Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 15650-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15650-1-AP, RRID:AB_2266805
- Product name
- MTO1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MTO1 antibody (Cat. #15650-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.
The MELAS mutation m.3243A>G alters the expression of mitochondrial tRNA fragments.
RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis.
Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.
microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases.
Severe respiratory complex III defect prevents liver adaptation to prolonged fasting.
The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome.
Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency.
Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.
Peng GX, Zhang Y, Wang QQ, Li QR, Xu H, Wang ED, Zhou XL
Nucleic acids research 2021 Mar 18;49(5):2816-2834
Nucleic acids research 2021 Mar 18;49(5):2816-2834
The MELAS mutation m.3243A>G alters the expression of mitochondrial tRNA fragments.
Meseguer S, Navarro-González C, Panadero J, Villarroya M, Boutoual R, Sánchez-Alcázar JA, Armengod ME
Biochimica et biophysica acta. Molecular cell research 2019 Sep;1866(9):1433-1449
Biochimica et biophysica acta. Molecular cell research 2019 Sep;1866(9):1433-1449
RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis.
Richter U, Evans ME, Clark WC, Marttinen P, Shoubridge EA, Suomalainen A, Wredenberg A, Wedell A, Pan T, Battersby BJ
Nature communications 2018 Sep 27;9(1):3966
Nature communications 2018 Sep 27;9(1):3966
Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.
Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME
Scientific reports 2018 Jan 18;8(1):1163
Scientific reports 2018 Jan 18;8(1):1163
microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases.
Meseguer S, Boix O, Navarro-González C, Villarroya M, Boutoual R, Emperador S, García-Arumí E, Montoya J, Armengod ME
Scientific reports 2017 Jul 24;7(1):6209
Scientific reports 2017 Jul 24;7(1):6209
Severe respiratory complex III defect prevents liver adaptation to prolonged fasting.
Kremer LS, L'hermitte-Stead C, Lesimple P, Gilleron M, Filaut S, Jardel C, Haack TB, Strom TM, Meitinger T, Azzouz H, Tebib N, Ogier de Baulny H, Touati G, Prokisch H, Lombès A
Journal of hepatology 2016 Aug;65(2):377-85
Journal of hepatology 2016 Aug;65(2):377-85
The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome.
Meseguer S, Martínez-Zamora A, García-Arumí E, Andreu AL, Armengod ME
Human molecular genetics 2015 Jan 1;24(1):167-84
Human molecular genetics 2015 Jan 1;24(1):167-84
Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency.
Boczonadi V, Smith PM, Pyle A, Gomez-Duran A, Schara U, Tulinius M, Chinnery PF, Horvath R
Human molecular genetics 2013 Nov 15;22(22):4602-15
Human molecular genetics 2013 Nov 15;22(22):4602-15
Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.
Ghezzi D, Baruffini E, Haack TB, Invernizzi F, Melchionda L, Dallabona C, Strom TM, Parini R, Burlina AB, Meitinger T, Prokisch H, Ferrero I, Zeviani M
American journal of human genetics 2012 Jun 8;90(6):1079-87
American journal of human genetics 2012 Jun 8;90(6):1079-87
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The MTO1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MTO1. This antibody recognizes human, mouse, rat antigen. The MTO1 antibody has been validated for the following applications: ELISA, WB analysis.