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antibody from GeneTex
Targeting: TET3
hCG_40738, MGC22014
Western blot Immunocytochemistry Immunoprecipitation Immunohistochemistry
Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [2]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- GTX121453 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX121453, RRID:AB_10723106
- Product name
- TET3 antibody [C3], C-term
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Bovine, Xenopus
- Host
- Rabbit
Submitted references Methyl-CpG Binding Domain Protein 2 Inhibits the Malignant Characteristic of Lung Adenocarcinoma through the Epigenetic Modulation of 10 to 11 Translocation 1 and miR-200s.
Retrieval-Induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation.
A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset.
Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.
TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility.
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.
Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.
Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer.
Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.
Spatiotemporal expression of DNA demethylation enzymes and histone demethylases in bovine embryos.
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.
Pei YF, Xu XN, Wang ZF, Wang FW, Wu WD, Geng JF, Liu XQ
The American journal of pathology 2019 Feb 5;
The American journal of pathology 2019 Feb 5;
Retrieval-Induced Upregulation of Tet3 in Pyramidal Neurons of the Dorsal Hippocampus Mediates Cocaine-Associated Memory Reconsolidation.
Liu C, Sun X, Wang Z, Le Q, Liu P, Jiang C, Wang F, Ma L
The international journal of neuropsychopharmacology 2018 Mar 1;21(3):255-266
The international journal of neuropsychopharmacology 2018 Mar 1;21(3):255-266
A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset.
Selimoglu-Buet D, Rivière J, Ghamlouch H, Bencheikh L, Lacout C, Morabito M, Diop M, Meurice G, Breckler M, Chauveau A, Debord C, Debeurme F, Itzykson R, Chapuis N, Willekens C, Wagner-Ballon O, Bernard OA, Droin N, Solary E
Nature communications 2018 Dec 21;9(1):5455
Nature communications 2018 Dec 21;9(1):5455
Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.
Lu F, Wiedmer A, Martin KA, Wickramasinghe PJMS, Kossenkov AV, Lieberman PM
Journal of virology 2017 Oct 15;91(20)
Journal of virology 2017 Oct 15;91(20)
TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility.
Ni K, Dansranjavin T, Rogenhofer N, Oeztuerk N, Deuker J, Bergmann M, Schuppe HC, Wagenlehner F, Weidner W, Steger K, Schagdarsurengin U
Human reproduction (Oxford, England) 2016 Jul;31(7):1411-24
Human reproduction (Oxford, England) 2016 Jul;31(7):1411-24
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X
Nature 2015 Sep 17;525(7569):389-393
Nature 2015 Sep 17;525(7569):389-393
Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.
Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM
Cardiovascular research 2015 Mar 1;105(3):279-91
Cardiovascular research 2015 Mar 1;105(3):279-91
Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.
Tampe B, Tampe D, Zeisberg EM, Müller GA, Bechtel-Walz W, Koziolek M, Kalluri R, Zeisberg M
EBioMedicine 2015 Jan;2(1):19-36
EBioMedicine 2015 Jan;2(1):19-36
Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer.
Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ohka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y
Cancer prevention research (Philadelphia, Pa.) 2015 Aug;8(8):702-11
Cancer prevention research (Philadelphia, Pa.) 2015 Aug;8(8):702-11
Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.
Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 4;112(31):E4236-45
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 4;112(31):E4236-45
Spatiotemporal expression of DNA demethylation enzymes and histone demethylases in bovine embryos.
Pagé-Larivière F, Sirard MA
Cellular reprogramming 2014 Feb;16(1):40-53
Cellular reprogramming 2014 Feb;16(1):40-53
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL
Cell reports 2014 Dec 11;9(5):1841-1855
Cell reports 2014 Dec 11;9(5):1841-1855
A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.
Loriot A, Van Tongelen A, Blanco J, Klaessens S, Cannuyer J, van Baren N, Decottignies A, De Smet C
Epigenetics 2014 Aug;9(8):1163-71
Epigenetics 2014 Aug;9(8):1163-71
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.
Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, Guo Y, Yao H, Megyola CM, Li D, Liu J, Pan W, Roden CA, Zhou XL, Heydari K, Chen J, Park IH, Ding Y, Zhang Y, Lu J
Cell reports 2013 Oct 31;5(2):471-81
Cell reports 2013 Oct 31;5(2):471-81
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.
Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG
Cell 2012 Dec 7;151(6):1200-13
Cell 2012 Dec 7;151(6):1200-13
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- TET3 antibody [C3], C-term detects TET3 protein by western blot analysis.A. 30 ?g 293T whole cell lysate/extractB. 30 ?g whole cell lysate/extract of Flag-human TET3-transfected 293T cells5% SDS-PAGETET3 antibody [C3], C-term (GTX121453) dilution: 1:5000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- TET3 antibody [C3], C-term detects TET3 protein by Western blot analysis.A. 30 £gg 293T whole cell lysate/extractB. 30 £gg whole cell lysate/extract of Flag-human TET3 transfected 293T cells5 % SDS-PAGETET3 antibody [C3], C-term (GTX121453) dilution: 1:5000
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- TET3 antibody [C3], C-term detects TET3 protein at cytoplasm and nucleus by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: TET3 protein stained by TET3 antibody [C3], C-term (GTX121453) diluted at 1:400.Red: phalloidin, a cytoskeleton marker, diluted at 1:50.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- TET3 antibody immunoprecipitates TET3 protein in IP experiments. IP Sample: cell lysate/extract of TET3 gene transfected 293T cells A. Cell lysate/extract of transfected 293T cell B. Control with 2 £gg of preimmune rabbit IgG C. Immunoprecipitation of TET3 by 2 £gg of TET3 antibody (GTX121453) 5% SDS-PAGE The immunoprecipitated TET3 protein was detected by TET3 antibody (GTX121453) diluted at 1:1000. EasyBlot anti-rabbit IgG (GTX221666-01) was used as a secondary reagent.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- TET3 antibody [C3], C-term detects TET3 protein at nucleus on mouse colon by immunohistochemical analysis. Sample: Paraffin-embedded mouse colon. TET3 antibody [C3], C-term (GTX121453) dilution: 1:500.
