho M, Kuniyasu H
International journal of molecular sciences 2019 Dec 30;21(1)
International journal of molecular sciences 2019 Dec 30;21(1)
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
Yu Y, Yang Y, Yang M, Wang C, Xie K, Yu Y
International immunopharmacology 2019 Apr;69:11-18
International immunopharmacology 2019 Apr;69:11-18
Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability.
Romaldini A, Ulivi V, Nardini M, Mastrogiacomo M, Cancedda R, Descalzi F
Cells 2019 Apr 9;8(4)
Cells 2019 Apr 9;8(4)
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
Alsousi AA, Igwe OJ
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single-center experience.
Attilia ML, Lattanzi B, Ledda R, Galli AM, Farcomeni A, Rotondo C, Di Gregorio V, Mennini G, Poli E, Attilia F, Ginanni Corradini S, Rossi M, Merli M
Clinical transplantation 2018 May;32(5):e13243
Clinical transplantation 2018 May;32(5):e13243
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.
Wang Z, Han Q, Guo YL, Liu XH, Qiu T
Acta cirurgica brasileira 2018 Mar;33(3):238-249
Acta cirurgica brasileira 2018 Mar;33(3):238-249
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Li S, Wei Y
Oncology letters 2018 Jun;15(6):9572-9576
Oncology letters 2018 Jun;15(6):9572-9576
Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.
Weng L, Guo L, Vachani A, Mesaros C, Blair IA
Analytical chemistry 2018 Jun 19;90(12):7552-7560
Analytical chemistry 2018 Jun 19;90(12):7552-7560
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines.
Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Kuwabara S
Clinical and experimental immunology 2018 Jul;193(1):47-54
Clinical and experimental immunology 2018 Jul;193(1):47-54
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization.
Gao T, Chen Z, Chen H, Yuan H, Wang Y, Peng X, Wei C, Yang J, Xu C
Biochemical and biophysical research communications 2018 Feb 26;497(1):430-436
Biochemical and biophysical research communications 2018 Feb 26;497(1):430-436
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Zhao X, Yin L, Fang L, Xu L, Sun P, Xu M, Liu K, Peng J
International immunopharmacology 2018 Dec;65:458-469
International immunopharmacology 2018 Dec;65:458-469
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Xu Z, Duan F, Lu H, Abdulkadhim Dragh M, Xia Y, Liang H, Hong L
Cell death & disease 2018 Dec 5;9(12):1170
Cell death & disease 2018 Dec 5;9(12):1170
Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.
Li M, Chen S, Shi X, Lyu C, Zhang Y, Tan M, Wang C, Zang N, Liu X, Hu Y, Shen J, Zhou L, Gu Y
Journal of neuroinflammation 2018 Aug 23;15(1):237
Journal of neuroinflammation 2018 Aug 23;15(1):237
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z
Frontiers in neuroscience 2017;11:583
Frontiers in neuroscience 2017;11:583
Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.
Lv ZH, Phuong TA, Jin SJ, Li XX, Xu M
Oncotarget 2017 Oct 31;8(53):91291-91305
Oncotarget 2017 Oct 31;8(53):91291-91305
Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.
Luo F, Herrup K, Qi X, Yang Y
Experimental neurology 2017 Jun;292:21-34
Experimental neurology 2017 Jun;292:21-34
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Khan MR, Xiang S, Song Z, Wu M
The EMBO journal 2017 Dec 1;36(23):3483-3500
The EMBO journal 2017 Dec 1;36(23):3483-3500
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium.
Yun BH, Chon SJ, Choi YS, Cho S, Lee BS, Seo SK
PloS one 2016;11(2):e0148165
PloS one 2016;11(2):e0148165
Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae.
Chen Q, Yin YX, Wei J, Tong M, Shen F, Zhao M, Chamley L
Cytokine 2016 Sep;85:30-6
Cytokine 2016 Sep;85:30-6
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS
PLoS biology 2016 Nov;14(11):e2000733
PLoS biology 2016 Nov;14(11):e2000733
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141
International immunopharmacology 2016 Jul;36:132-141
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury.
Fan H, Zhang K, Shan L, Kuang F, Chen K, Zhu K, Ma H, Ju G, Wang YZ
Molecular neurodegeneration 2016 Feb 3;11:14
Molecular neurodegeneration 2016 Feb 3;11:14
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X
Nature communications 2016 Aug 26;7:12646
Nature communications 2016 Aug 26;7:12646
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Owusu L, Wang B, Du Y, Li W, Xin Y
Journal of Cancer 2015;6(2):128-38
Journal of Cancer 2015;6(2):128-38
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Fan H, Tang HB, Kang J, Shan L, Song H, Zhu K, Wang J, Ju G, Wang YZ
Neuroscience 2015 Dec 17;311:362-73
Neuroscience 2015 Dec 17;311:362-73
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Guo X, Sesaki H, Qi X
The Biochemical journal 2014 Jul 1;461(1):137-46
The Biochemical journal 2014 Jul 1;461(1):137-46
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
miR-200c inhibits metastasis of breast cancer cells by targeting HMGB1.
Chang BP, Wang DS, Xing JW, Yang SH, Chu Q, Yu SY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Apr;34(2):201-206
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Apr;34(2):201-206
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, Xu Y, Liu K, Peng J
International immunopharmacology 2014 Apr;19(2):233-44
International immunopharmacology 2014 Apr;19(2):233-44
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J
The Journal of cell biology 2013 May 13;201(4):613-29
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 10829-1-AP(HMGB1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HMGB1 (IP:10829-1-AP, 3ug; Detection:10829-1-AP 1:500) with HepG2 cells lysate 2900ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMGB1. This antibody recognizes human,mouse,rat antigen. The HMGB1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.