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- References [5]
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- Product number
- ABIN2839143 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 6-36), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 6-36, N-Term
- Antibody clone number
- RB04106
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation.
Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
He L, Yang N, Isales CM, Shi XM
PloS one 2012;7(3):e31717
PloS one 2012;7(3):e31717
Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.
Schwamborn JC, Müller M, Becker AH, Püschel AW
The EMBO journal 2007 Mar 7;26(5):1410-22
The EMBO journal 2007 Mar 7;26(5):1410-22
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R
Proceedings of the National Academy of Sciences of the United States of America 2001 Jan 30;98(3):974-9
Proceedings of the National Academy of Sciences of the United States of America 2001 Jan 30;98(3):974-9
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.
Lin X, Liang M, Feng XH
The Journal of biological chemistry 2000 Nov 24;275(47):36818-22
The Journal of biological chemistry 2000 Nov 24;275(47):36818-22
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL
Molecular cell 2000 Dec;6(6):1365-75
Molecular cell 2000 Dec;6(6):1365-75
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Supportive validation
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- Experimental details
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
