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- Antibody Data
- Antigen structure
- References [381]
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- Product number
- 66031-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66031-1-Ig, RRID:AB_11042766
- Product name
- alpha Tubulin antibody
- Antibody type
- Monoclonal
- Description
- Alpha Tubulin antibody (Cat. #66031-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E4C11
- Vial size
- 150ul
Submitted references Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease.
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis.
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling.
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Sirt3 Maintains Microvascular Endothelial Adherens Junction Integrity to Alleviate Sepsis-Induced Lung Inflammation by Modulating the Interaction of VE-Cadherin and β-Catenin.
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors.
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development.
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
SLC25A21 Suppresses Cell Growth in Bladder Cancer via an Oxidative Stress-Mediated Mechanism.
ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats.
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1.
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
Androgen-dependent and DNA-binding-independent association of androgen receptor with chromatic regions coding androgen-induced noncoding RNAs.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.
Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells.
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Loss of E-cadherin due to road dust PM2.5 activates the EGFR in human pharyngeal epithelial cells.
Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells.
ORMDL1 is upregulated and associated with favorable outcomes in colorectal cancer.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle.
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis.
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis.
Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.
Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication.
Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis.
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver.
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication.
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants.
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic.
Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells.
Nuclear Lamin A/C Expression Is a Key Determinant of Paclitaxel Sensitivity.
Nitrogen-Doped Multiwalled Carbon Nanotubes Enhance Bone Remodeling through Immunomodulatory Functions.
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response.
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3.
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands.
Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases.
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells.
BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
p53 induces ARTS to promote mitochondrial apoptosis.
Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment.
Ginsenoside Rb1 protected PC12 cells from Aβ25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction.
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANASIM-Associated Proteins in Hypoxia.
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter.
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-κB pathway and mitochondrial dysfunction.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.
Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands.
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.
Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy.
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression.
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model.
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Oxytocin Alleviates MPTP-Induced Neurotoxicity in Mice by Targeting MicroRNA-26a/Death-Associated Protein Kinase 1 Pathway.
β-Actin facilitates etoposide-induced p53 nuclear import.
Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha.
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
ITM2A as a Tumor Suppressor and Its Correlation With PD-L1 in Breast Cancer.
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
A role of cellular translation regulation associated with toxic Huntingtin protein.
The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress.
SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency.
Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Nuclear import of NLS- RARα is mediated by importin α/β.
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress.
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells.
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Structural basis for DEAH-helicase activation by G-patch proteins.
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Generation and Application of Mouse Monoclonal Antibody Against Human Cytomegalovirus UL23.
ChREBP-β regulates thermogenesis in brown adipose tissue.
FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides.
RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling.
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT.
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy.
A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia.
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway.
Murine Cytomegalovirus Protein pM49 Interacts with pM95 and Is Critical for Viral Late Gene Expression.
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity.
lncMGPF is a novel positive regulator of muscle growth and regeneration.
DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway.
USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity.
Downregulation of miR-146b-5p via iodine involvement repressed papillary thyroid carcinoma cell proliferation.
Dual-engineered, "Trojanized" macrophages bio-modally eradicate tumors through biologically and photothermally deconstructing cancer cells in an on-demand, NIR-commanded, self-explosive manner.
ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo.
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD.
GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Effects of peptidoglycan on the development of steatohepatitis.
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis.
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.
Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.
Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome.
Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I.
Preparation and identification of polyclonal antibody against human cytomegalovirus encoding protein UL23.
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.
Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1.
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
Vacuolar protein sorting 4 is required for silkworm metamorphosis.
Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
PARP11 regulates total levels of type-I interferon receptor IFNAR1.
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma.
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade.
DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella.
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma.
Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication.
Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis.
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes.
Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Tranilast enhances the effect of anticancer agents in osteosarcoma.
WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis.
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.
Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis.
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality.
CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice.
TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ.
CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
The Legionella effector RavD binds phosphatidylinositol-3-phosphate and helps suppress endolysosomal maturation of the Legionella-containing vacuole.
β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy.
Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity.
Murine Cytomegalovirus Protein pM91 Interacts with pM79 and Is Critical for Viral Late Gene Expression.
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.
EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer.
UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment.
A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function.
Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents.
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.
Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes.
Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake.
MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6.
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
PMLIV overexpression promotes TGF-β-associated epithelial-mesenchymal transition and migration in MCF-7 cancer cells.
mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Anillin is required for tumor growth and regulated by miR-15a/miR-16-1 in HBV-related hepatocellular carcinoma.
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Quercetin attenuates AZT-induced neuroinflammation in the CNS.
MCPIP1 is a positive regulator of type I interferons antiviral activity.
CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.
Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
CMIP Promotes Proliferation and Metastasis in Human Glioma.
TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.
MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.
MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3.
Hydrogen peroxide promotes the expression of angiopoietin like 4 in RAW264.7 macrophages via MAPK pathways.
Tectorigenin attenuates the MPP+-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development.
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.
Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling.
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.
Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma.
Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor.
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant.
A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells.
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts.
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring.
Influence of miR-30b regulating humoral immune response by genetic difference.
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.
State estimation and prediction using clustered particle filters.
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Increased stathmin expression strengthens fear conditioning in epileptic rats.
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates.
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.
Analysis of grayscale characteristics in images of labeled microtubules from cultured cardiac myocytes.
TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.
Modulation of amylose content by structure-based modification of OsGBSS1 activity in rice (Oryza sativa L.).
Axl receptor tyrosine kinase expression in breast cancer.
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Yin F, Zheng PQ, Zhao LQ, Wang YZ, Miao NJ, Zhou ZL, Cheng Q, Chen PP, Xie HY, Li JY, Ni JY, Zhou L, Zhang W, Wang XX, Liu J, Lu LM
Acta pharmacologica Sinica 2022 Jan;43(1):86-95
Acta pharmacologica Sinica 2022 Jan;43(1):86-95
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y, Shao C
Oncogene 2022 Jan;41(3):427-443
Oncogene 2022 Jan;41(3):427-443
Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis.
Yan H, Li Q, Li M, Zou X, Bai N, Yu Z, Zhang J, Zhang D, Zhang Q, Wang J, Jia H, Wu Y, Hou Z
Molecular and cellular endocrinology 2022 Jan 1;539:111485
Molecular and cellular endocrinology 2022 Jan 1;539:111485
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L
Frontiers in cell and developmental biology 2021;9:623753
Frontiers in cell and developmental biology 2021;9:623753
PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling.
Guo XW, Zhang H, Huang JQ, Wang SN, Lu Y, Cheng B, Dong SH, Wang YY, Li FS, Li YW
Frontiers in molecular biosciences 2021;8:725274
Frontiers in molecular biosciences 2021;8:725274
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Zhuang L, Mao Y, Liu Z, Li C, Jin Q, Lu L, Tao R, Yan X, Chen K
Frontiers in cardiovascular medicine 2021;8:722908
Frontiers in cardiovascular medicine 2021;8:722908
Sirt3 Maintains Microvascular Endothelial Adherens Junction Integrity to Alleviate Sepsis-Induced Lung Inflammation by Modulating the Interaction of VE-Cadherin and β-Catenin.
Chen DQ, Shen MJ, Wang H, Li Y, Tang AL, Li S, Xiong MC, Guo Y, Zhang GQ
Oxidative medicine and cellular longevity 2021;2021:8978795
Oxidative medicine and cellular longevity 2021;2021:8978795
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Su X, Yang Y, Guo C, Zhang R, Sun S, Wang Y, Qiao Q, Fu Y, Pang Q
Oxidative medicine and cellular longevity 2021;2021:5549047
Oxidative medicine and cellular longevity 2021;2021:5549047
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors.
Anchoori RK, George L, Tseng SH, Lam B, Polkampally S, Amiano AD, Foran P, Tsingine H, Samanapally H, Carrizo Velasquez F, Das S, Xing D, Bin Salam A, Karanam B, Hung CF, Roden RBS
PloS one 2021;16(9):e0256937
PloS one 2021;16(9):e0256937
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Huang GZ, Wu QQ, Zheng ZN, Shao TR, Li F, Lu XY, Ye HY, Chen GX, Song YX, Zeng WS, Ai YL, Lv XZ
OncoTargets and therapy 2021;14:1275-1289
OncoTargets and therapy 2021;14:1275-1289
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Chen L, Yi C, Li W, Tseng Y, Zhang J, Liu J
Journal of Cancer 2021;12(1):89-98
Journal of Cancer 2021;12(1):89-98
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Han Y, Jiang M, He R, Lv X, Liao X, He Y, Zhang F, Long L, Jiang G, Peng Z, Tao L, Hu G, Meng J
Frontiers in pharmacology 2021;12:713572
Frontiers in pharmacology 2021;12:713572
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819
Frontiers in pharmacology 2021;12:709819
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Chen L, Han Z, Shi Z, Liu C, Lu Q
Frontiers in pharmacology 2021;12:697643
Frontiers in pharmacology 2021;12:697643
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.
SenGupta S, Hein LE, Xu Y, Zhang J, Konwerski JR, Li Y, Johnson C, Cai D, Smith JL, Parent CA
Frontiers in immunology 2021;12:659996
Frontiers in immunology 2021;12:659996
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development.
Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J
Theranostics 2021;11(9):4316-4334
Theranostics 2021;11(9):4316-4334
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J, Cheng J, Wu X
Theranostics 2021;11(8):3981-3995
Theranostics 2021;11(8):3981-3995
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Fan XJ, Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Feng WX, Wang YN, Liu Q, Hung MC, Wan XB
American journal of cancer research 2021;11(6):2838-2852
American journal of cancer research 2021;11(6):2838-2852
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
Zheng Q, Li P, Zhou X, Qiang Y, Fan J, Lin Y, Chen Y, Guo J, Wang F, Xue H, Xiong J, Li F
Theranostics 2021;11(18):8674-8691
Theranostics 2021;11(18):8674-8691
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Zhou F, Zhang L, Zhu K, Bai M, Zhang Y, Zhu Q, Wang S, Sheng C, Yuan M, Liu Y, Lu J, Shao L, Wang X, Zhou L
Theranostics 2021;11(10):4825-4838
Theranostics 2021;11(10):4825-4838
SLC25A21 Suppresses Cell Growth in Bladder Cancer via an Oxidative Stress-Mediated Mechanism.
Wang Y, Gao J, Hu S, Zeng W, Yang H, Chen H, Wang S
Frontiers in oncology 2021;11:682710
Frontiers in oncology 2021;11:682710
ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Cao C, He K, Li S, Ge Q, Liu L, Zhang Z, Zhang H, Wang X, Sun X, Ding L
Cellular signalling 2021 Sep;85:110062
Cellular signalling 2021 Sep;85:110062
Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats.
Otsuka S, Sakakima H, Tani A, Nakanishi K, Takada S, Norimatsu K, Maejima H, Maruyama I
Brain structure & function 2021 Sep;226(7):2169-2180
Brain structure & function 2021 Sep;226(7):2169-2180
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Ge X, Peng X, Li M, Ji F, Chen J, Zhang D
Pathology, research and practice 2021 Sep;225:153580
Pathology, research and practice 2021 Sep;225:153580
CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
Wang Y, Yan F, Nasar A, Chen ZS, Altorki NK, Stiles B, Narula N, Zhou P
The American journal of pathology 2021 Sep;191(9):1638-1650
The American journal of pathology 2021 Sep;191(9):1638-1650
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
Marcus JM, Hossain MI, Gagné JP, Poirier GG, McMahon LL, Cowell RM, Andrabi SA
Neurochemistry international 2021 Sep;148:105077
Neurochemistry international 2021 Sep;148:105077
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.
Li R, Zhu W, Huang P, Yang Y, Luo F, Dai W, Shen L, Pei W, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111803
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111803
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
Yang Z, Sun H, Ma W, Wu K, Peng G, Ou T, Wu S
FEBS open bio 2021 Sep;11(9):2631-2646
FEBS open bio 2021 Sep;11(9):2631-2646
Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1.
Zhu M, Liang Z, Pan J, Zhang X, Xue R, Cao G, Hu X, Gong C
Molecular therapy. Nucleic acids 2021 Sep 3;25:668-682
Molecular therapy. Nucleic acids 2021 Sep 3;25:668-682
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
Yang WB, Wu AC, Hsu TI, Liou JP, Lo WL, Chang KY, Chen PY, Kikkawa U, Yang ST, Kao TJ, Chen RM, Chang WC, Ko CY, Chuang JY
Cell death & disease 2021 Sep 28;12(10):884
Cell death & disease 2021 Sep 28;12(10):884
Androgen-dependent and DNA-binding-independent association of androgen receptor with chromatic regions coding androgen-induced noncoding RNAs.
Sawada T, Nishimura K, Mori J, Kanemoto Y, Kouzmenko A, Amano R, Hayakawa A, Tokiwa S, Shimmura H, Kato S
Bioscience, biotechnology, and biochemistry 2021 Sep 22;85(10):2121-2130
Bioscience, biotechnology, and biochemistry 2021 Sep 22;85(10):2121-2130
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Liu T, Li T, Chen X, Li Z, Feng M, Yao W, Wan L, Zhang C, Zhang Y
Journal of neuroinflammation 2021 Sep 16;18(1):211
Journal of neuroinflammation 2021 Sep 16;18(1):211
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.
Zhang H, Zhao X, Guo Y, Chen R, He J, Li L, Qiang Z, Yang Q, Liu X, Huang C, Lu R, Fang J, Cao Y, Huang J, Wang Y, Huang J, Chen GQ, Cheng J, Yu J
Nature communications 2021 Sep 13;12(1):5416
Nature communications 2021 Sep 13;12(1):5416
Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.
Zhou H, Su H, Chen W
International journal of molecular sciences 2021 Sep 1;22(17)
International journal of molecular sciences 2021 Sep 1;22(17)
Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells.
Amaya C, Luo S, Baigorri J, Baucells R, Smith ER, Xu XX
BMC cancer 2021 Sep 1;21(1):981
BMC cancer 2021 Sep 1;21(1):981
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
Li H, Zhao Z, Li X, Qin L, Wen W, Chen H, Qian P
Virologica Sinica 2021 Oct;36(5):1210-1219
Virologica Sinica 2021 Oct;36(5):1210-1219
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Petrova T, Zhang J, Nanda SK, Figueras-Vadillo C, Cohen P
The FEBS journal 2021 Oct;288(20):5909-5924
The FEBS journal 2021 Oct;288(20):5909-5924
Loss of E-cadherin due to road dust PM2.5 activates the EGFR in human pharyngeal epithelial cells.
Tung NT, Ho KF, Niu X, Sun J, Shen Z, Wu F, Cao J, Dung HB, Thuy TPC, Hsiao TC, Liu WT, Chuang HC
Environmental science and pollution research international 2021 Oct;28(38):53872-53887
Environmental science and pollution research international 2021 Oct;28(38):53872-53887
Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells.
Wang Q, Wu H, Hu J, Fu H, Qu Y, Yang Y, Cai KQ, Efimov A, Wu M, Yen T, Wang Y, Yang ZJ
Molecular cancer research : MCR 2021 Oct;19(10):1651-1665
Molecular cancer research : MCR 2021 Oct;19(10):1651-1665
ORMDL1 is upregulated and associated with favorable outcomes in colorectal cancer.
Wang Q, Liu W, Chen S, Luo Q, Li Y, Peng S, Wang H, Liu X, Chen D
Translational oncology 2021 Oct;14(10):101171
Translational oncology 2021 Oct;14(10):101171
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Lee JE, Kim N, Jung M, Mun JY, Yoo JY
Autophagy 2021 Oct 31;:1-16
Autophagy 2021 Oct 31;:1-16
Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.
Zhang X, Wang Z, Xu Q, Chen Y, Liu W, Zhong T, Li H, Quan C, Zhang L, Cui CP
iScience 2021 Oct 22;24(10):103097
iScience 2021 Oct 22;24(10):103097
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.
Li X, Li X, Xie C, Cai S, Li M, Jin H, Wu S, Cui J, Liu H, Zhao Y
Protein & cell 2021 Oct 22;
Protein & cell 2021 Oct 22;
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle.
Rigillo G, Basile V, Belluti S, Ronzio M, Sauta E, Ciarrocchi A, Latella L, Saclier M, Molinari S, Vallarola A, Messina G, Mantovani R, Dolfini D, Imbriano C
Nature communications 2021 Oct 14;12(1):6013
Nature communications 2021 Oct 14;12(1):6013
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis.
Otsuka S, Setoyama K, Takada S, Nakanishi K, Terashi T, Norimatsu K, Tani A, Sakakima H, Maruyama I, Tancharoen S, Tanaka E, Kikuchi K
Molecular neurobiology 2021 Nov;58(11):5602-5617
Molecular neurobiology 2021 Nov;58(11):5602-5617
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L, Gao S
Cell proliferation 2021 Nov;54(11):e13133
Cell proliferation 2021 Nov;54(11):e13133
Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis.
Hong H, Xiao J, Guo Q, Du J, Jiang Z, Lu S, Zhang H, Zhang X, Wang X
Experimental and therapeutic medicine 2021 Nov;22(5):1326
Experimental and therapeutic medicine 2021 Nov;22(5):1326
Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3.
Wen W, Li X, Yin M, Wang H, Qin L, Li H, Liu W, Zhao Z, Zhao Q, Chen H, Hu J, Qian P
Autophagy 2021 Nov;17(11):3763-3775
Autophagy 2021 Nov;17(11):3763-3775
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Xing Y, Wang L, Xu G, Guo S, Zhang M, Cheng G, Liu Y, Liu J
Research in veterinary science 2021 Nov;140:18-25
Research in veterinary science 2021 Nov;140:18-25
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, Li XD, Li ZY, Liu ZH, Peng YL, Li Z, Jiang LJ, Yao K, Ye YL, Lu WH, Zhang ZL, Zhou FJ, Liu ZW, Xie D, Yu CP
Redox biology 2021 Nov 27;48:102201
Redox biology 2021 Nov 27;48:102201
miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.
Xu H, Cui Y, Liu X, Zheng X, Liu J, Hu X, Gao F, Hu X, Li M, Wei X, Gao Y, Zhao Y
Molecular biology reports 2021 Nov 27;
Molecular biology reports 2021 Nov 27;
Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication.
Du L, Xie Y, Zheng K, Wang N, Gao M, Yu T, Cao L, Shao Q, Zou Y, Xia W, Fang Q, Zhao B, Guo D, Peng X, Pan JA
Redox biology 2021 Nov 26;48:102199
Redox biology 2021 Nov 26;48:102199
Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis.
Zhang J, Chen Y, Yin D, Feng F, An Q, Liu Z, An N, Xu J, Yi J, Gu S, Yin W, Wang Y, Hu X
Stem cell research & therapy 2021 Nov 20;12(1):579
Stem cell research & therapy 2021 Nov 20;12(1):579
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J
eLife 2021 Nov 19;10
eLife 2021 Nov 19;10
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nature communications 2021 Nov 18;12(1):6671
Nature communications 2021 Nov 18;12(1):6671
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
Belluti S, Semeghini V, Rigillo G, Ronzio M, Benati D, Torricelli F, Reggiani Bonetti L, Carnevale G, Grisendi G, Ciarrocchi A, Dominici M, Recchia A, Dolfini D, Imbriano C
Journal of experimental & clinical cancer research : CR 2021 Nov 15;40(1):362
Journal of experimental & clinical cancer research : CR 2021 Nov 15;40(1):362
Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.
Huang GZ, Lu ZY, Rao Y, Gao H, Lv XZ
Journal of cellular and molecular medicine 2021 May;25(9):4444-4454
Journal of cellular and molecular medicine 2021 May;25(9):4444-4454
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Huang C, Hao Q, Shi G, Zhou X, Zhang Y
Journal of molecular cell biology 2021 May 7;13(2):141-150
Journal of molecular cell biology 2021 May 7;13(2):141-150
Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
Chen F, Jiao XF, Meng F, Wang YS, Ding ZM, Miao YL, Xiong JJ, Huo LJ
International journal of molecular sciences 2021 May 3;22(9)
International journal of molecular sciences 2021 May 3;22(9)
One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver.
Sugasawa T, Ono S, Yonamine M, Fujita SI, Matsumoto Y, Aoki K, Nakano T, Tamai S, Yoshida Y, Kawakami Y, Takekoshi K
International journal of molecular sciences 2021 May 29;22(11)
International journal of molecular sciences 2021 May 29;22(11)
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM
Neuron 2021 May 19;109(10):1657-1674.e7
Neuron 2021 May 19;109(10):1657-1674.e7
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y
Cell death discovery 2021 May 16;7(1):107
Cell death discovery 2021 May 16;7(1):107
TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication.
Nie X, Xiao D, Ge Y, Xie Y, Zhou H, Zheng T, Li X, Liu H, Huang H, Zhao Y
Cell death and differentiation 2021 Mar;28(3):1062-1075
Cell death and differentiation 2021 Mar;28(3):1062-1075
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.
Liu Z, Chen Y, Niu B, Yin D, Feng F, Gu S, An Q, Xu J, An N, Zhang J, Yi J, Yin W, Qin X, Hu X
Clinical and translational medicine 2021 Mar;11(3):e373
Clinical and translational medicine 2021 Mar;11(3):e373
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.
Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G, Chan WY, Leung PCK, Qin Y
Molecular therapy. Nucleic acids 2021 Mar 5;23:132-141
Molecular therapy. Nucleic acids 2021 Mar 5;23:132-141
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Deng HX, Zhai H, Shi Y, Liu G, Lowry J, Liu B, Ryan ÉB, Yan J, Yang Y, Zhang N, Yang Z, Liu E, Ma YC, Siddique T
Communications biology 2021 Mar 25;4(1):396
Communications biology 2021 Mar 25;4(1):396
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
Peng Y, Zhang Z, Zhang A, Liu C, Sun Y, Peng Z, Liu Y
Aging 2021 Mar 24;13(7):10312-10325
Aging 2021 Mar 24;13(7):10312-10325
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Shen Z, Ji K, Cai Z, Huang C, He X, Xu H, Chen G
Aging 2021 Mar 19;13(7):9820-9837
Aging 2021 Mar 19;13(7):9820-9837
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants.
Ben Saad A, Vauthier V, Tóth Á, Janaszkiewicz A, Durand-Schneider AM, Bruneau A, Delaunay JL, Lapalus M, Mareux E, Garcin I, Gonzales E, Housset C, Aït-Slimane T, Jacquemin E, Di Meo F, Falguières T
Liver international : official journal of the International Association for the Study of the Liver 2021 Jun;41(6):1344-1357
Liver international : official journal of the International Association for the Study of the Liver 2021 Jun;41(6):1344-1357
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Li SS, Chen DM, Chen LB, Wei H, Wang JL, Xiao J, Huang YH, Lian YF
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
Sun XH, Xiao HM, Zhang M, Lin ZY, Yang Y, Chen R, Liu PQ, Huang KP, Huang HQ
Biochemical pharmacology 2021 Jun;188:114562
Biochemical pharmacology 2021 Jun;188:114562
RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic.
Ben Saad A, Vauthier V, Lapalus M, Mareux E, Bennana E, Durand-Schneider AM, Bruneau A, Delaunay JL, Gonzales E, Housset C, Aït-Slimane T, Guillonneau F, Jacquemin E, Falguières T
International journal of molecular sciences 2021 Jun 30;22(13)
International journal of molecular sciences 2021 Jun 30;22(13)
Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
Wang M, Feng LR, Li ZL, Ma KG, Chang KW, Chen XL, Yang PB, Ji SF, Ma YB, Han H, Ruganzua JB, Yang WN, Qian YH
Journal of neuroinflammation 2021 Jun 28;18(1):146
Journal of neuroinflammation 2021 Jun 28;18(1):146
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells.
Chen C, Lv Q, Li Y, Jin YH
Molecules (Basel, Switzerland) 2021 Jun 27;26(13)
Molecules (Basel, Switzerland) 2021 Jun 27;26(13)
Nuclear Lamin A/C Expression Is a Key Determinant of Paclitaxel Sensitivity.
Smith ER, Leal J, Amaya C, Li B, Xu XX
Molecular and cellular biology 2021 Jun 23;41(7):e0064820
Molecular and cellular biology 2021 Jun 23;41(7):e0064820
Nitrogen-Doped Multiwalled Carbon Nanotubes Enhance Bone Remodeling through Immunomodulatory Functions.
Li H, He D, Xiao X, Yu G, Hu G, Zhang W, Wen X, Lin Y, Li X, Lin H, Diao Y, Tang Y
ACS applied materials & interfaces 2021 Jun 2;13(21):25290-25305
ACS applied materials & interfaces 2021 Jun 2;13(21):25290-25305
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Liu Y, Liang G, Xu H, Dong W, Dong Z, Qiu Z, Zhang Z, Li F, Huang Y, Li Y, Wu J, Yin S, Zhang Y, Guo P, Liu J, Xi JJ, Jiang P, Han D, Yang CG, Xu MM
Cell metabolism 2021 Jun 1;33(6):1221-1233.e11
Cell metabolism 2021 Jun 1;33(6):1221-1233.e11
MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.
Ling Q, Li F, Zhang X, Mao S, Lin X, Pan J, Ye W, Wei W, Qian Y, Hu C, Huang X, Wang J, Wang H, Huang J, Wang Y, Jin J
EBioMedicine 2021 Jul;69:103441
EBioMedicine 2021 Jul;69:103441
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Cousin MA, Creighton BA, Breau KA, Spillmann RC, Torti E, Dontu S, Tripathi S, Ajit D, Edwards RJ, Afriyie S, Bay JC, Harper KM, Beltran AA, Munoz LJ, Falcon Rodriguez L, Stankewich MC, Person RE, Si Y, Normand EA, Blevins A, May AS, Bier L, Aggarwal V, Mancini GMS, van Slegtenhorst MA, Cremer K, Becker J, Engels H, Aretz S, MacKenzie JJ, Brilstra E, van Gassen KLI, van Jaarsveld RH, Oegema R, Parsons GM, Mark P, Helbig I, McKeown SE, Stratton R, Cogne B, Isidor B, Cacheiro P, Smedley D, Firth HV, Bierhals T, Kloth K, Weiss D, Fairley C, Shieh JT, Kritzer A, Jayakar P, Kurtz-Nelson E, Bernier RA, Wang T, Eichler EE, van de Laar IMBH, McConkie-Rosell A, McDonald MT, Kemppainen J, Lanpher BC, Schultz-Rogers LE, Gunderson LB, Pichurin PN, Yoon G, Zech M, Jech R, Winkelmann J, Undiagnosed Diseases Network., Genomics England Research Consortium., Beltran AS, Zimmermann MT, Temple B, Moy SS, Klee EW, Tan QK, Lorenzo DN
Nature genetics 2021 Jul;53(7):1006-1021
Nature genetics 2021 Jul;53(7):1006-1021
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J
Immunology 2021 Jul;163(3):278-292
Immunology 2021 Jul;163(3):278-292
HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response.
Zhang L, Huang F, Liu J, Xu Y, Miao Y, Yuan Y, Chen X, Zhang HG, Wang J, Zheng H, Zuo Y
Molecular immunology 2021 Jul;135:28-35
Molecular immunology 2021 Jul;135:28-35
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Zhang W, Zhang R, Zeng Y, Li Y, Chen Y, Zhou J, Zhang Y, Wang A, Zhu J, Liu Z, Yan Z, Huang JA
Cell death & disease 2021 Jul 31;12(8):755
Cell death & disease 2021 Jul 31;12(8):755
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X
Cell reports 2021 Jul 27;36(4):109421
Cell reports 2021 Jul 27;36(4):109421
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3.
Luo MT, Mu D, Yang X, Luo RH, Zheng HY, Chen M, Guo YQ, Zheng YT
Journal of virology 2021 Jul 26;95(16):e0002021
Journal of virology 2021 Jul 26;95(16):e0002021
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Chang H, Xu Q, Li J, Li M, Zhang Z, Ma H, Yang X
Cell death & disease 2021 Jul 21;12(8):725
Cell death & disease 2021 Jul 21;12(8):725
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
Yu L, Liu S, Wang C, Zhang C, Wen Y, Zhang K, Chen S, Huang H, Liu Y, Wu L, Han Z, Chen X, Li Z, Liu N
Stem cell research & therapy 2021 Jul 2;12(1):379
Stem cell research & therapy 2021 Jul 2;12(1):379
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Wen W, Li X, Wang H, Zhao Q, Yin M, Liu W, Chen H, Qian P
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):189-199
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):189-199
Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.
Gan W, Li X, Cui Y, Xiao T, Liu R, Wang M, Wei Y, Cui M, Ren S, Helian K, Ning W, Zhou H, Yang C
International immunopharmacology 2021 Jan;90:107230
International immunopharmacology 2021 Jan;90:107230
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR
Science advances 2021 Jan;7(5)
Science advances 2021 Jan;7(5)
The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
Goss KL, Koppenhafer SL, Waters T, Terry WW, Wen KK, Wu M, Ostergaard J, Gordon PM, Gordon DJ
Oncogene 2021 Jan;40(3):564-577
Oncogene 2021 Jan;40(3):564-577
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands.
Wang Y, Zhang H, Luo L, Zhou Y, Cao J, Xuan X, Suzuki H, Zhou J
PLoS neglected tropical diseases 2021 Jan;15(1):e0009074
PLoS neglected tropical diseases 2021 Jan;15(1):e0009074
Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).
Chen D, Liu L, Lu Y, Chen S
Bioorganic chemistry 2021 Jan;106:104495
Bioorganic chemistry 2021 Jan;106:104495
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA
The Journal of biological chemistry 2021 Jan-Jun;296:100355
The Journal of biological chemistry 2021 Jan-Jun;296:100355
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Liu X, Ge J, Chen C, Shen Y, Xie J, Zhu X, Liu M, Hu J, Chen L, Guo L, Zhou Q, Yan X, Qiu Y, Wan R, Marian AJ, Hong K
Cell death & disease 2021 Jan 5;12(1):25
Cell death & disease 2021 Jan 5;12(1):25
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases.
De Cesare V, Carbajo Lopez D, Mabbitt PD, Fletcher AJ, Soetens M, Antico O, Wood NT, Virdee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X
JCI insight 2021 Jan 25;6(2)
JCI insight 2021 Jan 25;6(2)
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
Suh BK, Lee SA, Park C, Suh Y, Kim SJ, Woo Y, Nhung TTM, Lee SB, Mun DJ, Goo BS, Choi HS, Kim SJ, Park SK
Molecular brain 2021 Jan 18;14(1):14
Molecular brain 2021 Jan 18;14(1):14
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
Chen H, Sa G, Li L, He S, Wu T
European journal of pharmacology 2021 Jan 15;891:173757
European journal of pharmacology 2021 Jan 15;891:173757
Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses.
Kang J, Pang Z, Zhou Z, Li X, Liu S, Cheng J, Liu P, Tan W, Wang Z, Wang T
Journal of virology 2021 Jan 13;95(3)
Journal of virology 2021 Jan 13;95(3)
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Li Y, Zhao Y, Li Y, Zhang X, Li C, Long N, Chen X, Bao L, Zhou J, Xie Y
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Liu Y, Huang Z, Wei Y, Zhang M, Li X, Yang S, Wang H
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells.
Zhang Y, Elechalawar CK, Hossen MN, Francek ER, Dey A, Wilhelm S, Bhattacharya R, Mukherjee P
Bioactive materials 2021 Feb;6(2):326-332
Bioactive materials 2021 Feb;6(2):326-332
BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.
Cheng Q, Feng Q, Xu Y, Zuo Y, Liu J, Yuan Y, Miao Y, Liu Y, Lei L, Guo T, Zhang L, Wu D, Zheng H
European journal of immunology 2021 Feb;51(2):296-310
European journal of immunology 2021 Feb;51(2):296-310
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G
Life science alliance 2021 Feb;4(2)
Life science alliance 2021 Feb;4(2)
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.
Guo X, Ma P, Li Y, Yang Y, Wang C, Xu T, Wang H, Li C, Mao B, Qi X
Cell death and differentiation 2021 Feb;28(2):640-656
Cell death and differentiation 2021 Feb;28(2):640-656
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.
Liu Y, Wang Y, Liu J, Kang R, Tang D
Cancer gene therapy 2021 Feb;28(1-2):55-63
Cancer gene therapy 2021 Feb;28(1-2):55-63
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Wu H, Chen Y, Li B, Li C, Guo J, You J, Hu X, Kuang D, Qi S, Liu P, Li L, Xu C
Biochemical pharmacology 2021 Feb;184:114353
Biochemical pharmacology 2021 Feb;184:114353
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Qi L, Zhang Y, Song F, Han Y, Ding Y
Bioorganic chemistry 2021 Feb;107:104625
Bioorganic chemistry 2021 Feb;107:104625
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
Lee SB, Park J, Kwak Y, Park YU, Nhung TTM, Suh BK, Woo Y, Suh Y, Cho E, Cho S, Park SK
Translational psychiatry 2021 Feb 4;11(1):110
Translational psychiatry 2021 Feb 4;11(1):110
p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X
Cell death & disease 2021 Feb 24;12(2):204
Cell death & disease 2021 Feb 24;12(2):204
Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment.
Zhou M, Zheng H, Li Y, Huang H, Min X, Dai S, Zhou W, Chen Z, Xu G, Chen Y
Aging 2021 Feb 17;13(5):6982-6998
Aging 2021 Feb 17;13(5):6982-6998
Ginsenoside Rb1 protected PC12 cells from Aβ25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction.
Changhong K, Peng Y, Yuan Z, Cai J
European journal of pharmacology 2021 Feb 15;893:173835
European journal of pharmacology 2021 Feb 15;893:173835
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.
Otsu K, Ida-Yonemochi H, Ikezaki S, Ema M, Hitomi J, Ohshima H, Harada H
Development (Cambridge, England) 2021 Feb 15;148(4)
Development (Cambridge, England) 2021 Feb 15;148(4)
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.
Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X
Investigative ophthalmology & visual science 2021 Feb 1;62(2):31
Investigative ophthalmology & visual science 2021 Feb 1;62(2):31
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
Ibe NU, Subramanian A, Mukherjee S
Life science alliance 2021 Dec;4(12)
Life science alliance 2021 Dec;4(12)
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Liu F, Pan R, Ding H, Gu L, Yang Y, Li C, Xu Y, Hu R, Chen H, Zhang X, Nie Y
Molecular oncology 2021 Dec;15(12):3738-3752
Molecular oncology 2021 Dec;15(12):3738-3752
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266
Molecular immunology 2021 Dec;140:250-266
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
Ni T, Zhang Q, Li Y, Huang C, Zhou T, Yan J, Chen ZJ
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANASIM-Associated Proteins in Hypoxia.
Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q
mSystems 2021 Dec 21;6(6):e0110921
mSystems 2021 Dec 21;6(6):e0110921
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H
iScience 2021 Dec 17;24(12):103396
iScience 2021 Dec 17;24(12):103396
Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter.
Chen JN, He YD, Liang HT, Cai TT, Chen Q, Zheng KW
Nucleic acids research 2021 Dec 16;49(22):12634-12643
Nucleic acids research 2021 Dec 16;49(22):12634-12643
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069
The EMBO journal 2021 Dec 15;40(24):e108069
Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-κB pathway and mitochondrial dysfunction.
Luo H, Gu R, Ouyang H, Wang L, Shi S, Ji Y, Bao B, Liao G, Xu B
Environmental pollution (Barking, Essex : 1987) 2021 Dec 1;290:118043
Environmental pollution (Barking, Essex : 1987) 2021 Dec 1;290:118043
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Zhang X, Zhang Y, Pan J, Zhu M, Liang Z, Shen Z, Dai K, Yan B, Dai Y, Xue R, Cao G, Hu X, Gong C
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
He X, Gao F, Hou J, Li T, Tan J, Wang C, Liu X, Wang M, Liu H, Chen Y, Yu Z, Yang M
The Journal of biological chemistry 2021 Aug;297(2):101002
The Journal of biological chemistry 2021 Aug;297(2):101002
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Xu L, Xu W, Li D, Yu X, Gao F, Qin Y, Yang Y, Zhao S
Cell death & disease 2021 Aug 9;12(8):780
Cell death & disease 2021 Aug 9;12(8):780
Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.
Jia H, Yang Y, Li M, Chu Y, Song H, Zhang J, Zhang D, Zhang Q, Xu Y, Wang J, Xu H, Zou X, Peng H, Hou Z
EMBO reports 2021 Aug 4;22(8):e51780
EMBO reports 2021 Aug 4;22(8):e51780
Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands.
Hu S, Wang Y, Xu Z, Zhou Y, Cao J, Zhang H, Zhou J
Parasites & vectors 2021 Aug 4;14(1):386
Parasites & vectors 2021 Aug 4;14(1):386
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.
Sun X, He Z, Guo L, Wang C, Lin C, Ye L, Wang X, Li Y, Yang M, Liu S, Hua X, Wen W, Lin C, Long Z, Zhang W, Li H, Jian Y, Zhu Z, Wu X, Lin H
Journal of experimental & clinical cancer research : CR 2021 Apr 30;40(1):149
Journal of experimental & clinical cancer research : CR 2021 Apr 30;40(1):149
Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy.
Xie S, Sun W, Zhang C, Dong B, Yang J, Hou M, Xiong L, Cai B, Liu X, Xue W
ACS nano 2021 Apr 27;15(4):7179-7194
ACS nano 2021 Apr 27;15(4):7179-7194
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Cai Y, Gu WT, Cheng K, Jia PF, Li F, Wang M, Zhang WF, Qiu JT, Wu ZB, Zhao WG
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression.
Schmitt BM, Boewe AS, Götz C, Philipp SE, Urbschat S, Oertel J, Menger MD, Laschke MW, Ampofo E
Cancers 2021 Apr 2;13(7)
Cancers 2021 Apr 2;13(7)
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model.
Chen M, Lu C, Lu H, Zhang J, Qin D, Liu S, Li X, Zhang L
Stem cell research & therapy 2021 Apr 12;12(1):232
Stem cell research & therapy 2021 Apr 12;12(1):232
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Jiang W, Ma P, Deng L, Liu Z, Wang X, Liu X, Long G
Journal of extracellular vesicles 2020;9(1):1716513
Journal of extracellular vesicles 2020;9(1):1716513
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Zhang T, Li H, Wang K, Xu B, Chen ZN, Bian H
Frontiers in cell and developmental biology 2020;8:784
Frontiers in cell and developmental biology 2020;8:784
Oxytocin Alleviates MPTP-Induced Neurotoxicity in Mice by Targeting MicroRNA-26a/Death-Associated Protein Kinase 1 Pathway.
Almansoub HAMM, Tang H, Wu Y, Wang DQ, Mahaman YAR, Salissou MTM, Lu Y, Hu F, Zhou LT, Almansob YAM, Liu D
Journal of Alzheimer's disease : JAD 2020;74(3):883-901
Journal of Alzheimer's disease : JAD 2020;74(3):883-901
β-Actin facilitates etoposide-induced p53 nuclear import.
Qi W, Li J, Pei X, Ke Y, Bu Q, Ni X
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Zhang Z, Yu X, Zhou B, Zhang J, Chang J
BioMed research international 2020;2020:5103272
BioMed research international 2020;2020:5103272
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Geng N, Wang X, Yu X, Wang R, Zhu Y, Zhang M, Liu J, Liu Y
Frontiers in immunology 2020;11:746
Frontiers in immunology 2020;11:746
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Zhang HG, Guo J, Yuan Y, Zuo Y, Liu J, Zhu L, Miao Y, Chen X, Jin L, Huang F, Ren T, He J, Shi W, Wen Z, Zhu C, Zheng H, Dong C, Qian F
Frontiers in microbiology 2020;11:597972
Frontiers in microbiology 2020;11:597972
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Wen W, Zhao Q, Yin M, Qin L, Hu J, Chen H, Li X, Qian P
Frontiers in immunology 2020;11:577838
Frontiers in immunology 2020;11:577838
Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha.
Yu X, Wang S, Wang J, Gong J, Shi J, Yu S
Pharmacology 2020;105(5-6):360-368
Pharmacology 2020;105(5-6):360-368
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
ITM2A as a Tumor Suppressor and Its Correlation With PD-L1 in Breast Cancer.
Zhang R, Xu T, Xia Y, Wang Z, Li X, Chen W
Frontiers in oncology 2020;10:581733
Frontiers in oncology 2020;10:581733
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
Qin T, Cheng L, Xiao Y, Qian W, Li J, Wu Z, Wang Z, Xu Q, Duan W, Wong L, Wu E, Ma Q, Ma J
Frontiers in oncology 2020;10:1038
Frontiers in oncology 2020;10:1038
A role of cellular translation regulation associated with toxic Huntingtin protein.
Joag H, Ghatpande V, Desai M, Sarkar M, Raina A, Shinde M, Chitale R, Deo A, Bose T, Majumdar A
Cellular and molecular life sciences : CMLS 2020 Sep;77(18):3657-3670
Cellular and molecular life sciences : CMLS 2020 Sep;77(18):3657-3670
The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress.
Chen KL, Wang Y, Lin ZP, Li HX
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):635-641
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):635-641
SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A, Yu J
Molecular oncology 2020 Sep;14(9):2288-2312
Molecular oncology 2020 Sep;14(9):2288-2312
Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
Li SB, Liu YY, Yuan L, Ji MF, Zhang A, Li HY, Tang LQ, Fang SG, Zhang H, Xing S, Li MZ, Zhong Q, Lin SJ, Liu WL, Huang P, Zeng YX, Zheng YM, Ling ZQ, Sui JH, Zeng MS
EMBO molecular medicine 2020 Sep 7;12(9):e12050
EMBO molecular medicine 2020 Sep 7;12(9):e12050
A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Maltby CJ, Schofield JPR, Houghton SD, O'Kelly I, Vargas-Caballero M, Deinhardt K, Coldwell MJ
Nucleic acids research 2020 Sep 25;48(17):9822-9839
Nucleic acids research 2020 Sep 25;48(17):9822-9839
Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
Qian G, Zhu L, Huang C, Liu Y, Ren Y, Ding Y, Qian W, Xu Q, Zheng H, Lv H
International immunopharmacology 2020 Oct;87:106763
International immunopharmacology 2020 Oct;87:106763
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.
Zhao X, Wang Y, He J, Deng R, Huang X, Guo Y, Li L, Xie R, Yu J
Molecular carcinogenesis 2020 Oct;59(10):1174-1187
Molecular carcinogenesis 2020 Oct;59(10):1174-1187
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Yong XLH, Cousin MA, Anggono V
Cell reports 2020 Oct 27;33(4):108312
Cell reports 2020 Oct 27;33(4):108312
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Ye C, Xiong W, Lei CT, Tang H, Su H, Yi F, Zhang C
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Zhong X, Ma Z, Su Y, Li Z, Liao Y, Pan X, Zang L, Zhou S
Life sciences 2020 Oct 1;258:118156
Life sciences 2020 Oct 1;258:118156
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Xu D, Liu L, Zhao Y, Yang L, Cheng J, Hua R, Zhang Z, Li Q
Journal of pineal research 2020 Nov;69(4):e12690
Journal of pineal research 2020 Nov;69(4):e12690
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
Zheng T, Zhou H, Li X, Peng D, Yang Y, Zeng Y, Liu H, Ren J, Zhao Y
Cell death and differentiation 2020 Nov;27(11):3162-3176
Cell death and differentiation 2020 Nov;27(11):3162-3176
MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency.
Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y
Journal of cellular physiology 2020 Nov;235(11):8826-8838
Journal of cellular physiology 2020 Nov;235(11):8826-8838
Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
Li XH, Chai RR, Chen GW, Zhang LF, Tan-Tai WJ, Shi HJ, Martin-DeLeon PA, O WS, Chen H
Asian journal of andrology 2020 Nov-Dec;22(6):583-589
Asian journal of andrology 2020 Nov-Dec;22(6):583-589
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Nuclear import of NLS- RARα is mediated by importin α/β.
Ye J, Zhong L, Xiong L, Li J, Yu L, Dan W, Yuan Z, Yao J, Zhong P, Liu J, Liu D, Liu B
Cellular signalling 2020 May;69:109567
Cellular signalling 2020 May;69:109567
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Science advances 2020 May;6(21):eaax3333
Science advances 2020 May;6(21):eaax3333
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Tang K, Li S, Li P, Xia Q, Yang R, Li T, Li L, Jiang Y, Qin X, Yang H, Wu C, You F, Tan Y, Liu Y
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.
Ke C, Hou H, Li J, Su K, Huang C, Lin Y, Lu Z, Du Z, Tan W, Yuan Z
Cancers 2020 May 4;12(5)
Cancers 2020 May 4;12(5)
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress.
Zhang J, Duan H, Feng Z, Han X, Gu C
Oncogenesis 2020 May 12;9(5):46
Oncogenesis 2020 May 12;9(5):46
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C, Yan Q, Shen S, Li X, Ma J
Journal of immunology (Baltimore, Md. : 1950) 2020 May 1;204(9):2589-2599
Journal of immunology (Baltimore, Md. : 1950) 2020 May 1;204(9):2589-2599
A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.
Fan J, Ji CC, Cheng YJ, Yao H, Chen XM, Zheng ZH, Wu SH
International journal of molecular medicine 2020 Mar;45(3):947-955
International journal of molecular medicine 2020 Mar;45(3):947-955
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
Yuan Y, Miao Y, Zeng C, Liu J, Chen X, Qian L, Wang X, Qian F, Yu Z, Wang J, Qian G, Fu Q, Lv H, Zheng H
Immunology 2020 Mar;159(3):309-321
Immunology 2020 Mar;159(3):309-321
A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
Liu DM, Cao ZX, Yan HL, Li W, Yang F, Zhao WJ, Diao QC, Tan YZ
Fitoterapia 2020 Mar;141:104484
Fitoterapia 2020 Mar;141:104484
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Park SY, Koh HC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells.
Teratake Y, Takashina T, Iijima K, Sakuma T, Yamamoto T, Ishizaka Y
British journal of cancer 2020 Mar;122(6):823-834
British journal of cancer 2020 Mar;122(6):823-834
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Zhao JF, Rodger CE, Allen GFG, Weidlich S, Ganley IG
Cell stress 2020 Mar 4;4(5):99-113
Cell stress 2020 Mar 4;4(5):99-113
Structural basis for DEAH-helicase activation by G-patch proteins.
Studer MK, Ivanović L, Weber ME, Marti S, Jonas S
Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 31;117(13):7159-7170
Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 31;117(13):7159-7170
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H
Nature communications 2020 Mar 2;11(1):1146
Nature communications 2020 Mar 2;11(1):1146
Generation and Application of Mouse Monoclonal Antibody Against Human Cytomegalovirus UL23.
Li W, Chai H, Feng L, Deng J, Yang X, Ran Y, Li H
Viral immunology 2020 Jun;33(5):378-383
Viral immunology 2020 Jun;33(5):378-383
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
Li YQ, Chen Y, Xu YF, He QM, Yang XJ, Li YQ, Hong XH, Huang SY, Tang LL, Liu N
Cancer science 2020 Jun;111(6):1991-2003
Cancer science 2020 Jun;111(6):1991-2003
Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides.
Wang Y, Hu S, Tuerdi M, Yu X, Zhang H, Zhou Y, Cao J, da Silva Vaz I Jr, Zhou J
Parasites & vectors 2020 Jun 5;13(1):288
Parasites & vectors 2020 Jun 5;13(1):288
RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling.
Ma P, An T, Zhu L, Zhang L, Wang H, Ren B, Sun B, Zhou X, Li Y, Mao B
Development (Cambridge, England) 2020 Jun 15;147(21)
Development (Cambridge, England) 2020 Jun 15;147(21)
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT.
Huang GZ, Wu QQ, Zheng ZN, Shao TR, Chen YC, Zeng WS, Lv XZ
Aging 2020 Jun 11;12(12):11667-11684
Aging 2020 Jun 11;12(12):11667-11684
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
Liu H, Xie S, Fang F, Kalvakolanu DV, Xiao W
Cell death & disease 2020 Jun 10;11(6):445
Cell death & disease 2020 Jun 10;11(6):445
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Shim MS, Nettesheim A, Hirt J, Liton PB
Autophagy 2020 Jul;16(7):1248-1261
Autophagy 2020 Jul;16(7):1248-1261
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Sun X, Huang K, Haiming X, Lin Z, Yang Y, Zhang M, Liu P, Huang H
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.
Sun Y, Pan H, Shen S, Xia Z, Yu Z, Li C, Sun P, Xin C
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 16;26:e921738
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 16;26:e921738
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Slemmons KK, Yeung C, Baumgart JT, Juarez JOM, McCalla A, Helman LJ
Cancer research 2020 Jul 15;80(14):3046-3056
Cancer research 2020 Jul 15;80(14):3046-3056
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation.
Tsai MH, Cheng HY, Nian FS, Liu C, Chao NH, Chiang KL, Chen SF, Tsai JW
Acta neuropathologica communications 2020 Jul 14;8(1):106
Acta neuropathologica communications 2020 Jul 14;8(1):106
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Su H, Ye C, Lei CT, Tang H, Zeng JY, Yi F, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
Koppenhafer SL, Goss KL, Terry WW, Gordon DJ
Molecular cancer research : MCR 2020 Jan;18(1):91-104
Molecular cancer research : MCR 2020 Jan;18(1):91-104
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Liu J, Jin L, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C, Zheng H
PLoS pathogens 2020 Jan;16(1):e1008215
PLoS pathogens 2020 Jan;16(1):e1008215
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
Lee S, Park H, Zhu PP, Jung SY, Blackstone C, Chang J
Science signaling 2020 Jan 7;13(613)
Science signaling 2020 Jan 7;13(613)
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
Yomtoubian S, Lee SB, Verma A, Izzo F, Markowitz G, Choi H, Cerchietti L, Vahdat L, Brown KA, Andreopoulou E, Elemento O, Chang J, Inghirami G, Gao D, Ryu S, Mittal V
Cell reports 2020 Jan 21;30(3):755-770.e6
Cell reports 2020 Jan 21;30(3):755-770.e6
High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy.
Su P, Ying M, Han Z, Xia J, Jin S, Li Y, Wang H, Xu F
Molecular brain 2020 Jan 13;13(1):5
Molecular brain 2020 Jan 13;13(1):5
A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia.
Wang X, Wang Y, Li L, Xue X, Xie H, Shi H, Hu Y
Oncogene 2020 Feb;39(9):1860-1874
Oncogene 2020 Feb;39(9):1860-1874
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway.
Ni R, Song G, Fu X, Song R, Li L, Pu W, Gao J, Hu J, Liu Q, He F, Zhang D, Huang G
Biomaterials 2020 Feb;232:119730
Biomaterials 2020 Feb;232:119730
Murine Cytomegalovirus Protein pM49 Interacts with pM95 and Is Critical for Viral Late Gene Expression.
Han T, Hao H, Sleman SS, Xuan B, Tang S, Yue N, Qian Z
Journal of virology 2020 Feb 28;94(6)
Journal of virology 2020 Feb 28;94(6)
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Yuan Y, Miao Y, Qian L, Zhang Y, Liu C, Liu J, Zuo Y, Feng Q, Guo T, Zhang L, Chen X, Jin L, Huang F, Zhang H, Zhang W, Li W, Xu G, Zheng H
Molecular cell 2020 Feb 20;77(4):734-747.e7
Molecular cell 2020 Feb 20;77(4):734-747.e7
Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.
Hong X, Liu N, Liang Y, He Q, Yang X, Lei Y, Zhang P, Zhao Y, He S, Wang Y, Li J, Li Q, Ma J, Li Y
Molecular cancer 2020 Feb 15;19(1):33
Molecular cancer 2020 Feb 15;19(1):33
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity.
Zachari M, Longo M, Ganley IG
Life science alliance 2020 Dec;3(12)
Life science alliance 2020 Dec;3(12)
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Lv W, Jin J, Xu Z, Luo H, Guo Y, Wang X, Wang S, Zhang J, Zuo H, Bai W, Peng Y, Tang J, Zhao S, Zuo B
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway.
Fujii A, Sunatani Y, Furuichi K, Fujimoto K, Adachi H, Iwabuchi K, Yokoyama H
Scientific reports 2020 Dec 17;10(1):22206
Scientific reports 2020 Dec 17;10(1):22206
USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity.
Peng Y, Guo J, Sun T, Fu Y, Zheng H, Dong C, Xiong S
Journal of immunology (Baltimore, Md. : 1950) 2020 Dec 1;205(11):3167-3178
Journal of immunology (Baltimore, Md. : 1950) 2020 Dec 1;205(11):3167-3178
Downregulation of miR-146b-5p via iodine involvement repressed papillary thyroid carcinoma cell proliferation.
Pan Y, Yun W, Shi B, Cui R, Liu C, Ding Z, Fan J, Jiang W, Tang J, Zheng T, Yu X, Liu Y
Journal of molecular endocrinology 2020 Aug;65(2):1-10
Journal of molecular endocrinology 2020 Aug;65(2):1-10
Dual-engineered, "Trojanized" macrophages bio-modally eradicate tumors through biologically and photothermally deconstructing cancer cells in an on-demand, NIR-commanded, self-explosive manner.
Huang L, Yan W, Cai B, Song Y, Lv Q, Wang G, Wang L, Wang Z
Biomaterials 2020 Aug;250:120021
Biomaterials 2020 Aug;250:120021
ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo.
Li M, Fan Y, Wang Y, Xu J, Xu H
Experimental and therapeutic medicine 2020 Aug;20(2):1371-1378
Experimental and therapeutic medicine 2020 Aug;20(2):1371-1378
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, Ren J, Wang W, Zhao Y
Molecular cell 2020 Aug 6;79(3):425-442.e7
Molecular cell 2020 Aug 6;79(3):425-442.e7
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD.
Li S, Wu Z, Li Y, Tantray I, De Stefani D, Mattarei A, Krishnan G, Gao FB, Vogel H, Lu B
Cell reports 2020 Aug 4;32(5):107989
Cell reports 2020 Aug 4;32(5):107989
GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
Guo S, Chunyu Lv, Ouyang S, Wang X, Liao A, Yuan S
Biochemical and biophysical research communications 2020 Aug 27;529(3):642-646
Biochemical and biophysical research communications 2020 Aug 27;529(3):642-646
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Arreal L, Piva M, Fernández S, Revandkar A, Schaub-Clerigué A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zúñiga-García P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A
Cell death and differentiation 2020 Apr;27(4):1186-1199
Cell death and differentiation 2020 Apr;27(4):1186-1199
Effects of peptidoglycan on the development of steatohepatitis.
Jin M, Lai Y, Zhao P, Shen Q, Su W, Yin Y, Zhang W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Domínguez JM, Pérez-Chacón G, Guillén MJ, Muñoz-Alonso MJ, Somovilla-Crespo B, Cibrián D, Acosta-Iborra B, Adrados M, Muñoz-Calleja C, Cuevas C, Sánchez-Madrid F, Avilés P, Zapata JM
Journal of hematology & oncology 2020 Apr 7;13(1):32
Journal of hematology & oncology 2020 Apr 7;13(1):32
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME
EMBO molecular medicine 2020 Apr 7;12(4):e11101
EMBO molecular medicine 2020 Apr 7;12(4):e11101
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi Y, Kurita A, Yamashita R, Takamatsu T, Ikushiro S, Mackenzie PI, Tanaka Y, Ishii Y
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis.
Aoudjehane L, Gautheron J, Le Goff W, Goumard C, Gilaizeau J, Nget CS, Savier E, Atif M, Lesnik P, Morichon R, Chrétien Y, Calmus Y, Scatton O, Housset C, Conti F
Disease models & mechanisms 2020 Apr 29;13(4)
Disease models & mechanisms 2020 Apr 29;13(4)
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Tang H, Chu Y, Huang Z, Cai J, Wang Z
Carcinogenesis 2020 Apr 22;41(2):182-193
Carcinogenesis 2020 Apr 22;41(2):182-193
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.
Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X, Jiang C, Gao S
Nature communications 2020 Apr 14;11(1):1813
Nature communications 2020 Apr 14;11(1):1813
CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH
Theranostics 2019;9(26):8392-8408
Theranostics 2019;9(26):8392-8408
The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.
Cheng F, Zhang P, Xiao Q, Li Y, Dong M, Wang H, Kuang D, He Y, Duan Q, Mao F, Wang B, Guo D
Frontiers in oncology 2019;9:447
Frontiers in oncology 2019;9:447
Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.
Liu N, Tong X, Huang W, Fu J, Xue X
BioMed research international 2019;2019:5249675
BioMed research international 2019;2019:5249675
Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome.
Chang HY, Cheng HY, Tsao AN, Liu C, Tsai JW
Frontiers in molecular neuroscience 2019;12:265
Frontiers in molecular neuroscience 2019;12:265
Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation.
Zhang J, Li L, Zhang Q, Yang X, Zhang C, Zhang X, Zhang D, Lv Y, Song H, Chen B, Liu Y, Hu J, Huang Y
Frontiers in pharmacology 2019;10:368
Frontiers in pharmacology 2019;10:368
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Nian FS, Li LL, Cheng CY, Wu PC, Lin YT, Tang CY, Ren BS, Tai CY, Fann MJ, Kao LS, Hong CJ, Tsai JW
Molecular neurobiology 2019 Sep;56(9):6095-6105
Molecular neurobiology 2019 Sep;56(9):6095-6105
Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I.
Wen W, Yin M, Zhang H, Liu T, Chen H, Qian P, Hu J, Li X
Virology 2019 Sep;535:122-129
Virology 2019 Sep;535:122-129
Preparation and identification of polyclonal antibody against human cytomegalovirus encoding protein UL23.
Chai H, Wu S, Deng J, Feng L, Yang X, Ran Y, Li H
Protein expression and purification 2019 Sep;161:78-83
Protein expression and purification 2019 Sep;161:78-83
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Martin-Hurtado A, Martin-Morales R, Robledinos-Antón N, Blanco R, Palacios-Blanco I, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR
Scientific reports 2019 Sep 25;9(1):13896
Scientific reports 2019 Sep 25;9(1):13896
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.
Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y, Fan Z
The EMBO journal 2019 Sep 2;38(17):e101110
The EMBO journal 2019 Sep 2;38(17):e101110
Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1.
Sun L, Büeler H
Biochemical and biophysical research communications 2019 Sep 17;517(2):376-382
Biochemical and biophysical research communications 2019 Sep 17;517(2):376-382
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
Xu D, Jiang X, He H, Liu D, Yang L, Chen H, Wu L, Geng G, Li Q
Life sciences 2019 Sep 1;232:116639
Life sciences 2019 Sep 1;232:116639
Vacuolar protein sorting 4 is required for silkworm metamorphosis.
Xia H, Chen L, Shao D, Liu X, Wang Q, Zhu F, Guo Z, Gao L, Chen K
Insect molecular biology 2019 Oct;28(5):728-738
Insect molecular biology 2019 Oct;28(5):728-738
Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.
Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer SL, Cullen JJ, Buettner GR
Molecular cancer research : MCR 2019 Oct;17(10):2102-2114
Molecular cancer research : MCR 2019 Oct;17(10):2102-2114
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
Li C, Chen W, Zheng L, Zhang B, Yang X, Zhang Q, Wang N, Wang Y, Yang J, Sha J, Zhou Z, Li X, Li Y, Shen XL
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
Guo T, Zuo Y, Qian L, Liu J, Yuan Y, Xu K, Miao Y, Feng Q, Chen X, Jin L, Zhang L, Dong C, Xiong S, Zheng H
Nature microbiology 2019 Nov;4(11):1872-1884
Nature microbiology 2019 Nov;4(11):1872-1884
PARP11 regulates total levels of type-I interferon receptor IFNAR1.
Guo T, Liu J, Chen X, Jin L, Huang F, Zheng H
Nature microbiology 2019 Nov;4(11):1771-1773
Nature microbiology 2019 Nov;4(11):1771-1773
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma.
Liu Y, Azizian NG, Dou Y, Pham LV, Li Y
Journal of hematology & oncology 2019 Nov 21;12(1):119
Journal of hematology & oncology 2019 Nov 21;12(1):119
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade.
Tsai YT, Wu AC, Yang WB, Kao TJ, Chuang JY, Chang WC, Hsu TI
International journal of molecular sciences 2019 Nov 11;20(22)
International journal of molecular sciences 2019 Nov 11;20(22)
DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella.
Li Y, Sha Y, Wang X, Ding L, Liu W, Ji Z, Mei L, Huang X, Lin S, Kong S, Lu J, Qin W, Zhang X, Zhuang J, Tang Y, Lu Z
Clinical genetics 2019 May;95(5):590-600
Clinical genetics 2019 May;95(5):590-600
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Yu X, Wu J, Hu M, Wu J, Zhu Q, Yang Z, Xie X, Feng YQ, Yue J
The international journal of biochemistry & cell biology 2019 May;110:111-121
The international journal of biochemistry & cell biology 2019 May;110:111-121
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM
eLife 2019 May 28;8
eLife 2019 May 28;8
p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma.
Wang T, Li K, Song H, Xu D, Liao Y, Jing B, Guo W, Hu M, Kuang Y, Sun B, Ling J, Zhang T, Xu J, Yao F, Deng J
Biochemical and biophysical research communications 2019 May 28;513(2):319-325
Biochemical and biophysical research communications 2019 May 28;513(2):319-325
Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication.
Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S, Wei F, Cai Q
Cell death & disease 2019 May 21;10(6):392
Cell death & disease 2019 May 21;10(6):392
Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Yukawa M, Okazaki M, Teratani Y, Furuta K, Toda T
Scientific reports 2019 May 14;9(1):7336
Scientific reports 2019 May 14;9(1):7336
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Otsuka S, Sakakima H, Terashi T, Takada S, Nakanishi K, Kikuchi K
Brain structure & function 2019 Mar;224(2):727-738
Brain structure & function 2019 Mar;224(2):727-738
Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis.
Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q
Cell reports 2019 Mar 26;26(13):3657-3671.e5
Cell reports 2019 Mar 26;26(13):3657-3671.e5
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, Hua R, Geng G, Yang L, Li Q
International journal of molecular sciences 2019 Mar 18;20(6)
International journal of molecular sciences 2019 Mar 18;20(6)
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
Terashi T, Otsuka S, Takada S, Nakanishi K, Ueda K, Sumizono M, Kikuchi K, Sakakima H
Neurological research 2019 Jun;41(6):510-518
Neurological research 2019 Jun;41(6):510-518
Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes.
Colicino EG, Stevens K, Curtis E, Rathbun L, Bates M, Manikas J, Amack J, Freshour J, Hehnly H
Molecular biology of the cell 2019 Jun 15;30(13):1598-1609
Molecular biology of the cell 2019 Jun 15;30(13):1598-1609
Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S
Human molecular genetics 2019 Jun 1;28(11):1822-1836
Human molecular genetics 2019 Jun 1;28(11):1822-1836
Tranilast enhances the effect of anticancer agents in osteosarcoma.
Nakashima T, Nagano S, Setoguchi T, Sasaki H, Saitoh Y, Maeda S, Komiya S, Taniguchi N
Oncology reports 2019 Jul;42(1):176-188
Oncology reports 2019 Jul;42(1):176-188
WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Zhang S, Song Z, An L, Liu X, Hu XW, Naz A, Zhou R, Guo X, He L, Zhu H
Cardiovascular research 2019 Jul 1;115(8):1320-1331
Cardiovascular research 2019 Jul 1;115(8):1320-1331
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O
Developmental cell 2019 Jan 28;48(2):184-199.e5
Developmental cell 2019 Jan 28;48(2):184-199.e5
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis.
Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X, Yu J
Oncogene 2019 Feb;38(9):1410-1431
Oncogene 2019 Feb;38(9):1410-1431
m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.
Xu D, Chen P, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L, Zhang W
American journal of physiology. Renal physiology 2019 Feb 1;316(2):F382-F395
American journal of physiology. Renal physiology 2019 Feb 1;316(2):F382-F395
Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Woo Y, Kim SJ, Suh BK, Kwak Y, Jung HJ, Nhung TTM, Mun DJ, Hong JH, Noh SJ, Kim S, Lee A, Baek ST, Nguyen MD, Choe Y, Park SK
eLife 2019 Dec 9;8
eLife 2019 Dec 9;8
Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis.
Wang Y, Guo Y, Tang C, Han X, Xu M, Sun J, Zhao Y, Zhang Y, Wang M, Cao X, Zhu X, Guo W
Cell reports 2019 Dec 3;29(10):3101-3117.e7
Cell reports 2019 Dec 3;29(10):3101-3117.e7
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Hanáková K, Bernatík O, Kravec M, Micka M, Kumar J, Harnoš J, Ovesná P, Paclíková P, Rádsetoulal M, Potěšil D, Tripsianes K, Čajánek L, Zdráhal Z, Bryja V
Cell communication and signaling : CCS 2019 Dec 23;17(1):170
Cell communication and signaling : CCS 2019 Dec 23;17(1):170
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Hao H, Han T, Xuan B, Sun Y, Tang S, Yue N, Qian Z
Journal of virology 2019 Dec 15;93(24)
Journal of virology 2019 Dec 15;93(24)
Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality.
Liu X, Zhang S, An L, Wu J, Hu X, Lai S, Mazhar H, Zou Y, He L, Zhu H
International journal of cardiology 2019 Dec 1;296:129-135
International journal of cardiology 2019 Dec 1;296:129-135
CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice.
Liu S, Liu X, Xiong H, Wang W, Liu Y, Yin L, Tu C, Wang H, Xiang X, Xu J, Duan B, Tao A, Zhao Z, Mei Z
Brain, behavior, and immunity 2019 Aug;80:711-724
Brain, behavior, and immunity 2019 Aug;80:711-724
TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ.
Lu H, Xiao J, Ke C, Ni X, Xiu R, Tian Q, Pan H, Zou L, Wang F, Ma T, Ji X, Yuan P, Liu L, Zhang J, Jia W, Duan Q, Zhu F
Cell death & disease 2019 Aug 5;10(8):583
Cell death & disease 2019 Aug 5;10(8):583
CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.
Li H, Jin X, Liu B, Zhang P, Chen W, Li Q
BMC cancer 2019 Aug 22;19(1):826
BMC cancer 2019 Aug 22;19(1):826
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, Aït-Slimane T, Meijer L, Falguières T
Scientific reports 2019 Apr 30;9(1):6653
Scientific reports 2019 Apr 30;9(1):6653
The Legionella effector RavD binds phosphatidylinositol-3-phosphate and helps suppress endolysosomal maturation of the Legionella-containing vacuole.
Pike CM, Boyer-Andersen R, Kinch LN, Caplan JL, Neunuebel MR
The Journal of biological chemistry 2019 Apr 19;294(16):6405-6415
The Journal of biological chemistry 2019 Apr 19;294(16):6405-6415
β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, Zhang L, Wang J, Zheng H
Frontiers in immunology 2018;9:2930
Frontiers in immunology 2018;9:2930
A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5+ intestinal stem cell maintenance.
Li Y, Liu Y, Liu B, Wang J, Wei S, Qi Z, Wang S, Fu W, Chen YG
Cell discovery 2018;4:49
Cell discovery 2018;4:49
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Li Y, Wu J, Yu X, Na S, Li K, Yang Z, Xie X, Yang J, Yue J
Oxidative medicine and cellular longevity 2018;2018:2917981
Oxidative medicine and cellular longevity 2018;2018:2917981
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy.
Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng B, Xie J, Zhang B
Drug design, development and therapy 2018;12:1255-1268
Drug design, development and therapy 2018;12:1255-1268
Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity.
Chen YA, Lu IL, Tsai JW
Frontiers in molecular neuroscience 2018;11:422
Frontiers in molecular neuroscience 2018;11:422
Murine Cytomegalovirus Protein pM91 Interacts with pM79 and Is Critical for Viral Late Gene Expression.
Pan D, Han T, Tang S, Xu W, Bao Q, Sun Y, Xuan B, Qian Z
Journal of virology 2018 Sep 15;92(18)
Journal of virology 2018 Sep 15;92(18)
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.
Mana-Capelli S, McCollum D
The Journal of biological chemistry 2018 Nov 23;293(47):18230-18241
The Journal of biological chemistry 2018 Nov 23;293(47):18230-18241
EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer.
Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, Huang J, Ma J
Cell death & disease 2018 Nov 19;9(12):1146
Cell death & disease 2018 Nov 19;9(12):1146
UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment.
Yu Q, Zhang H, Li Y, Liu C, Wang S, Liao X
Molecular neurobiology 2018 May;55(5):3812-3821
Molecular neurobiology 2018 May;55(5):3812-3821
A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function.
Cui X, Zhou Z, Zhu K, Feng R, Han J, Li M, Wang S, Li J, Zhang J, Jiang Q, Zhang W, Mu H, Liu Y, Hu Y
DNA and cell biology 2018 May;37(5):449-456
DNA and cell biology 2018 May;37(5):449-456
Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents.
Zhang L, Zhao Y, Wang J, Yang D, Zhao C, Wang C, Ma C, Cheng M
European journal of medicinal chemistry 2018 May 10;151:27-38
European journal of medicinal chemistry 2018 May 10;151:27-38
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.
Jheng GW, Hur SS, Chang CM, Wu CC, Cheng JS, Lee HH, Chung BC, Wang YK, Lin KH, Del Álamo JC, Chien S, Tsai JW
Biochemical and biophysical research communications 2018 Mar 11;497(3):869-875
Biochemical and biophysical research communications 2018 Mar 11;497(3):869-875
Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes.
Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, An N, Liu Z, Weng L, Chen S, Hu X, Yin W
EBioMedicine 2018 Jun;32:31-42
EBioMedicine 2018 Jun;32:31-42
Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Dai W, Miller WP, Toro AL, Black AJ, Dierschke SK, Feehan RP, Kimball SR, Dennis MD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;:fj201800413RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;:fj201800413RR
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
Jin W, Jin W, Pan D
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG
Cancer cell 2018 Jun 11;33(6):1004-1016.e5
Cancer cell 2018 Jun 11;33(6):1004-1016.e5
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
Wang D, Xiong M, Chen C, Du L, Liu Z, Shi Y, Zhang M, Gong J, Song X, Xiang R, Liu E, Tan X
Kidney international 2018 Jul;94(1):91-101
Kidney international 2018 Jul;94(1):91-101
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Zhang P, Song Y, Sun Y, Li X, Chen L, Yang L, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478
Proteomics 2018 Jul;18(14):e1700478
High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake.
Yen CH, Chang HS, Yang TH, Wang SF, Wu HC, Chen YC, Lin KJ, Wang S
International journal of molecular sciences 2018 Jul 22;19(7)
International journal of molecular sciences 2018 Jul 22;19(7)
MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6.
Dang Y, Wang X, Hao Y, Zhang X, Zhao S, Ma J, Qin Y, Chen ZJ
Cell death & disease 2018 Jan 24;9(2):106
Cell death & disease 2018 Jan 24;9(2):106
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H
Nature medicine 2018 Feb;24(2):213-223
Nature medicine 2018 Feb;24(2):213-223
Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.
Li W, Zhu W, Lv C, Qu H, Xu K, Li H, Li H, Du Y, Liu G, Wang Y, Wei HJ, Zhao HY
Oncology letters 2018 Feb;15(2):1881-1887
Oncology letters 2018 Feb;15(2):1881-1887
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG
Cell metabolism 2018 Feb 6;27(2):439-449.e5
Cell metabolism 2018 Feb 6;27(2):439-449.e5
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, Deng M, Huang Y
Cell death & disease 2018 Feb 2;9(2):141
Cell death & disease 2018 Feb 2;9(2):141
PMLIV overexpression promotes TGF-β-associated epithelial-mesenchymal transition and migration in MCF-7 cancer cells.
Liu Y, Wang JX, Huang D, Wang B, Li LL, Li XX, Ni P, Dong XL, Xia W, Yu CX, Xu WL, Chu WF, Zhao D
Journal of cellular physiology 2018 Dec;233(12):9575-9583
Journal of cellular physiology 2018 Dec;233(12):9575-9583
mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Koppenhafer SL, Goss KL, Terry WW, Gordon DJ
Molecular cancer therapeutics 2018 Dec;17(12):2676-2688
Molecular cancer therapeutics 2018 Dec;17(12):2676-2688
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.
Hsiao CJ, Chang CH, Ibrahim RB, Lin IH, Wang CH, Wang WJ, Tsai JW
Journal of cell science 2018 Dec 17;131(24)
Journal of cell science 2018 Dec 17;131(24)
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Chen C, Deng Y, Hu X, Ren H, Zhu J, Fu S, Xie J, Peng Y
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
Anillin is required for tumor growth and regulated by miR-15a/miR-16-1 in HBV-related hepatocellular carcinoma.
Lian YF, Huang YL, Wang JL, Deng MH, Xia TL, Zeng MS, Chen MS, Wang HB, Huang YH
Aging 2018 Aug 9;10(8):1884-1901
Aging 2018 Aug 9;10(8):1884-1901
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Kincaid RP, Lam VL, Chirayil RP, Randall G, Sullivan CS
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 7;115(32):8197-8202
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 7;115(32):8197-8202
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L, Chen S
FEBS letters 2018 Apr;592(8):1400-1411
FEBS letters 2018 Apr;592(8):1400-1411
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Ma Y, Yuan S, Tian X, Lin S, Wei S, Hu T, Chen S, Li X, Chen S, Wu D, Wang M, Guo D
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Qian G, Hu X, Li G, Ding Y, Zhu L, Zheng H, Li M, Li Z, Pan J, Li Y, Li G, Yang C, Liu Y, Xie Y, Lv H
Biochemical and biophysical research communications 2018 Apr 6;498(3):537-543
Biochemical and biophysical research communications 2018 Apr 6;498(3):537-543
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Quercetin attenuates AZT-induced neuroinflammation in the CNS.
Yang Y, Liu X, Wu T, Zhang W, Shu J, He Y, Tang SJ
Scientific reports 2018 Apr 18;8(1):6194
Scientific reports 2018 Apr 18;8(1):6194
MCPIP1 is a positive regulator of type I interferons antiviral activity.
Qian L, Zuo Y, Deng W, Miao Y, Liu J, Yuan Y, Guo T, Zhang L, Jin J, Wang J, Zheng H
Biochemical and biophysical research communications 2018 Apr 15;498(4):891-897
Biochemical and biophysical research communications 2018 Apr 15;498(4):891-897
CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.
Shi WP, Ju D, Li H, Yuan L, Cui J, Luo D, Chen ZN, Bian H
International journal of molecular sciences 2018 Apr 10;19(4)
International journal of molecular sciences 2018 Apr 10;19(4)
Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner.
Allgood SC, Romero Dueñas BP, Noll RR, Pike C, Lein S, Neunuebel MR
Frontiers in cellular and infection microbiology 2017;7:397
Frontiers in cellular and infection microbiology 2017;7:397
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
CMIP Promotes Proliferation and Metastasis in Human Glioma.
Wang B, Wu ZS, Wu Q
BioMed research international 2017;2017:5340160
BioMed research international 2017;2017:5340160
TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.
Wang JL, Qi Z, Li YH, Zhao HM, Chen YG, Fu W
Oncotarget 2017 Sep 19;8(41):70214-70225
Oncotarget 2017 Sep 19;8(41):70214-70225
MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Ji HP, Xiong Y, Song WT, Zhang ED, Gao ZL, Yao F, Su T, Zhou RR, Xia XB
Scientific reports 2017 Sep 12;7(1):11374
Scientific reports 2017 Sep 12;7(1):11374
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
Goss KL, Koppenhafer SL, Harmoney KM, Terry WW, Gordon DJ
Oncotarget 2017 Oct 20;8(50):87016-87032
Oncotarget 2017 Oct 20;8(50):87016-87032
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B, Yu J
Molecular cancer 2017 Oct 11;16(1):157
Molecular cancer 2017 Oct 11;16(1):157
IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.
Dang X, Zhu Q, He Y, Wang Y, Lu Y, Li X, Qi J, Wu H, Sun Y
Endocrinology 2017 Oct 1;158(10):3281-3291
Endocrinology 2017 Oct 1;158(10):3281-3291
MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3.
Bian H, Li F, Wang W, Zhao Q, Gao S, Ma J, Li X, Ren W, Qin C, Qi J
International journal of molecular medicine 2017 Nov;40(5):1495-1503
International journal of molecular medicine 2017 Nov;40(5):1495-1503
Hydrogen peroxide promotes the expression of angiopoietin like 4 in RAW264.7 macrophages via MAPK pathways.
Liu N, Cui C, Sun Y, Zhang F, Wang S, Su G, Cai X
Molecular medicine reports 2017 Nov;16(5):6128-6133
Molecular medicine reports 2017 Nov;16(5):6128-6133
Tectorigenin attenuates the MPP+-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.
Gong P, Deng F, Zhang W, Ji J, Liu J, Sun Y, Hu J
Experimental and therapeutic medicine 2017 Nov;14(5):4431-4437
Experimental and therapeutic medicine 2017 Nov;14(5):4431-4437
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R
Experimental cell research 2017 Nov 15;360(2):243-256
Experimental cell research 2017 Nov 15;360(2):243-256
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development.
Xia H, Shao D, Liu X, Wang Q, Zhou Y, Chen K
Journal of insect science (Online) 2017 May 1;17(3)
Journal of insect science (Online) 2017 May 1;17(3)
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
Liu G, Zhou L, Zhang H, Chen R, Zhang Y, Li L, Lu JY, Jiang H, Liu D, Qi S, Jiang YM, Yin K, Xie Z, Shi Y, Liu Y, Cao X, Chen YX, Zou D, Zhang WJ
Nature communications 2017 Mar 22;8:14824
Nature communications 2017 Mar 22;8:14824
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Yu Z, Sun Y, She X, Wang Z, Chen S, Deng Z, Zhang Y, Liu Q, Liu Q, Zhao C, Li P, Liu C, Feng J, Fu H, Li G, Wu M
Journal of hematology & oncology 2017 Jun 8;10(1):115
Journal of hematology & oncology 2017 Jun 8;10(1):115
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Wu T, Zhang J, Geng M, Tang SJ, Zhang W, Shu J
Scientific reports 2017 Jun 23;7(1):4117
Scientific reports 2017 Jun 23;7(1):4117
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Zhang C, Mao HL, Cao Y
Scientific reports 2017 Jun 19;7(1):3769
Scientific reports 2017 Jun 19;7(1):3769
Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.
Xie P, Yang JP, Cao Y, Peng LX, Zheng LS, Sun R, Meng DF, Wang MY, Mei Y, Qiang YY, Cao L, Xiang YQ, Luo DH, Yun JP, Huang BJ, Jia LJ, Qian CN
Cell death & disease 2017 Jun 1;8(6):e2834
Cell death & disease 2017 Jun 1;8(6):e2834
Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.
Yu H, Zhang X, Liu R, Li H, Xiao X, Zhou Y, Wei C, Yang M, Liao M, Zhao J, Xia Z, Liao Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712102
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712102
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.
Pirone L, Xolalpa W, Sigurðsson JO, Ramirez J, Pérez C, González M, de Sabando AR, Elortza F, Rodriguez MS, Mayor U, Olsen JV, Barrio R, Sutherland JD
Scientific reports 2017 Jan 18;7:40756
Scientific reports 2017 Jan 18;7:40756
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fan W, Liu T, Li X, Zhou Y, Wu M, Cui X, Chen H, Qian P
Molecular immunology 2017 Feb;82:114-122
Molecular immunology 2017 Feb;82:114-122
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Wang Y, Gu YH, Liu M, Bai Y, Wang HL
Molecular medicine reports 2017 Feb;15(2):673-680
Molecular medicine reports 2017 Feb;15(2):673-680
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Nakano M, Tamura Y, Yamato M, Kume S, Eguchi A, Takata K, Watanabe Y, Kataoka Y
Scientific reports 2017 Feb 14;7:42041
Scientific reports 2017 Feb 14;7:42041
Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
Yin J, Wang F, Kong Y, Wu R, Zhang G, Wang N, Wang L, Lu Z, Liang M
Journal of cellular and molecular medicine 2017 Dec;21(12):3506-3514
Journal of cellular and molecular medicine 2017 Dec;21(12):3506-3514
MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling.
Tang H, Lei CT, Ye C, Gao P, Wan C, Chen S, He FF, Wang YM, Su H, Zhang C
Journal of cellular and molecular medicine 2017 Dec;21(12):3435-3444
Journal of cellular and molecular medicine 2017 Dec;21(12):3435-3444
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Cifuentes-Muñoz N, Branttie J, Slaughter KB, Dutch RE
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K, Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L, Shieh J
Human molecular genetics 2017 Dec 15;26(24):4849-4860
Human molecular genetics 2017 Dec 15;26(24):4849-4860
A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.
Wang Z, Xia X, Yang X, Zhang X, Liu Y, Wu D, Fang Y, Liu Y, Xu J, Qiu Y, Zhou X
eLife 2017 Dec 12;6
eLife 2017 Dec 12;6
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.
Ma P, Ren B, Yang X, Sun B, Liu X, Kong Q, Li C, Mao B
Open biology 2017 Aug;7(8)
Open biology 2017 Aug;7(8)
Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma.
Li J, Chen H, Li X, Wang L, Gao A, Zhang P, Lin W, Gao W, Yang D, Guo X, Liu J, Dang Q, Sun Y
Molecular medicine reports 2017 Aug;16(2):1643-1652
Molecular medicine reports 2017 Aug;16(2):1643-1652
Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor.
Zhao P, Guo T, Qian L, Wang X, Yuan Y, Cheng Q, Zuo Y, Liu J, Miao Y, Feng Q, Zhang L, Wu S, Zheng H
Antiviral research 2017 Aug;144:120-129
Antiviral research 2017 Aug;144:120-129
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H
Scientific reports 2017 Aug 16;7(1):8474
Scientific reports 2017 Aug 16;7(1):8474
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133
Oncotarget 2017 Aug 1;8(31):51123-51133
Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant.
Wang L, Liu L, Qin L, Luo Q, Zhang Z
Science China. Life sciences 2017 Apr;60(4):333-344
Science China. Life sciences 2017 Apr;60(4):333-344
A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Tsai MH, Kuo PW, Myers CT, Li SW, Lin WC, Fu TY, Chang HY, Mefford HC, Chang YC, Tsai JW
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2016 Sep;20(5):788-94
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2016 Sep;20(5):788-94
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
El Najjar F, Cifuentes-Muñoz N, Chen J, Zhu H, Buchholz UJ, Moncman CL, Dutch RE
PLoS pathogens 2016 Sep;12(9):e1005922
PLoS pathogens 2016 Sep;12(9):e1005922
Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells.
Li Y, Liu YH, Hu YY, Chen L, Li JM
World journal of gastroenterology 2016 Oct 14;22(38):8528-8539
World journal of gastroenterology 2016 Oct 14;22(38):8528-8539
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.
Li L, Qian G, Zuo Y, Yuan Y, Cheng Q, Guo T, Liu J, Liu C, Zhang L, Zheng H
The Journal of biological chemistry 2016 Nov 25;291(48):24974-24985
The Journal of biological chemistry 2016 Nov 25;291(48):24974-24985
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
Hsu CC, Chang WC, Hsu TI, Liu JJ, Yeh SH, Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY
Journal of biomedical science 2016 Nov 18;23(1):81
Journal of biomedical science 2016 Nov 18;23(1):81
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Fritsch J, Fickers R, Klawitter J, Särchen V, Zingler P, Adam D, Janssen O, Krause E, Schütze S
Oncotarget 2016 Nov 15;7(46):75774-75789
Oncotarget 2016 Nov 15;7(46):75774-75789
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts.
Wang B, Sun J, Shi J, Guo Q, Tong X, Zhang J, Hu N, Hu Y
Journal of biomolecular screening 2016 Jul;21(6):634-42
Journal of biomolecular screening 2016 Jul;21(6):634-42
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H
PLoS pathogens 2016 Jul;12(7):e1005764
PLoS pathogens 2016 Jul;12(7):e1005764
Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring.
Park C, Lee SA, Hong JH, Suh Y, Park SJ, Suh BK, Woo Y, Choi J, Huh JW, Kim YM, Park SK
Molecular brain 2016 Jul 2;9(1):69
Molecular brain 2016 Jul 2;9(1):69
Influence of miR-30b regulating humoral immune response by genetic difference.
Duan ZQ, Shi JD, Wu MN, Hu NZ, Hu YZ
Immunologic research 2016 Feb;64(1):181-90
Immunologic research 2016 Feb;64(1):181-90
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX, Lu LM
Acta pharmacologica Sinica 2016 Feb;37(2):217-27
Acta pharmacologica Sinica 2016 Feb;37(2):217-27
Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.
Mukhopadhyay C, Triplett A, Bargar T, Heckman C, Wagner KU, Naramura M
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):E8228-E8237
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):E8228-E8237
State estimation and prediction using clustered particle filters.
Lee Y, Majda AJ
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):14609-14614
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):14609-14614
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Chen B, Liu J, Ho TT, Ding X, Mo YY
Oncogenesis 2016 Dec 12;5(12):e279
Oncogenesis 2016 Dec 12;5(12):e279
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D
Nature chemical biology 2016 Apr;12(4):218-25
Nature chemical biology 2016 Apr;12(4):218-25
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.
Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F, He QY, Zhang G, Wang T
Journal of proteome research 2015 Sep 4;14(9):3645-57
Journal of proteome research 2015 Sep 4;14(9):3645-57
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J
Nucleic acids research 2015 Sep 18;43(16):7945-60
Nucleic acids research 2015 Sep 18;43(16):7945-60
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Wang Z, Wu D, Liu Y, Xia X, Gong W, Qiu Y, Yang J, Zheng Y, Li J, Wang YF, Xiang Y, Hu Y, Zhou X
Science advances 2015 Oct;1(9):e1500228
Science advances 2015 Oct;1(9):e1500228
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z
Journal of virology 2015 Mar;89(6):3049-61
Journal of virology 2015 Mar;89(6):3049-61
Increased stathmin expression strengthens fear conditioning in epileptic rats.
Zhang L, Feng D, Tao H, DE X, Chang Q, Hu Q
Biomedical reports 2015 Jan;3(1):28-32
Biomedical reports 2015 Jan;3(1):28-32
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Lu M, Wu J, He F, Wang XL, Li C, Chen ZN, Bian H
Journal of molecular histology 2015 Feb;46(1):79-91
Journal of molecular histology 2015 Feb;46(1):79-91
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates.
Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Ed Dami T, Berti A, Stefani M, Casamenti F
Neurobiology of aging 2015 Feb;36(2):648-63
Neurobiology of aging 2015 Feb;36(2):648-63
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.
Li D, Wang X, Lan X, Li Y, Liu L, Yi J, Li J, Sun Q, Wang Y, Li H, Zhong N, Holmdahl R, Lu S
Molecular and cellular endocrinology 2015 Feb 15;402:1-12
Molecular and cellular endocrinology 2015 Feb 15;402:1-12
Analysis of grayscale characteristics in images of labeled microtubules from cultured cardiac myocytes.
Dang Y, Lan X, Zhang Q, Li L, Huang Y
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2015 Apr;21(2):334-42
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2015 Apr;21(2):334-42
TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.
Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu HH, Chu M, Li W, Zhuang G, Gao WQ
Oncotarget 2014 Oct 15;5(19):9498-513
Oncotarget 2014 Oct 15;5(19):9498-513
Modulation of amylose content by structure-based modification of OsGBSS1 activity in rice (Oryza sativa L.).
Liu D, Wang W, Cai X
Plant biotechnology journal 2014 Dec;12(9):1297-307
Plant biotechnology journal 2014 Dec;12(9):1297-307
Axl receptor tyrosine kinase expression in breast cancer.
D'Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ
Journal of clinical pathology 2014 Aug;67(8):690-6
Journal of clinical pathology 2014 Aug;67(8):690-6
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.
Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J, Yu J
The FEBS journal 2014 Aug;281(16):3766-75
The FEBS journal 2014 Aug;281(16):3766-75
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Yunlei Z, Zhe C, Yan L, Pengcheng W, Yanbo Z, Le S, Qianjin L
Molecular and cellular biochemistry 2013 Feb;374(1-2):81-9
Molecular and cellular biochemistry 2013 Feb;374(1-2):81-9
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The alpha Tubulin antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human alpha Tubulin. This antibody recognizes human,mouse,rat antigen. The alpha Tubulin antibody has been validated for the following applications: ELISA, IHC, IF, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot of Hela cell with anti-Tubulin-Alpha (66031-1-Ig) at various dilutions.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TUBA1B antibody 66031-1-lg at 1:50 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 66031-1-Ig(Tubulin-Alpha antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 66031-1-Ig(Tubulin-Alpha antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
