11-10046-25

antibody from ABEOMICS Inc.
Targeting: FNBP1 FBP17, KIAA0554
Provider product page for 11-10046-25

Antibody data

Product number
11-10046-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti- FNBP1 Antibody
Antibody type
Polyclonal
Description
FNBP1 (formin binding protein 1) also known as FBP17,is an F-BAR domain protein that belongs to the formin-binding-protein family. It has a powerful self-polymerizing ability that promotes actin nucleation on membranes. F-BAR domain of FBP17 is capable of self-polymerizing into filaments, which adhere to the flat bilayer sheets and form a spiral protein coat around the tubulated membrane that they then induce. The gene for FNB1 maps to chromosome 9q34 and consists of a C-terminal Src homology 3 domain and an N-terminal region that is homologous to the cell division cycle protein, cdc15, a regulator of the actin cytoskeleton. The assembly of FBP17 is dependent on WASP, and its dissociation by WASP inhibition strongly induces a self-organization of PSTPIP2, another F-BAR protein, at podosomes. Podosomes/invadopodia are highly dynamic adhesive actin-based structures with enrichment of matrix metalloproteases (MMPs) activity formed at the ventral surface of the cell body, which are seen in macrophages, osteoclasts, dendritic cells and some cancer cells.
Reactivity
Human, Mouse
Host
Rabbit
Antigen sequence
A partial length recombinant FNBP1
protein (amino acids 40-260) was us
ed as the immunogen for this antibo
dy.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
FNBP1 protein structure - 11-10046-25 shown in red.