Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS8265 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HPD polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human HPD.
- Description
- HPPD (4-hydroxyphenylpyruvate dioxygenase), also known as PPD, GLOD3 or HPD, is a 393 amino acid protein that belongs to the 4HPPD family and is involved in amino acid degradation. Existing as a homodimer, HPPD uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding HPPD are the cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK), both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures (associated with TYRO3) and hair and urine abnormalities (associated with HAWK). The gene encoding HPPD maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of HPD polyclonal antibody