abx130748

antibody from Abbexa

Targeting: BRCC3 BRCC36, C6.1A, CXorf53

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx130748

Provider

Abbexa

Product name

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody

Antibody type

Polyclonal

Description

Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) Antibody is a Rabbit Polyclonal against Lys-63-Specific Deubiquitinase BRCC36 (BRCC3). This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 µg

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.