GBF1

This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Description

Golgi brefeldin A resistant guanine nucleotide exchange factor 1

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (102245371 - 102382899)

Ensembl ID

ENSG00000107862  (ver. 103.38)

Orthologs

Mouse Gbf1: ENSMUSG00000025224

UniProt

Q92538

neXtProt

NX_Q92538

Human splice variants
Mouse splice variants

Protein structure