CABT-B9292

antibody from Creative Diagnostics

Targeting: DYNLL1 DLC1, DLC8, DNCL1, hdlc1, LC8, PIN

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9292

Provider

Creative Diagnostics

Product name

Mouse anti-Rat PIN monoclonal antibody, clone 5/QJO

Antibody type

Monoclonal

Description

PIN (protein inhibitor of nNOS) is a small protein of 89 amino acids initially described as a light chain subunit of dynein and as an inhibitor of the neuronal nitric oxide synthase isoform (nNOS). In vitro, PIN has been reported to bind to a unique nNOS domain encompassing amino acids 163-245. PIN inhibits nNOS activity and blocks the formation of the active nNOS dimer. Although ubiquitously expressed, PIN levels are reportedly highest in brain and testis. Immunolocalization studies in Drosophila melanogaster detected a cytoplasmic distribution of PIN. Partial-loss-of-function of PIN resulted in morphologic and developmental changes in the bristles, wings, and female sterility of D. melanogaster. Deletion of PIN resulted in lethality with the characteristic morphology of apoptotic cells.

Reactivity

Human, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

5/QJO

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.